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Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes

Authors: Zhirong Fu , Srinivas Akula , Anna-Karin Olsson , Lars Hellman

Journal: Dev Comp Immunol

PubMed ID: 34919980

Doi: 10.1016/j.dci.2021.104337

Products & Services: Gene Synthesis

Monosaccharide-mediated rational synthesis of a universal plasmonic platform with broad spectral fluorescence enhancement for high-sensitivity cancer biomarker analysis

Authors: Mengyao Liu, Yonghong Li, Wei Xing, Yuqin Zhang, Xi Xie, Jiadong Pang, Fangjian Zhou, Jiang Yang

Journal: J Nanobiotechnology

PubMed ID: 35399094

Doi: 10.1186/s12951-022-01359-z

Products & Services: Bacterial Expression

Generation of a host cell line containing a MAR-rich landing pad for site-specific integration and expression of transgenes

Authors: Claudia Oliviero, Steffen C Hinz, Jan P Bogen, Henri Kornmann, Björn Hock, Harald Kolmar, Gerrit Hagens

Journal: Biotechnol Prog

PubMed ID: 35396920

Doi: 10.1002/btpr.3254

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PACAP/GCGa Is an Important Modulator of the Amphioxus CNS-Hatschek's Pit Axis, the Homolog of the Vertebrate Hypothalamic-Pituitary Axis in the Basal Chordates

Authors: Jason S W On, Liuru Su, Hong Shen, Aloysius W R Arokiaraj, João C R Cardoso, Guang Li, Billy K C Chow

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35498398

Doi: 10.3389/fendo.2022.850040

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Fish allergens of turbot () parvalbumin triggers food allergy inducing maturation of bone marrow derived dendritic cells and driving Th2 immune response

Authors: Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Mengyao Xu, Ishfaq Ahmed, Guanzhi Chen, Yan Chen, Zhenxing Li

Journal: Food Funct

PubMed ID: 35322825

Doi: 10.1039/d1fo04070g

Products & Services: Proteins, Expression, Isolation and Analysis

Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity

Authors: Jiale Ren, Ni Li, Siyu Pei, Yannan Lian, Li Li, Yuchong Peng, Qiuli Liu, Jiacheng Guo, Xuege Wang, Ying Han, Guoying Zhang, Hanling Wang, Yaqi Li, Jun Jiang, Qintong Li, Minjia Tan, Junjie Peng, Guohong Hu, Yichuan Xiao, Xiong Li, Moubin Lin, Jun Qin

Journal: J Clin Invest

PubMed ID: 35230972

Doi: 10.1172/JCI153167

Products & Services: Recombinant Proteins

Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation

Authors: Fatemeh Adiliaghdam, Hajera Amatullah, Sreehaas Digumarthi, Tahnee L Saunders, Raza-Ur Rahman, Lai Ping Wong, Ruslan Sadreyev, Lindsay Droit, Jean Paquette, Philippe Goyette, John D Rioux, Richard Hodin, Kathie A Mihindukulasuriya, Scott A Handley, Kate L Jeffrey

Journal: Sci Immunol

PubMed ID: 35394816

Doi: 10.1126/sciimmunol.abn6660

Products & Services: Mammalian Expression

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

Authors: Andrea J Parsons, Sabrina I Ophir, J Andrew Duty, Thomas A Kraus, Kathryn R Stein, Thomas M Moran, Domenico Tortorella

Journal: Commun Biol

PubMed ID: 35468974

Doi: 10.1038/s42003-022-03294-z

Products & Services: Mammalian Expression

Exopolysaccharides from Pantoea alhagi NX-11 specifically improve its root colonization and rice salt resistance

Authors: Liang Sun, Lifangyu Cheng, Yuhang Ma, Peng Lei, Rui Wang, Yian Gu, Sha Li, Fuhai Zhang, Hong Xu

Journal: Int J Biol Macromol

PubMed ID: 35413311

Doi: 10.1016/j.ijbiomac.2022.04.015

Products & Services: Gene Synthesis

Synthetic carbohydrate-binding agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2

Authors: Oscar Francesconi, Lorena Donnici, Marco Fragai, Elisa Pesce, Mauro Bombaci, Alessandra Fasciani, Lara Manganaro, Matteo Conti, Renata Grifantini, Raffaele De Francesco, Cristina Nativi, Stefano Roelens

