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Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2

Authors: Brandon Leonard, Kannan Sankar, Matthew G Romei, Margaret J Tse, Nina Do, Yanli Yang, Wadim L Matochko, Jack Bevers, Sundeep Bollineni, Kiran Mukhyala, Kam Hon Hoi, Greg A Lazar

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35653561

Doi: 10.1073/pnas.2201562119

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Persistence of immune responses to the Sinopharm/BBIBP-CorV vaccine

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Pradeep Darshana Pushpakumara, Achala Kamaladasa, Dinuka Guruge, Ayesha Wijesinghe, Banuri Gunasekera, Shyrar Tanussiya Ramu, Heshan Kuruppu, Thushali Ranasinghe, Shashika Dayarathna, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Madushika Dissanayake, Tibutius Thanesh Jayadas, Anushika Mudunkotuwa, Gayasha Somathilake, Michael Harvie, Thashmi Nimasha, Saubhagya Danasekara, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Tao Dong, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: Immun Inflamm Dis

PubMed ID: 35634958

Doi: 10.1002/iid3.621

Products & Services: Proteins, Expression, Isolation and Analysis

Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation

Authors: Julia E Page, Meredith A Skiba, Truc Do, Andrew C Kruse, Suzanne Walker

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35733252

Doi: 10.1073/pnas.2201141119

Products & Services: Proteins, Expression, Isolation and Analysis

Metabolic engineering of Yarrowia lipolytica for scutellarin production

Authors: Yina Wang , Xiaonan Liu , Bihuan Chen , Wei Liu , Zhaokuan Guo , Xiangyu Liu , Xiaoxi Zhu , Jiayu Liu , Jin Zhang , Jing Li , Lei Zhang , Yadi Gao , Guanghui Zhang , Yan Wang, M Iqbal Choudhary, Shengchao Yang , Huifeng Jiang

Journal: Synth Syst Biotechnol.

PubMed ID: 35756963

Doi: 10.1016/j.synbio.2022.05.009

Products & Services: Codon Optimization

A chimeric MERS-CoV virus-like particle vaccine protects mice against MERS-CoV challenge

Authors: Jung-Eun Park, Ji-Hee Kim, Jae-Yeon Park, Sung-Hoon Jun, Hyun-Jin Shin

Journal: Virol J

PubMed ID: 35761402

Doi: 10.1186/s12985-022-01844-9

Products & Services: Mammalian Expression

Nuclear pore complex acetylation regulates mRNA export and cell cycle commitment in budding yeast

Authors: Mercè Gomar-Alba, Vasilisa Pozharskaia, Bogdan Cichocki, Celia Schaal, Arun Kumar, Basile Jacquel, Gilles Charvin, J Carlos Igual, Manuel Mendoza

Journal: EMBO J

PubMed ID: 35735140

Doi: 10.15252/embj.2021110271

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Extraoral expression and characterization of bitter taste receptors in (Mexican tetra fish)

Authors: Vikram Bhatia, Vivianne Cruz de Jesus, Feroz Ahmed Shaik, Appalaraju Jaggupilli, Nisha Singh, Prashen Chelikani, Devi Atukorallaya

Journal: FASEB Bioadv

PubMed ID: 36089978

Doi: 10.1096/fba.2022-00032

Products & Services: Recombinant Antibody Expression

A new Eimeria coccidian species (Apicomplexa: Eimeriidae) from Père David's deer (Elaphurus davidianus Milne-Edwards, 1866) in Dafeng Milu National Nature Reserve in Jiangsu Province, eastern China

Authors: Weimin Cai, Zeyang Suding, Lele Wang, Zhaofeng Hou, Dandan Liu, Siyang Huang, Jinjun Xu, Jianping Tao

Journal: BMC Vet Res

PubMed ID: 35655211

Doi: 10.1186/s12917-022-03308-2

Products & Services: GenParts™ DNA Fragments

Cloning, expression, and one-step purification/immobilization of two carbohydrate-binding module-tagged alcohol dehydrogenases

