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Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung inflammation

Authors: Koen K A Van Rompay, Katherine J Olstad, Rebecca L Sammak, Joseph Dutra, Jennifer K Watanabe, Jodie L Usachenko, Ramya Immareddy, Jamin W Roh, Anil Verma, Yashavanth Shaan Lakshmanappa, Brian A Schmidt, Clara Di Germanio, Nabeela Rizvi, Hongwei Liu, Zhong-Min Ma, Mars Stone, Graham Simmons, Larry J Dumont, A Mark Allen, Sarah Lockwood, Rachel E Pollard, Rafael Ramiro de Assis, JoAnn L Yee, Peter B Nham, Amir Ardeshir, Jesse D Deere, Aarti Jain, Philip L Felgner, Lark L Coffey, Smita S Iyer, Dennis J Hartigan-O'Connor, Michael P Busch, J Rachel Reader

Journal: PLoS Pathog

PubMed ID: 35443018

Doi: 10.1371/journal.ppat.1009925

Products & Services: Recombinant Antibody Expression

Formulation of simvastatin within high density lipoprotein enables potent tumour radiosensitisation

Authors: Pouya Dehghankelishadi, Michelle F Maritz, Nicole Dmochowska, Parisa Badiee, Edward Cheah, Ivan Kempson, Ross I Berbeco, Benjamin Thierry

Journal: J Control Release

PubMed ID: 35447296

Doi: 10.1016/j.jconrel.2022.04.017

Products & Services: Peptide Synthesis

Cathepsin B-Cleavable Polymeric Photosensitizer Prodrug for Selective Photodynamic Therapy: In Vitro Studies

Authors: Manish Jain, Jordan Bouilloux, Ines Borrego, Stéphane Cook, Hubert van den Bergh, Norbert Lange, Georges Wagnieres, Marie-Noelle Giraud

Journal: Pharmaceuticals (Basel)

PubMed ID: 35631388

Doi: 10.3390/ph15050564

Products & Services: Biochemicals

Tuning the Sensitivity of Genetically Encoded Fluorescent Potassium Indicators through Structure-Guided and Genome Mining Strategies

Authors: Cristina C Torres Cabán, Minghan Yang, Cuixin Lai, Lina Yang, Fedor V Subach, Brian O Smith, Kiryl D Piatkevich, Edward S Boyden

Journal: ACS Sens

PubMed ID: 35427452

Doi: 10.1021/acssensors.1c02201

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Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway

Authors: Xiaofang Wei, Juan Tan, Hui Gao

Journal: Bioengineered

PubMed ID: 35383535

Doi: 10.1080/21655979.2022.2060626

Products & Services: Custom DNA/RNA Oligos

Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants

Authors: Jason Z Zhang, Hsien-Wei Yeh, Alexandra C Walls, Basile I M Wicky, Kaitlin R Sprouse, Laura A VanBlargan, Rebecca Treger, Alfredo Quijano-Rubio, Minh N Pham, John C Kraft, Ian C Haydon, Wei Yang, Michelle DeWitt, John E Bowen, Cameron M Chow, Lauren Carter, Rashmi Ravichandran, Mark H Wener, Lance Stewart, David Veesler, Michael S Diamond, Alexander L Greninger, David M Koelle, David Baker

Journal: Nat Biotechnol

PubMed ID: 35484405

Doi: 10.1038/s41587-022-01280-8

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A third dose of mRNA-1273 vaccine improves SARS-CoV-2 immunity in HCT recipients with low antibody response after 2 doses

Authors: Elena Pettini, Annalisa Ciabattini, Gabiria Pastore, Jacopo Polvere, Simone Lucchesi, Fabio Fiorino, Francesca Montagnani, Alessandro Bucalossi, Monica Tozzi, Giuseppe Marotta, Donata Medaglini

Journal: Blood Adv

PubMed ID: 35073574

Doi: 10.1182/bloodadvances.2021006599

The recombinant defensin/HSA fusion protein that inhibits NF-κb associated with intensive macropinocytosis shows potent efficacy against pancreatic cancer

