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Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex

Authors: Kepeng Che, Ajaybabu V Pobbati, Caleb N Seavey, Yuriy Fedorov, Anton A Komar, Ashley Burtscher, Shuang Ma, Brian P Rubin

Journal: PLoS ONE

PubMed ID: 35417479

Doi: 10.1371/journal.pone.0266143

Products & Services: Gene Synthesis

PINK1/Parkin-mediated mitophagy as a protective mechanism against AFB-induced liver injury in mice

Authors: Qi Wang, Fubo Jia, Chen Guo, Yuping Wang, Xuliang Zhang, Yilong Cui, Miao Song, Zheng Cao, Yanfei Li

Journal: Food Chem Toxicol

PubMed ID: 35447291

Doi: 10.1016/j.fct.2022.113043

Products & Services: Proteins, Expression, Isolation and Analysis

Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes

Authors: Raffaele Marfella, Celestino Sardu, Nunzia D'Onofrio, Francesco Prattichizzo, Lucia Scisciola, Vincenzo Messina, Rosalba La Grotta, Maria Luisa Balestrieri, Paolo Maggi, Claudio Napoli, Antonio Ceriello, Giuseppe Paolisso

Journal: Nat Commun

PubMed ID: 35484164

Doi: 10.1038/s41467-022-30068-2

Products & Services: Recombinant Proteins

Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants

Authors: Wan-Ling Wu, Chen-Yi Chiang, Szu-Chia Lai, Chia-Yi Yu, Yu-Ling Huang, Hung-Chun Liao, Ching-Len Liao, Hsin-Wei Chen, Shih-Jen Liu

Journal: JCI Insight

PubMed ID: 35290246

Doi: 10.1172/jci.insight.157597

Products & Services: Mammalian Expression

Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P falciparum Malaria

Authors: Ananya Ray, Miti Mathur, Deepak Choubey, Krishanpal Karmodiya, Namita Surolia

Journal: MBio

PubMed ID: 35420484

Doi: 10.1128/mbio.00630-22

Products & Services: Catalog Antibody

A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors

Authors: Yanling Wu, Quanxiao Li, Yu Kong, Zhi Wang, Cheng Lei, Ji Li, Lulu Ding, Chunyu Wang, Yaping Cheng, Yaozhu Wei, Yuanlin Song, Zhenlin Yang, Chao Tu, Yu Ding, Tianlei Ying

Journal: Mol Ther

PubMed ID: 35462042

Doi: 10.1016/j.ymthe.2022.04.013

Products & Services: Mammalian Expression

RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5'-UTR

Authors: Jiaxiu Yan, Yifei Zhao, Juan Du, Yu Wang, Shaohua Wang, Qing Wang, Xu Zhao, Wei Xu, Ke Zhao

Journal: Mob DNA

PubMed ID: 35414110

Doi: 10.1186/s13100-022-00268-0

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Non-homologous End Joining-Mediated Insertional Mutagenesis Reveals a Novel Target for Enhancing Fatty Alcohols Production in

Authors: Mengxu Li, Jinlai Zhang, Qiuyan Bai, Lixia Fang, Hao Song, Yingxiu Cao

Journal: Front Microbiol

PubMed ID: 35547152

Doi: 10.3389/fmicb.2022.898884

Products & Services: Codon Optimization

The neural basis of heat seeking in a human-infective parasitic worm

Authors: Astra S Bryant, Felicitas Ruiz, Joon Ha Lee, Elissa A Hallem

Journal: Curr Biol

PubMed ID: 35483361

Doi: 10.1016/j.cub.2022.04.010

Products & Services: Gene Synthesis

Metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides F2 and 3,20-Di--Glc-DM

Authors: Fenglin Jiang, Chen Zhou, Yan Li, Haidong Deng, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang, Ping Zhu

Journal: Acta Pharm Sin B

PubMed ID: 35865098

Doi: 10.1016/j.apsb.2022.04.012

Products & Services: Mutant Libraries

Repurposing Halicin as a potent covalent inhibitor for the SARS-CoV-2 main protease

Authors: Kai S Yang, Syuan-Ting Alex Kuo, Lauren R Blankenship, Zhi Zachary Geng, Shuhua G Li, David H Russell, Xin Yan, Shiqing Xu, Wenshe Ray Liu

