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Functional Antagonism of Junctional Adhesion Molecule-A (JAM-A), Overexpressed in Breast Ductal Carcinoma In Situ (DCIS), Reduces HER2-Positive Tumor Progression

Authors: Yvonne E Smith, Guannan Wang, Ciara L Flynn, Stephen F Madden, Owen MacEneaney, Rodrigo G B Cruz, Cathy E Richards, Hanne Jahns, Marian Brennan, Mattia Cremona, Bryan T Hennessy, Katherine Sheehan, Alexander Casucci, Faizah A Sani, Lance Hudson, Joanna Fay, Sri H Vellanki, Siobhan O'Flaherty, Marc Devocelle, Arnold D K Hill, Kieran Brennan, Saraswati Sukumar, Ann M Hopkins

Journal: Cancers (Basel)

PubMed ID: 35267611

Doi: 10.3390/cancers14051303

Products & Services: Peptide Synthesis

Engineering Saccharomyces cerevisiae for the production and secretion of Affibody molecules

Authors: Veronica Gast, Anna Sandegren, Finn Dunås, Siri Ekblad, Rezan Güler, Staffan Thorén, Marta Tous Mohedano, Mikael Molin, Martin K M Engqvist, Verena Siewers

Journal: Microb Cell Fact

PubMed ID: 35264156

Doi: 10.1186/s12934-022-01761-0

Products & Services: Codon Optimization

COVID-19 Convalescent Plasma and Clinical Trials: Understanding Conflicting Outcomes

Authors: Daniele Focosi, Massimo Franchini, Liise-Anne Pirofski, Thierry Burnouf, Nigel Paneth, Michael J Joyner, Arturo Casadevall

Journal: Clin Microbiol Rev

PubMed ID: 35262370

Doi: 10.1128/cmr.00200-21

Products & Services: Protein and Antibody Isolation

Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling

Authors: Kelly J Culhane, Tejas M Gupte, Indrani Madhugiri, Chetan J Gadgil, Sivaraj Sivaramakrishnan

Journal: Nat Commun

PubMed ID: 35260563

Doi: 10.1038/s41467-022-28789-5

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MiR-183-5p overexpression in bone mesenchymal stem cell-derived exosomes protects against myocardial ischemia/reperfusion injury by targeting FOXO1

Authors: Shuai Mao, Jing Zhao, Zhao-Juan Zhang, Qin Zhao

Journal: Immunobiology

PubMed ID: 35314383

Doi: 10.1016/j.imbio.2022.152204

Products & Services: Recombinant Proteins

Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models

Authors: Giuseppe Palladino, Cheng Chang, Changkeun Lee, Nedzad Music, Ivna De Souza, Jonathan Nolasco, Samuel Amoah, Pirada Suphaphiphat, Gillis R Otten, Ethan C Settembre, Yingxia Wen

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35345593

Doi: 10.1016/j.omtm.2022.03.013

Products & Services: Mammalian Expression

Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY

Authors: Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda, Takamitsu Hosoya, Isao Kii

Journal: Protein Expr Purif

PubMed ID: 35307559

Doi: 10.1016/j.pep.2022.106089

Products & Services: PCR Cloning and Subcloning

METTL14-mediated N6-methyladenosine modification of Pten mRNA inhibits tumour progression in clear-cell renal cell carcinoma

Authors: Lili Zhang, Xiaofang Luo, Sen Qiao

Journal: Br J Cancer

PubMed ID: 35249103

Doi: 10.1038/s41416-022-01757-y

Products & Services: Gene Synthesis

Inactivated SARS-CoV-2 vaccine in primary Sjögren's syndrome: humoral response, safety, and effects on disease activity

Authors: Sandra Gofinet Pasoto, Ari Stiel Radu Halpern, Lissiane Karine Noronha Guedes, Ana Cristina Medeiros Ribeiro, Emily Neves Figueiredo Yuki, Carla Gonçalves Schahin Saad, Clovis Artur Almeida da Silva, Léonard de Vinci Kanda Kupa, Lorena Elizabeth Betancourt Villamarín, Victor Adriano de Oliveira Martins, Carolina Campagnoli Machado Freire Martins, Giordano Bruno Henriques Deveza, Elaine Pires Leon, Cleonice Bueno, Tatiana Nascimento Pedrosa, Roseli Eliana Beseggio Santos, Renata Soares, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Clin Rheumatol