Authors: Yi-Bo Du, Xiao-Fei Wang, Xiu-Jun Liu, Yi Li, Qing-Fang Miao, Min Jiang, Wei-Jin Sheng, Yong-Su Zhen

Journal: Biochem Pharmacol

PubMed ID: 35489393

Doi: 10.1016/j.bcp.2022.115057

Products & Services: Recombinant Antibody Expression

Functional differentiation of three pheromone binding proteins in Orthaga achatina using mixed-type sex pheromones

Authors: Yu-Xiao Si, Jin-Meng Guo, Hui Liao, Yu Li, Yu Ma, Yu-Wei Zhu, Zhi-Qiang Wei, Shuang-Lin Dong, Qi Yan

Journal: Pestic Biochem Physiol

PubMed ID: 35715036

Doi: 10.1016/j.pestbp.2022.105097

Products & Services: Proteins, Expression, Isolation and Analysis

Hypomethylation-mediated upregulation of the WASF2 promoter region correlates with poor clinical outcomes in hepatocellular carcinoma

Authors: Hye Ri Ahn, Geum Ok Baek, Moon Gyeong Yoon, Ju A Son, Jung Hwan Yoon, Jae Youn Cheong, Hyo Jung Cho, Ho Chul Kang, Jung Woo Eun, Soon Sun Kim

Journal: J Exp Clin Cancer Res

PubMed ID: 35477411

Doi: 10.1186/s13046-022-02365-7

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A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis

Authors: Lei Zhang, James E Kent, Meredith Whitaker, David C Young, Dominik Herrmann, Alexander E Aleshin, Ying-Hui Ko, Gino Cingolani, Jamil S Saad, D Branch Moody, Francesca M Marassi, Sabine Ehrt, Michael Niederweis

Journal: Nat Commun

PubMed ID: 35474308

Doi: 10.1038/s41467-022-29873-6

Products & Services: Polyclonal Antibody Services

L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases

Authors: Patricia Amara, Claire Saragaglia, Jean-Marie Mouesca, Lydie Martin, Yvain Nicolet

Journal: Nat Commun

PubMed ID: 35477710

Doi: 10.1038/s41467-022-29980-4

Products & Services: Codon Optimization

C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Carbapenemase OXA-23 by Impeding Deacylation

Authors: Nichole K Stewart, Marta Toth, Maha A Alqurafi, Weirui Chai, Thu Q Nguyen, Pojun Quan, Mijoon Lee, John D Buynak, Clyde A Smith, Sergei B Vakulenko

Journal: MBio

PubMed ID: 35420470

Doi: 10.1128/mbio.00367-22

Products & Services: PCR Cloning and Subcloning

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B11529

Authors: Tongqing Zhou, Lingshu Wang, John Misasi, Amarendra Pegu, Yi Zhang, Darcy R Harris, Adam S Olia, Chloe Adrienna Talana, Eun Sung Yang, Man Chen, Misook Choe, Wei Shi, I-Ting Teng, Adrian Creanga, Claudia Jenkins, Kwanyee Leung, Tracy Liu, Erik-Stephane D Stancofski, Tyler Stephens, Baoshan Zhang, Yaroslav Tsybovsky, Barney S Graham, John R Mascola, Nancy J Sullivan, Peter D Kwong

Journal: Science

PubMed ID: 35324257

Doi: 10.1126/science.abn8897

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Neutralization of Myotoxin II, a Phospholipase A Homologue from Venom, Using Peptides Discovered via Phage Display Technology

Authors: Andreas H Laustsen, Bengt H Gless, Timothy P Jenkins, Maria Meyhoff-Madsen, Johanna Bjärtun, Andreas S Munk, Saioa Oscoz, Julián Fernández, José María Gutiérrez, Bruno Lomonte, Brian Lohse

Journal: ACS Omega

PubMed ID: 35571794

Doi: 10.1021/acsomega.2c00280

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Targeting kinesin family member 21B by miR-132-3p represses cell proliferation, migration and invasion in gastric cancer