Journal: iScience

PubMed ID: 35434540

Doi: 10.1016/j.isci.2022.104239

Products & Services: Mammalian Expression

ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer

Authors: Eunju Kim, Yoon-Jin Kim, Zhiwei Ji, Jin Muk Kang, Marvin Wirianto, Keshav Raj Paudel, Joshua A Smith, Kaori Ono, Jin-Ah Kim, Kristin Eckel-Mahan, Xiaobo Zhou, Hyun Kyoung Lee, Ji Young Yoo, Seung-Hee Yoo, Zheng Chen

Journal: Cell Death Dis

PubMed ID: 35440077

Doi: 10.1038/s41419-022-04826-5

Products & Services: Recombinant Proteins

Identification of Phosphorylation and Other Post-Translational Modifications in the Central C4C5 Domains of Murine Cardiac Myosin Binding Protein C

Authors: Chang Yoon Doh, Katherine L Dominic, Caitlin E Swanberg, Nikhil Bharambe, Belinda B Willard, Ling Li, Rajesh Ramachandran, Julian E Stelzer

Journal: ACS Omega

PubMed ID: 35573219

Doi: 10.1021/acsomega.2c00799

Products & Services: Mutant Libraries

Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex

Authors: Kepeng Che, Ajaybabu V Pobbati, Caleb N Seavey, Yuriy Fedorov, Anton A Komar, Ashley Burtscher, Shuang Ma, Brian P Rubin

Journal: PLoS ONE

PubMed ID: 35417479

Doi: 10.1371/journal.pone.0266143

Products & Services: Gene Synthesis

PINK1/Parkin-mediated mitophagy as a protective mechanism against AFB-induced liver injury in mice

Authors: Qi Wang, Fubo Jia, Chen Guo, Yuping Wang, Xuliang Zhang, Yilong Cui, Miao Song, Zheng Cao, Yanfei Li

Journal: Food Chem Toxicol

PubMed ID: 35447291

Doi: 10.1016/j.fct.2022.113043

Products & Services: Proteins, Expression, Isolation and Analysis

Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes

Authors: Raffaele Marfella, Celestino Sardu, Nunzia D'Onofrio, Francesco Prattichizzo, Lucia Scisciola, Vincenzo Messina, Rosalba La Grotta, Maria Luisa Balestrieri, Paolo Maggi, Claudio Napoli, Antonio Ceriello, Giuseppe Paolisso

Journal: Nat Commun

PubMed ID: 35484164

Doi: 10.1038/s41467-022-30068-2

Products & Services: Recombinant Proteins

Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants

Authors: Wan-Ling Wu, Chen-Yi Chiang, Szu-Chia Lai, Chia-Yi Yu, Yu-Ling Huang, Hung-Chun Liao, Ching-Len Liao, Hsin-Wei Chen, Shih-Jen Liu

Journal: JCI Insight

PubMed ID: 35290246

Doi: 10.1172/jci.insight.157597

Products & Services: Mammalian Expression

Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P falciparum Malaria

Authors: Ananya Ray, Miti Mathur, Deepak Choubey, Krishanpal Karmodiya, Namita Surolia

Journal: MBio

PubMed ID: 35420484

Doi: 10.1128/mbio.00630-22

Products & Services: Catalog Antibody

A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors

Authors: Yanling Wu, Quanxiao Li, Yu Kong, Zhi Wang, Cheng Lei, Ji Li, Lulu Ding, Chunyu Wang, Yaping Cheng, Yaozhu Wei, Yuanlin Song, Zhenlin Yang, Chao Tu, Yu Ding, Tianlei Ying

Journal: Mol Ther

PubMed ID: 35462042

Doi: 10.1016/j.ymthe.2022.04.013

Products & Services: Mammalian Expression

RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5'-UTR

Authors: Jiaxiu Yan, Yifei Zhao, Juan Du, Yu Wang, Shaohua Wang, Qing Wang, Xu Zhao, Wei Xu, Ke Zhao

Journal: Mob DNA

PubMed ID: 35414110

Doi: 10.1186/s13100-022-00268-0

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Non-homologous End Joining-Mediated Insertional Mutagenesis Reveals a Novel Target for Enhancing Fatty Alcohols Production in