Authors: Mario Benito, Ramón Román, Garazi Ortiz, Antoni Casablancas, Gregorio Álvaro, Gloria Caminal, Gloria González, Marina Guillén

Journal: J Biol Eng

PubMed ID: 35765016

Doi: 10.1186/s13036-022-00295-8

Products & Services: GenParts™ DNA Fragments

Determination of the efficacy of using a serine protease gene as a DNA vaccine to protect against Vibrio parahaemolyticus infection in Litopenaeus vannamei

Authors: Naeem Madsari, Siriluk Maskaew, Sumalee Obchoei, Pattamaporn Kwankaew, Wilaiwan Senghoi, Prapaporn Utarabhand, Phanthipha Runsaeng

Journal: Dev Comp Immunol

PubMed ID: 35660488

Doi: 10.1016/j.dci.2022.104459

Products & Services: DNA Sequencing

Comparison of Selected Immune Parameters in a Single Infection and Co-Infection with Infectious Pancreatic Necrosis Virus with Other Viruses in Rainbow Trout

Authors: Joanna Maj-Paluch, Magdalena Wasiak, Łukasz Bocian, Michał Reichert

Journal: Pathogens

PubMed ID: 35745512

Doi: 10.3390/pathogens11060658

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Head-to-Head Comparison of 5 Anti-SARS-CoV-2 Assays Performance in One Hundred COVID-19 Vaccinees, over an 8-Month Course

Authors: Jakub Swadźba, Tomasz Anyszek, Andrzej Panek, Agnieszka Chojęta, Kinga Wyrzykowska, Emilia Martin

Journal: Diagnostics (Basel)

PubMed ID: 35741236

Doi: 10.3390/diagnostics12061426

Effect of Multivalency on Phase-Separated Droplets Consisting of Poly(PR) Dipeptide Repeats and RNA at the Solid/Liquid Interface

Authors: Chen Chen, Han Jia, Yoshiki Nakamura, Kohsuke Kanekura, Yuhei Hayamizu

Journal: ACS Omega

PubMed ID: 35721931

Doi: 10.1021/acsomega.2c00811

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Integrating In Vitro and In Silico Analysis of a Cationic Antimicrobial Peptide Interaction with Model Membranes of Colistin-Resistant Strains

Authors: Sandra Patricia Rivera-Sanchez, Iván Darío Ocampo-Ibáñez, Yamil Liscano, Natalia Martínez, Isamar Muñoz, Marcela Manrique-Moreno, Luis Martinez-Martinez, José Oñate-Garzon

Journal: Pharmaceutics

PubMed ID: 35745820

Doi: 10.3390/pharmaceutics14061248

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Template-Assisted Sequencing of SARS-CoV-2 and Influenza Monoclonal Antibodies by Mass Spectrometry

Authors: Michelle V Gadush, Giuseppe A Sautto, Hamssika Chandrasekaran, Alena Bensussan, Ted M Ross, Gregory C Ippolito, Maria D Person

Journal: J Proteome Res

PubMed ID: 35653804

Doi: 10.1021/acs.jproteome.1c00913

Products & Services: Mammalian Expression

Author Correction: Development of spirulina for the manufacture and oral delivery of protein therapeutics

Authors: Benjamin W Jester, Hui Zhao, Mesfin Gewe, Thomas Adame, Lisa Perruzza, David T Bolick, Jan Agosti, Nhi Khuong, Rolf Kuestner, Caitlin Gamble, Kendra Cruickshank, Jeremy Ferrara, Rachelle Lim, Troy Paddock, Colin Brady, Stacey Ertel, Miaohua Zhang, Alex Pollock, Jamie Lee, Jian Xiong, Michael Tasch, Tracy Saveria, David Doughty, Jacob Marshall, Damian Carrieri, Lauren Goetsch, Jason Dang, Nathaniel Sanjaya, David Fletcher, Anissa Martinez, Bryce Kadis, Kristjan Sigmar, Esha Afreen, Tammy Nguyen, Amanda Randolph, Alexandria Taber, Ashley Krzeszowski, Brittney Robinett, David B Volkin, Fabio Grassi, Richard Guerrant, Ryo Takeuchi, Brian Finrow, Craig Behnke, James Roberts

