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Glycosyltransferase engineering and multi-glycosylation routes development facilitating synthesis of high-intensity sweetener mogrosides

Authors: Jiao Li, Shicheng Mu, Jiangang Yang, Cui Liu, Yanfei Zhang, Peng Chen, Yan Zeng, Yueming Zhu, Yuanxia Sun

Journal: iScience

PubMed ID: 36248741

Doi: 10.1016/j.isci.2022.105222

Products & Services: Mutant Libraries

Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery

Authors: David J Douin, Lianne Siegel, Greg Grandits, Andrew Phillips, Neil R Aggarwal, Jason Baker, Samuel M Brown, Christina C Chang, Anna L Goodman, Birgit Grund, Elizabeth S Higgs, Catherine L Hough, Daniel D Murray, Roger Paredes, Mahesh Parmar, Sarah Pett, Mark N Polizzotto, Uriel Sandkovsky, Wesley H Self, Barnaby E Young, Abdel G Babiker, Victoria J Davey, Virginia Kan, Annetine C Gelijns, Gail Matthews, B Taylor Thompson, H Clifford Lane, James D Neaton, Jens D Lundgren, Adit A Ginde

Journal: Am J Respir Crit Care Med

PubMed ID: 35580040

Doi: 10.1164/rccm.202112-2836OC

Products & Services: Catalog Antibodies

Impact of hypertension on long-term humoral and cellular response to SARS-CoV-2 infection

Authors: Chang Chu, Anne Schönbrunn, Kristin Klemm, Volker von Baehr, Bernhard K Krämer, Saban Elitok, Berthold Hocher

Journal: Front Immunol

PubMed ID: 36119050

Doi: 10.3389/fimmu.2022.915001

The first molecular identification and phylogenetic analysis of tick-borne pathogens in captive wild animals from Lohi Bher zoo, Pakistan

Authors: Muhammad Uzair Mukhtar, Naveed Iqbal, Jifei Yang, Zeeshan Nawaz, Tan Li Peng

Journal: Parasitol Res

PubMed ID: 36114837

Doi: 10.1007/s00436-022-07666-6

Products & Services: DNA Sequencing

DNA Prime and Recombinant Protein Boost Vaccination Confers Chickens with Enhanced Protection against Chicken Infectious Anemia Virus

Authors: Ling Liu, Mingrong Yin, Yang Li, Hong Su, Lichun Fang, Xiaolong Sun, Shuang Chang, Peng Zhao, Yixin Wang

Journal: Viruses

PubMed ID: 36298670

Doi: 10.3390/v14102115

Products & Services: Protein and Antibody Isolation

Ras GTPase-activating proteins control neuronal circuit development in barrel cortex layer 4

Authors: Madhura S Rao, Hiromi Mizuno, Takuji Iwasato, Hidenobu Mizuno

Journal: Front Neurosci

PubMed ID: 36188467

Doi: 10.3389/fnins.2022.901774

Products & Services: Custom DNA/RNA Oligos

Engineered flavivirus vaccines control induction of crossreactive infection-enhancing and -neutralizing antibodies

Authors: Atsushi Yamanaka, Pimploy Rattanaamnuaychai, Mami Matsuda, Ryosuke Suzuki, Yoshiharu Matsuura, Masashi Tatsumi, Eiji Konishi

Journal: Vaccine

PubMed ID: 36109279

Doi: 10.1016/j.vaccine.2022.09.012

Products & Services: Mutagenesis Services

An alternative angiosperm DGAT1 topology and potential motifs in the N-terminus

Authors: Somrutai Winichayakul, Amy Curran, Roger Moraga, Ruth Cookson, Hong Xue, Tracey Crowther, Marissa Roldan, Greg Bryan, Nick Roberts

Journal: Front Plant Sci

PubMed ID: 36186081

Doi: 10.3389/fpls.2022.951389

Products & Services: PCR Cloning and Subcloning

Color-Switchable Nanosilicon Fluorescent Probes

Authors: Huai Chen, Jiang Xu, Yaping Wang, Da Wang, Raquel Ferrer-Espada, Yutong Wang, Jingjian Zhou, Adrián Pedrazo-Tardajos, Mei Yang, Jia-Heng Tan, Xiaoyu Yang, Lei Zhang, Ilya Sychugov, Shoudeng Chen, Sara Bals, Johan Paulsson, Zhenyu Yang

