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Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

Authors: Tim Krischuns, Catherine Isel, Petra Drncova, Maria Lukarska, Alexander Pflug, Sylvain Paisant, Vincent Navratil, Stephen Cusack, Nadia Naffakh

Journal: PLoS Pathog

PubMed ID: 35605026

Doi: 10.1371/journal.ppat.1010328

Products & Services: PCR Cloning and Subcloning

Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants

Authors: Yaning Li, Qing Fan, Bing Zhou, Yaping Shen, Yuanyuan Zhang, Lin Cheng, Furong Qi, Shuo Song, Yingying Guo, Renhong Yan, Bin Ju, Zheng Zhang

Journal: iScience

PubMed ID: 35607524

Doi: 10.1016/j.isci.2022.104431

Products & Services: Proteins, Expression, Isolation and Analysis

Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders

Authors: Elif Eroglu, Christopher Y T Yen, Yat-Long Tsoi, Nevin Witman, Ahmed Elewa, Alberto Joven Araus, Heng Wang, Tamara Szattler, Chimezie H Umeano, Jesper Sohlmér, Alexander Goedel, András Simon, Kenneth R Chien

Journal: Nat Cell Biol

PubMed ID: 35550612

Doi: 10.1038/s41556-022-00902-2

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Structure and Mechanism of a Cold-Adapted Bacterial Lipase

Authors: Florian van der Ent, Bjarte A Lund, Linn Svalberg, Miha Purg, Ghislean Chukwu, Mikael Widersten, Geir V Isaksen, Bjørn O Brandsdal, Johan Åqvist

Journal: Biochemistry

PubMed ID: 35503728

Doi: 10.1021/acs.biochem.2c00087

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Fermentative Indole Production via Bacterial Tryptophan Synthase Alpha Subunit and Plant Indole-3-Glycerol Phosphate Lyase Enzymes

Authors: Lenny Ferrer, Melanie Mindt, Maria Suarez-Diez, Tatjana Jilg, Maja Zagorščak, Jin-Ho Lee, Kristina Gruden, Volker F Wendisch, Katarina Cankar

Journal: J Agric Food Chem

PubMed ID: 35500281

Doi: 10.1021/acs.jafc.2c01042

Products & Services: PCR Cloning and Subcloning

Quantitative proteomics of HFD-induced fatty liver uncovers novel transcription factors of lipid metabolism

Authors: Shang Zhi, Zhang Congcong, Gao Zhiling, Qian Yihan, Xin Yijing, Liu Guanjie, Wang Fang, Sun Xuehua, Li Hongjie, Kong Xiaoni, Gao Yueqiu

Journal: Int J Biol Sci

PubMed ID: 35637971

Doi: 10.7150/ijbs.71431

Products & Services: Proteins, Expression, Isolation and Analysis

Comparison of pathogenicity of different subgenotype porcine reproductive and respiratory syndrome viruses isolated in China

Authors: Jie Zhang, Juan Bai, Yangyang Sun, Xing Liu, Yanni Gao, Xianwei Wang, Yuanqi Yang, Ping Jiang

Journal: Microb Pathog

PubMed ID: 35640766

Doi: 10.1016/j.micpath.2022.105607

Products & Services: DNA Sequencing

Complex protein interactions mediate Drosophila Lar function in muscle tissue

Authors: Jessica Kawakami, David Brooks, Rana Zalmai, Steven D Hartson, Samuel Bouyain, Erika R Geisbrecht

Journal: PLoS ONE

PubMed ID: 35622884

Doi: 10.1371/journal.pone.0269037

Products & Services: PCR Cloning and Subcloning

Sequestration of TDP-43 Aggregates by Cytoplasmic Expression of the proSAAS Chaperone

Authors: Juan R Peinado, Kriti Chaplot, Timothy S Jarvela, Edward M Barbieri, James Shorter, Iris Lindberg

Journal: ACS Chem Neurosci

PubMed ID: 35549000

Doi: 10.1021/acschemneuro.2c00156

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A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair

Authors: Susana Lechuga, Alexander X Cartagena-Rivera, Afshin Khan, Bert I Crawford, Vani Narayanan, Daniel E Conway, Jaakko Lehtimäki, Pekka Lappalainen, Florian Rieder, Michelle S Longworth, Andrei I Ivanov

Journal: FASEB J

PubMed ID: 35344227

Doi: 10.1096/fj.202200154R

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Humoral Immune Response Diversity to Different COVID-19 Vaccines: Implications for the "Green Pass" Policy