Journal: Nat Biotechnol

PubMed ID: 35440781

Doi: 10.1038/s41587-022-01323-0

Products & Services: Catalog Antibody

The Bufei Jianpi Formula Improves Mucosal Immune Function by Remodeling Gut Microbiota Through the SCFAs/GPR43/NLRP3 Pathway in Chronic Obstructive Pulmonary Disease Rats

Authors: Jing Mao, Ya Li, Qingqing Bian, Yinshuang Xuan, Jingmei Li, Zhikun Wang, Suxiang Feng, Xuefang Liu, Yange Tian, Suyun Li

Journal: Int J Chron Obstruct Pulmon Dis

PubMed ID: 35673595

Doi: 10.2147/COPD.S359428

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Time-dependent contraction of the SARS-CoV-2-specific T-cell responses in convalescent individuals

Authors: Edgar Ruz Fernandes, Juliana de Souza Apostolico, Lucas Cauê Jacintho, Maria Lucia Carnevale Marin, Roberto Carlos Vieira da Silva Júnior, Hélcio Rodrigues, Keity Souza Santos, Verônica Coelho, Silvia Beatriz Boscardin, Jorge Kalil, Edecio Cunha-Neto, Daniela Santoro Rosa

Journal: J Allergy Clin Immunol Glob

PubMed ID: 36203479

Doi: 10.1016/j.jacig.2022.05.002

Products & Services: Peptide Synthesis

Structure and Protein-Protein Interactions of Ice Nucleation Proteins Drive Their Activity

Authors: Susan Hartmann, Meilee Ling, Lasse S A Dreyer, Assaf Zipori, Kai Finster, Sarah Grawe, Lasse Z Jensen, Stella Borck, Naama Reicher, Taner Drace, Dennis Niedermeier, Nykola C Jones, Søren V Hoffmann, Heike Wex, Yinon Rudich, Thomas Boesen, Tina Šantl-Temkiv

Journal: Front Microbiol

PubMed ID: 35783412

Doi: 10.3389/fmicb.2022.872306

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Chemical Probes Targeting MBD2

Authors: Diane Erdmann, Jean Contreras, Rémy A Le Meur, Bruno Vitorge, Vincent Saverat, Ambre Tafit, Corinne Jallet, Véronique Cadet-Daniel, Corentin Bon, Phannarath Phansavath, Virginie Ratovelomanana-Vidal, Albert Jeltsch, Sophie Vichier-Guerre, J Iñaki Guijarro, Paola B Arimondo

Journal: ACS Chem Biol

PubMed ID: 35649238

Doi: 10.1021/acschembio.1c00959

Products & Services: Proteins, Expression, Isolation and Analysis

Antibody-based redirection of universal Fabrack-CAR T cells selectively kill antigen bearing tumor cells

Authors: Yi-Chiu Kuo, Cheng-Fu Kuo, Kurt Jenkins, Alfur Fu-Hsin Hung, Wen-Chung Chang, Miso Park, Brenda Aguilar, Renate Starr, Jonathan Hibbard, Christine Brown, John C Williams

Journal: J Immunother Cancer

PubMed ID: 35728874

Doi: 10.1136/jitc-2021-003752

Products & Services: Proteins, Expression, Isolation and Analysis

Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes

Authors: Jasmin Steudler, Timothy Ecott, Daniela C Ivan, Elisa Bouillet, Sabrina Walthert, Kristina Berve, Tobias P Dick, Britta Engelhardt, Giuseppe Locatelli

Journal: Glia

PubMed ID: 35762739

Doi: 10.1002/glia.24235

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Improved yield of recombinant human IFN-α2b from mammalian cells using heterologous signal peptide approach

Authors: Claire Wilkinson, Jacob Kyle, Meghna Irimpen, Sarah Stuart, Shylaja Mohandass, Andrew Sheperd, Kathrine J Smith, Michael J Mullin

Journal: Protein Expr Purif

PubMed ID: 35659600

Doi: 10.1016/j.pep.2022.106125

Products & Services: Gene Synthesis

Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening

Authors: Rui Zheng, Wenhao Yang, Yuting Wen, Liang Xie, Fang Shi, Danli Lu, Jiaxin Luo, Yan Li, Rui Zhang, Ting Chen, Lina Chen, Wenming Xu, Hanmin Liu

Journal: Cell Death Dis

PubMed ID: 35729109

Doi: 10.1038/s41419-022-05010-5

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 Neutralizing Antibodies Kinetics Postvaccination in Cancer Patients under Treatment with Immune Checkpoint Inhibition

Authors: Evangelos Terpos, Michalis Liontos, Oraianthi Fiste, Flora Zagouri, Alexandros Briasoulis, Aimilia D Sklirou, Christos Markellos, Efthymia Skafida, Alkistis Papatheodoridi, Angeliki Andrikopoulou, Konstantinos Koutsoukos, Maria Kaparelou, Vassiliki A Iconomidou, Ioannis P Trougakos, Meletios-Athanasios Dimopoulos

Journal: Cancers (Basel)

PubMed ID: 35681774

Doi: 10.3390/cancers14112796

Vaccination after SARS-CoV-2 infection increased antibody avidity against the Omicron variant compared to vaccination alone

Authors: Cas LeMaster, Eric S Geanes, Elizabeth R Fraley, Rangaraj Selvarangan, Todd Bradley

Journal: J Infect Dis

PubMed ID: 35714328

Doi: 10.1093/infdis/jiac247

Products & Services: Recombinant Antibody Expression

Investigation of Product Ions Generated by 193 nm Ultraviolet Photodissociation of Peptides and Proteins Containing Disulfide Bonds

Authors: Luis A Macias, Jennifer S Brodbelt

Journal: J Am Soc Mass Spectrom

PubMed ID: 35736955

Doi: 10.1021/jasms.2c00124

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Simultaneous One-Pot Interpenetrating Network Formation to Expand 3D Processing Capabilities

Authors: Abhishek P Dhand, Matthew D Davidson, Jonathan H Galarraga, Taimoor H Qazi, Ryan C Locke, Robert L Mauck, Jason A Burdick

Journal: Adv Mater

PubMed ID: 35510317

Doi: 10.1002/adma.202202261

Products & Services: Proteins, Expression, Isolation and Analysis

Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N-acetyltransferase

Authors: Husam M A B Alsarraf, Kien Lam Ung, Matt D Johansen, Juliette Dimon, Vincent Olieric, Laurent Kremer, Mickaël Blaise

Journal: FEBS Lett

PubMed ID: 35470425

Doi: 10.1002/1873-3468.14360

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An epitope-optimized human H3N2 influenza vaccine induces broadly protective immunity in mice and ferrets

Authors: Brianna L Bullard, Jennifer DeBeauchamp, Matthew J Pekarek, Erika Petro-Turnquist, Peter Vogel, Richard J Webby, Eric A Weaver

Journal: npj Vaccines

PubMed ID: 35739199

Doi: 10.1038/s41541-022-00492-y

Products & Services: Mammalian Expression

miR-452-3p Targets HDAC3 to Inhibit p65 Deacetylation and Activate the NF-κB Signaling Pathway in Early Brain Injury after Subarachnoid Hemorrhage

Authors: Junti Lu, Xiaodong Huang, Aiping Deng, Hong Yao, Gao Wu, Na Wang, Hui Gui, Mojie Ren, Shiwen Guo

