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Structural characterization of a dimerization interface in the CD28 transmembrane domain

Authors: Hongyi Wu, Ruiyu Cao, Maorong Wen, Hongjuan Xue, Bo OuYang

Journal: Structure

PubMed ID: 35397202

Doi: 10.1016/j.str.2022.03.004

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Multiple Polypyrimidine Tract Elements Regulate a Cooperative Mechanism for Triticum Mosaic Virus Internal Ribosomal Entry Site Activity

Authors: Helena Jaramillo-Mesa, Emma Fischer, Aurélie M Rakotondrafara

Journal: Front Plant Sci

PubMed ID: 35498652

Doi: 10.3389/fpls.2022.864832

Products & Services: Molecular Biology Reagents

Evaluation of biotransformation capacity of transplastomic plants and hairy roots of Nicotiana tabacum expressing human cytochrome P450 2D6

Authors: Y V Sheludko, I M Gerasymenko, F J Herrmann, H Warzecha

Journal: Transgenic Res

PubMed ID: 35416604

Doi: 10.1007/s11248-022-00305-x

Products & Services: Codon Optimization

Production of interferon gamma and interleukin 17A in chicken T-cell subpopulations hallmarks the stimulation with live, irradiated and killed avian pathogenic Escherichia coli

Authors: Sina Bagheri, Surya Paudel, Viskam Wijewardana, Richard Thiga Kangethe, Giovanni Cattoli, Michael Hess, Dieter Liebhart, Taniya Mitra

Journal: Dev Comp Immunol

PubMed ID: 35390358

Doi: 10.1016/j.dci.2022.104408

Products & Services: Molecular Biology Tools

A Recombinant Turkey Herpesvirus Expressing the F Protein of Newcastle Disease Virus Genotype XII Generated by NHEJ-CRISPR/Cas9 and Cre-LoxP Systems Confers Protection against Genotype XII Challenge in Chickens

Authors: Katherine Calderón, Aldo Rojas-Neyra, Brigith Carbajal-Lévano, Luis Luján-Valenzuela, Julio Ticona, Gisela Isasi-Rivas, Angela Montalvan, Manuel Criollo-Orozco, Edison Huaccachi-Gonzáles, Luis Tataje-Lavanda, Karla Lucia F Alvarez, Manolo Fernández-Sánchez, Manolo Fernández-Díaz, Na Tang, Yongxiu Yao, Venugopal Nair

Journal: Viruses

PubMed ID: 35458523

Doi: 10.3390/v14040793

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Circ_0047921 acts as the sponge of miR-1287-5p to stimulate lung cancer progression by regulating proliferation, migration, invasion, and glycolysis of lung cancer cells

Authors: Yuehua Xiao, Shequn Gu, Wenxiu Yao, Ling Qin, Jihui Luo

Journal: World J Surg Oncol

PubMed ID: 35365169

Doi: 10.1186/s12957-021-02466-1

Products & Services: Recombinant Proteins

Monoclonal antibody 7H22 binds the C-terminus of the cancer-oocyte antigen SAS1B through the hydrophilic face of a conserved amphipathic helix corresponding to one of only two regions predicted to be ordered

Authors: Max S G Legg, Susannah M L Gagnon, Cameron J Powell, Martin J Boulanger, Andra J J Li, Stephen V Evans

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35503210

Doi: 10.1107/S2059798322003011

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High-yield overproduction and purification of human aquaporins from

Authors: Tamim Al-Jubair, Jonas Hyld Steffen, Julie Winkel Missel, Philip Kitchen, Mootaz M Salman, Roslyn M Bill, Pontus Gourdon, Susanna Törnroth-Horsefield

Journal: STAR Protoc

PubMed ID: 35463467

Doi: 10.1016/j.xpro.2022.101298

Products & Services: Gene Synthesis

Immunogenicity and safety of homologous and heterologous ChAdOx1-S and mRNA-1273 vaccinations in healthy adults in Taiwan

Authors: Chun-Min Kang, Nan-Yao Lee, Chih-Hsueh Lin, Yuan-Shan Hsu, Yu-Chang Chang, Ming-Yi Chung, Ya-Fan Lee, Wen-Pin Tseng, Jhong-Lin Wu, Shey-Ying Chen, Min-Chi Lu, Wen-Chien Ko, Ping-Ing Lee, Po-Ren Hsueh