Authors: Bingtian Liu, Ling Qiang, Bingxin Guan, Zhipeng Ji

Journal: Bioengineered

PubMed ID: 35341446

Doi: 10.1080/21655979.2022.2054755

Products & Services: Custom Vector Construction

Mitochondrial micropeptide STMP1 promotes G1/S transition by enhancing mitochondrial complex IV activity

Authors: Ye Sang, Jin-Yu Liu, Feng-Yi Wang, Xiao-Yu Luo, Zi-Qi Chen, Shi-Mei Zhuang, Ying Zhu

Journal: Mol Ther

PubMed ID: 35450818

Doi: 10.1016/j.ymthe.2022.04.012

Products & Services: Polyclonal Antibody Services

Hapten-labeled fusion-polymerase chain reaction of multiple marker genes for the application of immunochromatographic test

Authors: Atsushi Tabata, Rina Shirai, Haruka Miki, Yukihiro Nishikawa, Tatsuya Kashima, Tomomi Aoyama, Shu Murakami, Momoyo Azuma, Toshifumi Tomoyasu, Hideaki Nagamune

Journal: J Biosci Bioeng

PubMed ID: 35450786

Doi: 10.1016/j.jbiosc.2022.03.006

Products & Services: Plasmid DNA Preparation

Identifying Small-Molecule Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase by Establishing a Fluorometric Assay

Authors: Xiaoming Bai, Hongmin Sun, Shuo Wu, Yuhuan Li, Lifei Wang, Bin Hong

Journal: Front Immunol

PubMed ID: 35464436

Doi: 10.3389/fimmu.2022.844749

Products & Services: Recombinant Antibody Expression

Conserved metabolic enzymes as vaccine antigens for giardiasis

Authors: Sozaburo Ihara, Yukiko Miyamoto, Christine H Y Le, Vivien N Tran, Elaine M Hanson, Marvin Fischer, Kurt Hanevik, Lars Eckmann

Journal: PLoS Negl Trop Dis

PubMed ID: 35468132

Doi: 10.1371/journal.pntd.0010323

Products & Services: Gene Synthesis

Armet from whitefly saliva acts as an effector to suppress plant defences by targeting tobacco cystatin

Authors: Hui Du, Hong-Xing Xu, Fang Wang, Li-Xin Qian, Shu-Sheng Liu, Xiao-Wei Wang

Journal: New Phytol

PubMed ID: 35238409

Doi: 10.1111/nph.18063

Products & Services: Proteins, Expression, Isolation and Analysis

Biomimetic biphasic curdlan-based scaffold for osteochondral tissue engineering applications - Characterization and preliminary evaluation of mesenchymal stem cell response in vitro

Authors: Katarzyna Klimek, Aleksandra Benko, Marta Vandrovcova, Martina Travnickova, Timothy E L Douglas, Marta Tarczynska, Antonin Broz, Krzysztof Gaweda, Grazyna Ginalska, Lucie Bacakova

Journal: Biomater Adv

PubMed ID: 35929204

Doi: 10.1016/j.bioadv.2022.212724

Products & Services: Mammalian Expression

SARS-CoV-2 nsp5 Exhibits Stronger Catalytic Activity and Interferon Antagonism than Its SARS-CoV Ortholog

Authors: Jiyao Chen, Zhuang Li, Jiahui Guo, Shangen Xu, Junwei Zhou, Qian Chen, Xue Tong, Dang Wang, Guiqing Peng, Liurong Fang, Shaobo Xiao

Journal: J Virol

PubMed ID: 35389264

Doi: 10.1128/jvi.00037-22

Products & Services: Proteins, Expression, Isolation and Analysis

Structural characterization of a dimerization interface in the CD28 transmembrane domain

Authors: Hongyi Wu, Ruiyu Cao, Maorong Wen, Hongjuan Xue, Bo OuYang

Journal: Structure

PubMed ID: 35397202

Doi: 10.1016/j.str.2022.03.004

Products & Services: GenParts™ DNA Fragments

Multiple Polypyrimidine Tract Elements Regulate a Cooperative Mechanism for Triticum Mosaic Virus Internal Ribosomal Entry Site Activity