Journal: Curr Res Chem Biol

PubMed ID: 35815070

Doi: 10.1016/j.crchbi.2022.100025

Products & Services: Proteins, Expression, Isolation and Analysis

A small molecule, CHClNOS, inhibits the function of the type III secretion system in Salmonella Typhimurium

Authors: Rerngwit Boonyom, Sittiruk Roytrakul, Patipat Thinwang

Journal: J Genet Eng Biotechnol

PubMed ID: 35380331

Doi: 10.1186/s43141-022-00336-1

Products & Services: GenParts™ DNA Fragments

Collagen type IV alpha 1 (COL4A1) silence hampers the invasion, migration and epithelial-mesenchymal transition (EMT) of gastric cancer cells through blocking Hedgehog signaling pathway

Authors: Xijuan Cui, Tao Shan, Lina Qiao

Journal: Bioengineered

PubMed ID: 35297303

Doi: 10.1080/21655979.2022.2053799

Products & Services: Proteins, Expression, Isolation and Analysis

QbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primary requirements of comparability to Keytruda®

Authors: Morteza Jaffar-Aghaei, Farzad Khanipour, Amir Maghsoudi, Rahim Sarvestani, Mahdi Mohammadian, Maryam Maleki, Forugh Havasi, Hossein Rahmani, Amir-Hossein Karagah, Mohammad-Reza Kazemali

Journal: Eur J Pharm Sci

PubMed ID: 35378209

Doi: 10.1016/j.ejps.2022.106171

Products & Services: Gene Synthesis

Full-Length Transcriptome Analysis Provides New Insights Into the Diversity of Immune-Related Genes in

Authors: Yi Zhang, Mengqi Ni, Yunhui Bai, Qiao Shi, Jinbin Zheng, Zhaoxia Cui

Journal: Front Immunol

PubMed ID: 35464434

Doi: 10.3389/fimmu.2022.843347

Products & Services: Proteins, Expression, Isolation and Analysis

Regulation of Mannitol Metabolism in Enterococcus faecalis and Association with Toxin-Antitoxin Locus Function

Authors: Srivishnupriya Anbalagan, Jessie Sadlon, Keith Weaver

Journal: J Bacteriol

PubMed ID: 35404112

Doi: 10.1128/jb.00047-22

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The C-terminal extension of VgrG4 from Klebsiella pneumoniae remodels host cell microfilaments

Authors: Talyta do Nascimento Soares, Verônica Silva Valadares, Gisele Cardoso Amorim, Mayara de Mattos Lacerda de Carvalho, Marcia Berrêdo-Pinho, Fábio Ceneviva Lacerda Almeida, Paulo Mascarello Bisch, Paulo Ricardo Batista, Letícia Miranda Santos Lery

Journal: Proteins

PubMed ID: 35430767

Doi: 10.1002/prot.26344

Products & Services: PCR Cloning and Subcloning

Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4

Authors: Karuna Mittal, Jaspreet Kaur, Shaligram Sharma, Nivya Sharma, Guanhao Wei, Ishita Choudhary, Precious Imhansi-Jacob, Nagini Maganti, Shrikant Pawar, Padmashree Rida, Michael S Toss, Mohammed Aleskandarany, Emiel A Janssen, Håvard Søiland, Meenakshi V Gupta, Michelle D Reid, Emad A Rakha, Ritu Aneja

Journal: Mol Cancer Res

PubMed ID: 34933912

Doi: 10.1158/1541-7786.MCR-20-0798

Products & Services: Plasmid DNA Preparation

Distribution of Charged Residues Affects the Average Size and Shape of Intrinsically Disordered Proteins

Authors: Greta Bianchi, Marco Mangiagalli, Alberto Barbiroli, Sonia Longhi, Rita Grandori, Carlo Santambrogio, Stefania Brocca

Journal: Biomolecules

PubMed ID: 35454150

Doi: 10.3390/biom12040561

Products & Services: Custom Vector Construction

as a Model of Unconventional Translation in Spinocerebellar Ataxia Type 3

Authors: Sean L Johnson, Matthew V Prifti, Alyson Sujkowski, Kozeta Libohova, Jessica R Blount, Luke Hong, Wei-Ling Tsou, Sokol V Todi

Journal: Cells

PubMed ID: 35406787

Doi: 10.3390/cells11071223

Products & Services: PCR Cloning and Subcloning

Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers

Authors: Chunhong Zheng, Joseph N Fass, Yi-Ping Shih, Andrew J Gunderson, Nelson Sanjuan Silva, Huayu Huang, Brady M Bernard, Venkatesh Rajamanickam, Joseph Slagel, Carlo B Bifulco, Brian Piening, Pippa H A Newell, Paul D Hansen, Eric Tran