Journal: J Clin Virol

PubMed ID: 35413588

Doi: 10.1016/j.jcv.2022.105156

Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration

Authors: Synne Arstad Bjørnestad, Noemi Antonella Guadagno, Ingrid Kjos, Cinzia Progida

Journal: iScience

PubMed ID: 35521520

Doi: 10.1016/j.isci.2022.104250

Products & Services: ORF cDNA Clones/MolecularCloud

Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial-mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer

Authors: Ziwen Lu, Sirui Yuan, Lingling Ruan, Zhigang Tu, Hanqing Liu

Journal: Cell Death Dis

PubMed ID: 35379775

Doi: 10.1038/s41419-022-04756-2

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Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge

Authors: Stian Foss, Alexandra Jonsson, Maria Bottermann, Ruth Watkinson, Heidrun E Lode, Martin B McAdam, Terje E Michaelsen, Inger Sandlie, Leo C James, Jan Terje Andersen

Journal: Sci Immunol

PubMed ID: 35486676

Doi: 10.1126/sciimmunol.abj1640

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Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor

Authors: Chunlong Ma, Yanmei Hu, Yuyin Wang, Juliana Choza, Jun Wang

Journal: ACS Infect Dis

PubMed ID: 35404564

Doi: 10.1021/acsinfecdis.1c00629

Products & Services: ORF cDNA Clones/MolecularCloud

Dual Role of HIV-1 Envelope Signal Peptide in Immune Evasion

Authors: Chitra Upadhyay, Priyanka Gadam Rao, Roya Feyznezhad

Journal: Viruses

PubMed ID: 35458538

Doi: 10.3390/v14040808

Products & Services: Polyclonal Antibody Services

Antagonist of Chrna1 prevents the pathogenesis of primary focal hyperhidrosis

Authors: Jian-Bo Lin, Nan-Long Lin, Xu Li, Ming-Qiang Kang

Journal: Ann Clin Transl Neurol

PubMed ID: 35393764

Doi: 10.1002/acn3.51558

Products & Services: Plasmid DNA Preparation

Dynamic immunodominance hierarchy of neutralizing antibody responses to evolving GII4 noroviruses

Authors: Kentaro Tohma, Lauren A Ford-Siltz, Joseph A Kendra, Gabriel I Parra

Journal: Cell Rep

PubMed ID: 35417705

Doi: 10.1016/j.celrep.2022.110689

Products & Services: Monoclonal Antibody Services

Sortase-mediated immobilization of lipase B (CalB) on graphene oxide; comparison with chemical approach

Authors: Faezeh Moosavi, Faezeh Ahrari, Gholamreza Ahmadian, Mehdi Mohammadi

Journal: Biotechnol Rep (Amst)

PubMed ID: 35686009

Doi: 10.1016/j.btre.2022.e00733

Products & Services: Plasmid DNA Preparation

lncRNA STAT4-AS1 Inhibited TH17 Cell Differentiation by Targeting RORt Protein

Authors: Hanlin He, Xiangjie Qiu, Mingming Qi, Ousman Bajinka, Ling Qin, Yurong Tan

Journal: J Immunol Res

PubMed ID: 35528611

Doi: 10.1155/2022/8307280

Products & Services: Gene Synthesis

Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood

Authors: Tetsuhiro Horie, Kazuya Fukasawa, Takanori Yamada, Seiya Mizuno, Takashi Iezaki, Kazuya Tokumura, Sayuki Iwahashi, Shiho Sakai, Akane Suzuki, Takuya Kubo, Ryoma Osumi, Akane Tomizawa, Hiroki Ochi, Shingo Sato, Katsuyuki Kaneda, Satoru Takahashi, Eiichi Hinoi

Journal: Stem Cells

PubMed ID: 35304894

Doi: 10.1093/stmcls/sxac011

Products & Services: Polyclonal Antibody Services

Dynamic modulation of enzyme activity by synthetic CRISPR-Cas6 endonucleases

Authors: Alexander A Mitkas, Mauricio Valverde, Wilfred Chen

Journal: Nat Chem Biol

PubMed ID: 35468950

Doi: 10.1038/s41589-022-01005-7

Products & Services: Monoclonal Antibody Services

Hydrophobic mismatch is a key factor in protein transport across lipid bilayer membranes via the Tat pathway

