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Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice

Authors: Forrest Jessop, Benjamin Schwarz, Dana Scott, Lydia M Roberts, Eric Bohrnsen, John R Hoidal, Catharine M Bosio

Journal: JCI Insight

PubMed ID: 35076028

Doi: 10.1172/jci.insight.155896

Products & Services: Proteins, Expression, Isolation and Analysis

Catalase () Gene Family in Wheat ( L): Evolution, Expression Pattern and Function Analysis

Authors: Yan Zhang, Lanjie Zheng, Liu Yun, Li Ji, Guanhui Li, Manchun Ji, Yong Shi, Xu Zheng

Journal: Int J Mol Sci

PubMed ID: 35008967

Doi: 10.3390/ijms23010542

Products & Services: Protein Tools

Investigating Constraints Along the Plant Secretory Pathway to Improve Production of a SARS-CoV-2 Spike Vaccine Candidate

Authors: Emmanuel Margolin, Matthew Verbeek, Warren de Moor, Ros Chapman, Ann Meyers, Georgia Schäfer, Anna-Lise Williamson, Edward Rybicki

Journal: Front Plant Sci

PubMed ID: 35058959

Doi: 10.3389/fpls.2021.798822

Products & Services: Mammalian Expression

Myricetin Allosterically Inhibits the Dengue NS2B-NS3 Protease by Disrupting the Active and Locking the Inactive Conformations

Authors: Mei Dang, Liangzhong Lim, Amrita Roy, Jianxing Song

Journal: ACS Omega

PubMed ID: 35097276

Doi: 10.1021/acsomega.1c05569

Products & Services: Recombinant Proteins

Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon

Authors: Dhana G Gorasia, Ignacio Lunar Silva, Catherine A Butler, Maïalène Chabalier, Thierry Doan, Eric Cascales, Paul D Veith, Eric C Reynolds

Journal: Microbiol Spectr

PubMed ID: 35019767

Doi: 10.1128/spectrum.01602-21

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Heterogeneous Ribonucleoprotein A1 (hnRNPA1) Interacts with the Nucleoprotein of the Influenza a Virus and Impedes Virus Replication

Authors: Ramandeep Kaur, Jyoti Batra, Olga Stuchlik, Matthew S Reed, Jan Pohl, Suryaprakash Sambhara, Sunil Kumar Lal

Journal: Viruses

PubMed ID: 35215793

Doi: 10.3390/v14020199

Products & Services: Mammalian Expression

Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

Authors: María Teresa Bueno-Carrasco, Jorge Cuéllar, Marte I Flydal, César Santiago, Trond-André Kråkenes, Rune Kleppe, José R López-Blanco, Miguel Marcilla, Knut Teigen, Sara Alvira, Pablo Chacón, Aurora Martinez, José M Valpuesta

Journal: Nat Commun

PubMed ID: 35013193

Doi: 10.1038/s41467-021-27657-y

Products & Services: Proteins, Expression, Isolation and Analysis

Immune escape mutations selected by neutralizing antibodies in natural HIV-1 infection can alter coreceptor usage repertoire of the transmitted/founder virus

Authors: Manukumar Honnayakanahalli Marichannegowda, Hongshuo Song

Journal: Virology

PubMed ID: 35144109

Doi: 10.1016/j.virol.2022.01.010

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EID1 plays a protective role in early-onset pre-eclampsia via promoting proliferation and invasion in trophoblast cells

Authors: Ying Li, Jiuxiang Feng, Yue Bian, Wei Cheng, Chong Qiao

Journal: Folia Histochem Cytobiol

PubMed ID: 35038162

Doi: 10.5603/FHC.a2022.0001

Products & Services: Plasmid DNA Preparation

Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging

Authors: Manning Y Huang, Meenakshi B Joshi, Michael J Boucher, Sujin Lee, Liza C Loza, Elizabeth A Gaylord, Tamara L Doering, Hiten D Madhani

Journal: Genetics

PubMed ID: 34791226

Doi: 10.1093/genetics/iyab180

Products & Services: Gene Synthesis

Cardiovascular-specific PSEN1 deletion leads to abnormalities in calcium homeostasis

Authors: Xiao-Wei Song, Feng Zhao, Jing Yang, Qing-Ning Yuan, Zhen-Yu Zeng, Ming Shen, Ying Tang, Mi Cao, Ya-Feng Shen, Song-Hua Li, Yong-Ji Yang, Hong Wu, Xian-Xian Zhao, Shu-Ting Hu

Journal: Cell Biol Int

PubMed ID: 34939719

Doi: 10.1002/cbin.11753

Products & Services: Proteins, Expression, Isolation and Analysis

Lipoxin A and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway

Authors: Fen Xu, Jiamin Zhang, Xiaoyan Zhou, Hua Hao

Journal: Exp Cell Res

PubMed ID: 35026282

Doi: 10.1016/j.yexcr.2022.113025

Products & Services: Peptide Synthesis

Molecular Characterization of Mg-Chelatase CHLI Subunit in Pea ( L)

Authors: Cai-Jun Wu, Jie Wang, Jun Zhu, Jing Ren, You-Xin Yang, Tao Luo, Lu-Xi Xu, Qing-Hong Zhou, Xu-Feng Xiao, Yu-Xin Zhou, Sha Luo

Journal: Front Plant Sci

PubMed ID: 35145539

Doi: 10.3389/fpls.2022.821683

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Genome-Wide Identification and Expression Profiles of Genes in L

Authors: Meng Lu, Xiang-Xiao Meng, Yi-Ming Zhang, Xue-Wen Zhu, Jun Li, Wei-Qiang Chen, Hui-Hua Wan, Si-Fan Wang, Xue Cao, Wei Sun, Yao-Lei Mi, Jun-Wen Zhai

Journal: Cannabis Cannabinoid Res

PubMed ID: 35020417

Doi: 10.1089/can.2021.0153

Products & Services: Protein Tools

Introducing an Artificial Deazaflavin Cofactor in and

Authors: Misun Lee, Jeroen Drenth, Milos Trajkovic, René M de Jong, Marco W Fraaije

Journal: ACS Synth Biol

PubMed ID: 35044755

Doi: 10.1021/acssynbio.1c00552

Products & Services: Bacterial Expression

Bioinformatics based discovery of new keratinases in protease family M36

Authors: Jingwen Qiu, Kristian Barrett, Casper Wilkens, Anne S Meyer

Journal: N Biotechnol

PubMed ID: 35032710

Doi: 10.1016/j.nbt.2022.01.004

Products & Services: Plasmid DNA Preparation

An Active Peptide-Based Packaging System to Improve the Freshness and Safety of Fish Products: A Case Study

Authors: Rosa Luisa Ambrosio, Marta Gogliettino, Bruna Agrillo, Yolande T R Proroga, Marco Balestrieri, Lorena Gratino, Daniela Cristiano, Gianna Palmieri, Aniello Anastasio

Journal: Foods

PubMed ID: 35159493

Doi: 10.3390/foods11030338

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Anti-aquaporin-4 immunoglobulin G colorimetric detection by silver nanoparticles

Authors: Akemi M Higa, Ariana S Moraes, Flávio M Shimizu, Raquel G Bueno, Luís A Peroni, Francisco T Strixino, Nise A C Sousa, Elenice Deffune, Ana Lívia C Bovolato, Osvaldo N Oliveira, Doralina G Brum, Fabio L Leite

Journal: Nanomedicine

PubMed ID: 35114406

Doi: 10.1016/j.nano.2022.102531

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Solid-Phase Extraction Approaches for Improving Oligosaccharide and Small Peptide Identification with Liquid Chromatography-High-Resolution Mass Spectrometry: A Case Study on Proteolyzed Almond Extract

Authors: Yu-Ping Huang, Randall C Robinson, Fernanda Furlan Goncalves Dias, Juliana Maria Leite Nobrega de Moura Bell, Daniela Barile