Authors: Mengxu Li, Jinlai Zhang, Qiuyan Bai, Lixia Fang, Hao Song, Yingxiu Cao

Journal: Front Microbiol

PubMed ID: 35547152

Doi: 10.3389/fmicb.2022.898884

Products & Services: Codon Optimization

The neural basis of heat seeking in a human-infective parasitic worm

Authors: Astra S Bryant, Felicitas Ruiz, Joon Ha Lee, Elissa A Hallem

Journal: Curr Biol

PubMed ID: 35483361

Doi: 10.1016/j.cub.2022.04.010

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Metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides F2 and 3,20-Di--Glc-DM

Authors: Fenglin Jiang, Chen Zhou, Yan Li, Haidong Deng, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang, Ping Zhu

Journal: Acta Pharm Sin B

PubMed ID: 35865098

Doi: 10.1016/j.apsb.2022.04.012

Products & Services: Mutant Libraries

Repurposing Halicin as a potent covalent inhibitor for the SARS-CoV-2 main protease

Authors: Kai S Yang, Syuan-Ting Alex Kuo, Lauren R Blankenship, Zhi Zachary Geng, Shuhua G Li, David H Russell, Xin Yan, Shiqing Xu, Wenshe Ray Liu

Journal: Curr Res Chem Biol

PubMed ID: 35815070

Doi: 10.1016/j.crchbi.2022.100025

Products & Services: Proteins, Expression, Isolation and Analysis

A small molecule, CHClNOS, inhibits the function of the type III secretion system in Salmonella Typhimurium

Authors: Rerngwit Boonyom, Sittiruk Roytrakul, Patipat Thinwang

Journal: J Genet Eng Biotechnol

PubMed ID: 35380331

Doi: 10.1186/s43141-022-00336-1

Products & Services: GenParts™ DNA Fragments

Collagen type IV alpha 1 (COL4A1) silence hampers the invasion, migration and epithelial-mesenchymal transition (EMT) of gastric cancer cells through blocking Hedgehog signaling pathway

Authors: Xijuan Cui, Tao Shan, Lina Qiao

Journal: Bioengineered

PubMed ID: 35297303

Doi: 10.1080/21655979.2022.2053799

Products & Services: Proteins, Expression, Isolation and Analysis

QbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primary requirements of comparability to Keytruda®

Authors: Morteza Jaffar-Aghaei, Farzad Khanipour, Amir Maghsoudi, Rahim Sarvestani, Mahdi Mohammadian, Maryam Maleki, Forugh Havasi, Hossein Rahmani, Amir-Hossein Karagah, Mohammad-Reza Kazemali

Journal: Eur J Pharm Sci

PubMed ID: 35378209

Doi: 10.1016/j.ejps.2022.106171

Products & Services: Gene Synthesis

Full-Length Transcriptome Analysis Provides New Insights Into the Diversity of Immune-Related Genes in

Authors: Yi Zhang, Mengqi Ni, Yunhui Bai, Qiao Shi, Jinbin Zheng, Zhaoxia Cui

Journal: Front Immunol

PubMed ID: 35464434

Doi: 10.3389/fimmu.2022.843347

Products & Services: Proteins, Expression, Isolation and Analysis

Regulation of Mannitol Metabolism in Enterococcus faecalis and Association with Toxin-Antitoxin Locus Function

Authors: Srivishnupriya Anbalagan, Jessie Sadlon, Keith Weaver

Journal: J Bacteriol

PubMed ID: 35404112

Doi: 10.1128/jb.00047-22

Products & Services: Stable Cell Lines

The C-terminal extension of VgrG4 from Klebsiella pneumoniae remodels host cell microfilaments

Authors: Talyta do Nascimento Soares, Verônica Silva Valadares, Gisele Cardoso Amorim, Mayara de Mattos Lacerda de Carvalho, Marcia Berrêdo-Pinho, Fábio Ceneviva Lacerda Almeida, Paulo Mascarello Bisch, Paulo Ricardo Batista, Letícia Miranda Santos Lery

Journal: Proteins

PubMed ID: 35430767

Doi: 10.1002/prot.26344

Products & Services: PCR Cloning and Subcloning

Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4

Authors: Karuna Mittal, Jaspreet Kaur, Shaligram Sharma, Nivya Sharma, Guanhao Wei, Ishita Choudhary, Precious Imhansi-Jacob, Nagini Maganti, Shrikant Pawar, Padmashree Rida, Michael S Toss, Mohammed Aleskandarany, Emiel A Janssen, Håvard Søiland, Meenakshi V Gupta, Michelle D Reid, Emad A Rakha, Ritu Aneja