Authors: Helena Jaramillo-Mesa, Emma Fischer, Aurélie M Rakotondrafara

Journal: Front Plant Sci

PubMed ID: 35498652

Doi: 10.3389/fpls.2022.864832

Products & Services: Molecular Biology Reagents

Evaluation of biotransformation capacity of transplastomic plants and hairy roots of Nicotiana tabacum expressing human cytochrome P450 2D6

Authors: Y V Sheludko, I M Gerasymenko, F J Herrmann, H Warzecha

Journal: Transgenic Res

PubMed ID: 35416604

Doi: 10.1007/s11248-022-00305-x

Products & Services: Codon Optimization

Production of interferon gamma and interleukin 17A in chicken T-cell subpopulations hallmarks the stimulation with live, irradiated and killed avian pathogenic Escherichia coli

Authors: Sina Bagheri, Surya Paudel, Viskam Wijewardana, Richard Thiga Kangethe, Giovanni Cattoli, Michael Hess, Dieter Liebhart, Taniya Mitra

Journal: Dev Comp Immunol

PubMed ID: 35390358

Doi: 10.1016/j.dci.2022.104408

Products & Services: Molecular Biology Tools

A Recombinant Turkey Herpesvirus Expressing the F Protein of Newcastle Disease Virus Genotype XII Generated by NHEJ-CRISPR/Cas9 and Cre-LoxP Systems Confers Protection against Genotype XII Challenge in Chickens

Authors: Katherine Calderón, Aldo Rojas-Neyra, Brigith Carbajal-Lévano, Luis Luján-Valenzuela, Julio Ticona, Gisela Isasi-Rivas, Angela Montalvan, Manuel Criollo-Orozco, Edison Huaccachi-Gonzáles, Luis Tataje-Lavanda, Karla Lucia F Alvarez, Manolo Fernández-Sánchez, Manolo Fernández-Díaz, Na Tang, Yongxiu Yao, Venugopal Nair

Journal: Viruses

PubMed ID: 35458523

Doi: 10.3390/v14040793

Products & Services: Catalog Antibody

Circ_0047921 acts as the sponge of miR-1287-5p to stimulate lung cancer progression by regulating proliferation, migration, invasion, and glycolysis of lung cancer cells

Authors: Yuehua Xiao, Shequn Gu, Wenxiu Yao, Ling Qin, Jihui Luo

Journal: World J Surg Oncol

PubMed ID: 35365169

Doi: 10.1186/s12957-021-02466-1

Products & Services: Recombinant Proteins

Monoclonal antibody 7H22 binds the C-terminus of the cancer-oocyte antigen SAS1B through the hydrophilic face of a conserved amphipathic helix corresponding to one of only two regions predicted to be ordered

Authors: Max S G Legg, Susannah M L Gagnon, Cameron J Powell, Martin J Boulanger, Andra J J Li, Stephen V Evans

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35503210

Doi: 10.1107/S2059798322003011

Products & Services: Peptide Synthesis

High-yield overproduction and purification of human aquaporins from

Authors: Tamim Al-Jubair, Jonas Hyld Steffen, Julie Winkel Missel, Philip Kitchen, Mootaz M Salman, Roslyn M Bill, Pontus Gourdon, Susanna Törnroth-Horsefield

Journal: STAR Protoc

PubMed ID: 35463467

Doi: 10.1016/j.xpro.2022.101298

Products & Services: Gene Synthesis

Immunogenicity and safety of homologous and heterologous ChAdOx1-S and mRNA-1273 vaccinations in healthy adults in Taiwan

Authors: Chun-Min Kang, Nan-Yao Lee, Chih-Hsueh Lin, Yuan-Shan Hsu, Yu-Chang Chang, Ming-Yi Chung, Ya-Fan Lee, Wen-Pin Tseng, Jhong-Lin Wu, Shey-Ying Chen, Min-Chi Lu, Wen-Chien Ko, Ping-Ing Lee, Po-Ren Hsueh

