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T cell receptors employ diverse strategies to target a p53 cancer neoantigen

Authors: Daichao Wu, Ragul Gowathaman, Brian G Pierce, Roy A Mariuzza

Journal: J Biol Chem

PubMed ID: 35124005

Doi: 10.1016/j.jbc.2022.101684

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Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trial

Authors: Carlo Scognamiglio Renner Araujo, Ana Cristina Medeiros-Ribeiro, Carla G S Saad, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Matheus Santos Rodrigues Silva, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Tatiana Pedrosa, Leonard de Vinci Kanda Kupa, Gioanna Zou, Rosa M R Pereira, Clóvis Artur Silva, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Ann Rheum Dis

PubMed ID: 35193873

Doi: 10.1136/annrheumdis-2021-221916

Products & Services: Protein and Antibody Isolation

Evolution and conserved functionality of organ size and shape regulator PEAPOD

Authors: Ruth Cookson, Somrutai Winichayakul, Hong Xue, Kim Richardson, Roger Moraga, Aurelie Laugraud, Ambarish Biswas, Greg Bryan, Nick Roberts

Journal: PLoS ONE

PubMed ID: 35148336

Doi: 10.1371/journal.pone.0263928

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Intensity and Dynamics of Anti-SARS-CoV-2 Immune Responses after BNT162b2 mRNA Vaccination: Implications for Public Health Vaccination Strategies

Authors: Matthaios Speletas, Ioanna Voulgaridi, Styliani Sarrou, Aikaterini Dadouli, Varvara A Mouchtouri, Dimitrios J Nikoulis, Maria Tsakona, Maria A Kyritsi, Athanasia-Marina Peristeri, Ioanna Avakian, Asimina Nasika, Paraskevi C Fragkou, Charalampos D Moschopoulos, Stamatia Zoubouneli, Ilias Onoufriadis, Lemonia Anagnostopoulos, Alexia Matziri, Georgia Papadamou, Aikaterini Theodoridou, Sotirios Tsiodras, Christos Hadjichristodoulou

Journal: Vaccines (Basel)

PubMed ID: 35214774

Doi: 10.3390/vaccines10020316

Differences in mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine immunogenicity among patients undergoing dialysis

Authors: Kevin Yau, Christopher T Chan, Kento T Abe, Yidi Jiang, Mohammad Atiquzzaman, Sarah I Mullin, Ellen Shadowitz, Lisa Liu, Ema Kostadinovic, Tatjana Sukovic, Anny Gonzalez, Margaret E McGrath-Chong, Matthew J Oliver, Jeffrey Perl, Jerome A Leis, Shelly Bolotin, Vanessa Tran, Adeera Levin, Peter G Blake, Karen Colwill, Anne-Claude Gingras, Michelle A Hladunewich

Journal: CMAJ

PubMed ID: 35115375

Doi: 10.1503/cmaj.211881

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The nsp15 Nuclease as a Good Target to Combat SARS-CoV-2: Mechanism of Action and Its Inactivation with FDA-Approved Drugs

Authors: Margarida Saramago, Vanessa G Costa, Caio S Souza, Cátia Bárria, Susana Domingues, Sandra C Viegas, Diana Lousa, Cláudio M Soares, Cecília M Arraiano, Rute G Matos

Journal: Microorganisms

PubMed ID: 35208797

Doi: 10.3390/microorganisms10020342

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The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

Authors: Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F Markmann, Emanuela Orsi, Jan Škrha, Maria Gabriella Camboni, Reza Abdi, A M James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zuccotti, Paolo Fiorina

Journal: Nat Commun

PubMed ID: 35115561

Doi: 10.1038/s41467-022-28360-2

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Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events

Authors: Siew C Ng, Ye Peng, Lin Zhang, Chris Kp Mok, Shilin Zhao, Amy Li, Jessica Yl Ching, Yingzhi Liu, Shuai Yan, Dream L S Chan, Jie Zhu, Chunke Chen, Adrian Ch Fung, Kenneth Ky Wong, David Sc Hui, Francis Kl Chan, Hein M Tun

