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G3BP/Rin-Binding Motifs Inserted into Flexible Regions of nsP2 Support RNA Replication of Chikungunya Virus

Authors: Sainan Wang, Andres Merits

Journal: J Virol

PubMed ID: 36226983

Doi: 10.1128/jvi.01278-22

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Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity

Authors: Sujith Rajan, Peter Hofer, Amanda Christiano, Matthew Stevenson, Louis Ragolia, Eugenia Villa-Cuesta, Susan K Fried, Raymond Lau, Collin Braithwaite, Rudolf Zechner, Gary J Schwartz, M Mahmood Hussain

Journal: Metabolism

PubMed ID: 36228741

Doi: 10.1016/j.metabol.2022.155331

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Development of CD163 receptor-based enzyme-linked immunosorbent assay for diagnosis of porcine reproductive and respiratory syndrome virus

Authors: Rajib Deb, Ajay Kumar Yadav, Gyanendra Singh Sengar, Joyshikh Sonowal, D Lalita, Seema Rani Pegu, Indra Singh, Ningthoukhongjam Linda, Pranab Jyoti Das, Satish Kumar, Prasanna Pal, Souvik Paul, Swaraj Rajkhowa, Vivek Kumar Gupta

Journal: 3 Biotech

PubMed ID: 36276438

Doi: 10.1007/s13205-022-03376-z

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LncRNA XIST from the bone marrow mesenchymal stem cell derived exosome promotes osteosarcoma growth and metastasis through miR-655/ACLY signal

Authors: Guanghui Zhu, Yu Xia, Ziyue Zhao, Aoyu Li, Hui Li, Tao Xiao

Journal: Cancer Cell Int

PubMed ID: 36309693

Doi: 10.1186/s12935-022-02746-0

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The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor

Authors: Dogus Murat Altintas, Simona Gallo, Cristina Basilico, Marina Cerqua, Alessio Bocedi, Annapia Vitacolonna, Orsola Botti, Elena Casanova, Ilaria Rancati, Chiara Milanese, Sara Notari, Giorgia Gambardella, Giorgio Ricci, Pier Giorgio Mastroberardino, Carla Boccaccio, Tiziana Crepaldi, Paolo Maria Comoglio

Journal: Int J Mol Sci

PubMed ID: 36293286

Doi: 10.3390/ijms232012427

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COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Authors: Giorgia Benegiamo, Maroun Bou Sleiman, Martin Wohlwend, Sandra Rodríguez-López, Ludger J E Goeminne, Pirkka-Pekka Laurila, Marie Klevjer, Minna K Salonen, Jari Lahti, Pooja Jha, Sara Cogliati, José Antonio Enriquez, Ben M Brumpton, Anja Bye, Johan G Eriksson, Johan Auwerx

Journal: Nat Metab

PubMed ID: 36253618

Doi: 10.1038/s42255-022-00655-0

Products & Services: Mammalian Expression

Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium

Authors: Léa Conchou, Bastien Doumèche, Frédéric Galisson, Sébastien Violot, Chloé Dugelay, Eric Diesis, Adeline Page, Anne-Lise Bienvenu, Stéphane Picot, Nushin Aghajari, Lionel Ballut

Journal: Commun Biol

PubMed ID: 36316540

Doi: 10.1038/s42003-022-04091-4

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APC/CCdc20-mediated degradation of Clb4 prompts astral microtubule stabilization at anaphase onset

Authors: Federico Zucca, Clara Visintin, Jiaming Li, Steven P Gygi, Rosella Visintin

Journal: J Cell Biol

PubMed ID: 36269172

Doi: 10.1083/jcb.202203089

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EP-Pred: A Machine Learning Tool for Bioprospecting Promiscuous Ester Hydrolases

Authors: Ruite Xiang, Laura Fernandez-Lopez, Ana Robles-Martín, Manuel Ferrer, Victor Guallar

Journal: Biomolecules

PubMed ID: 36291739

Doi: 10.3390/biom12101529

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Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack

Authors: Shuang Yang, Giorgos Hiotis, Yi Wang, Junjian Chen, Jia-Huai Wang, Mikyung Kim, Ellis L Reinherz, Thomas Walz

Journal: Nat Commun

PubMed ID: 36302771

Doi: 10.1038/s41467-022-34008-y

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Development of a simple PCR-RFLP technique for detection and differentiation of E histolytica, E dispar and E moshkovskii

Authors: Sanjib K Sardar, Seiki Kobayashi, Koushik Das, Yumiko Saito-Nakano, Shanta Dutta, Tomoyoshi Nozaki, Sandipan Ganguly

Journal: Parasitol Res

PubMed ID: 36308533

Doi: 10.1007/s00436-022-07706-1

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N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation

Authors: Yuhang Li, Yitian Li, Sennan Xu, Yue Chen, Pan Zhou, Ting Hu, Hua Li, Ying Liu, Yaping Xu, Jie Ren, Yan Qiu, Canzhong Lu

Journal: Pharmacol Res

PubMed ID: 36244543

Doi: 10.1016/j.phrs.2022.106491

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Achieving regioselective materials binding using multidomain peptides

Authors: Ruitao Jin, Nermina Brljak, Robert Sangrigoli, Tiffany R Walsh, Marc R Knecht

Journal: Nanoscale

PubMed ID: 36073151

Doi: 10.1039/d2nr03169h

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High-throughput genome editing in rice with a virus-based surrogate system

Authors: Yifu Tian, Dating Zhong, Xinbo Li, Rundong Shen, Han Han, Yuqin Dai, Qi Yao, Xuening Zhang, Qi Deng, Xuesong Cao, Jian-Kang Zhu, Yuming Lu

Journal: J Integr Plant Biol

PubMed ID: 36218268

Doi: 10.1111/jipb.13381

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Immunogenicity and reactogenicity of a third dose of BNT162b2 vaccine for COVID-19 after a primary regimen with BBIBP-CorV or BNT162b2 vaccines in Lima, Peru

Authors: Natalia Vargas-Herrera, Manuel Fernández-Navarro, Nestor E Cabezudo, Percy Soto-Becerra, Gilmer Solís-Sánchez, Stefan Escobar-Agreda, Javier Silva-Valencia, Luis Pampa-Espinoza, Ricardo Bado-Pérez, Lely Solari, Roger V Araujo-Castillo

Journal: PLoS ONE

PubMed ID: 36251630

Doi: 10.1371/journal.pone.0268419

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Bioelectrocatalytic CO Reduction by Redox Polymer-Wired Carbon Monoxide Dehydrogenase Gas Diffusion Electrodes

Authors: Jana M Becker, Anna Lielpetere, Julian Szczesny, João R C Junqueira, Patricia Rodríguez-Maciá, James A Birrell, Felipe Conzuelo, Wolfgang Schuhmann

Journal: ACS Appl Mater Interfaces

PubMed ID: 36194638

Doi: 10.1021/acsami.2c09547

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Lysyl-tRNA synthetase, a target for urgently needed M tuberculosis drugs

Authors: Simon R Green, Susan H Davis, Sebastian Damerow, Curtis A Engelhart, Michael Mathieson, Beatriz Baragaña, David A Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K Tamaki, Kirsteen I Buchanan, John Post, Karen Dowers, Sharon M Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C Kim, James M Bean, Navid Nahiyaan, Kyu Y Rhee, Qinglan Wang, Vee Y Tan, Helena I M Boshoff, Paul J Converse, Si-Yang Li, Yong S Chang, Nader Fotouhi, Anna M Upton, Eric L Nuermberger, Dirk Schnappinger, Kevin D Read, Lourdes Encinas, Robert H Bates, Paul G Wyatt, Laura A T Cleghorn

Journal: Nat Commun

PubMed ID: 36220877

Doi: 10.1038/s41467-022-33736-5

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Characterization of a GH5 endoxylanase from Penicillium funiculosum and its synergism with GH16 endo-1,3(4)-glucanase in saccharification of sugarcane bagasse