Authors: Binhan Hao, Wenjie Zhou, Steven M Theg

Journal: J Biol Chem

PubMed ID: 35490783

Doi: 10.1016/j.jbc.2022.101991

Products & Services: Proteins, Expression, Isolation and Analysis

Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold

Authors: Raphael J Eberle, Ian Gering, Markus Tusche, Philipp N Ostermann, Lisa Müller, Ortwin Adams, Heiner Schaal, Danilo S Olivier, Marcos S Amaral, Raghuvir K Arni, Dieter Willbold, Mônika A Coronado

Journal: Pharmaceuticals (Basel)

PubMed ID: 35631367

Doi: 10.3390/ph15050540

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AdpA, a developmental regulator, promotes ε-poly-l-lysine biosynthesis in Streptomyces albulus

Authors: Rui Huang , Honglu Liu , Wanwan Zhao , Siqi Wang , Shufang Wang , Jun Cai , Chao Yang

Journal: Microb Cell Fact

PubMed ID: 35397580

Doi: 10.1186/s12934-022-01785-6

Products & Services: Gene Synthesis Proteins, Expression, Isolation and Analysis

Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses

Authors: Yingdan Wang, Meiqin Liu, Yaping Shen, Yunping Ma, Xiang Li, Yuanyuan Zhang, Mei Liu, Xing-Lou Yang, Jun Chen, Renhong Yan, Die Luan, Yanqun Wang, Ying Chen, Qimin Wang, Haofeng Lin, Yaning Li, Kaiyue Wu, Tongyu Zhu, Jincun Zhao, Hongzhou Lu, Yumei Wen, Shibo Jiang, Fan Wu, Qiang Zhou, Zheng-Li Shi, Jinghe Huang

Journal: Cell Discov

PubMed ID: 35443747

Doi: 10.1038/s41421-022-00401-6

Products & Services: Codon Optimization Proteins, Expression, Isolation and Analysis

A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver

Authors: Anna Georgina Kopasz, Dávid Zsolt Pusztai , Réka Karkas, Liza Hudoba, Khaldoon Sadiq Ahmed Abdullah, Gergely Imre, Gabriella Pankotai-Bodó, Ede Migh, Andrea Nagy, András Kriston, Péter Germán，Andrea Bakné Drubi, Anna Molnár, Ildikó Fekete, Virág Éva Dani, Imre Ocsovszki, László Géza Puskás, Péter Horváth, Farkas Sükösd, Lajos Mátés

Journal: BMC Biol

PubMed ID: 35361222

Doi: 10.1186/s12915-022-01262-x

Products & Services: Gene Synthesis

Analyzing the Hypothalamus/Pituitary/Interrenal axis of the neopterygian fish, Lepisosteus oculatus: Co-localization of MC2R, MC5R, MRAP1, and MRAP2 in interrenal cells

Authors: Marty Kwok-Shing Wong, Robert M Dores

Journal: Gen Comp Endocrinol

PubMed ID: 35447133

Doi: 10.1016/j.ygcen.2022.114043

Products & Services: Molecular Biology Reagents

Developing all-in-one virus-like particles for Cas9 mRNA/single guide RNA co-delivery and aptamer-containing lentiviral vectors for improved gene expression

Authors: Manish Yadav , Anthony Atala , Baisong Lu

Journal: Int J Biol Macromol

PubMed ID: 35461863

Doi: 10.1016/j.ijbiomac.2022.04.114

Products & Services: Gene Synthesis

Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes

Authors: Zhirong Fu , Srinivas Akula , Anna-Karin Olsson , Lars Hellman

Journal: Dev Comp Immunol

PubMed ID: 34919980

Doi: 10.1016/j.dci.2021.104337

Products & Services: Gene Synthesis

Monosaccharide-mediated rational synthesis of a universal plasmonic platform with broad spectral fluorescence enhancement for high-sensitivity cancer biomarker analysis

Authors: Mengyao Liu, Yonghong Li, Wei Xing, Yuqin Zhang, Xi Xie, Jiadong Pang, Fangjian Zhou, Jiang Yang

Journal: J Nanobiotechnology

PubMed ID: 35399094

Doi: 10.1186/s12951-022-01359-z

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Generation of a host cell line containing a MAR-rich landing pad for site-specific integration and expression of transgenes

Authors: Claudia Oliviero, Steffen C Hinz, Jan P Bogen, Henri Kornmann, Björn Hock, Harald Kolmar, Gerrit Hagens

