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OvoA from ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities

Authors: Ronghai Cheng, Andrew C Weitz, Jared Paris, Yijie Tang, Jingyu Zhang, Heng Song, Nathchar Naowarojna, Kelin Li, Lu Qiao, Juan Lopez, Mark W Grinstaff, Lixin Zhang, Yisong Guo, Sean Elliott, Pinghua Liu

Journal: Chem Sci

PubMed ID: 35432880

Doi: 10.1039/d1sc05479a

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Structure of BrxA from Staphylococcus aureus, a bacilliredoxin involved in redox homeostasis in Firmicutes

Authors: Colin S McHugh, Paul D Cook

Journal: Acta Crystallogr F Struct Biol Commun

PubMed ID: 35400666

Doi: 10.1107/S2053230X22002400

Products & Services: Mutant Libraries

Identifying Function Determining Residues in Neuroimmune Semaphorin 4A

Authors: Svetlana P Chapoval, Mariah Lee, Aaron Lemmer, Oluwaseyi Ajayi, Xiulan Qi, Andrew F Neuwald, Achsah D Keegan

Journal: Int J Mol Sci

PubMed ID: 35328445

Doi: 10.3390/ijms23063024

Products & Services: Mutant Libraries

Melatonin Regulates Lipid Metabolism in Porcine Cumulus-Oocyte Complexes via the Melatonin Receptor 2

Authors: Jun-Xue Jin, Jing-Tao Sun, Chao-Qian Jiang, Hong-Di Cui, Ya Bian, Sanghoon Lee, Lianjin Zhang, Byeong Chun Lee, Zhong-Hua Liu

Journal: Antioxidants (Basel)

PubMed ID: 35453372

Doi: 10.3390/antiox11040687

Products & Services: Protein and Antibody Isolation

MicroRNA-378 contributes to osteoarthritis by regulating chondrocyte autophagy and bone marrow mesenchymal stem cell chondrogenesis

Authors: Lu Feng, Zhengmeng Yang, Yucong Li, Qi Pan, Xiaoting Zhang, Xiaomin Wu, Jessica Hiu Tung Lo, Haixing Wang, Shanshan Bai, Xuan Lu, Ming Wang, Sien Lin, Xiaohua Pan, Gang Li

Journal: Mol Ther Nucleic Acids

PubMed ID: 35474736

Doi: 10.1016/j.omtn.2022.03.016

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Neddylation is essential for β-catenin degradation in Wnt signaling pathway

Authors: Bojun Wang, Tiantian Wang, Huimin Zhu, Rong Yan, Xinru Li, Chengqian Zhang, Wanyu Tao, Xisong Ke, Piliang Hao, Yi Qu

Journal: Cell Rep

PubMed ID: 35320710

Doi: 10.1016/j.celrep.2022.110538

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Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury

Authors: Kurt Bachmaier, Andrew Stuart, Abhalaxmi Singh, Amitabha Mukhopadhyay, Sreeparna Chakraborty, Zhigang Hong, Li Wang, Yoshikazu Tsukasaki, Mark Maienschein-Cline, Balaji B Ganesh, Prasad Kanteti, Jalees Rehman, Asrar B Malik

Journal: ACS Nano

PubMed ID: 35230826

Doi: 10.1021/acsnano.1c09762

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Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

Authors: Zi-Wei Ye, Chon Phin Ong, Kaiming Tang, Yilan Fan, Cuiting Luo, Runhong Zhou, Peng Luo, Yun Cheng, Victor Sebastien Gray, Pui Wang, Hin Chu, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Honglin Chen, Zhiwei Chen, Kwok-Yung Yuen, Guang Sheng Ling, Shuofeng Yuan, Dong-Yan Jin

Journal: Cell Mol Immunol

PubMed ID: 35352010

Doi: 10.1038/s41423-022-00855-4

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Use of a Novel Detection Tool to Survey Orthohantaviruses in Wild-Caught Rodent Populations

Authors: Samuel M Goodfellow, Robert A Nofchissey, Chunyan Ye, Jonathan L Dunnum, Joseph A Cook, Steven B Bradfute

Journal: Viruses

PubMed ID: 35458412

Doi: 10.3390/v14040682

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Method for quantification of porcine type I interferon activity using luminescence, by direct and indirect means

Authors: Michael Puckette, J Barrera, M Schwarz, M Rasmussen

Journal: BMC Biotechnol

PubMed ID: 35351081

Doi: 10.1186/s12896-022-00743-9

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Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels

Authors: Neha Singh, András Zeke, Attila Reményi

Journal: Int J Mol Sci

PubMed ID: 35328741

Doi: 10.3390/ijms23063320

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Monomodular Pseudomonas aeruginosa phage JG004 lysozyme (Pae87) contains a bacterial surface-active antimicrobial peptide-like region and a possible substrate-binding subdomain

Authors: Roberto Vázquez, Mateo Seoane-Blanco, Virginia Rivero-Buceta, Susana Ruiz, Mark J van Raaij, Pedro García

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35362467

Doi: 10.1107/S2059798322000936

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An ArsRC fusion protein enhances arsenate sensing and detoxification

Authors: Jian Chen, Adriana E Galván, Venkadesh Sarkarai Nadar, Masafumi Yoshinaga, Barry P Rosen

Journal: Environ Microbiol

PubMed ID: 35229439

Doi: 10.1111/1462-2920.15957

Products & Services: Plasmid DNA Preparation

miR-2055 regulates lipid metabolism via fatty acid synthase expression

Authors: Yang Cheng, Tengfei Lu, Junliang Guo, Zhe Lin, Qiao Jin, Xiaoming Zhang, Zhen Zou

Journal: Open Biol

PubMed ID: 35232249

Doi: 10.1098/rsob.210307

Products & Services: Gene Synthesis

Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice

Authors: Saurav S Rout, Yunyun Di, Ulf Dittmer, Kathrin Sutter, Kerry J Lavender

Journal: AIDS

PubMed ID: 35084382

Doi: 10.1097/QAD.0000000000003111

Products & Services: Endotoxin Detection & Removal System

Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cells

Authors: Hang Yang, Huijun Yuan, Xiaohui Zhao, Meng Xun, Shangrui Guo, Nan Wang, Bing Liu, Hongliang Wang

Journal: Virol Sin

PubMed ID: 35272059

Doi: 10.1016/j.virs.2022.03.003

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Aquaporin OsPIP2;2 links the H2O2 signal and a membrane-anchored transcription factor to promote plant defense

Authors: Mou Zhang, Haotian Shi, Ningning Li, Nana Wei, Yan Tian, Jinfeng Peng, Xiaochen Chen, Liyuan Zhang, Meixiang Zhang, Hansong Dong

Journal: Plant Physiol

PubMed ID: 34958388

Doi: 10.1093/plphys/kiab604

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CD4+ T cells from COVID-19 mRNA vaccine recipients recognize a conserved epitope present in diverse coronaviruses

Authors: Bezawit A Woldemeskel, Arbor G Dykema, Caroline C Garliss, Saphira Cherfils, Kellie N Smith, Joel N Blankson

Journal: J Clin Invest

PubMed ID: 35061630

Doi: 10.1172/JCI156083

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Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

Authors: Rachid Essalmani, Jaspreet Jain, Delia Susan-Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David N Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Etienne Decroly, Tram Nq Pham, Éric A Cohen, Nabil G Seidah

Journal: J Virol

PubMed ID: 35343766

Doi: 10.1128/jvi.00128-22

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Combined Subcutaneous-Intranasal Immunization With Epitope-Based Antigens Elicits Binding and Neutralizing Antibody Responses in Serum and Mucosae Against PRRSV-2 and SARS-CoV-2

Authors: Mario Fragoso-Saavedra, Carmen Ramírez-Estudillo, Diana L Peláez-González, Jorge O Ramos-Flores, Gustavo Torres-Franco, Leandro Núñez-Muñoz, Gabriel Marcelino-Pérez, María G Segura-Covarrubias, Rogelio González-González, Roberto Ruiz-Medrano, Beatriz Xoconostle-Cázares, Amanda Gayosso-Vázquez, Silvia Reyes-Maya, Vianey Ramírez-Andoney, Rogelio A Alonso-Morales, Marco A Vega-López

Journal: Front Immunol

PubMed ID: 35432364

Doi: 10.3389/fimmu.2022.848054

Genetically engineered pH-responsive silk sericin nanospheres with efficient therapeutic effect on ulcerative colitis

Authors: Sheng Xu, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Huanhuan Tan, Ping Zhao, David L Kaplan, Feng Wang, Qingyou Xia

