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Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton

Authors: Arit Ghosh, Megan Coffin, Richard West, Velia M Fowler

Journal: FASEB J

PubMed ID: 35195928

Doi: 10.1096/fj.202101011R

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Circ_0007611 stimulates IL-1 receptor accessory protein to inhibit trophoblast cell proliferation and induce cell apoptosis

Authors: Haiyan Xing, Qing Ding, Hong Lu, Qun Li

Journal: Biol Reprod

PubMed ID: 35238896

Doi: 10.1093/biolre/ioac028

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Biodiversity and infrastructure interact to drive tourism to and within Costa Rica

Authors: Alejandra Echeverri, Jeffrey R Smith, Dylan MacArthur-Waltz, Katherine S Lauck, Christopher B Anderson, Rafael Monge Vargas, Irene Alvarado Quesada, Spencer A Wood, Rebecca Chaplin-Kramer, Gretchen C Daily

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35245152

Doi: 10.1073/pnas.2107662119

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Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators

Authors: Jared P Beyersdorf, Swapnil Bawage, Nahid Iglesias, Hannah E Peck, Ryan A Hobbs, Jay A Wroe, Chiara Zurla, Charles A Gersbach, Philip J Santangelo

Journal: ACS Nano

PubMed ID: 35357116

Doi: 10.1021/acsnano.1c10631

Products & Services: Gene Synthesis Custom mRNA synthesis

Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway

Authors: Yang Bai, Jiaqi Chen, Weijian Hu, Lei Wang, Yulian Wu, Shi'an Yu

Journal: Front Pharmacol

PubMed ID: 35401195

Doi: 10.3389/fphar.2022.847905

Products & Services: Protein Electrophoresis and Western

Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation

Authors: Lili Yang, Zhengjun Li, Yao Chen, Feiyan Chen, Haopeng Sun, Min Zhao, Yanqi Chen, Yali Wang, Wenlin Li, Li Zeng, Yaoyao Bian

Journal: Oxid Med Cell Longev

PubMed ID: 35308169

Doi: 10.1155/2022/9226022

Products & Services: Mutant Libraries

Modular engineering of coculture for efficient production of resveratrol from glucose and arabinose mixture

Authors: Jia Li, Zetian Qiu, Guang-Rong Zhao

Journal: Synth Syst Biotechnol

PubMed ID: 35330959

Doi: 10.1016/j.synbio.2022.03.001

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Mobility of FLOWERING LOCUS T protein as a systemic signal in trifoliate orange and its low accumulation in grafted juvenile scions

Authors: Yan-Mei Wu, Yu-Jiao Ma, Min Wang, Huan Zhou, Zhi-Meng Gan, Ren-Fang Zeng, Li-Xia Ye, Jing-Jing Zhou, Jin-Zhi Zhang, Chun-Gen Hu

Journal: Hortic Res

PubMed ID: 35702366

Doi: 10.1093/hr/uhac056

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PACER: a novel 3D plant cell wall model for the analysis of non-catalytic and enzymatic responses

Authors: Mareike Monschein, Edita Jurak, Tanja Paasela, Taru Koitto, Vera Lambauer, Mirko Pavicic, Thomas Enjalbert, Claire Dumon, Emma R Master

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 35296345

Doi: 10.1186/s13068-022-02128-8

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Function and Application of the CRISPR-Cas System in the Plant Pathogen

Authors: Michael Parcey, Steven Gayder, Alan J Castle, Antonet M Svircev

Journal: Appl Environ Microbiol

PubMed ID: 35285707

Doi: 10.1128/aem.02513-21

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Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus

Authors: Douglas N Brawley, David B Sauer, Jianping Li, Xuhui Zheng, Akiko Koide, Ganesh S Jedhe, Tiffany Suwatthee, Jinmei Song, Zheng Liu, Paramjit S Arora, Shohei Koide, Victor J Torres, Da-Neng Wang, Nathaniel J Traaseth

Journal: Nat Chem Biol

PubMed ID: 35361990

Doi: 10.1038/s41589-022-00994-9

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Expression in Wilms Tumor Is Regulated by Promoter Mutation or Hypermethylation, WT1, and N-MYC