Journal: ACS Nano

PubMed ID: 36107985

Doi: 10.1021/acsnano.2c07443

Products & Services: Catalog Peptides

Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens

Authors: John C Kraft, Minh N Pham, Laila Shehata, Mitch Brinkkemper, Seyhan Boyoglu-Barnum, Kaitlin R Sprouse, Alexandra C Walls, Suna Cheng, Mike Murphy, Deleah Pettie, Maggie Ahlrichs, Claire Sydeman, Max Johnson, Alyssa Blackstone, Daniel Ellis, Rashmi Ravichandran, Brooke Fiala, Samuel Wrenn, Marcos Miranda, Kwinten Sliepen, Philip J M Brouwer, Aleksandar Antanasijevic, David Veesler, Andrew B Ward, Masaru Kanekiyo, Marion Pepper, Rogier W Sanders, Neil P King

Journal: Cell Rep Med

PubMed ID: 36206752

Doi: 10.1016/j.xcrm.2022.100780

Products & Services: Mammalian Expression

The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling

Authors: Manoshi Gayen, Marc R Benoit, Qingyuan Fan, Jacob Hudobenko, Riqiang Yan

Journal: J Biol Chem

PubMed ID: 36162508

Doi: 10.1016/j.jbc.2022.102532

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Enhanced and Potency of a T Cell Epitope in the Ebola Virus Glycoprotein Following Amino Acid Replacement at HLA-A*02:01 Binding Positions

Authors: Sylvie Chabot, Yusra Gimie, Karam Obeid, Jaekwan Kim, Clement A Meseda, Krishnamurthy Konduru, Gerardo Kaplan, Li Sheng Fowler, Jerry P Weir, Keith Peden, Marian E Major

Journal: J Virol

PubMed ID: 36069549

Doi: 10.1128/jvi.01166-21

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An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension

Authors: Elisabeth Fuchs, Imke Rudnik-Jansen, Anders Dinesen, Denis Selnihhin, Ole Aalund Mandrup, Kader Thiam, Jørgen Kjems, Finn Skou Pedersen, Kenneth A Howard

Journal: Acta Biomater

PubMed ID: 36162760

Doi: 10.1016/j.actbio.2022.09.048

Products & Services: Plasmid DNA Preparation

Characterizing the Contributions of Various Clostridium perfringens Enterotoxin Properties to and Permeability Effects

Authors: Archana Shrestha, Mauricio A Navarro, Juliann Beingesser, Anibal G Armien, Francisco A Uzal, Bruce A McClane

Journal: mSphere

PubMed ID: 36069435

Doi: 10.1128/msphere.00276-22

Products & Services: Plasmid DNA Preparation

Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants

Authors: Zhaochun Chen, Peng Zhang, Yumiko Matsuoka, Yaroslav Tsybovsky, Kamille West, Celia Santos, Lisa F Boyd, Hanh Nguyen, Anna Pomerenke, Tyler Stephens, Adam S Olia, Baoshan Zhang, Valeria De Giorgi, Michael R Holbrook, Robin Gross, Elena Postnikova, Nicole L Garza, Reed F Johnson, David H Margulies, Peter D Kwong, Harvey J Alter, Ursula J Buchholz, Paolo Lusso, Patrizia Farci

Journal: Cell Rep

PubMed ID: 36302375

Doi: 10.1016/j.celrep.2022.111528

Products & Services: Mammalian Expression

Mechanistic understanding of human SLFN11

Authors: Felix J Metzner, Simon J Wenzl, Michael Kugler, Stefan Krebs, Karl-Peter Hopfner, Katja Lammens

Journal: Nat Commun

PubMed ID: 36115853

Doi: 10.1038/s41467-022-33123-0

Products & Services: Protein and Antibody Isolation

Effect of Foot-and-Mouth Disease Virus 2B Viroporin on Expression and Extraction of Mammalian Cell Culture Produced Foot-and-Mouth Disease Virus-like Particles

Authors: Victoria Primavera, Janine Simmons, Benjamin A Clark, John G Neilan, Michael Puckette

Journal: Vaccines (Basel)

PubMed ID: 36146583

Doi: 10.3390/vaccines10091506

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Automated model-predictive design of synthetic promoters to control transcriptional profiles in bacteria

Authors: Travis L LaFleur, Ayaan Hossain, Howard M Salis

Journal: Nat Commun

PubMed ID: 36056029

Doi: 10.1038/s41467-022-32829-5

Products & Services: Custom DNA/RNA Oligos

Viruses inhibit TIR gcADPR signaling to overcome bacterial defense

Authors: Azita Leavitt, Erez Yirmiya, Gil Amitai, Allen Lu, Jeremy Garb, Ehud Herbst, Benjamin R Morehouse, Samuel J Hobbs, Sadie P Antine, Zhen-Yu J Sun, Philip J Kranzusch, Rotem Sorek