Authors: Immacolata Polvere, Alfredina Parrella, Lucrezia Zerillo, Serena Voccola, Gaetano Cardinale, Silvia D'Andrea, Jessica Raffaella Madera, Romania Stilo, Pasquale Vito, Tiziana Zotti

Journal: Front Immunol

PubMed ID: 35634315

Doi: 10.3389/fimmu.2022.833085

Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer

Authors: Tingjia Zhu, Yixuan Cen, Zhuoye Chen, Yanan Zhang, Lu Zhao, Jiaying Wang, Weiguo Lu, Xing Xie, Xinyu Wang

Journal: Cell Death Dis

PubMed ID: 35595754

Doi: 10.1038/s41419-022-04943-1

Products & Services: Proteins, Expression, Isolation and Analysis

Epitope-Based Vaccines against the Major Outer Membrane Protein Variable Domain 4 Elicit Protection in Mice

Authors: Amanda L Collar, Alexandria C Linville, Susan B Core, Kathryn M Frietze

Journal: Vaccines (Basel)

PubMed ID: 35746483

Doi: 10.3390/vaccines10060875

Products & Services: Proteins, Expression, Isolation and Analysis

Covalent Adduct Formation in Methylthio-d-ribose-1-phosphate Isomerase: Reaction Intermediate or Artifact?

Authors: Vamsee M Veeramachineni, Subashi T Ubayawardhana, Andrew S Murkin

Journal: Biochemistry

PubMed ID: 35580612

Doi: 10.1021/acs.biochem.2c00142

Products & Services: Plasmid DNA Preparation

CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

Authors: Megan Lo, Amnon Sharir, Michael D Paul, Hayarpi Torosyan, Christopher Agnew, Amy Li, Cynthia Neben, Pauline Marangoni, Libin Xu, David R Raleigh, Natalia Jura, Ophir D Klein

Journal: Nat Commun

PubMed ID: 35504891

Doi: 10.1038/s41467-022-30186-x

Products & Services: Proteins, Expression, Isolation and Analysis

Coronavirus Disease 2019 Vaccine Booster Effects Are Seen in Human Milk Antibody Response

Authors: Jeffrey M Bender, Yesun Lee, Wesley A Cheng, Carolyn J Marentes Ruiz, Pia S Pannaraj

Journal: Front Nutr

PubMed ID: 35685893

Doi: 10.3389/fnut.2022.898849

Products & Services: Mammalian Expression

The key sulfometuron-methyl degrading bacteria isolation based on soil bacterial phylogenetic molecular ecological networks and application for bioremediation of contaminated soil by immobilization

Authors: Hao Zhang, Chun-Yang Liu, Xin Zhang, Hui-Ying Yang, Jie Sun, Cheng-Bin Liu, Na Li

Journal: Ecotoxicol Environ Saf

PubMed ID: 35561546

Doi: 10.1016/j.ecoenv.2022.113605

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of RBMX as a splicing regulator in Parkinsonian mimetic induced alternative splicing of α-synuclein

Authors: Swaroop Thonda, Ravali L Vinnakota, Swathi V Kona, Shasi V Kalivendi

Journal: Biochim Biophys Acta Gene Regul Mech

PubMed ID: 35577270

Doi: 10.1016/j.bbagrm.2022.194825

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Enhancing fluxes through the mevalonate pathway in Saccharomyces cerevisiae by engineering the HMGR and β-alanine metabolism

Authors: Surui Lu, Chenyao Zhou, Xuena Guo, Zhengda Du, Yanfei Cheng, Zhaoyue Wang, Xiuping He

Journal: Microb Biotechnol

PubMed ID: 35531990

Doi: 10.1111/1751-7915.14072

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Smartly responsive DNA-miRNA hybrids packaged in exosomes for synergistic enhancement of cancer cell apoptosis

Authors: Fan Zhang, Albertina N Isak, Shiqi Yang, Yuchen Song, Lingjie Ren, Chang Feng, Guifang Chen

Journal: Nanoscale

PubMed ID: 35421879

Doi: 10.1039/d1nr08539e

Products & Services: Gene Synthesis

Glutathione S-transferase: a candidate gene for berry color in muscadine grapes (Vitis rotundifolia)

Authors: Aruna Varanasi, Margaret Worthington, Lacy Nelson, Autumn Brown, Thomas Mason Chizk, Renee Threlfall, Luke Howard, Patrick Conner, Rosa Figueroa-Balderas, Mélanie Massonnet, Dario Cantu, John R Clark

Journal: G3 (Bethesda)

PubMed ID: 35302606

Doi: 10.1093/g3journal/jkac060

Products & Services: PCR and Cloning

Crosstalk between IL-15Rα tumor-associated macrophages and breast cancer cells reduces CD8 T cell recruitment