Journal: Mol Cancer Res

PubMed ID: 34933912

Doi: 10.1158/1541-7786.MCR-20-0798

Products & Services: Plasmid DNA Preparation

Distribution of Charged Residues Affects the Average Size and Shape of Intrinsically Disordered Proteins

Authors: Greta Bianchi, Marco Mangiagalli, Alberto Barbiroli, Sonia Longhi, Rita Grandori, Carlo Santambrogio, Stefania Brocca

Journal: Biomolecules

PubMed ID: 35454150

Doi: 10.3390/biom12040561

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as a Model of Unconventional Translation in Spinocerebellar Ataxia Type 3

Authors: Sean L Johnson, Matthew V Prifti, Alyson Sujkowski, Kozeta Libohova, Jessica R Blount, Luke Hong, Wei-Ling Tsou, Sokol V Todi

Journal: Cells

PubMed ID: 35406787

Doi: 10.3390/cells11071223

Products & Services: PCR Cloning and Subcloning

Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers

Authors: Chunhong Zheng, Joseph N Fass, Yi-Ping Shih, Andrew J Gunderson, Nelson Sanjuan Silva, Huayu Huang, Brady M Bernard, Venkatesh Rajamanickam, Joseph Slagel, Carlo B Bifulco, Brian Piening, Pippa H A Newell, Paul D Hansen, Eric Tran

Journal: Cancer Cell

PubMed ID: 35413272

Doi: 10.1016/j.ccell.2022.03.005

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DDX17 protects hepatocytes against oleic acid/palmitic acid-induced lipid accumulation

Authors: Xiaoyi Zhang, Tong An, Xiyue Zhang, Tao Shen, Hongxia Li, Lin Dou, Xiuqing Huang, Yong Man, Weiqing Tang, Jian Li

Journal: Biochem Biophys Res Commun

PubMed ID: 35533489

Doi: 10.1016/j.bbrc.2022.04.129

Products & Services: Mammalian Expression

CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Authors: Chuan Jin, Jing Ma, Mohanraj Ramachandran, Di Yu, Magnus Essand

Journal: Nat Biomed Eng

PubMed ID: 35379957

Doi: 10.1038/s41551-022-00875-5

Products & Services: PCR Cloning and Subcloning

Neutralization of SARS-CoV-2 Omicron sub-lineages BA1, BA11, and BA2

Authors: John P Evans, Cong Zeng, Panke Qu, Julia Faraone, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Tongqing Zhou, Gerard Lozanski, Rama Mallampalli, Linda J Saif, Eugene M Oltz, Peter J Mohler, Kai Xu, Richard J Gumina, Shan-Lu Liu

Journal: Cell Host Microbe

PubMed ID: 35526534

Doi: 10.1016/j.chom.2022.04.014

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Efficient CRISPR-Cas9-mediated genome editing for characterization of essential genes in

Authors: Gisele Fernanda Assine Picchi-Constante, Priscila Mazzocchi Hiraiwa, Martin Marek, Vanessa Zulkievicz Rogerio, Eloise Pavão Guerra-Slompo, Christophe Romier, Nilson Ivo Tonin Zanchin

Journal: STAR Protoc

PubMed ID: 35496799

Doi: 10.1016/j.xpro.2022.101324

Products & Services: Plasmid DNA Preparation

Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue

Authors: Lakshmi Prabhu, Matthew Martin, Lan Chen, Özlem Demir, Jiamin Jin, Xiumei Huang, Aishat Motolani, Mengyao Sun, Guanglong Jiang, Harikrishna Nakshatri, Melissa L Fishel, Steven Sun, Ahmad Safa, Rommie E Amaro, Mark R Kelley, Yunlong Liu, Zhong-Yin Zhang, Tao Lu

Journal: Genes Dis

PubMed ID: 37013054

Doi: 10.1016/j.gendis.2022.04.001

Products & Services: Proteins, Expression, Isolation and Analysis

The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development

Authors: Elodie Picarda, Phillip M Galbo, Haihong Zong, Meenu Rohini Rajan, Ville Wallenius, Deyou Zheng, Emma Börgeson, Rajat Singh, Jeffrey Pessin, Xingxing Zang

Journal: Sci Adv

PubMed ID: 35476450

Doi: 10.1126/sciadv.abm7012

Products & Services: Proteins, Expression, Isolation and Analysis

Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5

Authors: Lisa Merklinger, Johannes Bauer, Per A Pedersen, Rune Busk Damgaard, J Preben Morth

Journal: Life Sci Alliance

PubMed ID: 35459736

Doi: 10.26508/lsa.202101309

Products & Services: Codon Optimization

FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P-dependent switch

Authors: Nathan R Zaccai, Zuzana Kadlecova, Veronica Kane Dickson, Kseniya Korobchevskaya, Jan Kamenicky, Oleksiy Kovtun, Perunthottathu K Umasankar, Antoni G Wrobel, Jonathan G G Kaufman, Sally R Gray, Kun Qu, Philip R Evans, Marco Fritzsche, Filip Sroubek, Stefan Höning, John A G Briggs, Bernard T Kelly, David J Owen, Linton M Traub

Journal: Sci Adv

PubMed ID: 35486718

Doi: 10.1126/sciadv.abn2018

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Characterization of a universal neutralizing monoclonal antibody against Glaesserella parasuis CdtB

Authors: Qichao Chen, Huan Wang, Liang Li, Shibang Guo, Zhankui Liu, Zizhe Hu, Chen Tan, Huanchun Chen, Xiangru Wang

Journal: Vet Microbiol

PubMed ID: 35640412

Doi: 10.1016/j.vetmic.2022.109446

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LncRNA TSPEAR-AS1 predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma and promotes metastasis via miR-1915-5p

Authors: Yichuan Zhang, Fei Wang, Yu Wang

Journal: Virus Res

PubMed ID: 35477008

Doi: 10.1016/j.virusres.2022.198788

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Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans

Authors: Rasheduzzaman Chowdhury, Martine I Abboud, James Wiley, Anthony Tumber, Suzana Markolovic, Christopher J Schofield

Journal: Sci Rep

PubMed ID: 35410347

Doi: 10.1038/s41598-022-10028-y

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A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation

Authors: Benedetta Mattorre, Silvana Caristi, Simona Donato, Emilia Volpe, Marika Faiella, Alessandro Paiardini, Rosa Sorrentino, Fabiana Paladini

Journal: Int J Mol Sci

PubMed ID: 35563348

Doi: 10.3390/ijms23094961

Products & Services: Plasmid DNA Preparation

Examination of Genetic Control Elements in the Phototrophic Firmicute Heliomicrobium modesticaldum

Authors: Alexandria M Layton , Kevin E Redding

Journal: Microorganisms

PubMed ID: 35630321

Doi: 10.3390/microorganisms10050876

Products & Services: Gene Synthesis

Characterization of Genetic Variants of Uncertain Significance for the Gene in Patients With Adult Hypophosphatasia

Authors: Raquel Sanabria-de la Torre, Luis Martínez-Heredia, Sheila González-Salvatierra, Francisco Andújar-Vera, Iván Iglesias-Baena, Juan Miguel Villa-Suárez, Victoria Contreras-Bolívar, Mario Corbacho-Soto, Gonzalo Martínez-Navajas, Pedro J Real, Cristina García-Fontana, Manuel Muñoz-Torres, Beatriz García-Fontana

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35498405

Doi: 10.3389/fendo.2022.863940

Products & Services: Mutant Libraries

Identification of Potential Peptide Marker(s) for Evaluating Pork Meat Freshness via Mass Spectrometry-Based Peptidomics during Storage under Different Temperatures

Authors: Zhenqian Wei, Chen Dai, Anthony P Bassey, Changbo Tang, Yu Han, Chong Wang, Guanghong Zhou

Journal: Foods

PubMed ID: 35454731

Doi: 10.3390/foods11081144

Products & Services: Catalog Peptides

Exploration of Pyrrolysyl-tRNA Synthetase Activity in Yeast

Authors: Jessica T Stieglitz, Priyanka Lahiri, Matthew I Stout, James A Van Deventer

Journal: ACS Synth Biol

PubMed ID: 35417129

Doi: 10.1021/acssynbio.2c00001

Products & Services: Proteins, Expression, Isolation and Analysis

β-arrestin2 mediates the hippocampal dopaminergic system in autistic mouse through the ERK signaling pathway

Authors: Yu Zhou, Yamei Liu, Qingyu Peng, Feng Li, Fuxue Chen

Journal: Behav Brain Res

PubMed ID: 35398487

Doi: 10.1016/j.bbr.2022.113888

Products & Services: Proteins, Expression, Isolation and Analysis

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