Journal: Cancer Cell

PubMed ID: 35413272

Doi: 10.1016/j.ccell.2022.03.005

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DDX17 protects hepatocytes against oleic acid/palmitic acid-induced lipid accumulation

Authors: Xiaoyi Zhang, Tong An, Xiyue Zhang, Tao Shen, Hongxia Li, Lin Dou, Xiuqing Huang, Yong Man, Weiqing Tang, Jian Li

Journal: Biochem Biophys Res Commun

PubMed ID: 35533489

Doi: 10.1016/j.bbrc.2022.04.129

Products & Services: Mammalian Expression

CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Authors: Chuan Jin, Jing Ma, Mohanraj Ramachandran, Di Yu, Magnus Essand

Journal: Nat Biomed Eng

PubMed ID: 35379957

Doi: 10.1038/s41551-022-00875-5

Products & Services: PCR Cloning and Subcloning

Neutralization of SARS-CoV-2 Omicron sub-lineages BA1, BA11, and BA2

Authors: John P Evans, Cong Zeng, Panke Qu, Julia Faraone, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Tongqing Zhou, Gerard Lozanski, Rama Mallampalli, Linda J Saif, Eugene M Oltz, Peter J Mohler, Kai Xu, Richard J Gumina, Shan-Lu Liu

Journal: Cell Host Microbe

PubMed ID: 35526534

Doi: 10.1016/j.chom.2022.04.014

Products & Services: Custom Vector Construction

Efficient CRISPR-Cas9-mediated genome editing for characterization of essential genes in

Authors: Gisele Fernanda Assine Picchi-Constante, Priscila Mazzocchi Hiraiwa, Martin Marek, Vanessa Zulkievicz Rogerio, Eloise Pavão Guerra-Slompo, Christophe Romier, Nilson Ivo Tonin Zanchin

Journal: STAR Protoc

PubMed ID: 35496799

Doi: 10.1016/j.xpro.2022.101324

Products & Services: Plasmid DNA Preparation

Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue

Authors: Lakshmi Prabhu, Matthew Martin, Lan Chen, Özlem Demir, Jiamin Jin, Xiumei Huang, Aishat Motolani, Mengyao Sun, Guanglong Jiang, Harikrishna Nakshatri, Melissa L Fishel, Steven Sun, Ahmad Safa, Rommie E Amaro, Mark R Kelley, Yunlong Liu, Zhong-Yin Zhang, Tao Lu

Journal: Genes Dis

PubMed ID: 37013054

Doi: 10.1016/j.gendis.2022.04.001

Products & Services: Proteins, Expression, Isolation and Analysis

The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development

Authors: Elodie Picarda, Phillip M Galbo, Haihong Zong, Meenu Rohini Rajan, Ville Wallenius, Deyou Zheng, Emma Börgeson, Rajat Singh, Jeffrey Pessin, Xingxing Zang

Journal: Sci Adv

PubMed ID: 35476450

Doi: 10.1126/sciadv.abm7012

Products & Services: Proteins, Expression, Isolation and Analysis

Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5

Authors: Lisa Merklinger, Johannes Bauer, Per A Pedersen, Rune Busk Damgaard, J Preben Morth

Journal: Life Sci Alliance

PubMed ID: 35459736

Doi: 10.26508/lsa.202101309

Products & Services: Codon Optimization

FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P-dependent switch

Authors: Nathan R Zaccai, Zuzana Kadlecova, Veronica Kane Dickson, Kseniya Korobchevskaya, Jan Kamenicky, Oleksiy Kovtun, Perunthottathu K Umasankar, Antoni G Wrobel, Jonathan G G Kaufman, Sally R Gray, Kun Qu, Philip R Evans, Marco Fritzsche, Filip Sroubek, Stefan Höning, John A G Briggs, Bernard T Kelly, David J Owen, Linton M Traub

Journal: Sci Adv

PubMed ID: 35486718

Doi: 10.1126/sciadv.abn2018

Products & Services: Plasmid DNA Preparation

Characterization of a universal neutralizing monoclonal antibody against Glaesserella parasuis CdtB

Authors: Qichao Chen, Huan Wang, Liang Li, Shibang Guo, Zhankui Liu, Zizhe Hu, Chen Tan, Huanchun Chen, Xiangru Wang