Journal: Biotechnol Prog

PubMed ID: 35396920

Doi: 10.1002/btpr.3254

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PACAP/GCGa Is an Important Modulator of the Amphioxus CNS-Hatschek's Pit Axis, the Homolog of the Vertebrate Hypothalamic-Pituitary Axis in the Basal Chordates

Authors: Jason S W On, Liuru Su, Hong Shen, Aloysius W R Arokiaraj, João C R Cardoso, Guang Li, Billy K C Chow

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35498398

Doi: 10.3389/fendo.2022.850040

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Fish allergens of turbot () parvalbumin triggers food allergy inducing maturation of bone marrow derived dendritic cells and driving Th2 immune response

Authors: Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Mengyao Xu, Ishfaq Ahmed, Guanzhi Chen, Yan Chen, Zhenxing Li

Journal: Food Funct

PubMed ID: 35322825

Doi: 10.1039/d1fo04070g

Products & Services: Proteins, Expression, Isolation and Analysis

Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity

Authors: Jiale Ren, Ni Li, Siyu Pei, Yannan Lian, Li Li, Yuchong Peng, Qiuli Liu, Jiacheng Guo, Xuege Wang, Ying Han, Guoying Zhang, Hanling Wang, Yaqi Li, Jun Jiang, Qintong Li, Minjia Tan, Junjie Peng, Guohong Hu, Yichuan Xiao, Xiong Li, Moubin Lin, Jun Qin

Journal: J Clin Invest

PubMed ID: 35230972

Doi: 10.1172/JCI153167

Products & Services: Recombinant Proteins

Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation

Authors: Fatemeh Adiliaghdam, Hajera Amatullah, Sreehaas Digumarthi, Tahnee L Saunders, Raza-Ur Rahman, Lai Ping Wong, Ruslan Sadreyev, Lindsay Droit, Jean Paquette, Philippe Goyette, John D Rioux, Richard Hodin, Kathie A Mihindukulasuriya, Scott A Handley, Kate L Jeffrey

Journal: Sci Immunol

PubMed ID: 35394816

Doi: 10.1126/sciimmunol.abn6660

Products & Services: Mammalian Expression

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

Authors: Andrea J Parsons, Sabrina I Ophir, J Andrew Duty, Thomas A Kraus, Kathryn R Stein, Thomas M Moran, Domenico Tortorella

Journal: Commun Biol

PubMed ID: 35468974

Doi: 10.1038/s42003-022-03294-z

Products & Services: Mammalian Expression

Exopolysaccharides from Pantoea alhagi NX-11 specifically improve its root colonization and rice salt resistance

Authors: Liang Sun, Lifangyu Cheng, Yuhang Ma, Peng Lei, Rui Wang, Yian Gu, Sha Li, Fuhai Zhang, Hong Xu

Journal: Int J Biol Macromol

PubMed ID: 35413311

Doi: 10.1016/j.ijbiomac.2022.04.015

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Synthetic carbohydrate-binding agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2

Authors: Oscar Francesconi, Lorena Donnici, Marco Fragai, Elisa Pesce, Mauro Bombaci, Alessandra Fasciani, Lara Manganaro, Matteo Conti, Renata Grifantini, Raffaele De Francesco, Cristina Nativi, Stefano Roelens

Journal: iScience

PubMed ID: 35434540

Doi: 10.1016/j.isci.2022.104239

Products & Services: Mammalian Expression

ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer

Authors: Eunju Kim, Yoon-Jin Kim, Zhiwei Ji, Jin Muk Kang, Marvin Wirianto, Keshav Raj Paudel, Joshua A Smith, Kaori Ono, Jin-Ah Kim, Kristin Eckel-Mahan, Xiaobo Zhou, Hyun Kyoung Lee, Ji Young Yoo, Seung-Hee Yoo, Zheng Chen

Journal: Cell Death Dis

PubMed ID: 35440077

Doi: 10.1038/s41419-022-04826-5

Products & Services: Recombinant Proteins

Identification of Phosphorylation and Other Post-Translational Modifications in the Central C4C5 Domains of Murine Cardiac Myosin Binding Protein C

Authors: Chang Yoon Doh, Katherine L Dominic, Caitlin E Swanberg, Nikhil Bharambe, Belinda B Willard, Ling Li, Rajesh Ramachandran, Julian E Stelzer