Authors: Olusola A Ogunyewo, Omoaruemike E Okereke, Sandeep Kumar, Syed Shams Yazdani

Journal: Sci Rep

PubMed ID: 36241677

Doi: 10.1038/s41598-022-21529-1

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Nitric Oxide Negatively Regulates the Rapid Formation of Primordia by Inhibiting the Mitochondrial Gene

Authors: Ludan Hou, Chenyang Huang, Xiangli Wu, Jinxia Zhang, Mengran Zhao

Journal: J Fungi (Basel)

PubMed ID: 36294620

Doi: 10.3390/jof8101055

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A new family of CRISPR-type V nucleases with C-rich PAM recognition

Authors: Tomas Urbaitis, Giedrius Gasiunas, Joshua K Young, Zhenglin Hou, Sushmitha Paulraj, Egle Godliauskaite, Mantvyda M Juskeviciene, Migle Stitilyte, Monika Jasnauskaite, Megumu Mabuchi, G Brett Robb, Virginijus Siksnys

Journal: EMBO Rep

PubMed ID: 36268581

Doi: 10.15252/embr.202255481

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Author Correction: [C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease

Authors: Tharick A Pascoal, Mira Chamoun, Elad Lax, Hsiao-Ying Wey, Monica Shin, Kok Pin Ng, Min Su Kang, Sulantha Mathotaarachchi, Andrea L Benedet, Joseph Therriault, Firoza Z Lussier, Frederick A Schroeder, Jonathan M DuBois, Baileigh G Hightower, Tonya M Gilbert, Nicole R Zürcher, Changning Wang, Robert Hopewell, Mallar Chakravarty, Melissa Savard, Emilie Thomas, Sara Mohaddes, Sarah Farzin, Alyssa Salaciak, Stephanie Tullo, A Claudio Cuello, Jean-Paul Soucy, Gassan Massarweh, Heungsun Hwang, Eliane Kobayashi, Bradley T Hyman, Bradford C Dickerson, Marie-Christine Guiot, Moshe Szyf, Serge Gauthier, Jacob M Hooker, Pedro Rosa-Neto

Journal: Nat Commun

PubMed ID: 36192402

Doi: 10.1038/s41467-022-33668-0

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Molecular architecture of the glycogen- committed PP1/PTG holoenzyme

Authors: Marta Stefania Semrau, Gabriele Giachin, Sonia Covaceuszach, Alberto Cassetta, Nicola Demitri, Paola Storici, Graziano Lolli

Journal: Nat Commun

PubMed ID: 36261419

Doi: 10.1038/s41467-022-33693-z

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Regulation of PaRBOH1-mediated ROS production in Norway spruce by Ca binding and phosphorylation

Authors: Kaloian Nickolov, Adrien Gauthier, Kenji Hashimoto, Teresa Laitinen, Enni Väisänen, Tanja Paasela, Rabah Soliymani, Takamitsu Kurusu, Kristiina Himanen, Olga Blokhina, Kurt V Fagerstedt, Soile Jokipii-Lukkari, Hannele Tuominen, Hely Häggman, Gunnar Wingsle, Teemu H Teeri, Kazuyuki Kuchitsu, Anna Kärkönen

Journal: Front Plant Sci

PubMed ID: 36311083

Doi: 10.3389/fpls.2022.978586

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SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment

Authors: Wenbo Chen, Wuyang Zheng, Shixiao Liu, Qiang Su, Kangxi Ding, Ziguan Zhang, Ping Luo, Yong Zhang, Jianming Xu, Chundong Yu, Weihua Li, Zhengrong Huang

Journal: Int J Biol Sci

PubMed ID: 36263184

Doi: 10.7150/ijbs.74864

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Characterization of proteases from Irpex lacteus grown on minimally denatured soybean meals

Authors: Xiaoxu Zhu, Yufei Hua, Xiangzhen Kong, Xingfei Li, Yeming Chen, Caimeng Zhang

Journal: J Sci Food Agric

PubMed ID: 36317244

Doi: 10.1002/jsfa.12301

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Mediator subunit MED1 differentially modulates mutant thyroid hormone receptor intracellular dynamics in Resistance to Thyroid Hormone syndrome

Authors: Moyao Wang, Vincent R Roggero, Lizabeth A Allison

Journal: Mol Cell Endocrinol

PubMed ID: 36191835

Doi: 10.1016/j.mce.2022.111781

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Rational Design of a Thermostable 2' -Deoxyribosyltransferase for Nelarabine Production by Prediction of Disulfide Bond Engineering Sites

Authors: Guillermo Cruz, Javier Acosta, Jose Miguel Mancheño, Jon Del Arco, Jesús Fernández-Lucas

Journal: Int J Mol Sci

PubMed ID: 36233108

Doi: 10.3390/ijms231911806

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Herpes simplex virus lymphadenitis is associated with tumor reduction in a patient with chronic lymphocytic leukemia

Authors: Andres Chang, Anton M Sholukh, Andreas Wieland, David L Jaye, Mary Carrington, Meei-Li Huang, Hong Xie, Keith R Jerome, Pavitra Roychoudhury, Alexander L Greninger, Jean L Koff, Jonathon B Cohen, David M Koelle, Lawrence Corey, Christopher R Flowers, Rafi Ahmed

Journal: J Clin Invest

PubMed ID: 35862190

Doi: 10.1172/JCI161109

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Microarray-guided evaluation of the frequency, B-cell origins, and selectivity of human glycan-binding antibodies reveals new insights and novel antibodies

Authors: J Sebastian Temme, Jennifer A Crainic, Laura M Walker, Weizhun Yang, Zibin Tan, Xuefei Huang, Jeffrey C Gildersleeve

Journal: J Biol Chem

PubMed ID: 36087840

Doi: 10.1016/j.jbc.2022.102468

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Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

Authors: Xiyuan Zhang, Hannah E Lou, Vishaka Gopalan, Zhihui Liu, Hilda M Jafarah, Haiyan Lei, Paige Jones, Carly M Sayers, Marielle E Yohe, Prashant Chittiboina, Brigitte C Widemann, Carol J Thiele, Michael C Kelly, Sridhar Hannenhalli, Jack F Shern

Journal: Cell Rep

PubMed ID: 36130486

Doi: 10.1016/j.celrep.2022.111363

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Alamandine alleviated heart failure and fibrosis in myocardial infarction mice

Authors: Kun Zhao, Tianhua Xu, Yukang Mao, Xiaoguang Wu, Dongxu Hua, Yanhui Sheng, Peng Li

Journal: Biol Direct

PubMed ID: 36167556

Doi: 10.1186/s13062-022-00338-6

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Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors

Authors: Jordan R Willis, Zachary T Berndsen, Krystal M Ma, Jon M Steichen, Torben Schiffner, Elise Landais, Alessia Liguori, Oleksandr Kalyuzhniy, Joel D Allen, Sabyasachi Baboo, Oluwarotimi Omorodion, Jolene K Diedrich, Xiaozhen Hu, Erik Georgeson, Nicole Phelps, Saman Eskandarzadeh, Bettina Groschel, Michael Kubitz, Yumiko Adachi, Tina-Marie Mullin, Nushin B Alavi, Samantha Falcone, Sunny Himansu, Andrea Carfi, Ian A Wilson, John R Yates, James C Paulson, Max Crispin, Andrew B Ward, William R Schief

Journal: Immunity

PubMed ID: 36179689

Doi: 10.1016/j.immuni.2022.09.001

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Intranasal Immunization with Liposome-Displayed Receptor-Binding Domain Induces Mucosal Immunity and Protection against SARS-CoV-2

Authors: Wei-Chiao Huang, Kevin Chiem, Luis Martinez-Sobrido, Jonathan F Lovell

Journal: Pathogens

PubMed ID: 36145467

Doi: 10.3390/pathogens11091035

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Inactivated COVID-19 vaccines: durability of Covaxin/BBV152 induced immunity against variants of concern