Journal: Nature

PubMed ID: 36174646

Doi: 10.1038/s41586-022-05375-9

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Preclinical evaluation of new C-11 labeled benzo-1,4-dioxane PET radiotracers for brain α2C adrenergic receptors

Authors: Santosh Alluri，Seth M. Eisenberg，Laurel A. Grisanti，Miles Tanner，Nora D. Volkow，Sung Won Kim，Kun-Eek Kil

Journal: European Journal of Medicinal Chemistry

Doi: doi.org/10.1016/j.ejmech.2022.114764

Products & Services: ORF cDNA Clones/MolecularCloud

E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation

Authors: Keerthiraju E Ravichandran , Lars Kaduhr , Bozena Skupien-Rabian , Ekaterina Shvetsova , Mikołaj Sokołowski , Ros Cisław Krutyhołowa ,Dominika Kwasna , Cindy Brachmann , Sean Lin , Sebastian Guzman Perez , Piotr Wilk , Manuel Kösters , Przemysław Grudnik , Urszula Jankowska , Sebastian A Leidel , Raffael Schaffrath , Sebastian Glatt

Journal: EMBO J

PubMed ID: 36102610

Doi: 10.15252/embj.2022111318

Products & Services: Gene Synthesis

Engineering a powerful green cell factory for robust photoautotrophic diterpenoid production

Authors: Alexander Einhaus , Jasmin Steube , Robert Ansgar Freudenberg , Jonas Barczyk , Thomas Baier , Olaf Kruse

Journal: Metab Eng

PubMed ID: 35717002

Doi: 10.1016/j.ymben.2022.06.002

Products & Services: Gene Synthesis

Sodium Accumulation in Infected Cells and Ion Transporters Mistargeting in Nodules of : Two Ugly Items That Hinder Coping with Salt Stress Effects

Authors: Natalia A Trifonova, Roman Kamyshinsky, Teodoro Coba de la Peña, Maria I Koroleva, Olga Kulikova, Victoria Lara-Dampier, Pavel Pashkovskiy, Mikhail Presniakov, José J Pueyo, M Mercedes Lucas, Elena E Fedorova

Journal: Int J Mol Sci

PubMed ID: 36142539

Doi: 10.3390/ijms231810618

Products & Services: Catalog Antibodies

Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunity

Authors: Amir Ghaemi, Parisa Roshani Asl, Hedieh Zargaran, Delaram Ahmadi, Asim Ali Hashimi, Elahe Abdolalipour, Sahar Bathaeian, Seyed Mohammad Miri

Journal: Front Immunol

PubMed ID: 36159845

Doi: 10.3389/fimmu.2022.974364

Products & Services: Gene Fragments

Effects of TAMP family on the tight junction strand network and barrier function in epithelial cells

Authors: Akira C Saito, Chisato Endo, Yugo Fukazawa, Tomohito Higashi, Hideki Chiba

Journal: Ann N Y Acad Sci

PubMed ID: 36069127

Doi: 10.1111/nyas.14889

Products & Services: Gene Synthesis

Riboflavin salvage by Borrelia burgdorferi supports carbon metabolism and is essential for survival in the tick vector

Authors: Darlene Ramos, Amanda G Lasseter, Crystal L Richards, Benjamin Schwarz, Susmita Ghosh, Berta Victoria, Catharine M Bosio, Frank C Gherardini, Mollie W Jewett

Journal: Mol Microbiol

PubMed ID: 36054485

Doi: 10.1111/mmi.14977

Products & Services: ORF cDNA Clones/MolecularCloud

Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein

Authors: Xiaoxiao Ren, Huijuan Zhu, Keyong Deng, Xiaotong Ning, Lin Li, Dan Liu, Bin Yang, Chenyang Shen, Xianqiang Wang, Naqiong Wu, Shufeng Chen, Dongfeng Gu, Laiyuan Wang

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 36172865

Doi: 10.1161/ATVBAHA.122.318158

Products & Services: Protein and Antibody Isolation

De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

Authors: Meghan E Spears, Namgyu Lee, Sunyoung Hwang, Sung Jin Park, Anne E Carlisle, Rui Li, Mihir B Doshi, Aaron M Armando, Jenny Gao, Karl Simin, Lihua Julie Zhu, Paul L Greer, Oswald Quehenberger, Eduardo M Torres, Dohoon Kim