Authors: Carolyn M Jablonowski, Hyea Jin Gil, Emilia M Pinto, Prahalathan Pichavaram, Andrew M Fleming, Michael R Clay, Dongli Hu, Christopher L Morton, Shondra M Pruett-Miller, Baranda S Hansen, Xiang Chen, Karissa M Dieseldorff Jones, Yanling Liu, Xiaotu Ma, Jun Yang, Andrew M Davidoff, Gerard P Zambetti, Andrew J Murphy

Journal: Cancers (Basel)

PubMed ID: 35406427

Doi: 10.3390/cancers14071655

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A jacalin-like lectin domain-containing protein of Sclerospora graminicola acts as an apoplastic virulence effector in plant-oomycete interactions

Authors: Michie Kobayashi, Hiroe Utsushi, Koki Fujisaki, Takumi Takeda, Tetsuro Yamashita, Ryohei Terauchi

Journal: Mol Plant Pathol

PubMed ID: 35257477

Doi: 10.1111/mpp.13197

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Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host

Authors: Francesca D'Angelo, Elena Fernández-Fueyo, Pierre Simon Garcia, Helena Shomar, Martin Pelosse, Rita Rebelo Manuel, Ferhat Büke, Siyi Liu, Niels van den Broek, Nicolas Duraffourg, Carol de Ram, Martin Pabst, Emmanuelle Bouveret, Simonetta Gribaldo, Béatrice Py, Sandrine Ollagnier de Choudens, Frédéric Barras, Gregory Bokinsky

Journal: Elife

PubMed ID: 35244541

Doi: 10.7554/eLife.70936

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α-Melanocyte-stimulating hormone inhibition of oxytocin neurons switches to excitation in late pregnancy and lactation

Authors: Michael R Perkinson, Matthew K Kirchner, Meng Zhang, Rachael A Augustine, Javier E Stern, Colin H Brown

Journal: Physiol Rep

PubMed ID: 35312181

Doi: 10.14814/phy2.15226

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N-gene-complementary antisense-oligonucleotide directed molecular aggregation of dual-colour carbon dots, leading to efficient fluorometric sensing of SARS-COV-2 RNA

Authors: Zach Sheffield, Maha Alafeef, Parikshit Moitra, Priyanka Ray, Dipanjan Pan

Journal: Nanoscale

PubMed ID: 35297914

Doi: 10.1039/d1nr07169f

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Peptide mediated, enhanced toxicity of a bacterial pesticidal protein against southern green stink bug

Authors: Rahul Banerjee, Biviana Flores-Escobar, Nanasaheb P Chougule, Pablo Emiliano Cantón, Razvan Dumitru, Bryony C Bonning

Journal: Microb Biotechnol

PubMed ID: 35315236

Doi: 10.1111/1751-7915.14030

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Large-scale design and refinement of stable proteins using sequence-only models

Authors: Jedediah M Singer, Scott Novotney, Devin Strickland, Hugh K Haddox, Nicholas Leiby, Gabriel J Rocklin, Cameron M Chow, Anindya Roy, Asim K Bera, Francis C Motta, Longxing Cao, Eva-Maria Strauch, Tamuka M Chidyausiku, Alex Ford, Ethan Ho, Alexander Zaitzeff, Craig O Mackenzie, Hamed Eramian, Frank DiMaio, Gevorg Grigoryan, Matthew Vaughn, Lance J Stewart, David Baker, Eric Klavins

Journal: PLoS ONE

PubMed ID: 35286324

Doi: 10.1371/journal.pone.0265020

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SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes

Authors: LaNisha L Patterson, Thangam Sudha Velayutham, Caitlan D Byerly, Duc Cuong Bui, Jignesh Patel, Veljko Veljkovic, Slobodan Paessler, Jere W McBride

Journal: MBio

PubMed ID: 35357214

Doi: 10.1128/mbio.00076-22

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CRISPR/Cas9-Based Mutagenesis of Histone H31 in Spinal Dynorphinergic Neurons Attenuates Thermal Sensitivity in Mice

Authors: Zoltán Mészár, Éva Kókai, Rita Varga, László Ducza, Tamás Papp, Monika Béresová, Marianna Nagy, Péter Szücs, Angelika Varga

Journal: Int J Mol Sci

PubMed ID: 35328599

Doi: 10.3390/ijms23063178

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Ramifications of the HLA-I Allelic Reactivity of Anti-HLA-E*01:01 and Anti-HLA-E*01:03 Heavy Chain Monoclonal Antibodies in Comparison with Anti-HLA-I IgG Reactivity in Non-Alloimmunized Males, Melanoma-Vaccine Recipients, and End-Stage Renal Disease Patients