PubMed ID: 35306594

Doi: 10.1007/s10067-022-06134-x

Products & Services: Catalog Antibodies

Insight into Cellular Uptake and Transcytosis of Peptide Nanoparticles in Cells and Isolated Midgut

Authors: Erin McGraw, Jonathan D Roberts, Nitish Kunte, Matthew Westerfield, Xavier Streety, David Held, L Adriana Avila

Journal: ACS Omega

PubMed ID: 35415340

Doi: 10.1021/acsomega.1c06638

Products & Services: Molecular Biology Tools

Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production

Authors: Jin Zhao, Jiaoshan Chen, Congcong Wang, Yajie Liu, Minchao Li, Yanjun Li, Ruiting Li, Zirong Han, Junjian Wang, Ling Chen, Yuelong Shu, Genhong Cheng, Caijun Sun

Journal: PLoS Pathog

PubMed ID: 35235615

Doi: 10.1371/journal.ppat.1010366

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A TCR mimic monoclonal antibody reactive with the "public" phospho-neoantigen pIRS2/HLA-A*02:01 complex

Authors: Tao Dao, Sung Soo Mun, Zaki Molvi, Tatyana Korontsvit, Martin G Klatt, Abdul G Khan, Elisabeth K Nyakatura, Mary Ann Pohl, Thomas E White, Paul J Balderes, Ivo C Lorenz, Richard J O'Reilly, David A Scheinberg

Journal: JCI Insight

PubMed ID: 35260532

Doi: 10.1172/jci.insight.151624

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Metabolic engineering of Saccharomyces cerevisiae for gram-scale diosgenin production

Authors: Liping Xu , Dong Wang , Jing Chen , Bo Li , Qingyan Li , Pingping Liu , Ying Qin , Zhubo Dai , Feiyu Fan , Xueli Zhang

Journal: Metab Eng

PubMed ID: 35085779

Doi: 10.1016/j.ymben.2022.01.013

Products & Services: Codon Optimization

A randomized clinical trial of a booster dose with low versus standard dose of AZD1222 in adult after 2 doses of inactivated vaccines

Authors: Sira Nanthapisal, Thanyawee Puthanakit, Peera Jaru-Ampornpan, Rapisa Nantanee, Pimpayao Sodsai, Orawan Himananto, Jiratchaya Sophonphan, Pintip Suchartlikitwong, Narin Hiransuthikul, Pornpimon Angkasekwinai, Auchara Tangsathapornpong, Nattiya Hirankarn

Journal: Vaccine

PubMed ID: 35341647

Doi: 10.1016/j.vaccine.2022.03.036

Products & Services: Mammalian Expression

Overexpression of microRNA-107 suppressed proliferation, migration, invasion, and the PI3K/Akt signaling pathway and induced apoptosis by targeting Nin one binding (NOB1) protein in a hypopharyngeal squamous cell carcinoma cell line (FaDu)

Authors: Xin Gao, Xinlong Fan, Wei Zeng, Jiwang Liang, Nan Guo, Xiao Yang, Yuejiao Zhao

Journal: Bioengineered

PubMed ID: 35294329

Doi: 10.1080/21655979.2022.2051266

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Simultaneous Detection of Bladder Cancer Exosomal MicroRNAs Based on Inorganic Nanoflare and DNAzyme Walker

Authors: Xiao Zhang, Xiaowei Wei, Jijin Qi, Jie Shen, Junwen Xu, Guangyu Gong, Yong Wei, Jian Yang, Qingyi Zhu, Tingting Bai, Zhirui Guo, Xiaojun Qu, Yefei Zhu

