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Glycoside hydrolase from the GH76 family indicates that marine Salegentibacter sp Hel_I_6 consumes alpha-mannan from fungi
Authors: Vipul Solanki, Karen Krüger, Conor J Crawford, Alonso Pardo-Vargas, José Danglad-Flores, Kim Le Mai Hoang, Leeann Klassen, D Wade Abbott, Peter H Seeberger, Rudolf I Amann, Hanno Teeling, Jan-Hendrik Hehemann
Journal: ISME J
PubMed ID: 35414716
Doi: 10.1038/s41396-022-01223-w
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Deletion and tandem duplications of biosynthetic genes drive the diversity of triterpenoids in Aralia elata
Authors: Yu Wang, He Zhang, Hyok Chol Ri, Zeyu An, Xin Wang, Jia-Nan Zhou, Dongran Zheng, Hao Wu, Pengchao Wang, Jianfei Yang, Ding-Kun Liu, Diyang Zhang, Wen-Chieh Tsai, Zheyong Xue, Zhichao Xu, Peng Zhang, Zhong-Jian Liu, Hailong Shen, Yuhua Li
Journal: Nat Commun
PubMed ID: 35468919
Doi: 10.1038/s41467-022-29908-y
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Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit
Authors: Nicholas K Hurlburt, Leah J Homad, Irika Sinha, Madeleine F Jennewein, Anna J MacCamy, Yu-Hsin Wan, Jim Boonyaratanakornkit, Anton M Sholukh, Abigail M Jackson, Panpan Zhou, Dennis R Burton, Raiees Andrabi, Gabriel Ozorowski, Andrew B Ward, Leonidas Stamatatos, Marie Pancera, Andrew T McGuire
Journal: Commun Biol
PubMed ID: 35411021
Doi: 10.1038/s42003-022-03262-7
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Dynamic of anti-spike receptor binding domain (RBD) levels and short-term adverse events following a heterologous booster dose of BNT162b2 after two doses of CoronaVac in Thai health care workers
Authors: Amonrphat Kitro, Wachiranun Sirikul, Weeraya Thongkum, Suthinee Soponpong, Umpa Yasamut, Wuttipat Kiratipaisarl, Apiradee Kosai, Watchara Kasinrerk, Chatchai Tayapiwatana, Kriengkrai Srithanaviboonchai
Journal: Vaccine
PubMed ID: 35430106
Doi: 10.1016/j.vaccine.2022.04.020
Correction to "Febuxostat Prevents the Cytotoxicity of Propofol in Brain Endothelial Cells"
Authors: Jianli Hao, Weiqing Zhang, Rui Tong, Zeqing Huang
Journal: ACS Omega
PubMed ID: 35465124
Doi: 10.1021/acsomega.2c01716
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Topology of the Enterobacterial Common Antigen polymerase WzyE
Authors: Nicholas T Maczuga, Elizabeth N H Tran, Renato Morona
Journal: Microbiology (Reading)
PubMed ID: 35470793
Doi: 10.1099/mic.0.001183
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Recombinant Limosilactobacillus (Lactobacillus) delivering nanobodies against Clostridium perfringens NetB and alpha toxin confers potential protection from necrotic enteritis
Authors: Dharanesh Gangaiah, Valerie Ryan, Daphne Van Hoesel, Shrinivasrao P Mane, Enid T Mckinley, Nallakannu Lakshmanan, Nandakumar D Reddy, Edward Dolk, Arvind Kumar
Journal: Microbiologyopen
PubMed ID: 35478283
Doi: 10.1002/mbo3.1270
NEAT1: Culprit lncRNA linking PIG-C, MSLN, and CD80 in triple-negative breast cancer
Authors: Nada H Hussein, Reda A Eissa, M de Bruyn, Hend M El Tayebi
Journal: Life Sci
PubMed ID: 35378140
Doi: 10.1016/j.lfs.2022.120523
