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Bioactive Hydrolysates from : Optimal Process and Bioactive Properties

Authors: Sara A Cunha, Ezequiel R Coscueta, Paulo Nova, Joana Laranjeira Silva, Maria Manuela Pintado

Journal: Molecules

PubMed ID: 35458702

Doi: 10.3390/molecules27082505

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Blocking TGF- Expression Attenuates Tumor Growth in Lung Cancers, Potentially Mediated by Skewing Development of Neutrophils

Authors: Yifei Fang, Xiyao Li, Yuxuan Jiang, Zhihan Ge

Journal: J Oncol

PubMed ID: 35498537

Doi: 10.1155/2022/3447185

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Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants

Authors: Jessica Hong, Hyung Joon Kwon, Raul Cachau, Catherine Z Chen, Kevin John Butay, Zhijian Duan, Dan Li, Hua Ren, Tianyuzhou Liang, Jianghai Zhu, Venkata P Dandey, Negin P Martin, Dominic Esposito, Uriel Ortega-Rodriguez, Miao Xu, Mario J Borgnia, Hang Xie, Mitchell Ho

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35476528

Doi: 10.1073/pnas.2201433119

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Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions

Authors: Yubai Zhou, Sandip Mukherjee, Daowei Huang, Molee Chakraborty, Chunfang Gu, Guangning Zong, Michael A Stashko, Kenneth H Pearce, Stephen B Shears, Anutosh Chakraborty, Huanchen Wang, Xiaodong Wang

Journal: J Med Chem

PubMed ID: 35467861

Doi: 10.1021/acs.jmedchem.2c00220

Products & Services: Mammalian Expression

Gene Expression in a Humanized 21-Hydroxylase Mouse Model Does Not Affect Adrenocortical Morphology and Function

Authors: Tina Schubert, Nicole Reisch, Ronald Naumann, Ilka Reichardt, Dana Landgraf, Friederike Quitter, Shamini Ramkumar Thirumalasetty, Anne-Kristin Heninger, Mihail Sarov, Mirko Peitzsch, Angela Huebner, Katrin Koehler

Journal: J Endocr Soc

PubMed ID: 35592511

Doi: 10.1210/jendso/bvac062

Products & Services: Plasmid DNA Preparation

Ferritin Light Chain: A Candidate Autoantigen in Immuno-Related Pancytopenia

Authors: Yang Zhang, Shanfeng Hao, Na Xiao, Yu Zhang, Huaquan Wang, Lijuan Li, Rong Fu, Zonghong Shao

Journal: Front Immunol

PubMed ID: 35572557

Doi: 10.3389/fimmu.2022.851096

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Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells

Authors: Siyu Chen, Zhiquan Liu, Hao Yu, Liangxue Lai, Zhanjun Li

Journal: J Genet Genomics

PubMed ID: 35421582

Doi: 10.1016/j.jgg.2022.03.007

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NADH oxidase of Mycoplasma hyopneumoniae functions as a potential mediator of virulence

Authors: Fei Hao, Xing Xie, Zhixin Feng, Rong Chen, Yanna Wei, Jin Liu, Qiyan Xiong, Guoqing Shao, Johnson Lin

Journal: BMC Vet Res

PubMed ID: 35366872

Doi: 10.1186/s12917-022-03230-7

Products & Services: Bacterial Expression

TXNDC9 knockdown inhibits lung adenocarcinoma progression by targeting YWHAG

Authors: Jing Wang, Xiaotao Pan, Jie Li, Jin Zhao

Journal: Mol Med Rep

PubMed ID: 35485284

Doi: 10.3892/mmr.2022.12719

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Transcriptome analysis reveals the regulatory mechanism by which suppresses adventitious shoot formation in apple

Authors: Jiangping Mao, Doudou Ma, Chundong Niu, Xiaolong Ma, Ke Li, Muhammad Mobeen Tahir, Shiyue Chen, Xiuxiu Liu, Dong Zhang

Journal: Hortic Res

PubMed ID: 35669707

Doi: 10.1093/hr/uhac080

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Molecular spikes: a gold standard for single-cell RNA counting

Authors: Christoph Ziegenhain, Gert-Jan Hendriks, Michael Hagemann-Jensen, Rickard Sandberg

Journal: Nat Methods

PubMed ID: 35468967

Doi: 10.1038/s41592-022-01446-x

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Histone acetyltransferase GCN5-mediated lysine acetylation modulates salt stress aadaption of Trichoderma

Authors: Zhe Li, Hao Zhang, Chunjing Cai, Zhong Lin, Zhen Zhen, Jie Chu, Kai Guo

Journal: Appl Microbiol Biotechnol

PubMed ID: 35376971

Doi: 10.1007/s00253-022-11897-z

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Glycoside hydrolase from the GH76 family indicates that marine Salegentibacter sp Hel_I_6 consumes alpha-mannan from fungi

Authors: Vipul Solanki, Karen Krüger, Conor J Crawford, Alonso Pardo-Vargas, José Danglad-Flores, Kim Le Mai Hoang, Leeann Klassen, D Wade Abbott, Peter H Seeberger, Rudolf I Amann, Hanno Teeling, Jan-Hendrik Hehemann

Journal: ISME J

PubMed ID: 35414716

Doi: 10.1038/s41396-022-01223-w

Products & Services: Plasmid DNA Preparation

Deletion and tandem duplications of biosynthetic genes drive the diversity of triterpenoids in Aralia elata

Authors: Yu Wang, He Zhang, Hyok Chol Ri, Zeyu An, Xin Wang, Jia-Nan Zhou, Dongran Zheng, Hao Wu, Pengchao Wang, Jianfei Yang, Ding-Kun Liu, Diyang Zhang, Wen-Chieh Tsai, Zheyong Xue, Zhichao Xu, Peng Zhang, Zhong-Jian Liu, Hailong Shen, Yuhua Li

Journal: Nat Commun

PubMed ID: 35468919

Doi: 10.1038/s41467-022-29908-y

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Topology of the Enterobacterial Common Antigen polymerase WzyE

Authors: Nicholas T Maczuga, Elizabeth N H Tran, Renato Morona

Journal: Microbiology (Reading)

PubMed ID: 35470793

Doi: 10.1099/mic.0.001183

Products & Services: Polyclonal Antibody Services

Dynamic of anti-spike receptor binding domain (RBD) levels and short-term adverse events following a heterologous booster dose of BNT162b2 after two doses of CoronaVac in Thai health care workers

Authors: Amonrphat Kitro, Wachiranun Sirikul, Weeraya Thongkum, Suthinee Soponpong, Umpa Yasamut, Wuttipat Kiratipaisarl, Apiradee Kosai, Watchara Kasinrerk, Chatchai Tayapiwatana, Kriengkrai Srithanaviboonchai

Journal: Vaccine

PubMed ID: 35430106

Doi: 10.1016/j.vaccine.2022.04.020

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit

Authors: Nicholas K Hurlburt, Leah J Homad, Irika Sinha, Madeleine F Jennewein, Anna J MacCamy, Yu-Hsin Wan, Jim Boonyaratanakornkit, Anton M Sholukh, Abigail M Jackson, Panpan Zhou, Dennis R Burton, Raiees Andrabi, Gabriel Ozorowski, Andrew B Ward, Leonidas Stamatatos, Marie Pancera, Andrew T McGuire

Journal: Commun Biol

PubMed ID: 35411021

Doi: 10.1038/s42003-022-03262-7

Products & Services: Recombinant Proteins

Correction to "Febuxostat Prevents the Cytotoxicity of Propofol in Brain Endothelial Cells"

Authors: Jianli Hao, Weiqing Zhang, Rui Tong, Zeqing Huang

Journal: ACS Omega

PubMed ID: 35465124

Doi: 10.1021/acsomega.2c01716

Products & Services: Custom DNA/RNA Oligos

Recombinant Limosilactobacillus (Lactobacillus) delivering nanobodies against Clostridium perfringens NetB and alpha toxin confers potential protection from necrotic enteritis

Authors: Dharanesh Gangaiah, Valerie Ryan, Daphne Van Hoesel, Shrinivasrao P Mane, Enid T Mckinley, Nallakannu Lakshmanan, Nandakumar D Reddy, Edward Dolk, Arvind Kumar

Journal: Microbiologyopen

PubMed ID: 35478283

Doi: 10.1002/mbo3.1270

Products & Services: Proteins, Expression, Isolation and Analysis

NEAT1: Culprit lncRNA linking PIG-C, MSLN, and CD80 in triple-negative breast cancer

Authors: Nada H Hussein, Reda A Eissa, M de Bruyn, Hend M El Tayebi

Journal: Life Sci

PubMed ID: 35378140

Doi: 10.1016/j.lfs.2022.120523

Products & Services: Proteins, Expression, Isolation and Analysis

CCPG1 involved in corneal infection

Authors: Li-Mei Wang, Xiao-Meng Chen, Hai-Jing Yan, Shu Yan, Xiao-Yan Sun, Da-Wei Zhang, Hua Yang, Dan-Li Lu, Cheng-Ye Che

Journal: Int J Ophthalmol

PubMed ID: 35450172

Doi: 10.18240/ijo.2022.04.03

Products & Services: Proteins, Expression, Isolation and Analysis

Dataset of high-throughput ligand screening against the RNA Packaging Signals regulating Hepatitis B Virus nucleocapsid formation

Authors: Fardokht Abulwerdi, Farzad Fatehi, Iain W Manfield, Stuart F J Le Grice, John S Schneekloth, Reidun Twarock, Peter G Stockley, Nikesh Patel

Journal: Data Brief

PubMed ID: 35516001

Doi: 10.1016/j.dib.2022.108206

Products & Services: Proteins, Expression, Isolation and Analysis

Cloning and Organelle Expression of Bamboo Mitochondrial Complex I Subunits Nad1, Nad2, Nad4, and Nad5 in the Yeast

Authors: Hsieh-Chin Tsai, Cheng-Hung Hsieh, Ching-Wen Hsu, Yau-Heiu Hsu, Lee-Feng Chien

Journal: Int J Mol Sci

PubMed ID: 35409414

Doi: 10.3390/ijms23074054

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LPS Response Is Impaired by Urban Fine Particulate Matter

Authors: Natália de Souza Xavier Costa, Gabriel Ribeiro Júnior, Adair Aparecida Dos Santos Alemany, Luciano Belotti, Marcela Frota Cavalcante, Susan Ribeiro, Mariana Matera Veras, Esper Georges Kallás, Paulo Hilário Nascimento Saldiva, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva

Journal: Int J Mol Sci

PubMed ID: 35409273

Doi: 10.3390/ijms23073913

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Identification and characterization of novel endolysins targeting Gardnerella vaginalis biofilms to treat bacterial vaginosis

Authors: Sara Arroyo-Moreno, Matthew Cummings, David B Corcoran, Aidan Coffey, Ronan R McCarthy

Journal: NPJ Biofilms Microbiomes

PubMed ID: 35440653

Doi: 10.1038/s41522-022-00285-0

Products & Services: Proteins, Expression, Isolation and Analysis

Ethyl Gallate Dual-Targeting PTPN6 and PPARγ Shows Anti-Diabetic and Anti-Obese Effects

Authors: Dohee Ahn, Jinsoo Kim, Gibeom Nam, Xiaodi Zhao, Jihee Kwon, Ji Young Hwang, Jae Kwan Kim, Sun-Young Yoon, Sang J Chung

Journal: Int J Mol Sci

PubMed ID: 35563411

Doi: 10.3390/ijms23095020

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MicroRNA-217 modulates pancreatic cancer progression via targeting ATAD2

Authors: Madhuri Dutta, Biswajit Das, Debasish Mohapatra, Padmanava Behera, Shantibhusan Senapati, Anasuya Roychowdhury

Journal: Life Sci

PubMed ID: 35504332

Doi: 10.1016/j.lfs.2022.120592

Products & Services: Recombinant Proteins

Peptide Permeation across a Phosphocholine Membrane: An Atomically Detailed Mechanism Determined through Simulations and Supported by Experimentation

Authors: Alfredo E Cardenas, Chad I Drexler, Rachel Nechushtai, Ron Mittler, Assaf Friedler, Lauren J Webb, Ron Elber

Journal: J Phys Chem B

PubMed ID: 35388695

Doi: 10.1021/acs.jpcb.1c10966

Products & Services: Peptide Synthesis

A GH115 α-glucuronidase structure reveals dimerization-mediated substrate binding and a proton wire potentially important for catalysis

Authors: Casper Wilkens, Marlene Vuillemin, Bo Pilgaard, Igor Polikarpov, Jens Preben Morth

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35503213

Doi: 10.1107/S2059798322003527

Products & Services: Plasmid DNA Preparation

Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs

Authors: Helena Tossavainen, Hasan Uğurlu, Mikael Karjalainen, Maarit Hellman, Lina Antenucci, Riku Fagerlund, Kalle Saksela, Perttu Permi

Journal: Structure

PubMed ID: 35390274

Doi: 10.1016/j.str.2022.03.006

Products & Services: Recombinant Antibody Expression

Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response

Authors: Sammy Patyna, Timon Eckes, Benjamin F Koch, Stephan Sudowe, Anke Oftring, Niko Kohmer, Holger F Rabenau, Sandra Ciesek, Despina Avaniadi, Rahel Steiner, Ingeborg A Hauser, Josef M Pfeilschifter, Christoph Betz

Journal: Vaccines (Basel)

PubMed ID: 35455334

Doi: 10.3390/vaccines10040585

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BRAF Modulates Lipid Use and Accumulation

Authors: Jacqueline A Turner, Emily L Paton, Robert Van Gulick, Davide Stefanoni, Francesca Cendali, Julie Reisz, Richard P Tobin, Martin McCarter, Angelo D'Alessandro, Raul M Torres, William A Robinson, Kasey L Couts, Isabel R Schlaepfer

Journal: Cancers (Basel)

PubMed ID: 35565240

Doi: 10.3390/cancers14092110

Products & Services: Mutagenesis Services

production of pederin by labrenzin pathway expansion

Authors: Dina Kačar, Carmen Schleissner, Librada M Cañedo, Pilar Rodríguez, Fernando de la Calle, Carmen Cuevas, Beatriz Galán, José Luis García

Journal: Metab Eng Commun

PubMed ID: 35517715

Doi: 10.1016/j.mec.2022.e00198

Products & Services: PCR Cloning and Subcloning

NADPH-Cytochrome P450 Reductase Mediates the Fatty Acid Desaturation of ω3 and ω6 Desaturases from

Authors: Mingxuan Wang, Jing Li, Wenjie Cong, Jianguo Zhang

Journal: Curr Issues Mol Biol

PubMed ID: 35678654

Doi: 10.3390/cimb44050125

Products & Services: DNA Sequencing

Simultaneous Measurement of IgM and IgG Antibodies to SARS-CoV-2 Spike, RBD, and Nucleocapsid Multiplexed in a Single Assay on the xMAP INTELLIFLEX DR-SE Flow Analyzer

Authors: Andrew Cameron, Jessica L Bohrhunter, Claire A Porterfield, Rupinder Mangat, Michael H Karasick, Zachary Pearson, Stephen Angeloni, Nicole D Pecora

Journal: Microbiol Spectr

PubMed ID: 35389244

Doi: 10.1128/spectrum.02507-21

Products & Services: Proteins, Expression, Isolation and Analysis

Safety and Immunogenicity of a Booster Vaccination by CoronaVac or BNT162b2 in Previously Two-Dose Inactivated Virus Vaccinated Individuals with Negative Neutralizing Antibody

Authors: Kristi Tsz-Wan Lai, Emilie Yuen-Ting Lai Wan Loong, Terry Ling-Hiu Fung, Luke Wing-Pan Luk, Chor-Chiu Lau, Jonpaul Sze-Tsing Zee, Edmond Shiu-Kwan Ma, Bone Siu-Fai Tang

Journal: Vaccines (Basel)

PubMed ID: 35455305

Doi: 10.3390/vaccines10040556

Products & Services: Proteins, Expression, Isolation and Analysis

Immunoreactivity of humanized single-chain variable fragment against its functional epitope on domain 1 of CD147

Authors: Nutjeera Intasai, Kuntalee Rangnoi, Montarop Yamabhai, Thanathat Pamonsupornwichit, Weeraya Thongkum, Umpa Yasamut, Koollawat Chupradit, Nuchjira Takheaw, Piyarat Nimmanpipug, Chatchai Tayapiwatana

Journal: Sci Rep

PubMed ID: 35468972

Doi: 10.1038/s41598-022-10657-3

Products & Services: Bacterial Expression

A genetic toolkit and gene switches to limit Mycoplasma growth for biosafety applications

Authors: Alicia Broto, Erika Gaspari, Samuel Miravet-Verde, Vitor A P Martins Dos Santos, Mark Isalan

Journal: Nat Commun

PubMed ID: 35393441

Doi: 10.1038/s41467-022-29574-0

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pH-Responsive Polymer Nanoparticles for Efficient Delivery of Cas9 Ribonucleoprotein With or Without Donor DNA

Authors: Ruosen Xie, Xiuxiu Wang, Yuyuan Wang, Mingzhou Ye, Yi Zhao, Brian S Yandell, Shaoqin Gong

Journal: Adv Mater

PubMed ID: 35119139

Doi: 10.1002/adma.202110618

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Antimicrobial and Immunomodulatory Effects of Selected Chemokine and Antimicrobial Peptide on Cytokine Profile during Typhimurium Infection in Mouse

Authors: Astrid Tuxpan-Pérez, Marco Antonio Ibarra-Valencia, Blanca Elisa Estrada, Herlinda Clement, Ligia Luz Corrales-García, Gerardo Pavel Espino-Solis, Gerardo Corzo

Journal: Antibiotics (Basel)

PubMed ID: 35625251

Doi: 10.3390/antibiotics11050607

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Bma-LAD-2, an Intestinal Cell Adhesion Protein, as a Potential Therapeutic Target for Lymphatic Filariasis

Authors: Alexander F Flynn, Rebekah T Taylor, Marzena E Pazgier, Sasisekhar Bennuru, Alyssa R Lindrose, Spencer L Sterling, C Paul Morris, Brynna I Gleeson, Tim K Maugel, Thomas B Nutman, Edward Mitre

Journal: MBio

PubMed ID: 35475643

Doi: 10.1128/mbio.03742-21

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Multifunctional polyphenol-based silk hydrogel alleviate soxidative stress and enhances endogenous regeneration of osteochondral defects.

Authors: Wei Zhang 1 2 3, Yanan Zhang 1, Xiaolong Li 1, Zhicheng Cao 1 4, Qingyun Mo 1, Renwang Sheng 1, Chen Ling 1 4, Jiayu Chi 1, Qingqiang Yao 4 3, Jialin Chen 1 2 3, Hongmei Wang 1

Journal: Mater Today Bio

PubMed ID: 35469254

Doi: 10.1016/j.mtbio.2022.100251

Products & Services: Recombinant Proteins

A polyesterase from the Antarctic bacterium Moraxella sp degrades highly crystalline synthetic polymers

Authors: Efstratios Nikolaivits, George Taxeidis, Christina Gkountela, Stamatina Vouyiouka, Veselin Maslak, Jasmina Nikodinovic-Runic, Evangelos Topakas

Journal: J Hazard Mater

PubMed ID: 35452981

Doi: 10.1016/j.jhazmat.2022.128900

Products & Services: Bacterial Expression

Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry

Authors: Tanaya Bagga, Nikhil Kumar Tulsian, Yu Keung Mok, R Manjunatha Kini, J Sivaraman

Journal: Cell Mol Life Sci

PubMed ID: 35397701

Doi: 10.1007/s00018-022-04245-x

Products & Services: Plasmid DNA Preparation

Impaired Humoral Immunity with Concomitant Preserved T Cell Reactivity in IBD Patients on Treatment with Infliximab 6 Month after Vaccination with the SARS-CoV-2 mRNA Vaccine BNT162b2: A Pilot Study

Authors: Richard Vollenberg, Phil-Robin Tepasse, Eva Lorentzen, Tobias Max Nowacki

Journal: J Pers Med

PubMed ID: 35629116

Doi: 10.3390/jpm12050694

SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells

Authors: Anastasia A Minervina, Mikhail V Pogorelyy, Allison M Kirk, Jeremy Chase Crawford, E Kaitlynn Allen, Ching-Heng Chou, Robert C Mettelman, Kim J Allison, Chun-Yang Lin, David C Brice, Xun Zhu, Kasi Vegesana, Gang Wu, Sanchit Trivedi, Pratibha Kottapalli, Daniel Darnell, Suzanne McNeely, Scott R Olsen, Stacey Schultz-Cherry, Jeremie H Estepp, Maureen A McGargill, Joshua Wolf, Paul G Thomas

Journal: Nat Immunol

PubMed ID: 35383307

Doi: 10.1038/s41590-022-01184-4

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A Single-Domain TCR-like Antibody Selective for the Qa-1/Qdm Peptide Complex Enhances Tumoricidal Activity of NK Cells via Blocking the NKG2A Immune Checkpoint

Authors: Soroush Ghaffari, Katherine Upchurch-Ange, Susanne Gimlin, Trivendra Tripathi, Marjolein Sluijter, Jim Middelburg, Thorbald van Hall, Jon Weidanz

Journal: J Immunol

PubMed ID: 35418467

Doi: 10.4049/jimmunol.2100790

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insight into UV-B-activated UVR8 bound to COP1

Authors: Yidong Wang, Lixia Wang, Zeyuan Guan, Hongfei Chang, Ling Ma, Cuicui Shen, Liang Qiu, Junjie Yan, Delin Zhang, Jian Li, Xing Wang Deng, Ping Yin

Journal: Sci Adv

PubMed ID: 35442727

Doi: 10.1126/sciadv.abn3337

Products & Services: Proteins, Expression, Isolation and Analysis

Humoral immunity against SARS-CoV-2 variants including omicron in solid organ transplant recipients after three doses of a COVID-19 mRNA vaccine

Authors: Kapil K Saharia, Jennifer S Husson, Silke V Niederhaus, Thierry Iraguha, Stephanie V Avila, Youngchae J Yoo, Nancy M Hardy, Xiaoxuan Fan, Destiny Omili, Alice Crane, Amber Carrier, Wen Y Xie, Erica Vander Mause, Kim Hankey, Sherri Bauman, Patricia Lesho, Heather D Mannuel, Ashish Ahuja, Minu Mathew, James Avruch, John Baddley, Olga Goloubeva, Kirti Shetty, Saurabh Dahiya, Aaron P Rapoport, Tim Luetkens, Djordje Atanackovic

Journal: Clin Transl Immunology

PubMed ID: 35505864

Doi: 10.1002/cti2.1391

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Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu supplants entropically favoured Zn to form Cu clusters under physiological conditions

Authors: Matthew R Mehlenbacher, Rahma Elsiesy, Rabina Lakha, Rhiza Lyne E Villones, Marina Orman, Christina L Vizcarra, Gabriele Meloni, Dean E Wilcox, Rachel N Austin

Journal: Chem Sci

PubMed ID: 35655557

Doi: 10.1039/d2sc00676f

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