Authors: Mepur H Ravindranath, Narendranath M Ravindranath, Fatiha El Hilali, Senthamil R Selvan, Edward J Filippone

Journal: Antibodies (Basel)

PubMed ID: 35323192

Doi: 10.3390/antib11010018

Products & Services: Protein and Antibody Isolation

Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations

Authors: Zheng Fang Yang, Pankaj Panwar, Ciaran R McFarlane, Wietske E Tuinte, Marta Campiglio, Filip Van Petegem

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35238659

Doi: 10.1073/pnas.2120416119

Products & Services: Mammalian Expression

Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities

Authors: Suhail Khoja, Jenna Lambert, Matthew Nitzahn, Adam Eliav, YuChen Zhang, Mikayla Tamboline, Colleen T Le, Eram Nasser, Yunfeng Li, Puja Patel, Irina Zhuravka, Lindsay M Lueptow, Ilona Tkachyova, Shili Xu, Itzhak Nissim, Andreas Schulze, Gerald S Lipshutz

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35505663

Doi: 10.1016/j.omtm.2022.03.015

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Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules

Authors: Hui Jin, Kazuki Kishida, Noriko Arase, Sumiko Matsuoka, Wataru Nakai, Masako Kohyama, Tadahiro Suenaga, Ken Yamamoto, Takehiko Sasazuki, Hisashi Arase

Journal: Sci Adv

PubMed ID: 35245125

Doi: 10.1126/sciadv.abj9867

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The interaction of dengue virus capsid protein with negatively charged interfaces drives the in vitro assembly of nucleocapsid-like particles

Authors: Nathane C Mebus-Antunes, Wellington S Ferreira, Glauce M Barbosa, Thais C Neves-Martins, Gilberto Weissmuller, Fabio C L Almeida, Andrea T Da Poian

Journal: PLoS ONE

PubMed ID: 35231063

Doi: 10.1371/journal.pone.0264643

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Immunity to SARS-CoV-2: What Do We Know and Should We Be Testing for It?

Authors: Anisha Misra, Elitza S Theel

Journal: J Clin Microbiol

PubMed ID: 35249377

Doi: 10.1128/jcm.00482-21

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Association of Homologous and Heterologous Vaccine Boosters With COVID-19 Incidence and Severity in Singapore

Authors: Sharon Hui Xuan Tan, Rachael Pung, Lin-Fa Wang, David Chien Lye, Benjamin Ong, Alex R Cook, Kelvin Bryan Tan

Journal: JAMA

PubMed ID: 35147657

Doi: 10.1001/jama.2022.1922

Engineering a synthesis-friendly serum responsive promoter for antibiotic selection of genomic integration in cell-based therapy

Authors: Chee Ka Candice Lam, Kevin Truong

Journal: Biotechnol Lett

PubMed ID: 35294696

Doi: 10.1007/s10529-022-03244-z

Products & Services: PCR Cloning and Subcloning

Assay design for unambiguous identification and quantification of circulating pathogen-derived peptide biomarkers

Authors: Qingbo Shu, Shan Liu, Tonino Alonzi, Sylvia M LaCourse, Dhiraj Kumar Singh, Duran Bao, Dalton Wamalwa, Li Jiang, Christopher J Lyon, Grace John-Stewart, Deepak Kaushal, Delia Goletti, Tony Hu

Journal: Theranostics

PubMed ID: 35401822

Doi: 10.7150/thno.70373

Products & Services: Protein and Antibody Isolation

UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony

Authors: Sara Hegazi, Arthur H Cheng, Joshua J Krupp, Takafumi Tasaki, Jiashu Liu, Daniel A Szulc, Harrod H Ling, Julian Rios Garcia, Shavanie Seecharran, Tayebeh Basiri, Mehdi Amiri, Zobia Anwar, Safa Ahmad, Kamar Nayal, Nahum Sonenberg, Bao-Hua Liu, Hai-Ling Margaret Cheng, Joel D Levine, Hai-Ying Mary Cheng

Journal: Nat Commun

PubMed ID: 35332162

Doi: 10.1038/s41467-022-29244-1

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Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern

Authors: Jeroen Pollet, Ulrich Strych, Wen-Hsiang Chen, Leroy Versteeg, Brian Keegan, Bin Zhan, Junfei Wei, Zhuyun Liu, Jungsoon Lee, Rakhi Kundu, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar, Syamala Rani Thimmiraju, Brianna Lopez, Portia M Gillespie, Shannon Ronca, Jason T Kimata, Martin Reers, Vikram Paradkar, Peter Hotez, Maria Elena Bottazzi

Journal: biorxiv

PubMed ID: 34268512

Doi: 10.1101/2021.07.06.451353

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Glutathione binding to the plant Atm3 transporter and implications for the conformational coupling of ABC transporters

Authors: Chengcheng Fan, Douglas C Rees

Journal: Elife

PubMed ID: 35333177

Doi: 10.7554/eLife.76140

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Structural Basis for Human Receptor Recognition by SARS-CoV-2 Omicron Variant BA1

Authors: Qibin Geng, Ke Shi, Gang Ye, Wei Zhang, Hideki Aihara, Fang Li

Journal: J Virol

PubMed ID: 35343765

Doi: 10.1128/jvi.00249-22

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Mouse Adenovirus Type 1 E4orf6 Induces PKR Degradation

Authors: Berto Tejera-Hernández, Danielle E Goodman, Juan M Nevarez, Katherine R Spindler

Journal: J Virol

PubMed ID: 35285681

Doi: 10.1128/jvi.02063-21

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Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

Authors: Cheng Li, Wuqiang Zhan, Zhenlin Yang, Chao Tu, Gaowei Hu, Xiang Zhang, Wenping Song, Shujuan Du, Yuanfei Zhu, Keke Huang, Yu Kong, Meng Zhang, Qiyu Mao, Xiaodan Gu, Yi Zhang, Youhua Xie, Qiang Deng, Yuanlin Song, Zhenguo Chen, Lu Lu, Shibo Jiang, Yanling Wu, Lei Sun, Tianlei Ying

Journal: Cell

PubMed ID: 35344711

Doi: 10.1016/j.cell.2022.03.009

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A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder

Authors: Margit Kaldmäe, Thibault Vosselman, Xueying Zhong, Dilraj Lama, Gefei Chen, Mihkel Saluri, Nina Kronqvist, Jia Wei Siau, Aik Seng Ng, Farid J Ghadessy, Pierre Sabatier, Borivoj Vojtesek, Médoune Sarr, Cagla Sahin, Nicklas Österlund, Leopold L Ilag, Venla A Väänänen, Saikiran Sedimbi, Marie Arsenian-Henriksson, Roman A Zubarev, Lennart Nilsson, Philip J B Koeck, Anna Rising, Axel Abelein, Nicolas Fritz, Jan Johansson, David P Lane, Michael Landreh

Journal: Structure

PubMed ID: 35290795

Doi: 10.1016/j.str.2022.02.013

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Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice

Authors: Saurav S Rout, Yunyun Di, Ulf Dittmer, Kathrin Sutter, Kerry J Lavender

Journal: AIDS

PubMed ID: 35084382

Doi: 10.1097/QAD.0000000000003111

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Porcine circovirus 4 rescued from an infectious clone is replicable and pathogenic in vivo

Authors: Guyu Niu, Xinwei Zhang, Weilong Ji, Si Chen, Xue Li, Lin Yang, Liying Zhang, Hongsheng Ouyang, Chang Li, Linzhu Ren

Journal: Transbound Emerg Dis

PubMed ID: 35240007

Doi: 10.1111/tbed.14498

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A compact and simple method of achieving differential transgene expression by exploiting translational readthrough

Authors: James E Sillibourne, Giulia Agliardi, Matteo Righi, Katerina Smetanova, Grant Rowley, Simon Speller, Abigail Dolor, Katarina Lamb, Christopher Allen, Rajeev Karattil, Farhaan Parekh, Frederick Arce Vargas, Simon Thomas, Shaun Cordoba, Martin Pule

Journal: BioTechniques

PubMed ID: 35234525

Doi: 10.2144/btn-2021-0079

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A Protein vaccine with Alum/c-GAMP/poly(I:C) rapidly boosts robust immunity against SARS-CoV-2 and variants of concern