Dataset of high-throughput ligand screening against the RNA Packaging Signals regulating Hepatitis B Virus nucleocapsid formation
Authors: Fardokht Abulwerdi, Farzad Fatehi, Iain W Manfield, Stuart F J Le Grice, John S Schneekloth, Reidun Twarock, Peter G Stockley, Nikesh Patel
Journal: Data Brief
PubMed ID: 35516001
Doi: 10.1016/j.dib.2022.108206
CCPG1 involved in corneal infection
Authors: Li-Mei Wang, Xiao-Meng Chen, Hai-Jing Yan, Shu Yan, Xiao-Yan Sun, Da-Wei Zhang, Hua Yang, Dan-Li Lu, Cheng-Ye Che
Journal: Int J Ophthalmol
PubMed ID: 35450172
Doi: 10.18240/ijo.2022.04.03
Cloning and Organelle Expression of Bamboo Mitochondrial Complex I Subunits Nad1, Nad2, Nad4, and Nad5 in the Yeast
Authors: Hsieh-Chin Tsai, Cheng-Hung Hsieh, Ching-Wen Hsu, Yau-Heiu Hsu, Lee-Feng Chien
Journal: Int J Mol Sci
PubMed ID: 35409414
Doi: 10.3390/ijms23074054
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Ethyl Gallate Dual-Targeting PTPN6 and PPARγ Shows Anti-Diabetic and Anti-Obese Effects
Authors: Dohee Ahn, Jinsoo Kim, Gibeom Nam, Xiaodi Zhao, Jihee Kwon, Ji Young Hwang, Jae Kwan Kim, Sun-Young Yoon, Sang J Chung
Journal: Int J Mol Sci
PubMed ID: 35563411
Doi: 10.3390/ijms23095020
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LPS Response Is Impaired by Urban Fine Particulate Matter
Authors: Natália de Souza Xavier Costa, Gabriel Ribeiro Júnior, Adair Aparecida Dos Santos Alemany, Luciano Belotti, Marcela Frota Cavalcante, Susan Ribeiro, Mariana Matera Veras, Esper Georges Kallás, Paulo Hilário Nascimento Saldiva, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva
Journal: Int J Mol Sci
PubMed ID: 35409273
Doi: 10.3390/ijms23073913
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Identification and characterization of novel endolysins targeting Gardnerella vaginalis biofilms to treat bacterial vaginosis
Authors: Sara Arroyo-Moreno, Matthew Cummings, David B Corcoran, Aidan Coffey, Ronan R McCarthy
Journal: NPJ Biofilms Microbiomes
PubMed ID: 35440653
Doi: 10.1038/s41522-022-00285-0
MicroRNA-217 modulates pancreatic cancer progression via targeting ATAD2
Authors: Madhuri Dutta, Biswajit Das, Debasish Mohapatra, Padmanava Behera, Shantibhusan Senapati, Anasuya Roychowdhury
Journal: Life Sci
PubMed ID: 35504332
Doi: 10.1016/j.lfs.2022.120592
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Peptide Permeation across a Phosphocholine Membrane: An Atomically Detailed Mechanism Determined through Simulations and Supported by Experimentation
Authors: Alfredo E Cardenas, Chad I Drexler, Rachel Nechushtai, Ron Mittler, Assaf Friedler, Lauren J Webb, Ron Elber
Journal: J Phys Chem B
PubMed ID: 35388695
Doi: 10.1021/acs.jpcb.1c10966
Products & Services: Peptide Synthesis   
A GH115 α-glucuronidase structure reveals dimerization-mediated substrate binding and a proton wire potentially important for catalysis
Authors: Casper Wilkens, Marlene Vuillemin, Bo Pilgaard, Igor Polikarpov, Jens Preben Morth
Journal: Acta Crystallogr D Struct Biol
PubMed ID: 35503213
Doi: 10.1107/S2059798322003527
Products & Services: Plasmid DNA Preparation   
Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs
Authors: Helena Tossavainen, Hasan Uğurlu, Mikael Karjalainen, Maarit Hellman, Lina Antenucci, Riku Fagerlund, Kalle Saksela, Perttu Permi
Journal: Structure
PubMed ID: 35390274
Doi: 10.1016/j.str.2022.03.006
Products & Services: Recombinant Antibody Expression   
Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response
Authors: Sammy Patyna, Timon Eckes, Benjamin F Koch, Stephan Sudowe, Anke Oftring, Niko Kohmer, Holger F Rabenau, Sandra Ciesek, Despina Avaniadi, Rahel Steiner, Ingeborg A Hauser, Josef M Pfeilschifter, Christoph Betz
Journal: Vaccines (Basel)
PubMed ID: 35455334
Doi: 10.3390/vaccines10040585
Products & Services: Catalog Antibody   
BRAF Modulates Lipid Use and Accumulation
Authors: Jacqueline A Turner, Emily L Paton, Robert Van Gulick, Davide Stefanoni, Francesca Cendali, Julie Reisz, Richard P Tobin, Martin McCarter, Angelo D'Alessandro, Raul M Torres, William A Robinson, Kasey L Couts, Isabel R Schlaepfer
Journal: Cancers (Basel)
PubMed ID: 35565240
Doi: 10.3390/cancers14092110
Products & Services: Mutagenesis Services   
production of pederin by labrenzin pathway expansion
Authors: Dina Kačar, Carmen Schleissner, Librada M Cañedo, Pilar Rodríguez, Fernando de la Calle, Carmen Cuevas, Beatriz Galán, José Luis García
Journal: Metab Eng Commun
PubMed ID: 35517715
Doi: 10.1016/j.mec.2022.e00198
Products & Services: PCR Cloning and Subcloning   
NADPH-Cytochrome P450 Reductase Mediates the Fatty Acid Desaturation of ω3 and ω6 Desaturases from
Authors: Mingxuan Wang, Jing Li, Wenjie Cong, Jianguo Zhang
Journal: Curr Issues Mol Biol
PubMed ID: 35678654
Doi: 10.3390/cimb44050125
Products & Services: DNA Sequencing   
Simultaneous Measurement of IgM and IgG Antibodies to SARS-CoV-2 Spike, RBD, and Nucleocapsid Multiplexed in a Single Assay on the xMAP INTELLIFLEX DR-SE Flow Analyzer
Authors: Andrew Cameron, Jessica L Bohrhunter, Claire A Porterfield, Rupinder Mangat, Michael H Karasick, Zachary Pearson, Stephen Angeloni, Nicole D Pecora
Journal: Microbiol Spectr
PubMed ID: 35389244
Doi: 10.1128/spectrum.02507-21
Safety and Immunogenicity of a Booster Vaccination by CoronaVac or BNT162b2 in Previously Two-Dose Inactivated Virus Vaccinated Individuals with Negative Neutralizing Antibody
Authors: Kristi Tsz-Wan Lai, Emilie Yuen-Ting Lai Wan Loong, Terry Ling-Hiu Fung, Luke Wing-Pan Luk, Chor-Chiu Lau, Jonpaul Sze-Tsing Zee, Edmond Shiu-Kwan Ma, Bone Siu-Fai Tang
Journal: Vaccines (Basel)
PubMed ID: 35455305
Doi: 10.3390/vaccines10040556
Immunoreactivity of humanized single-chain variable fragment against its functional epitope on domain 1 of CD147
Authors: Nutjeera Intasai, Kuntalee Rangnoi, Montarop Yamabhai, Thanathat Pamonsupornwichit, Weeraya Thongkum, Umpa Yasamut, Koollawat Chupradit, Nuchjira Takheaw, Piyarat Nimmanpipug, Chatchai Tayapiwatana
Journal: Sci Rep
PubMed ID: 35468972
Doi: 10.1038/s41598-022-10657-3
Products & Services: Bacterial Expression   
A genetic toolkit and gene switches to limit Mycoplasma growth for biosafety applications
Authors: Alicia Broto, Erika Gaspari, Samuel Miravet-Verde, Vitor A P Martins Dos Santos, Mark Isalan
Journal: Nat Commun
PubMed ID: 35393441
Doi: 10.1038/s41467-022-29574-0