Journal: Anal Chem

PubMed ID: 35275615

Doi: 10.1021/acs.analchem.1c05588

Products & Services: Custom DNA/RNA Oligos

Characterization of Bud3 domains sufficient for bud neck targeting in

Authors: Madison N Schrock, Yao Yan, Megan E Goeckel, Erianna M Basgall, Isabel C Lewis, Katherine G Leonard, Megan Halloran, Gregory C Finnigan

Journal: Access Microbiol

PubMed ID: 35693471

Doi: 10.1099/acmi.0.000341

Products & Services: Protein and Antibody Isolation

Comparative performance of five recombinant and chimeric antigens in a time-resolved fluorescence immunoassay for detection of Toxoplasma gondii infection in cats

Authors: Ana Huertas-López, Marinela Contreras Rojo, Woraporn Sukhumavasi, Silvia Martínez-Subiela, Gema Álvarez-García, Nadia María López-Ureña, José Joaquín Cerón, Carlos Martínez-Carrasco

Journal: Vet Parasitol

PubMed ID: 35367904

Doi: 10.1016/j.vetpar.2022.109703

Products & Services: Recombinant Antibody Expression

A toolkit for recombinant production of seven human EGF family growth factors in active conformation

Authors: Arthur Schveitzer Ferreira, Amanda Lopacinski, Michel Batista, Priscila Mazzocchi Hiraiwa, Beatriz Gomes Guimarães, Nilson Ivo Tonin Zanchin

Journal: Sci Rep

PubMed ID: 35322149

Doi: 10.1038/s41598-022-09060-9

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The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells

Authors: Balaji T Moorthy, Chunhua Jiang, Devang M Patel, Yuguang Ban, Corin R O'Shea, Akhilesh Kumar, Tan Yuan, Michael D Birnbaum, Aldrin V Gomes, Xi Chen, Flavia Fontanesi, Theodore J Lampidis, Antoni Barrientos, Fangliang Zhang

Journal: Dev Cell

PubMed ID: 35247316

Doi: 10.1016/j.devcel.2022.02.010

Products & Services: Polyclonal Antibody Services

Expression of B subtilis Phytase gene driven by fruit specific E8 promoter for enhanced minerals, metabolites and phytonutrient in cucumber fruit

Authors: Komal K Sapara, Parinita Agarwal, Kapil Gupta, Pradeep K Agarwal

Journal: Food Res Int

PubMed ID: 35651010

Doi: 10.1016/j.foodres.2022.111138

Products & Services: Protein and Antibody Isolation

A multi-epitopes tandem antigen for five types of human adenoviruses and its application in development of multivalent IgM immunochromatographic strip test

Authors: Liqiang Zong, Yong Qi, Wei Li, Wanpeng Shen, Jiameng Li, Ruichen Lv, Nianhong Lu, Susu Zhuang, Qiyuan Gui, Dongming Zhou, Yingjia Xu, Zhao Nan, Yuexi Li

Journal: Diagn Microbiol Infect Dis

PubMed ID: 35378470

Doi: 10.1016/j.diagmicrobio.2022.115675

Products & Services: Gene Synthesis

Exogenous Annexin 1 inhibits Th17 cell differentiation induced by anti-TNF treatment via activating FPR2 in DSS-induced colitis

Authors: Xing Liu, Lulu Zhou, Wenjie Xin, Zichun Hua

Journal: Int Immunopharmacol

PubMed ID: 35306282

Doi: 10.1016/j.intimp.2022.108685

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Defining Biomarkers to Predict Natural Resolution in Shrimp Allergy

Authors: Surapon Piboonpocanun, Suttipong Ittiporn, Pisit Ubonsri, Anchalee Wangtan, Punchama Pacharn, Nualanong Visitsunthorn, Orathai Jirapongsananuruk

Journal: Allergy Asthma Immunol Res

PubMed ID: 35255538

Doi: 10.4168/aair.2022.14.2.210

Products & Services: Protein and Antibody Isolation

Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

Authors: Anusmita Sahoo, Edgar A Hodge, Celia C LaBranche, Tiffany M Styles, Xiaoying Shen, Narayanaiah Cheedarla, Ayalnesh Shiferaw, Gabriel Ozorowski, Wen-Hsin Lee, Andrew B Ward, Georgia D Tomaras, David C Montefiori, Darrell J Irvine, Kelly K Lee, Rama Rao Amara

Journal: Cell Rep

PubMed ID: 35235790

Doi: 10.1016/j.celrep.2022.110436

Products & Services: Gene Synthesis

Study of osmoadaptation mechanisms of halophilic Halomonas alkaliphila XH26 under salt stress by transcriptome and ectoine analysis

Authors: Tiantian Zhang, Xin Zhang, Yongzhen Li, Ning Yang, Lijuan Qiao, Zengqiang Miao, Jiangwa Xing, Derui Zhu

Journal: Extremophiles

PubMed ID: 35229247

Doi: 10.1007/s00792-022-01256-1

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Targeting insulin-like growth factor-1 receptor (IGF1R) for brain delivery of biologics

Authors: Wael Alata, Alvaro Yogi, Eric Brunette, Christie E Delaney, Henk van Faassen, Greg Hussack, Umar Iqbal, Kristin Kemmerich, Arsalan S Haqqani, Maria J Moreno, Danica B Stanimirovic

Journal: FASEB J

PubMed ID: 35192204

Doi: 10.1096/fj.202101644R

Products & Services: Gene Synthesis

ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve

Authors: Hye-Jin Park, Eric Tsai, Dennis Huang, Michael Weaver, Luciana Frick, Ace Alcantara, John J Moran, Julia Patzig, Carmen V Melendez-Vasquez, Gerald R Crabtree, M L Feltri, John Svaren, Patrizia Casaccia

Journal: iScience

PubMed ID: 35434551

Doi: 10.1016/j.isci.2022.104132

Products & Services: Protein and Antibody Isolation

Undiagnosed COVID-19 in households with a child with mitochondrial disease

Authors: Eliza M Gordon-Lipkin, Christopher Marcum, Shannon Kruk, Elizabeth Thompson, Sophie E M Kelly, Heather Kalish, Kaitlyn Sadtler, Peter J McGuire

Journal: medrxiv

PubMed ID: 35350208

Doi: 10.1101/2022.03.21.22272358

Products & Services: Recombinant Antibody Expression

MdMTA-mediated m A modification enhances drought tolerance by promoting mRNA stability and translation efficiency of genes involved in lignin deposition and oxidative stress

Authors: Nan Hou, Chaoshuo Li, Jieqiang He, Yu Liu, Sisi Yu, Mickael Malnoy, Muhammad Mobeen Tahir, Lingfei Xu, Fengwang Ma, Qingmei Guan

Journal: New Phytol

PubMed ID: 35246985

Doi: 10.1111/nph.18069

Products & Services: Protein and Antibody Isolation

PINK1/Parkin-mediated mitophagy is activated to protect against AFB-induced kidney damage in mice

Authors: Yuping Wang, Miao Song, Qi Wang, Chen Guo, Jian Zhang, Xuliang Zhang, Yilong Cui, Zheng Cao, Yanfei Li

Journal: Chem Biol Interact

PubMed ID: 35304092

Doi: 10.1016/j.cbi.2022.109884

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Enabling Efficient Genetic Manipulations in a Rare Actinomycete Shahu

Authors: Jie Li, Baiyang Wang, Qing Yang, Han Si, Yuting Zhao, Yanli Zheng, Wenfang Peng

Journal: Front Microbiol

PubMed ID: 35308340

Doi: 10.3389/fmicb.2022.848964

Products & Services: Gene Fragments

Tick Intrastadial Feeding and Its Role on IgE Production in the Murine Model of Alpha-gal Syndrome: The Tick "Transmission" Hypothesis

Authors: L Paulina Maldonado-Ruiz, Gunavanthi D Boorgula, Donghun Kim, Sherry D Fleming, Yoonseong Park