Journal: Gut

PubMed ID: 35140064

Doi: 10.1136/gutjnl-2021-326563

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Inhibition of base editors with anti-deaminases derived from viruses

Authors: Zhiquan Liu, Siyu Chen, Liangxue Lai, Zhanjun Li

Journal: Nat Commun

PubMed ID: 35105899

Doi: 10.1038/s41467-022-28300-0

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Sensitivity of eight types of ALK fusion variant to alectinib in ALK-transformed cells

Authors: Koh Furugaki, Naoki Harada, Yasushi Yoshimura

Journal: Anticancer Drugs

PubMed ID: 34520436

Doi: 10.1097/CAD.0000000000001249

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Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination

Authors: Christina Strauch, Thu-Huong Hoang, Frank Angenstein, Denise Manahan-Vaughan

Journal: Cereb Cortex

PubMed ID: 34379749

Doi: 10.1093/cercor/bhab226

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Chloroplast translational regulation uncovers nonessential photosynthesis genes as key players in plant cold acclimation

Authors: Yang Gao, Wolfram Thiele, Omar Saleh, Federico Scossa, Fayezeh Arabi, Hongmou Zhang, Arun Sampathkumar, Kristina Kühn, Alisdair Fernie, Ralph Bock, Mark A Schöttler, Reimo Zoschke

Journal: Plant Cell

PubMed ID: 35171295

Doi: 10.1093/plcell/koac056

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Vaccine Candidate Double Mutant Variants of Enterotoxigenic Heat-Stable Toxin

Authors: Ephrem Debebe Zegeye, Yuleima Diaz, Pål Puntervoll

Journal: Vaccines (Basel)

PubMed ID: 35214698

Doi: 10.3390/vaccines10020241

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Structural characterization of the Myxococcus xanthus encapsulin and ferritin-like cargo system gives insight into its iron storage mechanism

Authors: Elif Eren, Bing Wang, Dennis C Winkler, Norman R Watts, Alasdair C Steven, Paul T Wingfield

Journal: Structure

PubMed ID: 35150605

Doi: 10.1016/j.str.2022.01.008

Products & Services: Bacterial Expression

Optical Sensors and Actuators for Probing Proximity-Dependent Biotinylation in Living Cells

Authors: Rui Chen, Ningxia Zhang, Yubin Zhou, Ji Jing

Journal: Front Cell Neurosci

PubMed ID: 35250484

Doi: 10.3389/fncel.2022.801644

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Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-b1Induced OCT4/Nanog Pathway

Authors: Wenting Li, Xiaoqiong Duan, Chuanlong Zhu, Xiao Liu, Andre J Jeyarajan, Min Xu, Zeng Tu, Qiuju Sheng, Dong Chen, Chuanwu Zhu, Tuo Shao, Zhimeng Cheng, Shadi Salloum, Esperance A Schaefer, Annie J Kruger, Jacinta A Holmes, Raymond T Chung, Wenyu Lin

Journal: J Immunol

PubMed ID: 35022275

Doi: doi/10.4049/jimmunol.2001453

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CD137 Agonists Targeting CD137-Mediated Negative Regulation Show Enhanced Antitumor Efficacy in Lung Cancer

Authors: Ling Yi , Xin Jin , Jinghui Wang , Zhuohong Yan , Xu Cheng , Tao Wen , Bin Yang , Xiaojue Wang , Nanying Che , Zhidong Liu and Hongtao Zhang

Journal: Frontiers in Immunology

Doi: 10.3389/fimmu.2022.771809

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Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family

Authors: Jianmei Hou , Elizabeth V Nguyen , Minglyanna Surudoi , Michael J Roy , Onisha Patel , Isabelle S Lucet , Xiuquan Ma , Roger J Daly