Authors: Ru-Yan Zhang , Xu-Guang Yin , Shi-Hao Zhou , Hai-Wei Zhang , Jie Lu , Chen-Bin He , Jian Wang , Yu Wen , Yu-Ting Li , Yan-Ling Liu , Ran-Ran Feng , Dong Ding , Hua-Wei Wei , Rui Gong , Guang-Fu Yang , Jun Guo

Journal: Chem Commun

PubMed ID: 35244125

Doi: 10.1039/D2CC00271J

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Development of a p72 trimer-based colloidal gold strip for detection of antibodies against African swine fever virus

Authors: Rui Geng, Yaning Sun, Rui Li, Jifei Yang, Hongfang Ma, Zixuan Qiao, Qingxia Lu, Songlin Qiao, Gaiping Zhang

Journal: Appl Microbiol Biotechnol

PubMed ID: 35291024

Doi: 10.1007/s00253-022-11851-z

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Baohuoside I Inhibits Tumor Angiogenesis in Multiple Myeloma the Peroxisome Proliferator-Activated Receptor γ/Vascular Endothelial Growth Factor Signaling Pathway

Authors: Ying Chen, Lina Zhang, Xiaoyan Zang, Xuxing Shen, Jianyong Li, Lijuan Chen

Journal: Front Pharmacol

PubMed ID: 35341213

Doi: 10.3389/fphar.2022.822082

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Development and Validation of a Competitive ELISA Based on Bovine Monoclonal Antibodies for the Detection of Neutralizing Antibodies against Foot-and-Mouth Disease Virus Serotype A

Authors: Yimei Cao, Kun Li, Xiangchuan Xing, Guoqiang Zhu, Yuanfang Fu, Huifang Bao, Xingwen Bai, Pu Sun, Pinghua Li, Jing Zhang, Xueqing Ma, Jian Wang, Zhixun Zhao, Dong Li, Zaixin Liu, Zengjun Lu

Journal: J Clin Microbiol

PubMed ID: 35254106

Doi: 10.1128/jcm.02142-21

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Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

Authors: Juan Qin, Jingfeng Zhang, Lianyun Lin, Omid Haji-Ghassemi, Zhi Lin, Kenneth J Woycechowsky, Filip Van Petegem, Yan Zhang, Zhiguang Yuchi

Journal: Elife

PubMed ID: 35297759

Doi: 10.7554/eLife.75346

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ClpX/P-Dependent Degradation of Novel Substrates in Streptococcus mutans

Authors: Vivek Gurung, Indranil Biswas

Journal: J Bacteriol

PubMed ID: 35343773

Doi: 10.1128/jb.00594-21

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Restriction of viral gene expression and replication prevents immortalization of human keratinocytes by a beta-human papillomavirus

Authors: Tina M Rehm, Elke Straub, Thomas Iftner, Frank Stubenrauch

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35254896

Doi: 10.1073/pnas.2118930119

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Predictable NHEJ Insertion and Assessment of HDR Editing Strategies in Plants

Authors: Kutubuddin A Molla, Justin Shih, Matthew S Wheatley, Yinong Yang

Journal: Front Genome Ed

PubMed ID: 35481279

Doi: 10.3389/fgeed.2022.825236

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Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling

Authors: Maricel Gomez-Soler, Marina P. Gehring, Bernhard C. Lechtenberg,Elmer Zapata-Mercado, Alyssa Ruelos,Mike W. Matsumoto,Kalina Hristova,and Elena B. Pasquale

Journal: iScience

Doi: doi.org/10.1016/j.isci.2022.103870

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Global profiling of regulatory elements in the histone benzoylation pathway

Authors: Duo Wang , Fuxiang Yan , Ping Wu, Kexue Ge , Muchun Li , Tingting Li , Ying Gao , Chao Peng , Yong Chen

Journal: Nat Commun

PubMed ID: 35296687

Doi: 10.1038/s41467-022-29057-2

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A multifunctional enolase mediates cytoadhesion and interaction with host plasminogen and fibronectin in Mycoplasma hyorhinis

Authors: Jia Wang , Yanfei Yu , Yao Li , Shiyang Li , Li Wang , Yanna Wei , Yuzi Wu , Bala Pillay , Ademola Olufolahan Olaniran , Thamsanqa E Chiliza , Guoqing Shao , Zhixin Feng , Qiyan Xiong

Journal: Vet Res

PubMed ID: 35337383

Doi: 10.1186/s13567-022-01041-0

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