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Structural basis for product specificities of MLL family methyltransferases

Authors: Yanjing Li , Lijie Zhao , Yuebin Zhang , Ping Wu , Ying Xu , Jun Mencius , Yongxin Zheng , Xiaoman Wang , Wancheng Xu , Naizhe Huang , Xianwen Ye , Ming Lei , Pan Shi , Changlin Tian , Chao Peng , Guohui Li , Zhijun Liu , Shu Quan , Yong Chen

Journal: Mol Cell

PubMed ID: 36108631

Doi: 10.1016/j.molcel.2022.08.022

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Human melanocortin-2 receptor: Identifying a role for residues in the TM4, EC2, and TM5 domains in activation and trafficking as a result of co-expression with the accessory protein, Mrap1 in Chinese Hamster Ovary Cells.

Authors: Perry V Davis , Ciaran A Shaughnessy , Robert M Dores

Journal: Biomolecules

PubMed ID: 36291631

Doi: 10.3390/biom12101422

Products & Services: Gene Synthesis

Labeling Ebola Virus with a Self-Splicing Fluorescent Reporter

Authors: Baylee Heiden , Elke Mühlberger , Christopher W Lennon , Adam J Hume

Journal: Microorganisms

PubMed ID: 36363701

Doi: 10.3390/microorganisms10112110

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Advanced pathway engineering for phototrophic putrescine production

Authors: Robert A Freudenberg , Luisa Wittemeier , Alexander Einhaus , Thomas Baier , Olaf Kruse

Journal: Plant Biotechnol J

PubMed ID: 35748533

Doi: 10.1111/pbi.13879

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Crystal structure of an L-type lectin domain from archaea

Authors: Farha Khan, Kaza Suguna

Journal: Proteins

PubMed ID: 36301308

Doi: 10.1002/prot.26440

Products & Services: PCR Cloning and Subcloning

Authors: Eyby Leon, Claris Nde, Randall S Ray, Diego Preciado, Irene E Zohn

Journal: Am J Med Genet A

PubMed ID: 36263470

Doi: 10.1002/ajmg.a.62991

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Correction to: Selection of DNA aptamer and its application as an electrical biosensor for Zika virus detection in human serum

Authors: Goeun Park, Myoungro Lee, Jiatong Kang, Chulwhan Park, Junhong Min, Taek Lee

Journal: Nano Converg

PubMed ID: 36315359

Doi: 10.1186/s40580-022-00340-8

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Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance

Authors: Jaël S Copier , Marianne Bootsma , Chai A Ng , Arthur A M Wilde , Robin A Bertels , Hennie Bikker , Imke Christiaans , Saskia N van der Crabben , Janna A Hol , Tamara T Koopmann , Jeroen Knijnenburg , Aafke A J Lommerse , Jasper J van der Smagt , Connie R Bezzina , Jamie I Vandenberg , Arie O Verkerk , Daniela Q C M Barge-Schaapveld , Elisabeth M Lodder

Journal: Hum Mol Genet

PubMed ID: 36269083

Doi: 10.1093/hmg/ddac261

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Metabolomic analysis of rapeseed priming with H2O2 in response to germination under chilling stress

Authors: Zhiwei Gu, Duan Wang, Qingtao Gong, Juan You, Qingji Ren, Haimei An, Yongyin Zhou, Haidong Jiang

Journal: Plant Growth Regulation

Doi: 10.1007/s10725-022-00918-6

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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

Authors: Oguz Bolgi, Maria Silva-Garcia, Breyan Ross, Esther Pilla, Vijayalakshmi Kari, Markus Killisch, Melanie Spitzner, Nadine Stark, Christof Lenz, Konstantin Weiss, Laura Donzelli, Mark D Gorrell, Marian Grade, Jan Riemer, Henning Urlaub, Matthias Dobbelstein, Robert Huber, