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Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia

Authors: Houfang Long, Shengnan Zhang, Shuyi Zeng, Yilun Tong, Jun Liu, Cong Liu, Dan Li

Journal: Cell Rep

PubMed ID: 36130498

Doi: 10.1016/j.celrep.2022.111401

Products & Services: Protein Electrophoresis and Western

Protein Stabilization by Alginate Binding and Suppression of Thermal Aggregation

Authors: Roger Chang, Martin Gruebele, Deborah E Leckband

Journal: Biomacromolecules

PubMed ID: 36054903

Doi: 10.1021/acs.biomac.2c00297

Products & Services: Custom Vector Construction

Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly

Authors: Janine H Peterson, Matthew Thomas Doyle, Harris D Bernstein

Journal: MBio

PubMed ID: 36165532

Doi: 10.1128/mbio.02286-22

Products & Services: Monoclonal Antibody Services

De Novo design of a humanized antiCD33 antibody-oridonin conjugate for acute myeloid leukemia therapy

Authors: Hui Feng, Yi Liu, Mengyao Zhang, Ruimin Liu, Jincheng Wang, Wenjuan Wang, Pengcheng He, Penghui Zhang, Fan Niu

Journal: Biochem Biophys Res Commun

PubMed ID: 36122452

Doi: 10.1016/j.bbrc.2022.09.032

Products & Services: Plasmid DNA Preparation

Unveiling the Essential Role of Arkadia's Non-RING Elements in the Ubiquitination Process

Authors: Maria Birkou, Georgia N Delegkou, Konstantinos D Marousis, Nefeli Fragkaki, Tamara Toro, Vasso Episkopou, Georgios A Spyroulias

Journal: Int J Mol Sci

PubMed ID: 36142504

Doi: 10.3390/ijms231810585

Products & Services: Bacterial Expression

Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Authors: Saeedeh Ghorbanalipoor, Shirin Emtenani, Melissa Parker, Mayumi Kamaguchi, Colin Osterloh, Manuela Pigors, Natalie Gross, Stanislav Khil'chenko, Anika Kasprick, Sabrina Patzelt, Diana Wortmann, Ibrahim O Ibrahim, Kentaro Izumi, Stephanie Goletz, Katharina Boch, Kathrin Kalies, Katja Bieber, Paul Smith, Enno Schmidt, Ralf J Ludwig

Journal: Front Immunol

PubMed ID: 36248903

Doi: 10.3389/fimmu.2022.865241

Products & Services: Protein and Antibody Isolation

A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation

Authors: Yinnian Feng, Xiang Zhao, Adam K White, K Christopher Garcia, Polly M Fordyce

Journal: Nat Methods

PubMed ID: 36064771

Doi: 10.1038/s41592-022-01592-2

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Immunoglobulin yolk targeting spike 1, receptor binding domain of spike glycoprotein and nucleocapsid of SARS-CoV-2 blocking RBD-ACE2 binding interaction

Authors: Meliana Eka Saputri, Siti Aisyah Rahmalia Effendi, Rifa Nadila, Syauqi Azzam Fajar, Retno Damajanti Soejoedono, Ekowati Handharyani, Okti Nadia Poetri

Journal: Int Immunopharmacol

PubMed ID: 36183680

Doi: 10.1016/j.intimp.2022.109280

Comprehensive analysis of mitogenome of native Henan pig breeds with 58 worldwide pig breeds

Authors: Menghao Zhang, Chen Zhang, Panyang Hu, Lidan Shi, Mingming Ju, Ben Zhang, Xinjian Li, Xuelei Han, Kejun Wang, Xiuling Li, Ruimin Qiao

Journal: Anim Genet

PubMed ID: 36071602

Doi: 10.1111/age.13261

Products & Services: DNA Sequencing

The CD4 T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn's disease

Authors: Thomas K Pedersen, Eric M Brown, Damian R Plichta, Joachim Johansen, Shaina W Twardus, Toni M Delorey, Helena Lau, Hera Vlamakis, James J Moon, Ramnik J Xavier, Daniel B Graham

Journal: Immunity

PubMed ID: 36115338

Doi: 10.1016/j.immuni.2022.08.016

Products & Services: Protein and Antibody Isolation

Dynamic Actin Filament Traps Mediate Active Diffusion of Vesicular Stomatitis Virus Ribonucleoproteins

Authors: Steven J Moran, Shelby Puckett, David A Ornelles, Jed C Macosko, George Holzwarth, Douglas S Lyles

Journal: J Virol

PubMed ID: 36135365

Doi: 10.1128/jvi.00934-22

Products & Services: Plasmid DNA Preparation

PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design

Authors: Jeetendra Kumar Nag, Hodaya Malka, Shoshana Sedley, Priyanga Appasamy, Tatyana Rudina, Tgst Levi, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit

Journal: Mol Cancer Ther

PubMed ID: 36066448

Doi: 10.1158/1535-7163.MCT-21-0946

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Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats

Authors: Mingyue Ji, Yong Li, Yun Liu, Genshan Ma

Journal: J Cardiovasc Pharmacol

PubMed ID: 36067399

Doi: 10.1097/FJC.0000000000001291

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Boosting the Cannabidiol Production in Engineered by Harnessing the Vacuolar Transporter BPT1

Authors: Jie Qiu, Kangxin Hou, Qiang Li, Jialin Chen, Xiwen Li, Hongping Hou, Liqiang Wang, Jia Liu, Qiang Xue, Caixia Wang

Journal: J Agric Food Chem

PubMed ID: 36122349

Doi: 10.1021/acs.jafc.2c05468

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Nanobody-based RFP-dependent Cre recombinase for selective anterograde tracing in RFP-expressing transgenic animals

Authors: Ayumu Inutsuka, Sho Maejima, Hiroyuki Mizoguchi, Ryosuke Kaneko, Rei Nomura, Keiko Takanami, Hirotaka Sakamoto, Tatsushi Onaka

Journal: Commun Biol

PubMed ID: 36114373

Doi: 10.1038/s42003-022-03944-2

Products & Services: Codon Optimization

Role of lipopolysaccharide in antimicrobial and cell penetrating peptide membrane interactions probed by deuterium NMR of whole cells

Authors: Sarika Kumari, Michael R Morrow, Valerie Booth

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 36155053

Doi: 10.1016/j.bbamem.2022.184053

Products & Services: Bacterial Expression

A new blocking ELISA for detection of foot-and-mouth disease non-structural protein (NSP) antibodies in a broad host range

Authors: Madhusudan Hosamani, Shreya Gopinath, B P Sreenivasa, Subhasmita Behera, Suresh H Basagoudanavar, Ashok Boora, Durlav P Bora, Pankaj Deka, Veerakyathappa Bhanuprakash, Raj Kumar Singh, Aniket Sanyal, Klaas Weerdmeester, Aldo Dekker

Journal: Appl Microbiol Biotechnol

PubMed ID: 36089639

Doi: 10.1007/s00253-022-12151-2

Products & Services: Protein and Antibody Isolation

Synthetic evolution of herbicide resistance using a T7 RNAP-based random DNA base editor

Authors: Haroon Butt, Jose Luis Moreno Ramirez, Magdy Mahfouz

Journal: Life Sci Alliance

PubMed ID: 36171140

Doi: 10.26508/lsa.202201538

Products & Services: Mutagenesis Services

Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus

Authors: Scott A Rush, Gurpreet Brar, Ching-Lin Hsieh, Emilie Chautard, Jennifer N Rainho-Tomko, Chris D Slade, Christine A Bricault, Ana Kume, James Kearns, Rachel Groppo, Sophia T Mundle, Linong Zhang, Danilo Casimiro, Tong-Ming Fu, Joshua M DiNapoli, Jason S McLellan

Journal: Cell Rep

PubMed ID: 36130517

Doi: 10.1016/j.celrep.2022.111399

Products & Services: Protein and Antibody Isolation

Effects of TAMP family on the tight junction strand network and barrier function in epithelial cells

Authors: Akira C Saito, Chisato Endo, Yugo Fukazawa, Tomohito Higashi, Hideki Chiba

Journal: Ann N Y Acad Sci

PubMed ID: 36069127

Doi: 10.1111/nyas.14889

Products & Services: Gene Synthesis

Riboflavin salvage by Borrelia burgdorferi supports carbon metabolism and is essential for survival in the tick vector

Authors: Darlene Ramos, Amanda G Lasseter, Crystal L Richards, Benjamin Schwarz, Susmita Ghosh, Berta Victoria, Catharine M Bosio, Frank C Gherardini, Mollie W Jewett

Journal: Mol Microbiol

PubMed ID: 36054485

Doi: 10.1111/mmi.14977

Products & Services: ORF cDNA Clones/MolecularCloud

Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein

Authors: Xiaoxiao Ren, Huijuan Zhu, Keyong Deng, Xiaotong Ning, Lin Li, Dan Liu, Bin Yang, Chenyang Shen, Xianqiang Wang, Naqiong Wu, Shufeng Chen, Dongfeng Gu, Laiyuan Wang

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 36172865

Doi: 10.1161/ATVBAHA.122.318158

Products & Services: Protein and Antibody Isolation

De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

Authors: Meghan E Spears, Namgyu Lee, Sunyoung Hwang, Sung Jin Park, Anne E Carlisle, Rui Li, Mihir B Doshi, Aaron M Armando, Jenny Gao, Karl Simin, Lihua Julie Zhu, Paul L Greer, Oswald Quehenberger, Eduardo M Torres, Dohoon Kim

Journal: Cell Rep

PubMed ID: 36170811

Doi: 10.1016/j.celrep.2022.111415

Products & Services: Gene Synthesis

RUP2 facilitates UVR8 redimerization via two interfaces

Authors: Lixia Wang, Yidong Wang, Hongfei Chang, Hui Ren, Xinquan Wu, Jia Wen, Zeyuan Guan, Ling Ma, Liang Qiu, Junjie Yan, Delin Zhang, Xi Huang, Ping Yin

Journal: Plant Commun

PubMed ID: 36065466

Doi: 10.1016/j.xplc.2022.100428

Products & Services: Catalog Peptides

Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

Authors: Cathrine Scheepers, Prudence Kgagudi, Nonkululeko Mzindle, Elin S Gray, Thandeka Moyo-Gwete, Bronwen E Lambson, Brent Oosthuysen, Batsirai Mabvakure, Nigel J Garrett, Salim S Abdool Karim, Lynn Morris, Penny L Moore

Journal: PLoS Pathog

PubMed ID: 36054228

Doi: 10.1371/journal.ppat.1010450

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Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins

Authors: Edem Gavor, Yeu Khai Choong, Yonghao Liu, Julien Pompon, Eng Eong Ooi, Yu Keung Mok, Haiyan Liu, R Manjunatha Kini, J Sivaraman

Journal: PLoS Negl Trop Dis

PubMed ID: 36070318

Doi: 10.1371/journal.pntd.0010743

Products & Services: Insect Expression

Anti-Phytophthora Activity of Halofuginone and the Corresponding Mode of Action

Authors: Saisai Zhang, Jialing Cai, Yimeng Xie, Xinyu Zhang, Xilang Yang, Shenyuan Lin, Wensheng Xiang, Ji Zhang

Journal: J Agric Food Chem

PubMed ID: 36126316

Doi: 10.1021/acs.jafc.2c04266

Products & Services: Protein and Antibody Isolation

Body Weight is Inversely Associated with Anti-SARS-CoV-2 Antibody Levels after BNT162b2 mRNA Vaccination in Young and Middle Aged Adults

Authors: Su Youn Nam, Seong Woo Jeon, Deuk Kju Jung, Sung-Jae Heo

Journal: Infect Chemother

PubMed ID: 36196609

Doi: 10.3947/ic.2022.0089

Products & Services: Recombinant Proteins

Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA275

Authors: Qian Wang, Sho Iketani, Zhiteng Li, Yicheng Guo, Andre Yanchen Yeh, Michael Liu, Jian Yu, Zizhang Sheng, Yaoxing Huang, Lihong Liu, David D Ho

Journal: Cell Host Microbe

PubMed ID: 36108630

Doi: 10.1016/j.chom.2022.09.002

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Heterologous Expression and Catalytic Properties of Codon-Optimized Small-Sized Bromelain from MD2 Pineapple

Authors: Rafida Razali, Fikran Aranda Fahrudin, Vijay Kumar Subbiah, Kazufumi Takano, Cahyo Budiman

Journal: Molecules

PubMed ID: 36144767

Doi: 10.3390/molecules27186031

Products & Services: Bacterial Expression

A nuclear import pathway exploited by pathogenic noncoding RNAs

Authors: Junfei Ma, Shachinthaka D Dissanayaka Mudiyanselage, Woong June Park, Mo Wang, Ryuta Takeda, Bin Liu, Ying Wang

Journal: Plant Cell

PubMed ID: 35877068

Doi: 10.1093/plcell/koac210

Products & Services: Protein and Antibody Isolation

Activated AMP-activated protein kinase prevents hepatic steatosis, oxidative stress and inflammation in primary chicken hepatocytes

Authors: Yao Yao, Longlong Li, Huihui Wang, Ying Yang, Haitian Ma

Journal: Front Physiol

PubMed ID: 36160867

Doi: 10.3389/fphys.2022.974825

Products & Services: Gene Synthesis

ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation

Authors: Haruka Hiraoka, Jiewen Wang, Tadashi Nakano, Yasuhiro Hirano, Shinichi Yamazaki, Yasushi Hiraoka, Tokuko Haraguchi

Journal: FEBS Open Bio

PubMed ID: 36054629

Doi: 10.1002/2211-5463.13480

Products & Services: Gene Fragments

Co-expression and Interaction of Pax6 with Genes and Proteins of Immunological Surveillance in the Brain of Mice

Authors: Shashank Kumar Maurya, Rajnikant Mishra

Journal: Neurotox Res

PubMed ID: 36069979

Doi: 10.1007/s12640-022-00562-y

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Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

Authors: Andrea Raspadori, Valentina Vignali, Anna Murello, Gabriele Giachin, Bruno Samorì, Motomasa Tanaka, Carlos Bustamante, Giampaolo Zuccheri, Giuseppe Legname

Journal: Biology (Basel)

PubMed ID: 36138837

Doi: 10.3390/biology11091358

Products & Services: Plasmid DNA Preparation

Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma

Authors: Akira Nakamizo, Yuichiro Miyamatsu, Haruka Hirose, Toshiyuki Amano, Satoshi Matsuo, Minako Fujiwara, Teppei Shimamura, Koji Yoshimoto

Journal: Sci Rep

PubMed ID: 36175487

Doi: 10.1038/s41598-022-20613-w

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Splice-switch oligonucleotide-based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC-driven hepatocellular carcinoma

Authors: Dexter Kai Hao Thng, Tan Boon Toh, Paolo Pigini, Lissa Hooi, Yock Young Dan, Pierce Kah-Hoe Chow, Glenn Kunnath Bonney, Masturah Bte Mohd Abdul Rashid, Ernesto Guccione, Dave Keng Boon Wee, Edward Kai-Hua Chow

Journal: Bioeng Transl Med

PubMed ID: 36684069

Doi: 10.1002/btm2.10363

Products & Services: Protein and Antibody Isolation

OsAMT1;1 and OsAMT1;2 Coordinate Root Morphological and Physiological Responses to Ammonium for Efficient Nitrogen Foraging in Rice

Authors: Xiangyu Wu, Xiaoxiao Xie, Shan Yang, Qianyu Yin, Huairong Cao, Xiaonan Dong, Jing Hui, Zhi Liu, Zhongtao Jia, Chuanzao Mao, Lixing Yuan

Journal: Plant&cell physiology

PubMed ID: 35861152

Doi: 10.1093/pcp/pcac104

Products & Services: Antibody Modification and Purification Services

Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models

Authors: Hengkai Chen, Zhenli Li, Liman Qiu, Xiuqing Dong, Geng Chen, Yingjun Shi, Linsheng Cai, Wenhan Liu,Honghao Ye,Yang Zhou,Jiahe Ouyang, Zhixiong Cai and Xiaolong Liu

Journal: J Immunother Cancer

PubMed ID: 36113894

Doi: 10.1136/jitc-2021-004389

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The gene regulates dimorphic sexual and aggressive behaviors in

Authors: Caihong Han, Qionglin Peng, Mengshi Sun, Xinyu Jiang, Xiangbin Su, Jiangtao Chen, Mingze Ma, Huan Zhu, Xiaoxiao Ji, Yufeng Pan

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36067320

Doi: 10.1073/pnas.2201513119

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Engineered CRISPR prime editors with compact, untethered reverse transcriptases

Authors: Julian Grünewald, Bret R Miller, Regan N Szalay, Peter K Cabeceiras, Christopher J Woodilla, Eliza Jane B Holtz, Karl Petri, J Keith Joung