Journal: Foods

PubMed ID: 35159490

Doi: 10.3390/foods11030340

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Protection and Alleviated Inflammation Induced by Virus-like Particle Vaccines Containing MSP-8, MSP-9 and RAP1

Authors: Su-Hwa Lee, Ki-Back Chu, Hae-Ji Kang, Fu-Shi Quan

Journal: Vaccines (Basel)

PubMed ID: 35214662

Doi: 10.3390/vaccines10020203

Products & Services: Codon Optimization

Protection and Alleviated Inflammation Induced by Virus-like Particle Vaccines Containing MSP-8, MSP-9 and RAP1

Authors: Su-Hwa Lee, Ki-Back Chu, Hae-Ji Kang, Fu-Shi Quan

Journal: Vaccines (Basel)

PubMed ID: 35214662

Doi: 10.3390/vaccines10020203

Products & Services: Codon Optimization

Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations

Authors: Anju Jaiswal, D Dash, Rashmi Singh

Journal: Toxicol Appl Pharmacol

PubMed ID: 34998855

Doi: 10.1016/j.taap.2021.115861

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Heterologous Expression and Functional Characterization of CAP18 from

Authors: Mahla Nikpoor, Azadeh Lohrasbi-Nejad, Jafar Zolala

Journal: Rep Biochem Mol Biol

PubMed ID: 35291606

Doi: 10.52547/rbmb.10.4.622

Products & Services: Proteins, Expression, Isolation and Analysis

ROS-regulated phosphorylation of ITPKB by CAMK2G drives cisplatin resistance in ovarian cancer

Authors: Jie Li, Cuimiao Zheng, Mingshuo Wang, Anna D Umano, Qingyuan Dai, Chunyu Zhang, Hua Huang, Qing Yang, Xianzhi Yang, Jingyi Lu, Wenfeng Pan, Bo Li, Shuzhong Yao, Chaoyun Pan

Journal: Oncogene

PubMed ID: 35039634

Doi: 10.1038/s41388-021-02149-x

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Multifunctional liposomal nanostructure-mediated siRNA/bortezomib co-delivery for SHARP1 knockdown in MLL-AF6 acute myeloid leukemia

Authors: Sameh A Mohammed, Yang Ju

Journal: Biomater Adv

PubMed ID: 35577689

Doi: 10.1016/j.msec.2022.112663

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Human α-defensin 6 (HD6) suppresses CRC proliferation and metastasis through abolished EGF/EGFR signaling pathway

Authors: Po-Li Wei, Jang-Chun Lin, Chin-Sheng Hung, Precious Takondwa Makondi, Uyanga Batzorig, Tung-Cheng Chang, Chien-Yu Huang, Yu-Jia Chang

Journal: Int J Med Sci

PubMed ID: 34975297

Doi: 10.7150/ijms.64850

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Control of subunit stoichiometry in single-chain MspA nanopores

Authors: Mikhail Pavlenok, Luning Yu, Dominik Herrmann, Meni Wanunu, Michael Niederweis

Journal: Biophys J

PubMed ID: 35101416

Doi: 10.1016/j.bpj.2022.01.022

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Activity-based protein profiling reveals dynamic substrate-specific cellulase secretion by saprotrophic basidiomycetes

Authors: Nicholas G S McGregor, Casper de Boer, Mikhaaeel Santos, Mireille Haon, David Navarro, Sybrin Schroder, Jean-Guy Berrin, Herman S Overkleeft, Gideon J Davies

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 35418096

Doi: 10.1186/s13068-022-02107-z

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Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity

Authors: Swarna Bais, Abigail Norwillo, Gordon Ruthel, De'Broski R Herbert, Bruce D Freedman, Robert M Greenberg

Journal: Biochimie

PubMed ID: 34990770

Doi: 10.1016/j.biochi.2021.12.018

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Analysis of RNA-containing compartments by hybridization and proximity labeling in cultured human cells

Authors: Karen Yap, Tek Hong Chung, Eugene V Makeyev

Journal: STAR Protoc

PubMed ID: 35128480

Doi: 10.1016/j.xpro.2022.101139

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The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential

Authors: Lu Wang, Xi Wang, Xiying Lv, Qiushuo Jin, Hongcai Shang, Chih-Chen Wang, Lei Wang

Journal: Redox Biol

PubMed ID: 35077997

Doi: 10.1016/j.redox.2022.102244

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A transcriptional biosensor to monitor single cancer cell therapeutic responses by bioluminescence microscopy

Authors: Audrey Champagne, Pallavi Jain, Lauriane Vélot, Julie Riopel, Véronique Lefebvre, Bertrand Neveu, Frédéric Pouliot

Journal: Theranostics

PubMed ID: 34976196

Doi: 10.7150/thno.63744

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High level production of stable human serum albumin in Pichia pastoris and characterization of the recombinant product

Authors: Nitu Maity, Avijeet S Jaswal, Ashwani Gautam, Vikram Sahai, Saroj Mishra

Journal: Bioprocess Biosyst Eng

PubMed ID: 34999948

Doi: 10.1007/s00449-021-02670-z

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A phage parasite deploys a nicking nuclease effector to inhibit viral host replication

Authors: Kristen N LeGault, Zachary K Barth, Peter DePaola, Kimberley D Seed

Journal: Nucleic Acids Res

PubMed ID: 35066583

Doi: 10.1093/nar/gkac002

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Inhibiting L1CAM Reverses Cisplatin Resistance of Triple Negative Breast Cancer Cells by Blocking AKT Signaling Pathway

Authors: Lu-Yao Zhang, Zhi-Xin Shen, Lu Guo

Journal: Cancer Invest

PubMed ID: 35040385

Doi: 10.1080/07357907.2021.2016801

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theLiTE™: A Screening Platform to Identify Compounds that Reinforce Tight Junctions

Authors: Teresa Lopes Gomes, Virgínia de Oliveira-Marques, Richard John Hampson, António Jacinto, Luciana Vieira de Moraes, Rui Gonçalo Martinho

Journal: Front Pharmacol

PubMed ID: 35069190

Doi: 10.3389/fphar.2021.752787

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Characterization of male-biased fatty acid desaturase in the jewel wasp Nasonia vitripennis and its role in pheromone production

Authors: Jian-Qiu Cheng, Yu-Mei Tao, Jing Li, Yong-Zhuo Chen, Hao-Yuan Hu

Journal: J Exp Zool B Mol Dev Evol

PubMed ID: 34995007

Doi: 10.1002/jez.b.23120

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Porcine circovirus type 2 infection inhibits the activation of type I interferon signaling via capsid protein and host gC1qR

Authors: Zhenyu Wang, Jing Chen, Qiong-Ge Zhang, Kai Huang, Dan Ma, Qian Du, Dewen Tong, Yong Huang

Journal: Vet Microbiol

PubMed ID: 35085949

Doi: 10.1016/j.vetmic.2022.109354

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Hybridization chain reaction circuit-based electrochemiluminescent biosensor for SARS-cov-2 RdRp gene assay

Authors: Kai Zhang, Zhenqiang Fan, Yue Huang, Yuedi Ding, Minhao Xie, Minghe Wang

Journal: Talanta

PubMed ID: 34998144

Doi: 10.1016/j.talanta.2022.123207

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Self-Assembly of Flagellin into Immunostimulatory Ring-like Nanostructures as an Antigen Delivery System

Authors: Mélanie Côté-Cyr, Ximena Zottig, Laurie Gauthier, Denis Archambault, Steve Bourgault

Journal: ACS Biomater Sci Eng

PubMed ID: 35080372

Doi: 10.1021/acsbiomaterials.1c01332

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SARS-CoV-2 Seroprevalence Among Whole Blood Donors During First Wave of Covid-19 Pandemic in India

Authors: Srinivasa Rao Chunchu, Ushasree Ravula, Vikram Kumar Gente, Srinivas Bacchu, S Pandu Ranga Rao, Srujaleswari Mooli