Products & Services: Mutagenesis Services   
pH-Responsive Polymer Nanoparticles for Efficient Delivery of Cas9 Ribonucleoprotein With or Without Donor DNA
Authors: Ruosen Xie, Xiuxiu Wang, Yuyuan Wang, Mingzhou Ye, Yi Zhao, Brian S Yandell, Shaoqin Gong
Journal: Adv Mater
PubMed ID: 35119139
Doi: 10.1002/adma.202110618
Products & Services: Catalog Peptides   
Antimicrobial and Immunomodulatory Effects of Selected Chemokine and Antimicrobial Peptide on Cytokine Profile during Typhimurium Infection in Mouse
Authors: Astrid Tuxpan-Pérez, Marco Antonio Ibarra-Valencia, Blanca Elisa Estrada, Herlinda Clement, Ligia Luz Corrales-García, Gerardo Pavel Espino-Solis, Gerardo Corzo
Journal: Antibiotics (Basel)
PubMed ID: 35625251
Doi: 10.3390/antibiotics11050607
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Bma-LAD-2, an Intestinal Cell Adhesion Protein, as a Potential Therapeutic Target for Lymphatic Filariasis
Authors: Alexander F Flynn, Rebekah T Taylor, Marzena E Pazgier, Sasisekhar Bennuru, Alyssa R Lindrose, Spencer L Sterling, C Paul Morris, Brynna I Gleeson, Tim K Maugel, Thomas B Nutman, Edward Mitre
Journal: MBio
PubMed ID: 35475643
Doi: 10.1128/mbio.03742-21
Products & Services: Gene Synthesis   
Multifunctional polyphenol-based silk hydrogel alleviate soxidative stress and enhances endogenous regeneration of osteochondral defects.
Authors: Wei Zhang 1 2 3, Yanan Zhang 1, Xiaolong Li 1, Zhicheng Cao 1 4, Qingyun Mo 1, Renwang Sheng 1, Chen Ling 1 4, Jiayu Chi 1, Qingqiang Yao 4 3, Jialin Chen 1 2 3, Hongmei Wang 1
Journal: Mater Today Bio
PubMed ID: 35469254
Doi: 10.1016/j.mtbio.2022.100251
Products & Services: Recombinant Proteins   
A polyesterase from the Antarctic bacterium Moraxella sp degrades highly crystalline synthetic polymers
Authors: Efstratios Nikolaivits, George Taxeidis, Christina Gkountela, Stamatina Vouyiouka, Veselin Maslak, Jasmina Nikodinovic-Runic, Evangelos Topakas
Journal: J Hazard Mater
PubMed ID: 35452981
Doi: 10.1016/j.jhazmat.2022.128900
Products & Services: Bacterial Expression   
Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry
Authors: Tanaya Bagga, Nikhil Kumar Tulsian, Yu Keung Mok, R Manjunatha Kini, J Sivaraman
Journal: Cell Mol Life Sci
PubMed ID: 35397701
Doi: 10.1007/s00018-022-04245-x
Products & Services: Plasmid DNA Preparation   
Impaired Humoral Immunity with Concomitant Preserved T Cell Reactivity in IBD Patients on Treatment with Infliximab 6 Month after Vaccination with the SARS-CoV-2 mRNA Vaccine BNT162b2: A Pilot Study
Authors: Richard Vollenberg, Phil-Robin Tepasse, Eva Lorentzen, Tobias Max Nowacki
Journal: J Pers Med
PubMed ID: 35629116
Doi: 10.3390/jpm12050694
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells
Authors: Anastasia A Minervina, Mikhail V Pogorelyy, Allison M Kirk, Jeremy Chase Crawford, E Kaitlynn Allen, Ching-Heng Chou, Robert C Mettelman, Kim J Allison, Chun-Yang Lin, David C Brice, Xun Zhu, Kasi Vegesana, Gang Wu, Sanchit Trivedi, Pratibha Kottapalli, Daniel Darnell, Suzanne McNeely, Scott R Olsen, Stacey Schultz-Cherry, Jeremie H Estepp, Maureen A McGargill, Joshua Wolf, Paul G Thomas
Journal: Nat Immunol