Authors: Wenlong Zhang, Qing Zhang, Nanfei Yang, Qian Shi, Huifang Su, Tingsheng Lin, Zhonglei He, Wenxin Wang, Hongqian Guo, Pingping Shen

Journal: Cancer Commun (Lond)

PubMed ID: 35615815

Doi: 10.1002/cac2.12311

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A Novel Ig Domain-Containing C-Type Lectin Triggers the Intestine-Hemocyte Axis to Regulate Antibacterial Immunity in Crab

Authors: Kaimin Zhou, Yukai Qin, Yu Song, Ke Zhao, Weijuan Pan, Xingyu Nan, Yue Wang, Qun Wang, Weiwei Li

Journal: J Immunol

PubMed ID: 35508356

Doi: 10.4049/jimmunol.2101027

Products & Services: Gene Synthesis

Self-Assembling Nanovaccine Confers Complete Protection Against Zika Virus Without Causing Antibody-Dependent Enhancement

Authors: Heng Rong, Mi Qi, Jingdi Pan, Yuhan Sun, Jiawang Gao, Xiaowei Zhang, Wei Li, Bo Zhang, Xian-En Zhang, Zongqiang Cui

Journal: Front Immunol

PubMed ID: 35615356

Doi: 10.3389/fimmu.2022.905431

Products & Services: Recombinant Proteins

Structural basis of sodium-dependent bile salt uptake into the liver

Authors: Kapil Goutam, Francesco S Ielasi, Els Pardon, Jan Steyaert, Nicolas Reyes

Journal: Nature

PubMed ID: 35545671

Doi: 10.1038/s41586-022-04723-z

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Duo Cadherin-Functionalized Microparticles Synergistically Induce Chondrogenesis and Cartilage Repair of Stem Cell Aggregates

Authors: Xueping Wang, Xingquan Xu, Yan Zhang, Xueying An, Xue Zhang, Guoqiang Chen, Qing Jiang, Jun Yang

Journal: Adv Healthc Mater

PubMed ID: 35485302

Doi: 10.1002/adhm.202200246

Products & Services: Mammalian Expression

Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region

Authors: Morgan S Haines, Eduardo Ramirez, Kendall B E Moore, Jessica S Fortin

Journal: Biochem Biophys Rep

PubMed ID: 35664543

Doi: 10.1016/j.bbrep.2022.101284

Products & Services: Peptide Synthesis

Antibodies targeting the European lobster (Palinurus elephas) vitellogenin developed by mRNA isolation and in-silico-designed antigenic peptides

Authors: Faustina B Cannea, Maria Cristina Follesa, Cristina Porcu, Rossano Rossino, Alessandra Olianas, Antonio Rescigno, Alessandra Padiglia

Journal: Biol Open

PubMed ID: 35452506

Doi: 10.1242/bio.059019

Products & Services: Peptide Synthesis

Small, charged proteins in salmon louse (Lepeophtheirus salmonis) secretions modulate Atlantic salmon (Salmo salar) immune responses and coagulation

Authors: Aina-Cathrine Øvergård, Helena M D Midtbø, Lars A Hamre, Michael Dondrup, Gro E K Bjerga, Øivind Larsen, Jiwan Kumar Chettri, Kurt Buchmann, Frank Nilsen, Sindre Grotmol

Journal: Sci Rep

PubMed ID: 35568726

Doi: 10.1038/s41598-022-11773-w

Products & Services: Plasmid DNA Preparation

Functional validation of a novel AAAS variant in an atypical presentation of Allgrove syndrome

Authors: Erica L Macke, Joel A Morales-Rosado, Sarah K Macklin-Mantia, Christopher T Schmitz, Björn Oskarsson, Eric W Klee, Klaas J Wierenga

Journal: Mol Genet Genomic Med

PubMed ID: 35570467

Doi: 10.1002/mgg3.1966

Products & Services: Gene Synthesis

SARS-CoV-2 BA1 variant is neutralized by vaccine booster-elicited serum but evades most convalescent serum and therapeutic antibodies

Authors: Sabrina Lusvarghi, Simon D Pollett, Sabari Nath Neerukonda, Wei Wang, Richard Wang, Russell Vassell, Nusrat J Epsi, Anthony C Fries, Brian K Agan, David A Lindholm, Christopher J Colombo, Rupal Mody, Evan C Ewers, Tahaniyat Lalani, Anuradha Ganesan, Emilie Goguet, Monique Hollis-Perry, Si'Ana A Coggins, Mark P Simons, Leah C Katzelnick, Gregory Wang, David R Tribble, Lisa Bentley, Ann E Eakin, Christopher C Broder, Karl J Erlandson, Eric D Laing, Timothy H Burgess, Edward Mitre, Carol D Weiss

Journal: Sci Transl Med

PubMed ID: 35380448

Doi: 10.1126/scitranslmed.abn8543

Products & Services: Plasmid DNA Preparation

Lactoferrin Inhibition of the Complex Formation between ACE2 Receptor and SARS CoV-2 Recognition Binding Domain

Authors: Roberta Piacentini, Laura Centi, Mattia Miotto, Edoardo Milanetti, Lorenzo Di Rienzo, Martina Pitea, Paolo Piazza, Giancarlo Ruocco, Alberto Boffi, Giacomo Parisi

Journal: Int J Mol Sci

PubMed ID: 35628247

Doi: 10.3390/ijms23105436

Products & Services: Proteins, Expression, Isolation and Analysis

Computational approach for binding prediction of SARS-CoV-2 with neutralizing antibodies

Authors: Daria Beshnova, Yan Fang, Mingjian Du, Yehui Sun, Fenghe Du, Jianfeng Ye, Zhijian James Chen, Bo Li

Journal: Comput Struct Biotechnol J

PubMed ID: 35530743

Doi: 10.1016/j.csbj.2022.04.038

Products & Services: Gene Synthesis

α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins

Authors: Weidong Jing, Jordan Lo Pilato, Callum Kay, Shouya Feng, Daniel Enosi Tuipulotu, Anukriti Mathur, Cheng Shen, Chinh Ngo, Anyang Zhao, Lisa A Miosge, Sidra A Ali, Elizabeth E Gardiner, Milena M Awad, Dena Lyras, Avril A B Robertson, Nadeem O Kaakoush, Si Ming Man

Journal: Sci Immunol

PubMed ID: 35594341

Doi: 10.1126/sciimmunol.abm1803

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An Immunoinformatic Strategy to Develop New Multi-epitope Vaccine

Authors:

Journal: INT J PEPT RES THER

PubMed ID: 35573911

Doi: 10.1007/s10989-022-10406-0

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Constitutively Active STAT5b Feminizes Mouse Liver Gene Expression

Authors: Dana Lau-Corona, Hong Ma, Cameron Vergato, Andre Sarmento-Cabral, Mercedes Del Rio-Moreno, Rhonda D Kineman, David J Waxman

Journal: Endocrinology

PubMed ID: 35396838

Doi: 10.1210/endocr/bqac046

Products & Services: Gene Synthesis

Characterization of a New Multifunctional GH20 β--Acetylglucosaminidase From sp GC72 and Its Application in Converting Chitin Into Acetyl Glucosamine

Authors: Yan Chen, Ning Zhou, Xueman Chen, Guoguang Wei, Alei Zhang, Kequan Chen, Pingkai Ouyang

Journal: Front Microbiol

PubMed ID: 35620090

Doi: 10.3389/fmicb.2022.874908

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Lentiviral gene therapy prevents anti-human acid α-glucosidase antibody formation in murine Pompe disease

Authors: Qiushi Liang, Eva C Vlaar, Fabio Catalano, Joon M Pijnenburg, Merel Stok, Yvette van Helsdingen, Arnold G Vulto, Wendy W J Unger, Ans T van der Ploeg, W W M Pim Pijnappel, Niek P van Til

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35662813

Doi: 10.1016/j.omtm.2022.04.016

Products & Services: Mammalian Expression

Biosynthesis of valerenic acid by engineered Saccharomyces cerevisiae

Authors: Mengya Zhao, Chuanbo Zhang, Haibin Wang, Shifan He, Wenyu Lu

Journal: Biotechnol Lett

PubMed ID: 35643816

Doi: 10.1007/s10529-022-03264-9

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A proof-of-concept study on the use of a fluorescein-based 18F-tracer for pretargeted PET

Authors: Hugo Helbert , Emily M Ploeg , Douwe F Samplonius , Simon N Blok , Ines F Antunes , Verena I Böhmer , Gert Luurtsema , Rudi A J O Dierckx , Ben L Feringa , Philip H Elsinga , Wiktor Szymanski , Wijnand Helfrich

Journal: EJNMMI Radiopharm Chem .