Journal: Acta Biomater

PubMed ID: 35288310

Doi: 10.1016/j.actbio.2022.03.012

Products & Services: Protein and Antibody Isolation

SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women

Authors: Youri Lee, Gabrielle Grubbs, Sabrina C Ramelli, Andrea R Levine, Allison Bathula, Kapil Saharia, Madeleine Purcell, Shreya Singireddy, Colleen L Dugan, Lindsey Kirchoff, Allison Lankford, Sarah Cipriano, Ryan A Curto, Jocelyn Wu, Katherine Raja, Emily Kelley, Daniel Herr, Kevin M Vannella, Supriya Ravichandran, Juanjie Tang, Anthony Harris, Mohammad Sajadi, Daniel S Chertow, Alison Grazioli, Surender Khurana

Journal: EBioMedicine

PubMed ID: 35301181

Doi: 10.1016/j.ebiom.2022.103940

Products & Services: Catalog Antibodies

Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention

Authors: Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang

Journal: Stem Cell Res Ther

PubMed ID: 35313965

Doi: 10.1186/s13287-022-02787-2

Products & Services: Gene Fragments

CTNNBL1 restricts HIV-1 replication by suppressing viral DNA integration into the cell genome

Authors: Guoxin Liang, Yang He, Li Zhao, Jiayue Ouyang, Wenqing Geng, Xiaowei Zhang, Xiaoxu Han, Yongjun Jiang, Haibo Ding, Ying Xiong, Jinxiu Dong, Mei Liu, Hong Shang

Journal: Cell Rep

PubMed ID: 35294870

Doi: 10.1016/j.celrep.2022.110533

Products & Services: Plasmid DNA Preparation

RNA chain length and stoichiometry govern surface tension and stability of protein-RNA condensates

Authors: Rabia Laghmach, Ibraheem Alshareedah, Matthew Pham, Muralikrishna Raju, Priya R Banerjee, Davit A Potoyan

Journal: iScience

PubMed ID: 35378855

Doi: 10.1016/j.isci.2022.104105

Products & Services: Protein and Antibody Isolation

HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people

Authors: Jennifer R Habel, Andrea T Nguyen, Louise C Rowntree, Christopher Szeto, Nicole A Mifsud, E Bridie Clemens, Liyen Loh, Weisan Chen, Steve Rockman, Jane Nelson, Jane Davies, Adrian Miller, Steven Y C Tong, Jamie Rossjohn, Stephanie Gras, Anthony W Purcell, Luca Hensen, Katherine Kedzierska, Patricia T Illing

Journal: PLoS Pathog

PubMed ID: 35255101

Doi: 10.1371/journal.ppat.1010337

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Physical Interaction between Cyclin-Dependent Kinase 5 (CDK5) and Clock Factors Affects the Circadian Rhythmicity in Peripheral Oscillators

Authors: Jürgen A Ripperger, Rohit Chavan, Urs Albrecht, Andrea Brenna

Journal: Clocks Sleep

PubMed ID: 35323171

Doi: 10.3390/clockssleep4010017

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Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress

Authors: Aijun Liu, Yonglin Zhang, Shucan Xun, Guangzhi Zhou, Li Lin, Yong Mei

Journal: Peptides

PubMed ID: 35304156

Doi: 10.1016/j.peptides.2022.170786

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The receptor-like cytosolic kinase RIPK activates NADP-malic enzyme 2 to generate NADPH for fueling ROS production

Authors: Binyan Wu, Ping Li, Xiufang Hong, Cuihong Xu, Ran Wang, Yan Liang

Journal: Mol Plant

PubMed ID: 35276409

Doi: 10.1016/j.molp.2022.03.003

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Peptide-based simple detection of SARS-CoV-2 with electrochemical readout

Authors: Dayana Soto, Jahir Orozco

Journal: Anal Chim Acta

PubMed ID: 35414399

Doi: 10.1016/j.aca.2022.339739

Products & Services: Recombinant Antibody Expression

Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue

Authors: Federico Cerullo, Sebastian Filbeck, Pratik Rajendra Patil, Hao-Chih Hung, Haifei Xu, Julia Vornberger, Florian W Hofer, Jaro Schmitt, Guenter Kramer, Bernd Bukau, Kay Hofmann, Stefan Pfeffer, Claudio A P Joazeiro

Journal: Nature

PubMed ID: 35264791

Doi: 10.1038/s41586-022-04487-6

Products & Services: Protein and Antibody Isolation

Understanding desaturation/hydroxylation activity of castor stearoyl Δ9-Desaturase through rational mutagenesis

Authors: Michal Tupec , Martin Culka , Aleš Machara , Stanislav Machácˇek , Daniel Bím , Aleš Svatoš , Lubomír Rulíšek , Iva Pichová

Journal: Elsevier B.V.

