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An AAV vaccine targeting the RBD of the SARS-CoV-2 S protein induces effective neutralizing antibody titers in mice and canines

Authors: Fei Liu, Canbin Feng, Shiqi Xu, Qiang Wu, Jian Tang, Yan Chen, Ruisheng Xu, Fuliang Chen, Ni Gao, Zhengzheng Xu, Shihui Gu, Yang Lan, Haibo Zhou, Xinde Hu, Xiaojing Wang

Journal: Vaccine

PubMed ID: 35094871

Doi: 10.1016/j.vaccine.2022.01.030

Products & Services: Mammalian Expression

ADAM17 regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the EGFR/ERK signaling pathway

Authors: Xin Le, You-Fen Fan

Journal: J Plast Surg Hand Surg

PubMed ID: 34978504

Doi: 10.1080/2000656X.2021.2017944

Products & Services: Gene Synthesis

Downregulation of estrogen receptor-α36 expression attenuates metastasis of hepatocellular carcinoma cells

Authors: Ruobing Wang, Jiaming Chen, Haiyan Yu, Zhixuan Wei, Min Ma, Xueyan Ye, Weiqi Wu, Hongfei Chen, Zhengqi Fu

Journal: Environ Toxicol

PubMed ID: 35044086

Doi: 10.1002/tox.23469

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Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021

Authors: Shirley Ll Kwok, Samuel Ms Cheng, Jennifer Ns Leung, Kathy Leung, Cheuk-Kwong Lee, Js Malik Peiris, Joseph T Wu

Journal: Euro Surveill

PubMed ID: 35027105

Doi: 10.2807/1560-7917.ES.2022.27.2.2101197

Products & Services: Proteins, Expression, Isolation and Analysis

Self-assembling ferritin nanoparticles coupled with linear sequences from canine distemper virus haemagglutinin protein elicit robust immune responses

Authors: Bo Wang, Shuang Li, Yongbo Qiao, Yu Fu, Jiaojiao Nie, Shun Jiang, Xin Yao, Yi Pan, Linye Zhao, Congmei Wu, Yuhua Shi, Yuhe Yin, Yaming Shan

Journal: J Nanobiotechnology

PubMed ID: 35012571

Doi: 10.1186/s12951-021-01229-0

Products & Services: Codon Optimization

K-edge anomalous SAXS for protein solution structure modeling

Authors: Karman Virk, Kento Yonezawa, Komal Choukate, Lucky Singh, Nobutaka Shimizu, Barnali Chaudhuri

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35102886

Doi: 10.1107/S205979832101247X

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Genome-wide identification and expression pattern analysis of the TCP transcription factor family in

Authors: Li Yu, Qiangwen Chen, Jiarui Zheng, Feng Xu, Jiabao Ye, Weiwei Zhang, Yongling Liao, Xiaoyan Yang

Journal: Plant Signal Behav

PubMed ID: 35068346

Doi: 10.1080/15592324.2021.1994248

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Efficacy of an ALDH peptide-based dendritic cell vaccine targeting cancer stem cells

Authors: Fei Liao, Jing Zhang, Yangyang Hu, Alireza Hassani Najafabadi, James J Moon, Max S Wicha, Bashir Kaspo, Joel Whitfield, Alfred E Chang, Qiao Li

Journal: Cancer Immunol Immunother

PubMed ID: 35098344

Doi: 10.1007/s00262-021-03129-6

Products & Services: Recombinant Proteins

miR-223 in exosomes from bone marrow mesenchymal stem cells ameliorates rheumatoid arthritis via downregulation of NLRP3 expression in macrophages

Authors: Ying Huang, Daomin Lu, Wukai Ma, Jun Liu, Qiaoyi Ning, Fang Tang, Long Li

Journal: Mol Immunol

PubMed ID: 35042119

Doi: 10.1016/j.molimm.2022.01.002

Products & Services: Gene Synthesis

A Pig-a conditional knock-out mice model mediated by Vav-iCre: stable GPI-deficient and mild hemolysis