Journal: J Clin Virol

PubMed ID: 35413588

Doi: 10.1016/j.jcv.2022.105156

Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration

Authors: Synne Arstad Bjørnestad, Noemi Antonella Guadagno, Ingrid Kjos, Cinzia Progida

Journal: iScience

PubMed ID: 35521520

Doi: 10.1016/j.isci.2022.104250

Products & Services: ORF cDNA Clones/MolecularCloud

Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial-mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer

Authors: Ziwen Lu, Sirui Yuan, Lingling Ruan, Zhigang Tu, Hanqing Liu

Journal: Cell Death Dis

PubMed ID: 35379775

Doi: 10.1038/s41419-022-04756-2

Products & Services: Catalog Peptides

Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge

Authors: Stian Foss, Alexandra Jonsson, Maria Bottermann, Ruth Watkinson, Heidrun E Lode, Martin B McAdam, Terje E Michaelsen, Inger Sandlie, Leo C James, Jan Terje Andersen

Journal: Sci Immunol

PubMed ID: 35486676

Doi: 10.1126/sciimmunol.abj1640

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Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor

Authors: Chunlong Ma, Yanmei Hu, Yuyin Wang, Juliana Choza, Jun Wang

Journal: ACS Infect Dis

PubMed ID: 35404564

Doi: 10.1021/acsinfecdis.1c00629

Products & Services: ORF cDNA Clones/MolecularCloud

Dual Role of HIV-1 Envelope Signal Peptide in Immune Evasion

Authors: Chitra Upadhyay, Priyanka Gadam Rao, Roya Feyznezhad

Journal: Viruses

PubMed ID: 35458538

Doi: 10.3390/v14040808

Products & Services: Polyclonal Antibody Services

Antagonist of Chrna1 prevents the pathogenesis of primary focal hyperhidrosis

Authors: Jian-Bo Lin, Nan-Long Lin, Xu Li, Ming-Qiang Kang

Journal: Ann Clin Transl Neurol

PubMed ID: 35393764

Doi: 10.1002/acn3.51558

Products & Services: Plasmid DNA Preparation

Dynamic immunodominance hierarchy of neutralizing antibody responses to evolving GII4 noroviruses

Authors: Kentaro Tohma, Lauren A Ford-Siltz, Joseph A Kendra, Gabriel I Parra

Journal: Cell Rep

PubMed ID: 35417705

Doi: 10.1016/j.celrep.2022.110689

Products & Services: Monoclonal Antibody Services

Sortase-mediated immobilization of lipase B (CalB) on graphene oxide; comparison with chemical approach

Authors: Faezeh Moosavi, Faezeh Ahrari, Gholamreza Ahmadian, Mehdi Mohammadi

Journal: Biotechnol Rep (Amst)

PubMed ID: 35686009

Doi: 10.1016/j.btre.2022.e00733

Products & Services: Plasmid DNA Preparation

lncRNA STAT4-AS1 Inhibited TH17 Cell Differentiation by Targeting RORt Protein

Authors: Hanlin He, Xiangjie Qiu, Mingming Qi, Ousman Bajinka, Ling Qin, Yurong Tan

Journal: J Immunol Res

PubMed ID: 35528611

Doi: 10.1155/2022/8307280

Products & Services: Gene Synthesis

Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood

Authors: Tetsuhiro Horie, Kazuya Fukasawa, Takanori Yamada, Seiya Mizuno, Takashi Iezaki, Kazuya Tokumura, Sayuki Iwahashi, Shiho Sakai, Akane Suzuki, Takuya Kubo, Ryoma Osumi, Akane Tomizawa, Hiroki Ochi, Shingo Sato, Katsuyuki Kaneda, Satoru Takahashi, Eiichi Hinoi