PubMed ID: 35383307
Doi: 10.1038/s41590-022-01184-4
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A Single-Domain TCR-like Antibody Selective for the Qa-1/Qdm Peptide Complex Enhances Tumoricidal Activity of NK Cells via Blocking the NKG2A Immune Checkpoint
Authors: Soroush Ghaffari, Katherine Upchurch-Ange, Susanne Gimlin, Trivendra Tripathi, Marjolein Sluijter, Jim Middelburg, Thorbald van Hall, Jon Weidanz
Journal: J Immunol
PubMed ID: 35418467
Doi: 10.4049/jimmunol.2100790
Structural insight into UV-B-activated UVR8 bound to COP1
Authors: Yidong Wang, Lixia Wang, Zeyuan Guan, Hongfei Chang, Ling Ma, Cuicui Shen, Liang Qiu, Junjie Yan, Delin Zhang, Jian Li, Xing Wang Deng, Ping Yin
Journal: Sci Adv
PubMed ID: 35442727
Doi: 10.1126/sciadv.abn3337
Humoral immunity against SARS-CoV-2 variants including omicron in solid organ transplant recipients after three doses of a COVID-19 mRNA vaccine
Authors: Kapil K Saharia, Jennifer S Husson, Silke V Niederhaus, Thierry Iraguha, Stephanie V Avila, Youngchae J Yoo, Nancy M Hardy, Xiaoxuan Fan, Destiny Omili, Alice Crane, Amber Carrier, Wen Y Xie, Erica Vander Mause, Kim Hankey, Sherri Bauman, Patricia Lesho, Heather D Mannuel, Ashish Ahuja, Minu Mathew, James Avruch, John Baddley, Olga Goloubeva, Kirti Shetty, Saurabh Dahiya, Aaron P Rapoport, Tim Luetkens, Djordje Atanackovic
Journal: Clin Transl Immunology
PubMed ID: 35505864
Doi: 10.1002/cti2.1391
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Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu supplants entropically favoured Zn to form Cu clusters under physiological conditions
Authors: Matthew R Mehlenbacher, Rahma Elsiesy, Rabina Lakha, Rhiza Lyne E Villones, Marina Orman, Christina L Vizcarra, Gabriele Meloni, Dean E Wilcox, Rachel N Austin
Journal: Chem Sci
PubMed ID: 35655557
Doi: 10.1039/d2sc00676f
Products & Services: Codon Optimization   
Tripartite motif containing 63, regulated by E26 transformation specific variant 4, facilitates the thyroid carcinoma progression and the AKT, p38, and ERK signaling pathways
Authors: Jingni He, Ying Zhang, Baiyu Yao, Lidong Wang, Zhong Tian
Journal: Mol Cell Endocrinol
PubMed ID: 35390449
Doi: 10.1016/j.mce.2022.111639
Products & Services: Gene Synthesis   
Melatonin Mediated Differential Regulation of Drought Tolerance in Sensitive and Tolerant Varieties of Upland Cotton (
Authors: Laha Supriya, Pullaiahgari Durgeshwar, Mehanathan Muthamilarasan, Gudipalli Padmaja
Journal: Front Plant Sci
PubMed ID: 35444676
Doi: 10.3389/fpls.2022.821353
Nutrient sensitive protein -GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis
Authors: Shama Parween, Thilina T Alawathugoda, Ashok D Prabakaran, S Thameem Dheen, Randall H Morse, Bright Starling Emerald, Suraiya A Ansari
Journal: Life Sci Alliance
PubMed ID: 35470239
Doi: 10.26508/lsa.202201385
Peptide of Infective Larval Extract That Harnesses Growth of Human Hepatoma Cells
Authors: Pichet Ruenchit, Onrapak Reamtong, Ladawan Khowawisetsut, Poom Adisakwattana, Monrat Chulanetra, Kasem Kulkeaw, Wanpen Chaicumpa
Journal: Front Cell Infect Microbiol
PubMed ID: 35558100
Doi: 10.3389/fcimb.2022.882608
Products & Services: Peptide Synthesis   
Restoration of Sarco/Endoplasmic Reticulum Ca-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca Depletion
Authors: Wen Zhang, Fanghua Ye, Nan Pang, Miriam Kessi, Juan Xiong, Shimeng Chen, Jing Peng, Li Yang, Fei Yin
Journal: Front Pharmacol
PubMed ID: 35517826
Doi: 10.3389/fphar.2022.877175
Products & Services: Mutagenesis Services   
BDSF Is a Degradation-Prone Quorum-Sensing Signal Detected by the Histidine Kinase RpfC of pv
Authors: Xiu-Qi Tian, Yao Wu, Zhen Cai, Wei Qian
Journal: Appl Environ Microbiol
PubMed ID: 35369702
Doi: 10.1128/aem.00031-22
Products & Services: Recombinant Proteins   
Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol
Authors: Rodrigo Ochoa, Victoria Alves Santos Lunardelli, Daniela Santoro Rosa, Alessandro Laio, Pilar Cossio
Journal: Front Immunol
PubMed ID: 35572587
Doi: 10.3389/fimmu.2022.862851
Products & Services: Peptide Synthesis   
A conserved module regulates receptor kinase signalling in immunity and development
Authors: Thomas A DeFalco, Pauline Anne, Sean R James, Andrew C Willoughby, Florian Schwanke, Oliver Johanndrees, Yasmine Genolet, Paul Derbyshire, Qian Wang, Surbhi Rana, Anne-Marie Pullen, Frank L H Menke, Cyril Zipfel, Christian S Hardtke, Zachary L Nimchuk
Journal: Nat Plants
PubMed ID: 35422079
Doi: 10.1038/s41477-022-01134-w
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Gain-of-function and loss-of-function GABRB3 variants lead to distinct clinical phenotypes in patients with developmental and epileptic encephalopathies
Authors: Nathan L Absalom, Vivian W Y Liao, Katrine M H Johannesen, Elena Gardella, Julia Jacobs, Gaetan Lesca, Zeynep Gokce-Samar, Alexis Arzimanoglou, Shimriet Zeidler, Pasquale Striano, Pierre Meyer, Ira Benkel-Herrenbrueck, Inger-Lise Mero, Jutta Rummel, Mary Chebib, Rikke S Møller, Philip K Ahring
Journal: Nat Commun
PubMed ID: 35383156
Doi: 10.1038/s41467-022-29280-x
Products & Services: PCR Cloning and Subcloning   
The Readthrough Isoform AQP4ex Is Constitutively Phosphorylated in the Perivascular Astrocyte Endfeet of Human Brain
Authors: Roberta Pati, Claudia Palazzo, Onofrio Valente, Pasqua Abbrescia, Raffaella Messina, Nicoletta Concetta Surdo, Konstantinos Lefkimmiatis, Francesco Signorelli, Grazia Paola Nicchia, Antonio Frigeri
Journal: Biomolecules
PubMed ID: 35625560
Doi: 10.3390/biom12050633
Products & Services: Polyclonal Antibody Services   
Engineered RBCs Encapsulating Antigen Induce Multi-Modal Antigen-Specific Tolerance and Protect Against Type 1 Diabetes
Authors: Colin J Raposo, Judith D Cserny, Gloria Serena, Jonathan N Chow, Patricia Cho, Hanyang Liu, David Kotler, Armon Sharei, Howard Bernstein, Shinu John
Journal: Front Immunol
PubMed ID: 35444659
Doi: 10.3389/fimmu.2022.869669
Role of the anillin-like protein in growth of Cryptococcus neoformans at human host temperature
Authors: Congyue A Peng, Sophie Altamirano, Namrata Paladugu, Logan P Crowe, Inas F Aboobakar, Srikripa Chandrasekaran, Lukasz Kozubowski
Journal: Fungal Genet Biol
PubMed ID: 35472450
Doi: 10.1016/j.fgb.2022.103697
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