Journal: Sci Signal

PubMed ID: 35192416

Doi: 10.1126/scisignal.abj3

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Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells

Authors: Shenglong Zhu , Wei Wang , Jingwei Zhang , Siyu Ji , Zhe Jing , Yong Q Chen

Journal: Cell Mol Biol Lett

PubMed ID: 35109789

Doi: 10.1186/s11658-022-00314-y

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Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses

Authors: Brendan T Freitas, Daniil A Ahiadorme, Rahul S Bagul, Ian A Durie, Samir Ghosh, Jarvis Hill, Naomi E Kramer, Jackelyn Murray, Brady M O'Boyle, Emmanuel Onobun, Michael G Pirrone, Justin D Shepard, Suzanne Enos, Yagya P Subedi, Kapil Upadhyaya, Ralph A Tripp, Brian S Cummings, David Crich, Scott D Pegan

Journal: ACS Infect Dis

PubMed ID: 35199517

Doi: 10.1021/acsinfecdis.1c00631

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Biochemical and Biophysical Characterisation of the Hepatitis E Virus Guanine-7-Methyltransferase

Authors: Preeti Hooda, Mohd Ishtikhar, Shweta Saraswat, Pooja Bhatia, Deepali Mishra, Aditya Trivedi, Rajkumar Kulandaisamy, Soumya Aggarwal, Manoj Munde, Nemat Ali, Abdullah F AlAsmari, Mohd A Rauf, Krishna K Inampudi, Deepak Sehgal

Journal: Molecules

PubMed ID: 35268608

Doi: 10.3390/molecules27051505

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DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse

Authors: Kelsey S Moore, Reece Moore, Diana B Fulmer, Lilong Guo, Cortney Gensemer, Rebecca Stairley, Janiece Glover, Tyler C Beck, Jordan E Morningstar, Rachel Biggs, Rupak Muhkerjee, Alexander Awgulewitsch, Russell A Norris

Journal: J Cardiovasc Dev Dis

PubMed ID: 35200715

Doi: 10.3390/jcdd9020062

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Comprehensive mapping of SARS-CoV-2 peptide epitopes for development of a highly sensitive serological test for total and neutralizing antibodies

Authors: Garima Kumar, Sarah Sterrett, Lucinda Hall, Edlue Tabengwa, Kazuhito Honjo, Michael Larimer, Randall S Davis, Paul A Goepfert, Benjamin M Larimer

Journal: Protein Eng Des Sel

PubMed ID: 35174857

Doi: 10.1093/protein/gzab033

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Systematic profiling of antigen bias in humoral response against SARS-CoV-2

Authors: Nana Wei, Qiujing Wang, Zhibing Lin, Liyun Xu, Zheen Zhang, Yan Wang, Zhejuan Yang, Lue Li, Tingxiao Zhao, Lu Wang, Haifei Lou, Mingfang Han, Mingliang Ma, Yaosheng Jiang, Jinmiao Lu, Shilan Zhu, Li Cui, Shibo Li

Journal: Virus Res

PubMed ID: 35176329

Doi: 10.1016/j.virusres.2022.198711

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A Novel TRIM9 Protein Promotes NF-κB Activation Through Interacting With LvIMD in Shrimp During WSSV Infection

Authors: Mingzhe Sun, Shihao Li, Songjun Jin, Xuechun Li, Jianhai Xiang, Fuhua Li

Journal: Front Immunol

PubMed ID: 35281067

Doi: 10.3389/fimmu.2022.819881

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Distribution of non-synonymous Vkorc1 mutations in roof rats (Rattus rattus) in France and in Spain - consequences for management

Authors: Marlène Damin-Pernik, Abdessalem Hammed, Ludivine Giraud, Joffrey Goulois, Etienne Benoît, Virginie Lattard