Journal: Nat Biotechnol

PubMed ID: 36163548

Doi: 10.1038/s41587-022-01473-1

Products & Services: Plasmid DNA Preparation

The plant nucleoplasmin AtFKBP43 needs its extended arms for histone interaction

Authors: Ajit Kumar Singh, Ketul Saharan, Somanath Baral, Dileep Vasudevan

Journal: Biochim Biophys Acta Gene Regul Mech

PubMed ID: 36058470

Doi: 10.1016/j.bbagrm.2022.194872

Products & Services: Bacterial Expression

Treatment of Sindbis Virus-Infected Neurons with Antibody to E2 Alters Synthesis of Complete and nsP1-Expressing Defective Viral RNAs

Authors: Jane X Yeh, Yunfan Fan, Maggie L Bartlett, Xiaoyan Zhang, Norah Sadowski, Debra A Hauer, Winston Timp, Diane E Griffin

Journal: MBio

PubMed ID: 36069441

Doi: 10.1128/mbio.02221-22

Products & Services: Plasmid DNA Preparation

Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors

Authors: Hadar Cohen, Noam Baram, Chaya Mushka Fridman, Liat Edry-Botzer, Dor Salomon, Motti Gerlic

Journal: Elife

PubMed ID: 36155655

Doi: 10.7554/eLife.82766

Products & Services: Protein and Antibody Isolation

Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE

Authors: Brendan Miller, Su-Jeong Kim, Hemal H Mehta, Kevin Cao, Hiroshi Kumagai, Neehar Thumaty, Naphada Leelaprachakul, Henry Jiao, Joan Vaughan, Jolene Diedrich, Alan Saghatelian, Thalida E Arpawong, Eileen M Crimmins, Nilüfer Ertekin-Taner, Meral A Tubi, Evan T Hare, Meredith N Braskie, Léa Décarie-Spain, Scott E Kanoski, Francine Grodstein, David A Bennett, Lu Zhao, Arthur W Toga, Junxiang Wan, Kelvin Yen, Pinchas Cohen

Journal: Mol Psychiatry

PubMed ID: 36127429

Doi: 10.1038/s41380-022-01769-3

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Computer vision enabled funnel adapted sensing tube (FAST) for power-free and pipette-free nucleic acid detection

Authors: Mengdi Bao, Shuhuan Zhang, Chad Ten Pas, Stephen J Dollery, Ruth V Bushnell, F N U Yuqing, Rui Liu, Guoyu Lu, Gregory J Tobin, Ke Du

Journal: Lab Chip

PubMed ID: 36111877

Doi: 10.1039/d2lc00586g

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Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover

Authors: Sihan Li, Ken Ikeuchi, Misaki Kato, Robert Buschauer, Takato Sugiyama, Shungo Adachi, Hideo Kusano, Tohru Natsume, Otto Berninghausen, Yoshitaka Matsuo, Thomas Becker, Roland Beckmann, Toshifumi Inada

Journal: Mol Cell

PubMed ID: 36113412

Doi: 10.1016/j.molcel.2022.08.018

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mRNA Vaccine Designing Using Chikungunya Virus E Glycoprotein through Immunoinformatics-Guided Approaches

Authors: Samavia Jaan, Aqal Zaman, Sarfraz Ahmed, Mohibullah Shah, Suvash Chandra Ojha

Journal: Vaccines (Basel)

PubMed ID: 36146554

Doi: 10.3390/vaccines10091476

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Evasion of neutralizing antibody responses by the SARS-CoV-2 BA275 variant

Authors: Panke Qu, John P Evans, Yi-Min Zheng, Claire Carlin, Linda J Saif, Eugene M Oltz, Kai Xu, Richard J Gumina, Shan-Lu Liu

Journal: Cell Host Microbe

PubMed ID: 36240764

Doi: 10.1016/j.chom.2022.09.015

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Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers

Authors: Seth P Jones, Kali H Cook, Melody L Holmquist, Liam J Almekinder, Annie M Delaney, Ryhl Charles, Natalie Labbe, Janai Perdue, Niaya Jackson, Michael E Pichichero, Ravinder Kaur, Lea V Michel, Michael L Gleghorn

Journal: Proteins

PubMed ID: 36065600

Doi: 10.1002/prot.26418

Products & Services: Protein and Antibody Isolation