PubMed ID: 35239034

Doi: 10.1186/s41181-022-00155-2

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Cell-Penetrating Peptide TAT-HuR-HNS3 Suppresses Proinflammatory Gene Expression via Competitively Blocking Interaction of HuR with Its Partners

Authors: Ke Wang, Haibin Tong, Yitian Gao, Lan Xia, Xin Jin, Xiaoxue Li, Xianlu Zeng, Istvan Boldogh, Yueshuang Ke, Xueqing Ba

Journal: J Immunol

PubMed ID: 35444028

Doi: 10.4049/jimmunol.2200002

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Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast

Authors: Tengfei Liu , Yuanwei Gou , Bei Zhang , Rui Gao , Chang Dong , Mingming Qi , Lihong Jiang , Xuanwei Ding , Chun Li , Jiazhang Lian

Journal: Biotechnol Bioeng

PubMed ID: 35060115

Doi: doi.org/10.1002/bit.28040

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Thioester-Assisted Sortase-A - Mediated Ligation

Authors: Chong Zuo 1, Ruichao Ding 1, Xiangwei Wu , Yuanxia Wang , Guo-Chao Chu, Lu-Jun Liang, Huasong Ai ， Ze-Bin Tong , Junxiong Mao , Qingyun Zheng , Tian Wang , Zichen Li , Lei Liu, Demeng Sun

Journal: Angew Chem Int Ed Engl

PubMed ID: 35514243

Doi: 10.1002/anie.202201887

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An Arabidopsis pre-RNA processing8a (prp8a) missense allele restores splicing of a subset of mis-spliced mRNAs

Authors: Roxanna J Llinas , Jia Qi Xiong , Natalie M Clark , Sarah E Burkhart , Bonnie Bartel

Journal: Plant Physiol

PubMed ID: 35608297

Doi: 10.1093/plphys/kiac221

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Adaptation-Proof SARS-CoV-2 Vaccine Design

Authors: Yashavantha L Vishweshwaraiah, Brianna Hnath, Brendan Rackley, Jian Wang, Abhinay Gontu, Morgan Chandler, Kirill A Afonin, Suresh V Kuchipudi, Neil Christensen, Neela H Yennawar, Nikolay V Dokholyan

Journal: biorxiv

PubMed ID: 35611332

Doi: doi.org/10.1002/adfm.202206055

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Effective-Component Compatibility of Bufei Yishen Formula III Combined with Electroacupuncture Suppresses Inflammatory Response in Rats with Chronic Obstructive Pulmonary Disease via Regulating SIRT1/NF-B Signaling

Authors: Fanli Jin, Lanxi Zhang, Kai Chen, Yufang Miao, Yang Liu, Yange Tian, Jiansheng Li

Journal: Biomed Res Int

PubMed ID: 35586807

Doi: 10.1155/2022/3360771

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3,5,3'-Triiodothyronine-Loaded Liposomes Inhibit Hepatocarcinogenesis Inflammation-Associated Macrophages

Authors: Gangqi Sun, Xiaojuan Hou, Luyao Zhang, Hengyan Zhang, Changchun Shao, Fengwei Li, Chen Zong, Rong Li, Junxia Shi, Xue Yang, Li Zhang

Journal: Front Oncol

PubMed ID: 35646705

Doi: 10.3389/fonc.2022.877982

Products & Services: Proteins, Expression, Isolation and Analysis

Identification and Functional Characterization of Peptides With Antimicrobial Activity From the Syphilis Spirochete,

Authors: Simon Houston, Ethan Schovanek, Kate M E Conway, Sarah Mustafa, Alloysius Gomez, Raghavendran Ramaswamy, Ayman Haimour, Martin J Boulanger, Lisa A Reynolds, Caroline E Cameron

Journal: Front Microbiol

PubMed ID: 35722306

Doi: 10.3389/fmicb.2022.888525

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Carboxymethylcellulose biofunctionalized ternary quantum dots for subcellular-targeted brain cancer nanotheranostics

Authors: Alexandra A P Mansur, Mayara R B Paiva, Oliver A L Cotta, Luciana M Silva, Isadora C Carvalho, Nádia S V Capanema, Sandhra M Carvalho, Érica A Costa, Nelson R Martin, Roselene Ecco, Beatriz S Santos, Silvia L Fialho, Zélia I P Lobato, Herman S Mansur

Journal: Int J Biol Macromol

PubMed ID: 35513094

Doi: 10.1016/j.ijbiomac.2022.04.207

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The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors

Authors: Robert D Murphy, Tiantian Chen, Jianping Lin, Rongjun He, Li Wu, Caden R Pearson, Savita Sharma, Carl D Vander Kooi, Anthony P Sinai, Zhong-Yin Zhang, Craig W Vander Kooi, Matthew S Gentry

Journal: J Biol Chem

PubMed ID: 35640720

Doi: 10.1016/j.jbc.2022.102089

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