Doi: 10.1016/j.csbj.2022.03.010

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Structural and functional characterizations of infectivity and immune evasion of SARS-COV-2Omicron

Authors: Zhen Cui, Pan Liu, Nan Wang, Lei Wang, Kaiyue Fan, Qianhui Zhu, Kang Wang, Ruihong Chen, Rui Feng, Zijing Jia, Minnan Yang, Ge Xu, Boling Zhu, Wangjun Fu, Tianming Chu, Leilei Feng, Yide Wang, Xinran Pei, Peng Yang, Xiaoliang Sunney Xie, Lei Cao, Yunlong Cao, Xiangxi Wang

Journal: Cell

PubMed ID: 35120603

Doi: 10.1016/j.cell.2022.01.019

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Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET

Authors: Rhye-Samuel Kanassatega, Thomas A Bunch, Victoria C Lepak, Christopher Wang, Brett A Colson

Journal: J Mol Cell Cardiol

PubMed ID: 35227736

Doi: 10.1016/j.yjmcc.2022.02.005

Products & Services: Gene Fragments

Serum TK1 protein and C-reactive protein correlate to treatment response and predict survival in dogs with hematologic malignancies

Authors: S Saellström, H Sharif, K K Jagarlamudi, H Rönnberg, L Wang, S Eriksson

Journal: Res Vet Sci

PubMed ID: 35245727

Doi: 10.1016/j.rvsc.2022.02.019

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CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling

Authors: Dan Chen, Yi Zhang, Lian Ji, Yubin Wu

Journal: Cell Biol Int

PubMed ID: 35143104

Doi: 10.1002/cbin.11777

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CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling

Authors: Dan Chen, Yi Zhang, Lian Ji, Yubin Wu

Journal: Cell Biol Int

PubMed ID: 35143104

Doi: 10.1002/cbin.11777

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Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance

Authors: Xiaorong Chen, Noah P Bradley, Wei Lu, Katherine L Wahl, Mei Zhang, Hua Yuan, Xian-Feng Hou, Brandt F Eichman, Gong-Li Tang

Journal: Nucleic Acids Res

PubMed ID: 35191495

Doi: 10.1093/nar/gkac085

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Cathepsin B inhibitor alleviates Th1, Th17, and Th22 transcription factor signaling dysregulation in experimental autoimmune encephalomyelitis

Authors: Mushtaq A Ansari, Ahmed Nadeem, Musaad A Alshammari, Sabry M Attia, Saleh A Bakheet, Mohammad R Khan, Thamer H Albekairi, Abdullah F Alasmari, Khaled Alhosaini, Faleh Alqahtani, Haneen A Al-Mazroua, Sheikh F Ahmad

Journal: Exp Neurol

PubMed ID: 35122866

Doi: 10.1016/j.expneurol.2022.113997

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Rapid screening of aptamers for fluorescent targets by integrated digital PCR and flow cytometry

Authors: Xiaona Fang, Wenjing Li, Tian Gao, Qurat Ul Ain Zahra, Zhaofeng Luo, Renjun Pei

Journal: Talanta

PubMed ID: 35180537

Doi: 10.1016/j.talanta.2022.123302

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Lanthanide-based β-Tricalcium Phosphate Upconversion Nanoparticles as an Effective Theranostic Nonviral Vectors for Image-Guided Gene Therapy

Authors: Flavia Rodrigues Oliveira Silva, Nelson Batista Lima, Maria Helena Bellini, Luiz Felipe Silva Teixeira, Eric Yiwei Du, Niloufar Jamshidi, Justin Gooding, Adam David Martin, Alexander Macmillan, Christopher Peter Marquis, Pall Thordarson

Journal: Nanotheranostics

PubMed ID: 35223382

Doi: 10.7150/ntno.68789

Products & Services: Mammalian Expression

Immunological characterization of chicken tumor necrosis factor-α (TNF-α) using new sets of monoclonal antibodies specific for poultry TNF-α

Authors: Mingmin Lu, Youngsub Lee, Charles Li, Hyun S Lillehoj

Journal: Dev Comp Immunol

PubMed ID: 35157961

Doi: 10.1016/j.dci.2022.104374

Products & Services: Protein and Antibody Isolation

Metal Dependence and Functional Diversity of Type I Cas3 Nucleases

Authors: Sining Sun, Zunyu He, Paul Jiang, Rishika Baral, Maria-Eirini Pandelia