Authors: Nathella Pavan Kumar, V V Banurekha, C P Girish Kumar, Arul Nancy, Chandrasekaran Padmapriyadarsini, Sakila Shankar, Luke Elizabeth Hanna, Manoj Murhekar, K R Uma Devi, Subash Babu

Journal: J Travel Med

PubMed ID: 35900009

Doi: 10.1093/jtm/taac088

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High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity

Authors: Rodrigo Vazquez-Lombardi, Johanna S Jung, Fabrice S Schlatter, Anna Mei, Natalia Rodrigues Mantuano, Florian Bieberich, Kai-Lin Hong, Jakub Kucharczyk, Edo Kapetanovic, Erik Aznauryan, Cédric R Weber, Alfred Zippelius, Heinz Läubli, Sai T Reddy

Journal: Immunity

PubMed ID: 36174557

Doi: 10.1016/j.immuni.2022.09.004

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mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts

Authors: Denzil Furtado, Christina Cortez-Jugo, Ya Hui Hung, Ashley I Bush, Frank Caruso

Journal: Mol Pharm

PubMed ID: 36125338

Doi: 10.1021/acs.molpharmaceut.2c00463

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A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity

Authors: Lian-Sheng Cheng, Yong-Feng Cheng, Wen-Ting Liu, Aolin Shen, Dayan Zhang, Tingjuan Xu, Wu Yin, Min Cheng, Xiaopeng Ma, Fengrong Wang, Qun Zhao, Xiaoli Zeng, Yan Zhang, Guodong Shen

Journal: J Transl Med

PubMed ID: 36076251

Doi: 10.1186/s12967-022-03619-w

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Plant transcripts with long or structured uORFs in NDL2 5' UTR can escape NMD in a reinitiation independent manner

Authors: Miryam A Cymerman, Helen Saul, Ronit Farhi, Karina Vexler, Dror Gottlieb, Irina Berezin, Orit Shaul

Journal: J Exp Bot

PubMed ID: 36169317

Doi: 10.1093/jxb/erac385

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Fluorescence Spectroscopy of Low-Level Endogenous β-Adrenergic Receptor Expression at the Plasma Membrane of Differentiating Human iPSC-Derived Cardiomyocytes

Authors: Philipp Gmach, Marc Bathe-Peters, Narasimha Telugu, Duncan C Miller, Paolo Annibale

Journal: Int J Mol Sci

PubMed ID: 36142320

Doi: 10.3390/ijms231810405

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Ras GTPase-activating proteins control neuronal circuit development in barrel cortex layer 4

Authors: Madhura S Rao, Hiromi Mizuno, Takuji Iwasato, Hidenobu Mizuno

Journal: Front Neurosci

PubMed ID: 36188467

Doi: 10.3389/fnins.2022.901774

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Engineered flavivirus vaccines control induction of crossreactive infection-enhancing and -neutralizing antibodies

Authors: Atsushi Yamanaka, Pimploy Rattanaamnuaychai, Mami Matsuda, Ryosuke Suzuki, Yoshiharu Matsuura, Masashi Tatsumi, Eiji Konishi

Journal: Vaccine

PubMed ID: 36109279

Doi: 10.1016/j.vaccine.2022.09.012

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An alternative angiosperm DGAT1 topology and potential motifs in the N-terminus

Authors: Somrutai Winichayakul, Amy Curran, Roger Moraga, Ruth Cookson, Hong Xue, Tracey Crowther, Marissa Roldan, Greg Bryan, Nick Roberts

Journal: Front Plant Sci

PubMed ID: 36186081

Doi: 10.3389/fpls.2022.951389

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Color-Switchable Nanosilicon Fluorescent Probes