Journal: Vet Microbiol

PubMed ID: 35640412

Doi: 10.1016/j.vetmic.2022.109446

Products & Services: Peptide Synthesis

LncRNA TSPEAR-AS1 predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma and promotes metastasis via miR-1915-5p

Authors: Yichuan Zhang, Fei Wang, Yu Wang

Journal: Virus Res

PubMed ID: 35477008

Doi: 10.1016/j.virusres.2022.198788

Products & Services: Custom DNA/RNA Oligos

Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans

Authors: Rasheduzzaman Chowdhury, Martine I Abboud, James Wiley, Anthony Tumber, Suzana Markolovic, Christopher J Schofield

Journal: Sci Rep

PubMed ID: 35410347

Doi: 10.1038/s41598-022-10028-y

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A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation

Authors: Benedetta Mattorre, Silvana Caristi, Simona Donato, Emilia Volpe, Marika Faiella, Alessandro Paiardini, Rosa Sorrentino, Fabiana Paladini

Journal: Int J Mol Sci

PubMed ID: 35563348

Doi: 10.3390/ijms23094961

Products & Services: Plasmid DNA Preparation

Characterization of Genetic Variants of Uncertain Significance for the Gene in Patients With Adult Hypophosphatasia

Authors: Raquel Sanabria-de la Torre, Luis Martínez-Heredia, Sheila González-Salvatierra, Francisco Andújar-Vera, Iván Iglesias-Baena, Juan Miguel Villa-Suárez, Victoria Contreras-Bolívar, Mario Corbacho-Soto, Gonzalo Martínez-Navajas, Pedro J Real, Cristina García-Fontana, Manuel Muñoz-Torres, Beatriz García-Fontana

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35498405

Doi: 10.3389/fendo.2022.863940

Products & Services: Mutant Libraries

Identification of Potential Peptide Marker(s) for Evaluating Pork Meat Freshness via Mass Spectrometry-Based Peptidomics during Storage under Different Temperatures

Authors: Zhenqian Wei, Chen Dai, Anthony P Bassey, Changbo Tang, Yu Han, Chong Wang, Guanghong Zhou

Journal: Foods

PubMed ID: 35454731

Doi: 10.3390/foods11081144

Products & Services: Catalog Peptides

Exploration of Pyrrolysyl-tRNA Synthetase Activity in Yeast

Authors: Jessica T Stieglitz, Priyanka Lahiri, Matthew I Stout, James A Van Deventer

Journal: ACS Synth Biol

PubMed ID: 35417129

Doi: 10.1021/acssynbio.2c00001

Products & Services: Proteins, Expression, Isolation and Analysis

β-arrestin2 mediates the hippocampal dopaminergic system in autistic mouse through the ERK signaling pathway

Authors: Yu Zhou, Yamei Liu, Qingyu Peng, Feng Li, Fuxue Chen

Journal: Behav Brain Res

PubMed ID: 35398487

Doi: 10.1016/j.bbr.2022.113888

Products & Services: Proteins, Expression, Isolation and Analysis

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

Authors: Beverly Y Mok, Anna V Kotrys, Aditya Raguram, Tony P Huang, Vamsi K Mootha, David R Liu

Journal: Nat Biotechnol

PubMed ID: 35379961

Doi: 10.1038/s41587-022-01256-8

Products & Services: Mammalian Expression

Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells

Authors: Kareem A Heslop, Pieter Burger, Christiana Kappler, Ashish K Solanki, Monika Gooz, Yuri K Peterson, Catherine Mills, Thomas Benton, Stephen A Duncan, Patrick M Woster, Eduardo N Maldonado

Journal: Biomed Pharmacother

PubMed ID: 35447542

Doi: 10.1016/j.biopha.2022.112928

Products & Services: Plasmid DNA Preparation

Ultrasensitive CRISPR/Cas12a-Driven SERS Biosensor for On-Site Nucleic Acid Detection and Its Application to Milk Authenticity Testing

Authors: Ruiyuan Pan, Jianghua Liu, Panxue Wang, Di Wu, Jian Chen, Yongning Wu, Guoliang Li

Journal: J Agric Food Chem

PubMed ID: 35380812

Doi: 10.1021/acs.jafc.1c08262

Products & Services: Custom DNA/RNA Oligos

The development of a candidate of desensitization vaccines against Der f 2 nearly without IgE-binding activity