Journal: ACS Omega

PubMed ID: 35573219

Doi: 10.1021/acsomega.2c00799

Products & Services: Mutant Libraries

Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex

Authors: Kepeng Che, Ajaybabu V Pobbati, Caleb N Seavey, Yuriy Fedorov, Anton A Komar, Ashley Burtscher, Shuang Ma, Brian P Rubin

Journal: PLoS ONE

PubMed ID: 35417479

Doi: 10.1371/journal.pone.0266143

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PINK1/Parkin-mediated mitophagy as a protective mechanism against AFB-induced liver injury in mice

Authors: Qi Wang, Fubo Jia, Chen Guo, Yuping Wang, Xuliang Zhang, Yilong Cui, Miao Song, Zheng Cao, Yanfei Li

Journal: Food Chem Toxicol

PubMed ID: 35447291

Doi: 10.1016/j.fct.2022.113043

Products & Services: Proteins, Expression, Isolation and Analysis

Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes

Authors: Raffaele Marfella, Celestino Sardu, Nunzia D'Onofrio, Francesco Prattichizzo, Lucia Scisciola, Vincenzo Messina, Rosalba La Grotta, Maria Luisa Balestrieri, Paolo Maggi, Claudio Napoli, Antonio Ceriello, Giuseppe Paolisso

Journal: Nat Commun

PubMed ID: 35484164

Doi: 10.1038/s41467-022-30068-2

Products & Services: Recombinant Proteins

Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants

Authors: Wan-Ling Wu, Chen-Yi Chiang, Szu-Chia Lai, Chia-Yi Yu, Yu-Ling Huang, Hung-Chun Liao, Ching-Len Liao, Hsin-Wei Chen, Shih-Jen Liu

Journal: JCI Insight

PubMed ID: 35290246

Doi: 10.1172/jci.insight.157597

Products & Services: Mammalian Expression

Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P falciparum Malaria

Authors: Ananya Ray, Miti Mathur, Deepak Choubey, Krishanpal Karmodiya, Namita Surolia

Journal: MBio

PubMed ID: 35420484

Doi: 10.1128/mbio.00630-22

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A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors

Authors: Yanling Wu, Quanxiao Li, Yu Kong, Zhi Wang, Cheng Lei, Ji Li, Lulu Ding, Chunyu Wang, Yaping Cheng, Yaozhu Wei, Yuanlin Song, Zhenlin Yang, Chao Tu, Yu Ding, Tianlei Ying

Journal: Mol Ther

PubMed ID: 35462042

Doi: 10.1016/j.ymthe.2022.04.013

Products & Services: Mammalian Expression

RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5'-UTR

Authors: Jiaxiu Yan, Yifei Zhao, Juan Du, Yu Wang, Shaohua Wang, Qing Wang, Xu Zhao, Wei Xu, Ke Zhao

Journal: Mob DNA

PubMed ID: 35414110

Doi: 10.1186/s13100-022-00268-0

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Non-homologous End Joining-Mediated Insertional Mutagenesis Reveals a Novel Target for Enhancing Fatty Alcohols Production in

Authors: Mengxu Li, Jinlai Zhang, Qiuyan Bai, Lixia Fang, Hao Song, Yingxiu Cao

Journal: Front Microbiol

PubMed ID: 35547152

Doi: 10.3389/fmicb.2022.898884

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The neural basis of heat seeking in a human-infective parasitic worm

Authors: Astra S Bryant, Felicitas Ruiz, Joon Ha Lee, Elissa A Hallem

Journal: Curr Biol

PubMed ID: 35483361

Doi: 10.1016/j.cub.2022.04.010

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Metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides F2 and 3,20-Di--Glc-DM

Authors: Fenglin Jiang, Chen Zhou, Yan Li, Haidong Deng, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang, Ping Zhu

Journal: Acta Pharm Sin B

PubMed ID: 35865098

Doi: 10.1016/j.apsb.2022.04.012

Products & Services: Mutant Libraries

Repurposing Halicin as a potent covalent inhibitor for the SARS-CoV-2 main protease

Authors: Kai S Yang, Syuan-Ting Alex Kuo, Lauren R Blankenship, Zhi Zachary Geng, Shuhua G Li, David H Russell, Xin Yan, Shiqing Xu, Wenshe Ray Liu

Journal: Curr Res Chem Biol

PubMed ID: 35815070

Doi: 10.1016/j.crchbi.2022.100025

Products & Services: Proteins, Expression, Isolation and Analysis

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