Authors: Yingying Chen, Hui Liu, Lijie Zeng, Liyan Li, Dan Lu, Zhaoyun Liu, Rong Fu

Journal: Exp Hematol Oncol

PubMed ID: 35033195

Doi: 10.1186/s40164-022-00254-5

Products & Services: Proteins, Expression, Isolation and Analysis

A Pig-a conditional knock-out mice model mediated by Vav-iCre: stable GPI-deficient and mild hemolysis

Authors: Yingying Chen, Hui Liu, Lijie Zeng, Liyan Li, Dan Lu, Zhaoyun Liu, Rong Fu

Journal: Exp Hematol Oncol

PubMed ID: 35033195

Doi: 10.1186/s40164-022-00254-5

Products & Services: Proteins, Expression, Isolation and Analysis

Bioinformatics based discovery of new keratinases in protease family M36

Authors: Jingwen Qiu, Kristian Barrett, Casper Wilkens, Anne S Meyer

Journal: N Biotechnol

PubMed ID: 35032710

Doi: 10.1016/j.nbt.2022.01.004

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Clinical Potential of lncRNA PPP1R26-AS1 in Breast Cancer and Its Contribution to Cancer Progression

Authors: Shuping Zhou, Shaoli Zhang, Hui Zhang, Junxia Ma, Huangzhen Dai, Lili Qu, Meixiang Zhou

Journal: Mol Biotechnol

PubMed ID: 35064892

Doi: 10.1007/s12033-022-00452-w

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Antibody Responses after SARS-CoV-2 Vaccination in Patients with Liver Diseases

Authors: Athanasios-Dimitrios Bakasis, Kleopatra Bitzogli, Dimitrios Mouziouras, Abraham Pouliakis, Maria Roumpoutsou, Andreas V Goules, Theodoros Androutsakos

Journal: Viruses

PubMed ID: 35215801

Doi: 10.3390/v14020207

Antibody Responses after SARS-CoV-2 Vaccination in Patients with Liver Diseases

Authors: Athanasios-Dimitrios Bakasis, Kleopatra Bitzogli, Dimitrios Mouziouras, Abraham Pouliakis, Maria Roumpoutsou, Andreas V Goules, Theodoros Androutsakos

Journal: Viruses

PubMed ID: 35215801

Doi: 10.3390/v14020207

Protein production, kinetic and biophysical characterization of three human dihydroorotate dehydrogenase mutants associated with Miller syndrome

Authors: Juan Manuel Orozco Rodriguez, Ewa Krupinska, Hanna Wacklin-Knecht, Wolfgang Knecht

Journal: Nucleosides Nucleotides Nucleic Acids

PubMed ID: 35094635

Doi: 10.1080/15257770.2021.2023749

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Lewis fucose is a key moiety for the recognition of histo-blood group antigens by GI9 norovirus, as revealed by structural analysis

Authors: Tomomi Kimura-Someya, Miyuki Kato-Murayama, Kazushige Katsura, Naoki Sakai, Kazutaka Murayama, Kazuharu Hanada, Mikako Shirouzu, Yuichi Someya

Journal: FEBS Open Bio

PubMed ID: 35038379

Doi: 10.1002/2211-5463.13370

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Characterization of a Broadly Neutralizing Monoclonal Antibody against SARS-CoV-2 Variants

Authors: Tasnim Saifudin Zakir, Tao Meng, Lee Ching Pei Carmen, Justin Jang Hann Chu, Raymond Tzer Pin Lin, Mookkan Prabakaran

Journal: Viruses

PubMed ID: 35215823

Doi: 10.3390/v14020230

Products & Services: Recombinant Proteins

Preparation of Edible Films with and Lactobionic Acid Produced by Sweet Whey Fermentation