Journal: Pestic Biochem Physiol

PubMed ID: 35430058

Doi: 10.1016/j.pestbp.2022.105052

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Evaluation of Hydroxycarboxylic Acid Receptor 1 (HCAR1) as a Building Block for Genetically Encoded Extracellular Lactate Biosensors

Authors: Joel Wellbourne-Wood, Marc Briquet, Maxime Alessandri, Francesca Binda, Maylis Touya, Jean-Yves Chatton

Journal: Biosensors (Basel)

PubMed ID: 35323413

Doi: 10.3390/bios12030143

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Establishment of a lncRNA-miRNA-mRNA network in a rat model of atrial fibrosis by whole transcriptome sequencing

Authors: Bo Zhao, Weiding Wang, Yu Liu, Siyu Guan, Manman Wang, Fang Song, Wenfeng Shangguan, Shuai Miao, Xiaowei Zhang, Huijia Liu, Enzhao Liu, Xue Liang

Journal: J Interv Card Electrophysiol

PubMed ID: 35124782

Doi: 10.1007/s10840-022-01120-4

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Immunodominant conformational and linear IgE epitopes lie in a single segment of Ara h 2

Authors: Stéphane Hazebrouck, Sarita U Patil, Blanche Guillon, Nicole Lahood, Stephen C Dreskin, Karine Adel-Patient, Hervé Bernard

Journal: J Allergy Clin Immunol

PubMed ID: 35150723

Doi: 10.1016/j.jaci.2021.12.796

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Molecular basis of receptor binding and antibody neutralization of Omicron

Authors: Qin Hong, Wenyu Han, Jiawei Li, Shiqi Xu, Yifan Wang, Cong Xu, Zuyang Li, Yanxing Wang, Chao Zhang, Zhong Huang, Yao Cong

Journal: Nature

PubMed ID: 35228716

Doi: 10.1038/s41586-022-04581-9

Products & Services: Mammalian Expression

DNA Vaccines Expressing the Envelope and Membrane Proteins Provide Partial Protection Against SARS-CoV-2 in Mice

Authors: Jinni Chen, Yao Deng, Baoying Huang, Di Han, Wen Wang, Mengjing Huang, Chengcheng Zhai, Zhimin Zhao, Ren Yang, Ying Zhao, Wenling Wang, Desheng Zhai, Wenjie Tan

Journal: Front Immunol

PubMed ID: 35281016

Doi: 10.3389/fimmu.2022.827605

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Human Milk SARS-CoV-2 Antibodies up to 6 Months After Vaccination

Authors: Stephanie E Perez, Luis Diego Luna Centeno, Wesley A Cheng, Carolyn Jennifer Marentes Ruiz, Yesun Lee, Zion Congrave-Wilson, Rebecca L Powell, Lisa Stellwagen, Pia S Pannaraj

Journal: Pediatrics

PubMed ID: 34981122

Doi: 10.1542/peds.2021-054260

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Identification, functional characterization, assembly and structure of ToxIN type III toxin-antitoxin complex from E coli

Authors: Parthasarathy Manikandan, Sankaran Sandhya, Kavyashree Nadig, Souradip Paul, Narayanaswamy Srinivasan, Ulli Rothweiler, Mahavir Singh

Journal: Nucleic Acids Res

PubMed ID: 35018473

Doi: 10.1093/nar/gkab1264

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Alterations in calmodulin-cardiac ryanodine receptor molecular recognition in congenital arrhythmias

Authors: Giuditta Dal Cortivo , Carlo Giorgio Barracchia , Valerio Marino , Mariapina D'Onofrio , Daniele Dell'Orco

Journal: Cell Mol Life Sci

PubMed ID: 35133504

Doi: 10.1007/s00018-022-04165-w

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The Structure of the Arabidopsis PEX4-PEX22 Peroxin Complex—Insights Into Ubiquitination at the Peroxisomal Membrane

Authors: Melissa S Traver , Sarah E Bradford , Jose Luis Olmos Jr , Zachary J Wright , Mitchell D Miller , Weijun Xu , George N Phillips Jr , Bonnie Bartel