Journal: Stem Cells

PubMed ID: 35304894

Doi: 10.1093/stmcls/sxac011

Products & Services: Polyclonal Antibody Services

Dynamic modulation of enzyme activity by synthetic CRISPR-Cas6 endonucleases

Authors: Alexander A Mitkas, Mauricio Valverde, Wilfred Chen

Journal: Nat Chem Biol

PubMed ID: 35468950

Doi: 10.1038/s41589-022-01005-7

Products & Services: Monoclonal Antibody Services

Hydrophobic mismatch is a key factor in protein transport across lipid bilayer membranes via the Tat pathway

Authors: Binhan Hao, Wenjie Zhou, Steven M Theg

Journal: J Biol Chem

PubMed ID: 35490783

Doi: 10.1016/j.jbc.2022.101991

Products & Services: Proteins, Expression, Isolation and Analysis

Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold

Authors: Raphael J Eberle, Ian Gering, Markus Tusche, Philipp N Ostermann, Lisa Müller, Ortwin Adams, Heiner Schaal, Danilo S Olivier, Marcos S Amaral, Raghuvir K Arni, Dieter Willbold, Mônika A Coronado

Journal: Pharmaceuticals (Basel)

PubMed ID: 35631367

Doi: 10.3390/ph15050540

Products & Services: Catalog Antibody

AdpA, a developmental regulator, promotes ε-poly-l-lysine biosynthesis in Streptomyces albulus

Authors: Rui Huang , Honglu Liu , Wanwan Zhao , Siqi Wang , Shufang Wang , Jun Cai , Chao Yang

Journal: Microb Cell Fact

PubMed ID: 35397580

Doi: 10.1186/s12934-022-01785-6

Products & Services: Gene Synthesis Proteins, Expression, Isolation and Analysis

Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses

Authors: Yingdan Wang, Meiqin Liu, Yaping Shen, Yunping Ma, Xiang Li, Yuanyuan Zhang, Mei Liu, Xing-Lou Yang, Jun Chen, Renhong Yan, Die Luan, Yanqun Wang, Ying Chen, Qimin Wang, Haofeng Lin, Yaning Li, Kaiyue Wu, Tongyu Zhu, Jincun Zhao, Hongzhou Lu, Yumei Wen, Shibo Jiang, Fan Wu, Qiang Zhou, Zheng-Li Shi, Jinghe Huang

Journal: Cell Discov

PubMed ID: 35443747

Doi: 10.1038/s41421-022-00401-6

Products & Services: Codon Optimization Proteins, Expression, Isolation and Analysis

A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver

Authors: Anna Georgina Kopasz, Dávid Zsolt Pusztai , Réka Karkas, Liza Hudoba, Khaldoon Sadiq Ahmed Abdullah, Gergely Imre, Gabriella Pankotai-Bodó, Ede Migh, Andrea Nagy, András Kriston, Péter Germán，Andrea Bakné Drubi, Anna Molnár, Ildikó Fekete, Virág Éva Dani, Imre Ocsovszki, László Géza Puskás, Péter Horváth, Farkas Sükösd, Lajos Mátés

Journal: BMC Biol

PubMed ID: 35361222

Doi: 10.1186/s12915-022-01262-x

Products & Services: Gene Synthesis

Analyzing the Hypothalamus/Pituitary/Interrenal axis of the neopterygian fish, Lepisosteus oculatus: Co-localization of MC2R, MC5R, MRAP1, and MRAP2 in interrenal cells

Authors: Marty Kwok-Shing Wong, Robert M Dores

Journal: Gen Comp Endocrinol

PubMed ID: 35447133

Doi: 10.1016/j.ygcen.2022.114043

Products & Services: Molecular Biology Reagents

Developing all-in-one virus-like particles for Cas9 mRNA/single guide RNA co-delivery and aptamer-containing lentiviral vectors for improved gene expression

Authors: Manish Yadav , Anthony Atala , Baisong Lu

Journal: Int J Biol Macromol

PubMed ID: 35461863

Doi: 10.1016/j.ijbiomac.2022.04.114

Products & Services: Gene Synthesis

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