Authors: Huai Chen, Jiang Xu, Yaping Wang, Da Wang, Raquel Ferrer-Espada, Yutong Wang, Jingjian Zhou, Adrián Pedrazo-Tardajos, Mei Yang, Jia-Heng Tan, Xiaoyu Yang, Lei Zhang, Ilya Sychugov, Shoudeng Chen, Sara Bals, Johan Paulsson, Zhenyu Yang

Journal: ACS Nano

PubMed ID: 36107985

Doi: 10.1021/acsnano.2c07443

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Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens

Authors: John C Kraft, Minh N Pham, Laila Shehata, Mitch Brinkkemper, Seyhan Boyoglu-Barnum, Kaitlin R Sprouse, Alexandra C Walls, Suna Cheng, Mike Murphy, Deleah Pettie, Maggie Ahlrichs, Claire Sydeman, Max Johnson, Alyssa Blackstone, Daniel Ellis, Rashmi Ravichandran, Brooke Fiala, Samuel Wrenn, Marcos Miranda, Kwinten Sliepen, Philip J M Brouwer, Aleksandar Antanasijevic, David Veesler, Andrew B Ward, Masaru Kanekiyo, Marion Pepper, Rogier W Sanders, Neil P King

Journal: Cell Rep Med

PubMed ID: 36206752

Doi: 10.1016/j.xcrm.2022.100780

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The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling

Authors: Manoshi Gayen, Marc R Benoit, Qingyuan Fan, Jacob Hudobenko, Riqiang Yan

Journal: J Biol Chem

PubMed ID: 36162508

Doi: 10.1016/j.jbc.2022.102532

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Viruses inhibit TIR gcADPR signaling to overcome bacterial defense

Authors: Azita Leavitt, Erez Yirmiya, Gil Amitai, Allen Lu, Jeremy Garb, Ehud Herbst, Benjamin R Morehouse, Samuel J Hobbs, Sadie P Antine, Zhen-Yu J Sun, Philip J Kranzusch, Rotem Sorek

Journal: Nature

PubMed ID: 36174646

Doi: 10.1038/s41586-022-05375-9

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Glycosyltransferase engineering and multi-glycosylation routes development facilitating synthesis of high-intensity sweetener mogrosides

Authors: Jiao Li, Shicheng Mu, Jiangang Yang, Cui Liu, Yanfei Zhang, Peng Chen, Yan Zeng, Yueming Zhu, Yuanxia Sun

Journal: iScience

PubMed ID: 36248741

Doi: 10.1016/j.isci.2022.105222

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Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery

Authors: David J Douin, Lianne Siegel, Greg Grandits, Andrew Phillips, Neil R Aggarwal, Jason Baker, Samuel M Brown, Christina C Chang, Anna L Goodman, Birgit Grund, Elizabeth S Higgs, Catherine L Hough, Daniel D Murray, Roger Paredes, Mahesh Parmar, Sarah Pett, Mark N Polizzotto, Uriel Sandkovsky, Wesley H Self, Barnaby E Young, Abdel G Babiker, Victoria J Davey, Virginia Kan, Annetine C Gelijns, Gail Matthews, B Taylor Thompson, H Clifford Lane, James D Neaton, Jens D Lundgren, Adit A Ginde

Journal: Am J Respir Crit Care Med

PubMed ID: 35580040

Doi: 10.1164/rccm.202112-2836OC

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Impact of hypertension on long-term humoral and cellular response to SARS-CoV-2 infection

Authors: Chang Chu, Anne Schönbrunn, Kristin Klemm, Volker von Baehr, Bernhard K Krämer, Saban Elitok, Berthold Hocher

Journal: Front Immunol

PubMed ID: 36119050

Doi: 10.3389/fimmu.2022.915001

The first molecular identification and phylogenetic analysis of tick-borne pathogens in captive wild animals from Lohi Bher zoo, Pakistan

Authors: Muhammad Uzair Mukhtar, Naveed Iqbal, Jifei Yang, Zeeshan Nawaz, Tan Li Peng

Journal: Parasitol Res

PubMed ID: 36114837

Doi: 10.1007/s00436-022-07666-6

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