Journal: Cell Rep

PubMed ID: 36170811

Doi: 10.1016/j.celrep.2022.111415

Products & Services: Gene Synthesis

RUP2 facilitates UVR8 redimerization via two interfaces

Authors: Lixia Wang, Yidong Wang, Hongfei Chang, Hui Ren, Xinquan Wu, Jia Wen, Zeyuan Guan, Ling Ma, Liang Qiu, Junjie Yan, Delin Zhang, Xi Huang, Ping Yin

Journal: Plant Commun

PubMed ID: 36065466

Doi: 10.1016/j.xplc.2022.100428

Products & Services: Catalog Peptides

Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

Authors: Cathrine Scheepers, Prudence Kgagudi, Nonkululeko Mzindle, Elin S Gray, Thandeka Moyo-Gwete, Bronwen E Lambson, Brent Oosthuysen, Batsirai Mabvakure, Nigel J Garrett, Salim S Abdool Karim, Lynn Morris, Penny L Moore

Journal: PLoS Pathog

PubMed ID: 36054228

Doi: 10.1371/journal.ppat.1010450

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Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins

Authors: Edem Gavor, Yeu Khai Choong, Yonghao Liu, Julien Pompon, Eng Eong Ooi, Yu Keung Mok, Haiyan Liu, R Manjunatha Kini, J Sivaraman

Journal: PLoS Negl Trop Dis

PubMed ID: 36070318

Doi: 10.1371/journal.pntd.0010743

Products & Services: Insect Expression

Anti-Phytophthora Activity of Halofuginone and the Corresponding Mode of Action

Authors: Saisai Zhang, Jialing Cai, Yimeng Xie, Xinyu Zhang, Xilang Yang, Shenyuan Lin, Wensheng Xiang, Ji Zhang

Journal: J Agric Food Chem

PubMed ID: 36126316

Doi: 10.1021/acs.jafc.2c04266

Products & Services: Protein and Antibody Isolation

SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins

Authors: Tyler D R Vance, Patrick Yip, Elisabet Jiménez, Sheng Li, Diana Gawol, James Byrnes, Isabel Usón, Ahmed Ziyyat, Jeffrey E Lee

Journal: Commun Biol

PubMed ID: 36115925

Doi: 10.1038/s42003-022-03883-y

Products & Services: Protein and Antibody Isolation

EuRBG10 involved in indole alkaloids biosynthesis in Eucommia ulmoides induced by drought and salt stresses

Authors: Yanjun Zuo, Bairu Li, Suixia Guan, Jingyu Jia, Xinjie Xu, Zilong Zhang, Zheng Lu, Xin Li, Xinyue Pang

Journal: J Plant Physiol

PubMed ID: 36179396

Doi: 10.1016/j.jplph.2022.153813

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Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia

Authors: Houfang Long, Shengnan Zhang, Shuyi Zeng, Yilun Tong, Jun Liu, Cong Liu, Dan Li

Journal: Cell Rep

PubMed ID: 36130498

Doi: 10.1016/j.celrep.2022.111401

Products & Services: Protein Electrophoresis and Western

Protein Stabilization by Alginate Binding and Suppression of Thermal Aggregation

Authors: Roger Chang, Martin Gruebele, Deborah E Leckband

Journal: Biomacromolecules

PubMed ID: 36054903

Doi: 10.1021/acs.biomac.2c00297

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Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly

Authors: Janine H Peterson, Matthew Thomas Doyle, Harris D Bernstein

Journal: MBio

PubMed ID: 36165532

Doi: 10.1128/mbio.02286-22

Products & Services: Monoclonal Antibody Services

De Novo design of a humanized antiCD33 antibody-oridonin conjugate for acute myeloid leukemia therapy

Authors: Hui Feng, Yi Liu, Mengyao Zhang, Ruimin Liu, Jincheng Wang, Wenjuan Wang, Pengcheng He, Penghui Zhang, Fan Niu

Journal: Biochem Biophys Res Commun

PubMed ID: 36122452

Doi: 10.1016/j.bbrc.2022.09.032

Products & Services: Plasmid DNA Preparation

Co-expression and Interaction of Pax6 with Genes and Proteins of Immunological Surveillance in the Brain of Mice

Authors: Shashank Kumar Maurya, Rajnikant Mishra

Journal: Neurotox Res

PubMed ID: 36069979

Doi: 10.1007/s12640-022-00562-y

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Comprehensive analysis of mitogenome of native Henan pig breeds with 58 worldwide pig breeds