Authors: Sara Sáez-Orviz, Ismael Marcet, Manuel Rendueles, Mario Díaz

Journal: Membranes (Basel)

PubMed ID: 35207037

Doi: 10.3390/membranes12020115

Products & Services: Proteins, Expression, Isolation and Analysis

Antibody response following SARS-CoV-2 vaccination among patients with type 2 diabetes mellitus: A systematic review

Authors: Nanny Natalia M Soetedjo, Maria Riastuti Iryaningrum, Sherly Lawrensia, Hikmat Permana

Journal: Diabetes Metab Syndr

PubMed ID: 35104750

Doi: 10.1016/j.dsx.2022.102406

Products & Services: Protein Reagents and Products

Oral subunit SARS-CoV-2 vaccine induces systemic neutralizing IgG, IgA and cellular immune responses and can boost neutralizing antibody responses primed by an injected vaccine

Authors: Jacob Pitcovski, Nady Gruzdev, Anna Abzach, Chen Katz, Ran Ben-Adiva, Michal Brand-Shwartz, Itamar Yadid, Einav Ratzon-Ashkenazi, Ken Emquies, Hadasa Israeli, Hadar Haviv, Irena Rapoport, Itai Bloch, Roy Shadmon, Zohar Eitan, Dalia Eliahu, Talia Hilel, Morris Laster, Sigal Kremer-Tal, Tamara Byk-Tennenbaum, Ehud Shahar

Journal: Vaccine

PubMed ID: 35078662

Doi: 10.1016/j.vaccine.2022.01.025

Products & Services: Proteins, Expression, Isolation and Analysis

LbCas12a-D156R Efficiently Edits Effector Binding Elements to Generate Canker-Resistant Citrus Plants

Authors: Hongge Jia, Yuanchun Wang, Hang Su, Xiaoen Huang, Nian Wang

Journal: Cells

PubMed ID: 35159125

Doi: 10.3390/cells11030315

Products & Services: Molecular Biology Reagents

Neutralizing Activity and SARS-CoV-2 Vaccine mRNA Persistence in Serum and Breastmilk After BNT162b2 Vaccination in Lactating Women

Authors: Kee Thai Yeo, Wan Ni Chia, Chee Wah Tan, Chengsi Ong, Joo Guan Yeo, Jinyan Zhang, Su Li Poh, Amanda Jin Mei Lim, Kirsten Hui Zhi Sim, Nursyuhadah Sutamam, Camillus Jian Hui Chua, Salvatore Albani, Lin-Fa Wang, Mei Chien Chua

Journal: Front Immunol

PubMed ID: 35087517

Doi: 10.3389/fimmu.2021.783975

Products & Services: Mammalian Expression

Neutralizing Activity and SARS-CoV-2 Vaccine mRNA Persistence in Serum and Breastmilk After BNT162b2 Vaccination in Lactating Women

Journal: Front Immunol

PubMed ID: 35087517

Doi: 10.3389/fimmu.2021.783975

Products & Services: Mammalian Expression

The Linker Region Promotes Activity and Binding Efficiency of Modular LPMO towards Polymeric Substrate

Authors: Aishwarya Srivastava, Pragya Nagar, Sumit Rathore, Nidhi Adlakha

Journal: Microbiol Spectr

PubMed ID: 35080440

Doi: 10.1128/spectrum.02697-21

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CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA

Authors: Simin Chen, Zhaoyu Zhang, Baoxin Zhang, Qing Huang, Yi Liu, Yi Qiu, Xinmiao Long, Minghua Wu, Zuping Zhang

Journal: Int J Biol Sci

PubMed ID: 35002529

Doi: 10.7150/ijbs.66114

Products & Services: Plasmid DNA Preparation

Elemicin exposure induced aberrant lipid metabolism via modulation of gut microbiota in mice

Authors: Yi Zhang, Mufan Ji, Zhenyang Gu, Wenlong Pei, Jun Zhu, Qian Wu, Lei Li, Zhan Zhang