Authors: Xiao-Jing Ling, Chen Pan, Ling-Xiao Tan, Ying Zhu, Yu-Xing Yang, Xiao-Fei Zeng, Jin-Lyu Sun, Ji-Fu Wei, Chen Lu

Journal: Immunobiology

PubMed ID: 35580444

Doi: 10.1016/j.imbio.2022.152217

Products & Services: Proteins, Expression, Isolation and Analysis

A novel multifunctional anti-PD-L1-CD16a-IL15 induces potent cancer cell killing in PD-L1-positive tumour cells

Authors: Yumei Li, Lingjun Wu, Yueying Liu, Siwen Ma, Biyi Huang, Xianjing Feng, Hui Wang

Journal: Transl Oncol

PubMed ID: 35477065

Doi: 10.1016/j.tranon.2022.101424

Products & Services: Mammalian Expression

The Model for Mucolipidosis Type IV

Authors: Claire Y Allan, Paul R Fisher

Journal: Front Cell Dev Biol

PubMed ID: 35493081

Doi: 10.3389/fcell.2022.741967

Products & Services: Proteins, Expression, Isolation and Analysis

Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action

Authors: Johannes Gubat, Karthik Selvaraju, Linda Sjöstrand, Dhananjay Kumar Singh, Maria V Turkina, Bernhard Schmierer, Pierre Sabatier, Roman A Zubarev, Stig Linder, Pádraig D'Arcy

Journal: Front Oncol

PubMed ID: 35530310

Doi: 10.3389/fonc.2022.852980

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Mechanistic insights into consumption of the food additive xanthan gum by the human gut microbiota

Authors: Matthew P Ostrowski, Sabina Leanti La Rosa, Benoit J Kunath, Andrew Robertson, Gabriel Pereira, Live H Hagen, Neha J Varghese, Ling Qiu, Tianming Yao, Gabrielle Flint, James Li, Sean P McDonald, Duna Buttner, Nicholas A Pudlo, Matthew K Schnizlein, Vincent B Young, Harry Brumer, Thomas M Schmidt, Nicolas Terrapon, Vincent Lombard, Bernard Henrissat, Bruce Hamaker, Emiley A Eloe-Fadrosh, Ashootosh Tripathi, Phillip B Pope, Eric C Martens

Journal: Nat Microbiol

PubMed ID: 35365790

Doi: 10.1038/s41564-022-01093-0

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G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2

Authors: Wei Xu, Frank Bearoff, Sandhya Kortagere

Journal: Pharmacol Res

PubMed ID: 35429668

Doi: 10.1016/j.phrs.2022.106223

Products & Services: Proteins, Expression, Isolation and Analysis

Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate

Authors: Akihiro Honda, Shotaro Kamata, Makoto Akahane, Yui Machida, Kie Uchii, Yui Shiiyama, Yuki Habu, Saeka Miyawaki, Chihiro Kaneko, Takuji Oyama, Isao Ishii

Journal: Int J Mol Sci

PubMed ID: 35563117

Doi: 10.3390/ijms23094726

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CLEVER assay: A visual and rapid RNA extraction-free detection of SARS-CoV-2 based on CRISPR-Cas integrated RT-LAMP technology

Authors: Akansha Bhatt, Zeeshan Fatima, Munindra Ruwali, Chitra Seetharam Misra, Shyam Sunder Rangu, Devashish Rath, Ashok Rattan, Saif Hameed

Journal: J Appl Microbiol

PubMed ID: 35396760

Doi: 10.1111/jam.15571

Products & Services: Plasmid DNA Preparation

A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse Models

Authors: Anurupa A Ghosh, Dinesh Kumar Verma, Gabriela Cabrera, Kwadwo Ofori, Karina Hernandez-Quijada, Jae-Kwan Kim, Joo Hee Chung, Michael Moore, Sung Hwan Moon, Jong Bok Seo, Yong-Hwan Kim

Journal: Int J Mol Sci

PubMed ID: 35457082

Doi: 10.3390/ijms23084262

Products & Services: Proteins, Expression, Isolation and Analysis

Bioactive Hydrolysates from : Optimal Process and Bioactive Properties

Authors: Sara A Cunha, Ezequiel R Coscueta, Paulo Nova, Joana Laranjeira Silva, Maria Manuela Pintado

Journal: Molecules

PubMed ID: 35458702

Doi: 10.3390/molecules27082505

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