Journal: Indian J Hematol Blood Transfus

PubMed ID: 35125705

Doi: 10.1007/s12288-021-01512-y

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Heterologous immunization with BNT162b2 followed by mRNA-1273 in dialysis patients: seroconversion and presence of neutralizing antibodies

Authors: Niko Kohmer, Holger F Rabenau, Sandra Ciesek, Bernhard K Krämer, Uwe Göttmann, Christine Keller, Daniela Rose, Carsten Blume, Michael Thomas, Alexander Lammert, Anne Lammert

Journal: Nephrol Dial Transplant

PubMed ID: 35099023

Doi: 10.1093/ndt/gfac018

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Multimerization of the GATA4 transcription factor regulates transcriptional activity and cardiomyocyte hypertrophic response

Authors: Satoshi Shimizu, Yoichi Sunagawa, Naruto Hajika, Natsumi Yorimitsu, Yasufumi Katanasaka, Masafumi Funamoto, Yusuke Miyazaki, Nurmila Sari, Kana Shimizu, Koji Hasegawa, Tatsuya Morimoto

Journal: Int J Biol Sci

PubMed ID: 35173540

Doi: 10.7150/ijbs.65664

Products & Services: Proteins, Expression, Isolation and Analysis

Circular RNA circFGFR1 Functions as an Oncogene in Glioblastoma Cells through Sponging to hsa-miR-224-5p

Authors: Qian Zhang, Shan Chen, Yingwei Zhen, Peng Gao, Zhenyu Zhang, Hao Guo, Yong Wang

Journal: J Immunol Res

PubMed ID: 35059468

Doi: 10.1155/2022/7990251

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Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

Authors: Yaw Bia Tan, Laura Sandra Lello, Xin Liu, Yee-Song Law, Congbao Kang, Julien Lescar, Jie Zheng, Andres Merits, Dahai Luo

Journal: Nucleic Acids Res

PubMed ID: 35037043

Doi: 10.1093/nar/gkab1302

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A combination of multiple autoantibodies is associated with the risk of Alzheimer's disease and cognitive impairment

Authors: Sung-Mi Shim, Young Ho Koh, Jong-Hoon Kim, Jae-Pil Jeon

Journal: Sci Rep

PubMed ID: 35079008

Doi: 10.1038/s41598-021-04556-2

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Combinatorial therapy using RNAi and curcumin nano-architectures regresses tumors in breast and colon cancer models

Authors: Aviral Kumar, Amarnath Singam, Guruprasadh Swaminathan, Naresh Killi, Naveen Kumar Tangudu, Jedy Jose, Rathna Gundloori Vn, Lekha Dinesh Kumar

Journal: Nanoscale

PubMed ID: 34913453

Doi: 10.1039/d1nr04411g

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Improved myocardial performance in infarcted rat heart by injection of disulfide-cross-linked chitosan hydrogels loaded with basic fibroblast growth factor

Authors: Bo Fu, Xiaobei Wang, Zhengda Chen, Nan Jiang, Zhigang Guo, Yuhui Zhang, Shaopeng Zhang, Xiankun Liu, Li Liu

Journal: J Mater Chem B

PubMed ID: 35014648

Doi: 10.1039/d1tb01961a

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GroEL Chaperonin-Based Assay for Early Diagnosis of Scrub Typhus

Authors: Nitaya Indrawattana, Pisinee Aiumurai, Nawannaporn Sae-Lim, Watee Seesuay, Onrapak Reamtong, Manas Chongsa-Nguan, Wanpen Chaicumpa, Nitat Sookrung

Journal: Diagnostics (Basel)

PubMed ID: 35054302

Doi: 10.3390/diagnostics12010136

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Molecular Characterization of Mg-Chelatase CHLI Subunit in Pea ( L)

Authors: Cai-Jun Wu, Jie Wang, Jun Zhu, Jing Ren, You-Xin Yang, Tao Luo, Lu-Xi Xu, Qing-Hong Zhou, Xu-Feng Xiao, Yu-Xin Zhou, Sha Luo

Journal: Front Plant Sci

PubMed ID: 35145539

Doi: 10.3389/fpls.2022.821683

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