Journal: Toxicology

PubMed ID: 34979169

Doi: 10.1016/j.tox.2021.153088

Products & Services: Custom DNA/RNA Oligos

Modified Sawhorse Waveform for the Voltammetric Detection of Oxytocin

Authors: Favian A Liu, Negar Ardabili, Izaiah Brown, Harmain Rafi, Clarice Cook, Rodanthi Nikopoulou, Arianna Lopez, Shouzhong Zou, Matthew R Hartings, Alexander G Zestos

Journal: J Electrochem Soc

PubMed ID: 35185166

Doi: 10.1149/1945-7111/ac4aae

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Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates

Authors: Stéphane Pillet, Prabhu S Arunachalam, Guadalupe Andreani, Nadia Golden, Jane Fontenot, Pyone Pyone Aye, Katharina Röltgen, Gabrielle Lehmicke, Philipe Gobeil, Charlotte Dubé, Sonia Trépanier, Nathalie Charland, Marc-André D'Aoust, Kasi Russell-Lodrigue, Christopher Monjure, Robert V Blair, Scott D Boyd, Rudolf P Bohm, Jay Rappaport, François Villinger, Nathalie Landry, Bali Pulendran, Brian J Ward

Journal: Cell Mol Immunol

PubMed ID: 34983950

Doi: 10.1038/s41423-021-00809-2

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Evolutionary Origin of the Carotenoid Cleavage Oxygenase Family in Plants and Expression of Pepper Genes in Response to Abiotic Stresses

Authors: Yixiu Yao, Li Jia, Yuan Cheng, Meiying Ruan, Qingjing Ye, Rongqing Wang, Zhuping Yao, Guozhi Zhou, Jia Liu, Jiahong Yu, Peng Zhang, Yuhe Yin, Weiping Diao, Hongjian Wan

Journal: Front Plant Sci

PubMed ID: 35126418

Doi: 10.3389/fpls.2021.792832

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Improved yield, stability, and cleavage reaction of a novel tobacco etch virus protease mutant

Authors: Sergio Enríquez-Flores, José Ignacio De la Mora-De la Mora, Luis Antonio Flores-López, Nallely Cabrera, Cynthia Fernández-Lainez, Gloria Hernández-Alcántara, Carlos Enrique Guerrero-Beltrán, Gabriel López-Velázquez, Itzhel García-Torres

Journal: Appl Microbiol Biotechnol

PubMed ID: 35092453

Doi: 10.1007/s00253-022-11786-5

Products & Services: Gene Synthesis

N-glycolylneuraminic acid binding of avian and equine H7 influenza A viruses

Authors: Cindy M Spruit, Xueyong Zhu, Ilhan Tomris, María Ríos Carrasco, Alvin X Han, Frederik Broszeit, Roosmarijn van der Woude, Kim M Bouwman, Michel M T Luu, Keita Matsuno, Yoshihiro Sakoda, Colin A Russell, Ian A Wilson, Geert-Jan Boons, Robert P de Vries

Journal: J Virol

PubMed ID: 35044215

Doi: 10.1128/jvi.02120-21

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pVHL-mediated SMAD3 degradation suppresses TGF-β signaling

Authors: Jun Zhou , Yasamin Dabiri , Rodrigo A Gama-Brambila, Shahrouz Ghafoory , Mukaddes Altinbay , Arianeb Mehrabi , Mohammad Golriz , Biljana Blagojevic , Stefanie Reuter , Kang Han , Anna Seidel , Ivan Đikić , Stefan Wölfl , Xinlai Cheng

Journal: J Cell Biol

PubMed ID: 34860252

Doi: 10.1083/jcb.202012097

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Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay

Authors: Yusen Xiang, Guanglei Zhai, Yaozong Li, Mengge Wang, Xixiang Chen, Ruyu Wang, Hang Xie, Weidong Zhang, Guangbo Ge, Qian Zhang, Yechun Xu, Amedeo Caflisch, Jianrong Xu, Hongzhuan Chen, Lili Chen

Journal: Int J Biol Macromol

PubMed ID: 36521705

Doi: 10.1016/j.ijbiomac.2022.12.057

Products & Services: Recombinant Proteins

Genomic distribution of signal transducer and activator of transcription (STAT) family in colorectal cancer

Authors: Yanping Hu, Yifen Shen, Yang Zhao, Ying Tang, Chao Liu, Yongchun Gu, Tao Yang, Yihang Shen

Journal: Hum Cell

PubMed ID: 36284066

Doi: 10.1007/s13577-022-00815-0

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Embracing enzyme promiscuity with activity-based compressed biosensing

Authors: Brandon Alexander Holt, Hong Seo Lim, Anirudh Sivakumar, Hathaichanok Phuengkham, Melanie Su, McKenzie Tuttle, Yilin Xu, Haley Liakakos, Peng Qiu, Gabriel A Kwong

Journal: Cell Rep Methods

PubMed ID: 36814844

Doi: 10.1016/j.crmeth.2022.100372

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The Hinge Region of the Israeli Acute Paralysis Virus Internal Ribosome Entry Site Directs Ribosomal Positioning, Translational Activity, and Virus Infection

Authors: Mathew P Kirby, Ciara Stevenson, Liam J Worrall, Yihang Chen, Christina Young, Jisoo Youm, Natalie C J Strynadka, Douglas W Allan, Eric Jan

Journal: J Virol

PubMed ID: 35019716

Doi: 10.1128/JVI.01330-21

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In silico, in vitro and in vivo safety evaluation of Limosilactobacillus reuteri strains ATCC PTA-126787 & ATCC PTA-126788 for potential probiotic applications

Authors: Dharanesh Gangaiah, Shrinivasrao P Mane, Nilesh R Tawari, Nallakannu Lakshmanan, Valerie Ryan, Alyssa Volland, Dwi Susanti, Milind Patel, Abraham Abouzeid, Emily B Helmes, Arvind Kumar

Journal: PLoS ONE

PubMed ID: 35081129

Doi: 10.1371/journal.pone.0262663

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Catalase () Gene Family in Wheat ( L): Evolution, Expression Pattern and Function Analysis

Authors: Yan Zhang, Lanjie Zheng, Liu Yun, Li Ji, Guanhui Li, Manchun Ji, Yong Shi, Xu Zheng

Journal: Int J Mol Sci

PubMed ID: 35008967

Doi: 10.3390/ijms23010542

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SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability

Authors: Manami Hiraiwa, Kazuya Fukasawa, Takashi Iezaki, Hemragul Sabit, Tetsuhiro Horie, Kazuya Tokumura, Sayuki Iwahashi, Misato Murata, Masaki Kobayashi, Akane Suzuki, Gyujin Park, Katsuyuki Kaneda, Tomoki Todo, Atsushi Hirao, Mitsutoshi Nakada, Eiichi Hinoi

Journal: Commun Biol

PubMed ID: 35017630

Doi: 10.1038/s42003-021-02950-0

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Preclinical Evaluation of Chicken Egg Yolk Antibody (IgY) Anti-RBD Spike SARS-CoV-2-A Candidate for Passive Immunization against COVID-19

Authors: Hendris Wongso, Isa Mahendra, Wyanda Arnafia, Idar Idar, Muhammad Yusuf, Arifudin Achmad, Holis A Holik, Ahmad Kurniawan, Iim Halimah, Maula E Sriyani, Teguh H A Wibawa, Muhamad B Febrian, Yanuar Setiadi, Eva M Widyasari, Isti Daruwati, Crhisterra E Kusumaningrum, Toto Subroto

Journal: Vaccines (Basel)