Journal: Neurocrit Care

PubMed ID: 35641805

Doi: 10.1007/s12028-022-01509-z

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A compact, low-cost, and binary sensing (BiSense) platform for noise-free and self-validated impedimetric detection of COVID-19 infected patients

Authors: Razieh Salahandish, Pezhman Jalali, Hamed Osouli Tabrizi, Jae Eun Hyun, Fatemeh Haghayegh, Mahmood Khalghollah, Azam Zare, Byron M Berenger, Yan Dong Niu, Ebrahim Ghafar-Zadeh, Amir Sanati-Nezhad

Journal: Biosens Bioelectron

PubMed ID: 35728365

Doi: 10.1016/j.bios.2022.114459

Products & Services: Proteins, Expression, Isolation and Analysis

Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors

Authors: Nicolas Çuburu, Lukasz Bialkowski, Sergio M Pontejo, Shiv K Sethi, Alexander T F Bell, Rina Kim, Cynthia D Thompson, Douglas R Lowy, John T Schiller

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35749366

Doi: 10.1073/pnas.2116738119

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Recapitulating early human development with 8C-like cells

Authors: Xiu Yu, Shiqi Liang, Manqi Chen, Hanwen Yu, Ruiqi Li, Yuliang Qu, Xuhui Kong, Ruirui Guo, Rongyan Zheng, Zsuzsanna Izsvák, Chuanbo Sun, Mingzhu Yang, Jichang Wang

Journal: Cell Rep

PubMed ID: 35732112

Doi: 10.1016/j.celrep.2022.110994

Products & Services: Proteins, Expression, Isolation and Analysis

Insights Into the Effect of Rice Stripe Virus P2 on Rice Defense by Comparative Proteomic Analysis

Authors: Zihang Yang, Hehong Zhang, Xiaoxiang Tan, Zhongyan Wei, Caiyi Wen, Zongtao Sun, Bingjian Sun, Jianping Chen

Journal: Front Microbiol

PubMed ID: 35747367

Doi: 10.3389/fmicb.2022.897589

Products & Services: Gene Synthesis

Construction of a synthetic Saccharomyces cerevisiae pan-genome neo-chromosome

Authors: Dariusz R Kutyna, Cristobal A Onetto, Thomas C Williams, Hugh D Goold, Ian T Paulsen, Isak S Pretorius, Daniel L Johnson, Anthony R Borneman

Journal: Nat Commun

PubMed ID: 35750675

Doi: 10.1038/s41467-022-31305-4

Products & Services: Plasmid DNA Preparation

Pore-Forming Cardiotoxin VVA2 (Volvatoxin A2) Variant I82E/L86K Is an Atypical Duplex-Specific Nuclease

Authors: Jia-Qi Lu, Jia-Wen Shou, Ka-Ching Lo, Yun-Sang Tang, Wei-Wei Shi, Pang-Chui Shaw

Journal: Toxins (Basel)

PubMed ID: 35737053

Doi: 10.3390/toxins14060392

Products & Services: GenParts™ DNA Fragments

Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity

Authors: Dipika Sharma, Mandeep Singh, Punit Kaur, Uddipan Das

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35775983

Doi: 10.1107/S2059798322005290

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Disease-linked mutations cause exposure of a protein quality control degron

Authors: Caroline Kampmeyer, Sven Larsen-Ledet, Morten Rose Wagnkilde, Mathias Michelsen, Henriette K M Iversen, Sofie V Nielsen, Søren Lindemose, Alberto Caregnato, Tommer Ravid, Amelie Stein, Kaare Teilum, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

Journal: Structure

PubMed ID: 35700725

Doi: 10.1016/j.str.2022.05.016

Products & Services: Gene Synthesis

Duplication of horizontally acquired GH5_2 enzymes played a central role in the evolution of longhorned beetles

Authors: Na Ra Shin, Daniel Doucet, Yannick Pauchet

Journal: Mol Biol Evol

PubMed ID: 35763818

Doi: 10.1093/molbev/msac128

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DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism

Authors: Diti Chatterjee Bhowmick, Arianne Aslamy, Supriyo Bhattacharya, Eunjin Oh, Miwon Ahn, Debbie C Thurmond

Journal: Diabetes

PubMed ID: 35377441

Doi: 10.2337/db21-0681

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A novel dual-targeting delivery system for specific delivery of CRISPR/Cas9 using hyaluronic acid, chitosan and AS1411

Authors: Zahra Khademi, Mohammad Ramezani, Mona Alibolandi, Mohammad Reza Zirak, Zahra Salmasi, Khalil Abnous, Seyed Mohammad Taghdisi

Journal: Carbohydr Polym

PubMed ID: 35725215

Doi: 10.1016/j.carbpol.2022.119691

Products & Services: Plasmid DNA Preparation

A Novel Flavi-like Virus in Alfalfa ( L) Crops along the Snake River Valley

Authors: Jennifer Dahan, Yuri I Wolf, Gardenia E Orellana, Erik J Wenninger, Eugene V Koonin, Alexander V Karasev

Journal: Viruses

PubMed ID: 35746792

Doi: 10.3390/v14061320

Products & Services: PCR and Cloning

Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1

Authors: Jianxiu Zhang, Ying-Ying Wang, Zhao-Qian Pan, Yulu Li, Jianhua Sui, Li-Lin Du, Keqiong Ye

Journal: Nat Commun

PubMed ID: 35752625

Doi: 10.1038/s41467-022-31439-5

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SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebraﬁsh

Authors: Fang Liang, Yu Zhang, Lin Li, Yexin Yang, Ji-Feng Fei, Yanmei Liu, Wei Qin

Journal: Nat Commun

PubMed ID: 35701400

Doi: 10.1038/s41467-022-31034-8

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Structure−Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification

Authors: Hua Yang , Ruxue Yan , Yue Li , Zhaoxin Lu , Xiaomei Bie , Haizhen Zhao , Fengxia Lu , Meirong Chen

Journal: J Agric Food Chem

PubMed ID: 35613468

Doi: 10.1021/acs.jafc.2c01083

Products & Services: Gene Synthesis

The Pre-Existing Human Antibody Repertoire to Computationally Optimized Influenza H1 Hemagglutinin Vaccines

Authors: Kaito Nagashima, John V Dzimianski, Julianna Han, Nada Abbadi, Aaron D Gingerich, Fredejah Royer, Sara O'Rourke, Giuseppe A Sautto, Ted M Ross, Andrew B Ward, Rebecca M DuBois, Jarrod J Mousa

Journal: J Immunol

PubMed ID: 35697384

Doi: 10.4049/jimmunol.2101171

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Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx

Authors: Tae Gun Kang, Kee Woong Kwon, Kyungsoo Kim, Insuk Lee, Myeong Joon Kim, Sang-Jun Ha, Sung Jae Shin

Journal: Nat Commun

PubMed ID: 35672321

Doi: 10.1038/s41467-022-30914-3

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Senescent cells limit p53 activity via multiple mechanisms to remain viable

Authors: Ines Sturmlechner, Chance C Sine, Karthik B Jeganathan, Cheng Zhang, Raul O Fierro Velasco, Darren J Baker, Hu Li, Jan M van Deursen

Journal: Nat Commun

PubMed ID: 35764649

Doi: 10.1038/s41467-022-31239-x

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of inositol lipid metabolism in gut-associated Bacteroidetes

Authors: Stacey L Heaver, Henry H Le, Peijun Tang, Arnaud Baslé, Claudia Mirretta Barone, Dai Long Vu, Jillian L Waters, Jon Marles-Wright, Elizabeth L Johnson, Dominic J Campopiano, Ruth E Ley

Journal: Nat Microbiol

PubMed ID: 35725777

Doi: 10.1038/s41564-022-01152-6

Products & Services: Plasmid DNA Preparation