Journal: Front Cell Dev Biol

PubMed ID: 35300425

Doi: 10.3389/fcell.2022.838923

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A continuous assay set to screen and characterize novel protein N-acetyltransferases unveils rice GNAT2 activity

Authors: Thomas Asensio , Cyril Dian , Jean-Baptiste Boyer , Frédéric Rivière, Thierry Meinnel , Carmela Giglione

Journal: Front Plant Sci

PubMed ID: 35273627

Doi: 10.3389/fpls.2022.832144

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An Enhanced Hybrid Screening Approach to Identify Potent Inhibitors for the SARS-CoV-2 Main Protease From the NCI Compound Library

Authors: Shuhua G Li, Kai S Yang, Lauren R Blankenship, Chia-Chuan D Cho, Shiqing Xu, Hongbin Wang, Wenshe Ray Liu

Journal: Front Chem

PubMed ID: 35252116

Doi: 10.3389/fchem.2022.816576

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Enrofloxacin Promotes Plasmid-Mediated Conjugation Transfer of Fluoroquinolone-Resistance Gene

Authors: Yue Zhao, Zhengzheng Cao, Luqing Cui, Tianyu Hu, Kaixuan Guo, Fan Zhang, Xiangru Wang, Zhong Peng, Quan Liu, Menghong Dai

Journal: Front Microbiol

PubMed ID: 35250901

Doi: 10.3389/fmicb.2021.773664

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Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

Authors: Jacqueto Zephyr, Desaboini Nageswara Rao, Sang V Vo, Mina Henes, Klajdi Kosovrasti, Ashley N Matthew, Adam K Hedger, Jennifer Timm, Elise T Chan, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer

Journal: J Mol Biol

PubMed ID: 35183560

Doi: 10.1016/j.jmb.2022.167503

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Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration

Authors: Elena I Ilina, Camille Cialini, Dietlind L Gerloff, Maitane Duarte Garcia-Escudero, Céline Jeanty, Marie-Laëtitia Thézénas, Antoine Lesur, Vincent Puard, François Bernardin, Alina Moter, Anne Schuster, Monika Dieterle, Anna Golebiewska, Jean-Jacques Gérardy, Gunnar Dittmar, Simone P Niclou, Tanja Müller, Michel Mittelbronn

Journal: iScience

PubMed ID: 35198895

Doi: 10.1016/j.isci.2022.103842

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Characterization and Interaction Analysis of the Secondary Cell Wall Synthesis-Related Transcription Factor in Lamb

Authors: Peizhen Chen, Rong Li, Lingzhi Zhu, Qingqing Hao, Sheng Yao, Jiahe Liu, Kongshu Ji

Journal: Int J Mol Sci

PubMed ID: 35216196

Doi: 10.3390/ijms23042079

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Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria

Authors: Gregor L Weiss, Fabian Eisenstein, Ann-Katrin Kieninger, Jingwei Xu, Hannah A Minas, Milena Gerber, Miki Feldmüller, Iris Maldener, Karl Forchhammer, Martin Pilhofer

Journal: Nat Microbiol

PubMed ID: 35165386

Doi: 10.1038/s41564-021-01055-y

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Development of an efficient and precise adenine base editor (ABE) with expanded target range in allotetraploid cotton (Gossypium hirsutum)

Authors: Guanying Wang, Zhongping Xu, Fuqiu Wang, Yuefan Huang, Yanfeng Xin, Sijia Liang, Bo Li, Huan Si, Lin Sun, Qiongqiong Wang, Xiao Ding, Xiangqian Zhu, Luo Chen, Lu Yu, Keith Lindsey, Xianlong Zhang, Shuangxia Jin

Journal: BMC Biol

PubMed ID: 35164736

Doi: 10.1186/s12915-022-01232-3

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WIN site inhibition disrupts a subset of WDR5 function