PubMed ID: 35062789

Doi: 10.3390/vaccines10010128

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Engineering His-Tagged Senecavirus A for One-Step Purification of Viral Antigens

Authors: Junhao Fan, Peiyu Xiao, Dongni Kong, Xinran Liu, Liang Meng, Tongqing An, Xuehui Cai, Haiwei Wang, Li Yu

Journal: Vaccines (Basel)

PubMed ID: 35214628

Doi: 10.3390/vaccines10020170

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Targeting the gp130/STAT3 Axis Attenuates Tumor Microenvironment Mediated Chemoresistance in Group 3 Medulloblastoma Cells

Authors: Lakshana Sreenivasan, Ling Vicky Li, Pascal Leclair, Chinten James Lim

Journal: Cells

PubMed ID: 35159191

Doi: 10.3390/cells11030381

Products & Services: Recombinant Proteins

OsMYB103 is essential for tapetum degradation in rice

Authors: Ting Lei, Lisha Zhang, Ping Feng, Yang Liu, Wuzhong Yin, Lina Shang, Guanghua He, Nan Wang

Journal: Theor Appl Genet

PubMed ID: 35018498

Doi: 10.1007/s00122-021-04007-6

Products & Services: Proteins, Expression, Isolation and Analysis

Exogenous Production of N-acetylmuramyl-L Alanine Amidase (LysM2) from Siphoviridae Phage Affecting Anti-Gram-Negative Bacteria: Evaluation of Its Structure and Function

Authors: Morteza Miri, Sepideh Yazdianpour, Shamsozoha Abolmaali, Shakiba Darvish Alipour Astaneh

Journal: Avicenna J Med Biotechnol

PubMed ID: 35509364

Doi: 10.18502/ajmb.v14i1.8169

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Reduced DNAJC3 Expression Affects Protein Translocation across the ER Membrane and Attenuates the Down-Modulating Effect of the Translocation Inhibitor Cyclotriazadisulfonamide

Authors: Eva Pauwels, Becky Provinciael, Anita Camps, Enno Hartmann, Kurt Vermeire

Journal: Int J Mol Sci

PubMed ID: 35054769

Doi: 10.3390/ijms23020584

Products & Services: Proteins, Expression, Isolation and Analysis

Dimensionless parameter predicts bacterial prodrug success

Authors: Brandon Alexander Holt, McKenzie Tuttle, Yilin Xu, Melanie Su, Joachim J Røise, Xioajian Wang, Niren Murthy, Gabriel A Kwong

Journal: Mol Syst Biol

PubMed ID: 35005851

Doi: 10.15252/msb.202110495

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Immunogenicity of a recombinant VSV-Vectored SARS-CoV vaccine induced robust immunity in rhesus monkeys after single-dose immunization

Authors: Dan Shan, Xiaoyan Tang, Renqiang Liu, Dan Pan, Xijun Wang, Jinying Ge, Zhiyuan Wen, Zhigao Bu

Journal: Virol Sin

PubMed ID: 35234625

Doi: 10.1016/j.virs.2022.01.002

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Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors

Authors: Daichao Wu, Alexander Kolesnikov, Rui Yin, Johnathan D Guest, Ragul Gowthaman, Anton Shmelev, Yana Serdyuk, Dmitry V Dianov, Grigory A Efimov, Brian G Pierce, Roy A Mariuzza

Journal: Nat Commun

PubMed ID: 35013235

Doi: 10.1038/s41467-021-27669-8

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Selective Coimmobilization of His-Tagged Enzymes on Yttrium-Stabilized Zirconia-Based Membranes for Continuous Asymmetric Bioreductions

Authors: Daniel Andrés-Sanz, Eleftheria Diamanti, Desirè Di Silvo, Jonas Gurauskis, Fernando López-Gallego

Journal: ACS Appl Mater Interfaces

PubMed ID: 35020352

Doi: 10.1021/acsami.1c20738

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