Journal: Front Immunol

PubMed ID: 35309294

Doi: 10.3389/fimmu.2022.844262

Products & Services: Protein and Antibody Isolation

Spherical nucleic acids as an infectious disease vaccine platform

Authors: Michelle H Teplensky, Max E Distler, Caroline D Kusmierz, Michael Evangelopoulos, Haley Gula, Derek Elli, Anastasia Tomatsidou, Vlad Nicolaescu, Ian Gelarden, Anjana Yeldandi, Daniel Batlle, Dominique Missiakas, Chad A Mirkin

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35312341

Doi: 10.1073/pnas.2119093119

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Influence of Proteolysis on the Binding Capacity of Flavor Compounds to Myofibrillar Proteins

Authors: Hao Li, Rui Zheng, Fangfang Zuo, Chengyu Qian, Zhengan Yao, Ruipeng Dong, Di Zhao, Chunbao Li

Journal: Foods

PubMed ID: 35327313

Doi: 10.3390/foods11060891

Products & Services: Protein and Antibody Isolation

A thermostable Cas12b from Brevibacillus leverages one-pot discrimination of SARS-CoV-2 variants of concern

Authors: Long T Nguyen, Nicolas C Macaluso, Brianna L M Pizzano, Melanie N Cash, Jan Spacek, Jan Karasek, Megan R Miller, John A Lednicky, Rhoel R Dinglasan, Marco Salemi, Piyush K Jain

Journal: EBioMedicine

PubMed ID: 35290826

Doi: 10.1016/j.ebiom.2022.103926

Products & Services: Bacterial Expression

Robust, persistent adaptive immune responses to SARS-CoV-2 in the oropharyngeal lymphoid tissue of children

Authors: Kalpana Manthiram, Qin Xu, Pedro Milanez-Almeida, Andrew Martins, Andrea Radtke, Kenneth Hoehn, Jinguo Chen, Can Liu, Juanjie Tang, Gabrielle Grubbs, Sydney Stein, Sabrina Ramelli, Juraj Kabat, Hengameh Behzadpour, Maria Karkanitsa, Jacquelyn Spathies, Heather Kalish, Lela Kardava, Martha Kirby, Foo Cheung, Silvia Preite, Patrick Duncker, Nahir Romero, Diego Preciado, Lyuba Gitman, Galina Koroleva, Grace Smith, Arthur Shaffer, Ian McBain, Stefania Pittaluga, Ronald Germain, Richard Apps, Kaitlyn Sadtler, Susan Moir, Daniel Chertow, Steven Kleinstein, Surender Khurana, John Tsang, Pamela Mudd, Pamela Schwartzberg

Journal: Res Sq

PubMed ID: 35350206

Doi: 10.21203/rs.3.rs-1276578/v1

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The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with β-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking

Authors: Gaetan-Nagim Degroot, Valentin Lepage, Marc Parmentier, Jean-Yves Springael

Journal: Cells

PubMed ID: 35326488

Doi: 10.3390/cells11061037

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An In Vivo Screen to Identify Short Peptide Mimotopes with Enhanced Antitumor Immunogenicity

Authors: Xuedan He, Shiqi Zhou, Breandan Quinn, Dushyant Jahagirdar, Joaquin Ortega, Mark D Long, Scott I Abrams, Jonathan F Lovell

Journal: Cancer Immunol Res

PubMed ID: 34992135

Doi: 10.1158/2326-6066.CIR-21-0332

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Anti-SARS-CoV-2 equine F (Ab') immunoglobulin as a possible therapy for COVID-19