Authors: Andrew J Siladi, Jing Wang, Andrea C Florian, Lance R Thomas, Joy H Creighton, Brittany K Matlock, David K Flaherty, Shelly L Lorey, Gregory C Howard, Stephen W Fesik, April M Weissmiller, Qi Liu, William P Tansey

Journal: Sci Rep

PubMed ID: 35115608

Doi: 10.1038/s41598-022-05947-9

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TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A

Authors: X Rosa Ma, Mercedes Prudencio, Yuka Koike, Sarat C Vatsavayai, Garam Kim, Fred Harbinski, Adam Briner, Caitlin M Rodriguez, Caiwei Guo, Tetsuya Akiyama, H Broder Schmidt, Beryl B Cummings, David W Wyatt, Katherine Kurylo, Georgiana Miller, Shila Mekhoubad, Nathan Sallee, Gemechu Mekonnen, Laura Ganser, Jack D Rubien, Karen Jansen-West, Casey N Cook, Sarah Pickles, Björn Oskarsson, Neill R Graff-Radford, Bradley F Boeve, David S Knopman, Ronald C Petersen, Dennis W Dickson, James Shorter, Sua Myong, Eric M Green, William W Seeley, Leonard Petrucelli, Aaron D Gitler

Journal: Nature

PubMed ID: 35197626

Doi: 10.1038/s41586-022-04424-7

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Non-Invasive Monitoring for Rejection in Kidney Transplant Recipients After SARS-CoV-2 mRNA Vaccination

Authors: Ayman Al Jurdi, Rodrigo B Gassen, Thiago J Borges, Zhabiz Solhjou, Frank E Hullekes, Isadora T Lape, Orhan Efe, Areej Alghamdi, Poojan Patel, John Y Choi, Mostafa T Mohammed, Brigid Bohan, Vikram Pattanayak, Ivy Rosales, Paolo Cravedi, Camille N Kotton, Jamil R Azzi, Leonardo V Riella

Journal: Front Immunol

PubMed ID: 35281011

Doi: 10.3389/fimmu.2022.838985

miR-145-5p inhibits the proliferation of glioma stem cells by targeting translationally controlled tumor protein

Authors: Qiujian Zhang, Zhe Cheng, Lei Shi, Gengsheng Mao

Journal: J Cancer

PubMed ID: 35371310

Doi: 10.7150/jca.65543

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A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination

Authors: Sarah F Andrews, Julie E Raab, Jason Gorman, Rebecca A Gillespie, Crystal S F Cheung, Reda Rawi, Lauren Y Cominsky, Jeffrey C Boyington, Adrian Creanga, Chen-Hsiang Shen, Darcy R Harris, Adam S Olia, Alexandra F Nazzari, Tongqing Zhou, Katherine V Houser, Grace L Chen, John R Mascola, Barney S Graham, Masaru Kanekiyo, Julie E Ledgerwood, Peter D Kwong, Adrian B McDermott

Journal: Nat Med

PubMed ID: 35115707

Doi: 10.1038/s41591-021-01636-8

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In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles

Authors: Fang-Yi Su, Qingyang Henry Zhao, Shreyas N Dahotre, Lena Gamboa, Swapnil Subhash Bawage, Aaron D Silva Trenkle, Ali Zamat, Hathaichanok Phuengkham, Rafi Ahmed, Philip J Santangelo, Gabriel A Kwong

Journal: Sci Adv

PubMed ID: 35196075

Doi: 10.1126/sciadv.abm7950

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Selective Detection of Serogroup 1 and 5 with a Digital Photocorrosion Biosensor Using Antimicrobial Peptide-Antibody Sandwich Strategy

Authors: M Amirul Islam, Walid M Hassen, Ishika Ishika, Azam F Tayabali, Jan J Dubowski

Journal: Biosensors (Basel)

PubMed ID: 35200365

Doi: 10.3390/bios12020105

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