Authors: Menghao Zhang, Chen Zhang, Panyang Hu, Lidan Shi, Mingming Ju, Ben Zhang, Xinjian Li, Xuelei Han, Kejun Wang, Xiuling Li, Ruimin Qiao

Journal: Anim Genet

PubMed ID: 36071602

Doi: 10.1111/age.13261

Products & Services: DNA Sequencing

The CD4 T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn's disease

Authors: Thomas K Pedersen, Eric M Brown, Damian R Plichta, Joachim Johansen, Shaina W Twardus, Toni M Delorey, Helena Lau, Hera Vlamakis, James J Moon, Ramnik J Xavier, Daniel B Graham

Journal: Immunity

PubMed ID: 36115338

Doi: 10.1016/j.immuni.2022.08.016

Products & Services: Protein and Antibody Isolation

Dynamic Actin Filament Traps Mediate Active Diffusion of Vesicular Stomatitis Virus Ribonucleoproteins

Authors: Steven J Moran, Shelby Puckett, David A Ornelles, Jed C Macosko, George Holzwarth, Douglas S Lyles

Journal: J Virol

PubMed ID: 36135365

Doi: 10.1128/jvi.00934-22

Products & Services: Plasmid DNA Preparation

PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design

Authors: Jeetendra Kumar Nag, Hodaya Malka, Shoshana Sedley, Priyanga Appasamy, Tatyana Rudina, Tgst Levi, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit

Journal: Mol Cancer Ther

PubMed ID: 36066448

Doi: 10.1158/1535-7163.MCT-21-0946

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Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats

Authors: Mingyue Ji, Yong Li, Yun Liu, Genshan Ma

Journal: J Cardiovasc Pharmacol

PubMed ID: 36067399

Doi: 10.1097/FJC.0000000000001291

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Boosting the Cannabidiol Production in Engineered by Harnessing the Vacuolar Transporter BPT1

Authors: Jie Qiu, Kangxin Hou, Qiang Li, Jialin Chen, Xiwen Li, Hongping Hou, Liqiang Wang, Jia Liu, Qiang Xue, Caixia Wang

Journal: J Agric Food Chem

PubMed ID: 36122349

Doi: 10.1021/acs.jafc.2c05468

Products & Services: Protein and Antibody Isolation

The Musashi proteins direct post-transcriptional control of protein expression and alternate exon splicing in vertebrate photoreceptors

Authors: Fatimah Matalkah, Bohye Jeong, Macie Sheridan, Eric Horstick, Visvanathan Ramamurthy, Peter Stoilov

Journal: Commun Biol

PubMed ID: 36153373

Doi: 10.1038/s42003-022-03990-w

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Disease-associated inosine misincorporation into RNA hinders translation

Authors: Jacob H Schroader, Lindsey A Jones, Ryan Meng, Hannah K Shorrock, Jared I Richardson, Sharon M Shaughnessy, Qishan Lin, Thomas J Begley, J Andrew Berglund, Gabriele Fuchs, Mark T Handley, Kaalak Reddy

Journal: Nucleic Acids Res

PubMed ID: 35979951

Doi: 10.1093/nar/gkac709

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mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations

Authors: Juan Manuel Carreño, Gagandeep Singh, Johnstone Tcheou, Komal Srivastava, Charles Gleason, Hiromi Muramatsu, Parnavi Desai, Judith A Aberg, Rachel L Miller, Paris Study Group, Norbert Pardi, Viviana Simon, Florian Krammer

Journal: Vaccine

PubMed ID: 36115801

Doi: 10.1016/j.vaccine.2022.08.024

Products & Services: Codon Optimization

H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity

Authors: Huasong Ai , Maoshen Sun , Aijun Liu , Zixian Sun , Tingting Liu , Lin Cao , Lujun Liang , Qian Qu , Zichen Li , Zhiheng Deng , Zebin Tong , Guochao Chu , Xiaolin Tian , Haiteng Deng , Suwen Zhao , Jia-Bin Li , Zhiyong Lou , Lei Liu

Journal: Nat Chem Biol

PubMed ID: 35739357

Doi: 10.1038/s41589-022-01067-7

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The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA–protein cross-link

Authors: Katherine A Paulin , David Cortez , Brandt F Eichman

Journal: J Biol Chem

PubMed ID: 35934051

Doi: 10.1016/j.jbc.2022.102307

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