Authors: Viviane Fongaro Botosso, Soraia Attie Calil Jorge, Renato Mancini Astray, Ana Marcia de Sá Guimarães, Monica Beatriz Mathor, Patrícia Dos Santos de Carneiro, Edison Luiz Durigon, Dimas Covas, Danielle Bruna Leal de Oliveira, Ricardo das Neves Oliveira, Durvanei Augusto Maria, Silas Fernandes Eto, Neuza Maria Frazatti Gallina, Giselle Pidde, Carla Cristina Squaiella-Baptistão, Dilza Trevisan Silva, Isadora Maria Villas-Boas, Dayanne Carla Fernandes, Aline Vivian Vatti Auada, Alexandre Campos Banari, Antônio Francisco de Souza Filho, Camila Bianconi, Carla Lilian de Agostini Utescher, Denise Cristina André Oliveira, Douglas Oscar Ceolin Mariano, Flávia Ferreira Barbosa, Giuliana Rondon, Josana Kapronezai, Juliana Galvão da Silva, Mauricio Barbugiani Goldfeder, Priscila Comone, Regis Edgar Castilho Junior, Taiana Tainá Silva Pereira, Fan Hui Wen, Denise V Tambourgi, Ana Marisa Chudzinski-Tavassi

Journal: Sci Rep

PubMed ID: 35273234

Doi: 10.1038/s41598-022-07793-1

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Ubiquitylation is required for the incorporation of the Notch receptor into intraluminal vesicles to prevent prolonged and ligand-independent activation of the pathway

Authors: Björn Schnute, Hideyuki Shimizu, Marvin Lyga, Martin Baron, Thomas Klein

Journal: BMC Biol

PubMed ID: 35264151

Doi: 10.1186/s12915-022-01245-y

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Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

Authors: Roei D Mazor, Nachum Nathan, Amit Gilboa, Liat Stoler-Barak, Lihee Moss, Inna Solomonov, Assaf Hanuna, Yalin Divinsky, Merav D Shmueli, Hadas Hezroni, Irina Zaretsky, Michael Mor, Ofra Golani, Gad Sabah, Ariella Jakobson-Setton, Natalia Yanichkin, Meora Feinmesser, Daliah Tsoref, Lina Salman, Effi Yeoshoua, Eyal Peretz, Inna Erlich, Netta Mendelson Cohen, Jonathan M Gershoni, Natalia Freund, Yifat Merbl, Gur Yaari, Ram Eitan, Irit Sagi, Ziv Shulman

Journal: Cell

PubMed ID: 35305314

Doi: 10.1016/j.cell.2022.02.012

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Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98

Authors: Lisa Diez, Larisa E Kapinos, Janine Hochmair, Sabrina Huebschmann, Alvaro Dominguez-Baquero, Amelie Vogt, Marija Rankovic, Markus Zweckstetter, Roderick Y H Lim, Susanne Wegmann

Journal: Int J Mol Sci

PubMed ID: 35408855

Doi: 10.3390/ijms23073495

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Genome-wide investigation of maize RAD51 binding affinity through phage display

Authors: Claire Milsted, Bo Dai, Nelson Garcia, Lu Yin, Yan He, Shahryar Kianian, Wojciech Pawlowski, Changbin Chen

Journal: BMC Genomics

PubMed ID: 35279087

Doi: 10.1186/s12864-022-08419-6

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Gestational Leucylation Suppresses Embryonic T-Box Transcription Factor 5 Signal and Causes Congenital Heart Disease

Authors: Xuan Zhang , Lian Liu , Wei-Cheng Chen , Feng Wang , Yi-Rong Cheng , Yi-Meng Liu , Yang-Fan Lai , Rui-Jia Zhang , Ya-Nan Qiao , Yi-Yuan Yuan , Yan Lin , Wei Xu , Jing Cao , Yong-Hao Gui , Jian-Yuan Zhao

Journal: Adv Sci (Weinh)

PubMed ID: 35320615

Doi: 10.1002/advs.202201034

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Milk Fat Globule Membrane Alleviates Short Bowel Syndrome-Associated Liver Injury in Rats Through Inhibiting Autophagy and NLRP3 Inflammasome Activation

Authors: Zhicai Yu , Shanshan Huang , Ying Li , Yang Niu , Honghao Chen , Jiang Wu

Journal: Front Nutr

PubMed ID: 35308293

Doi: 10.3389/fnut.2022.758762

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Efficient C-to-G Base Editing with Improved Target Compatibility Using Engineered Deaminase-nCas9 Fusions

Authors: Siyu Chen, Zhiquan Liu, Liangxue Lai, Zhanjun Li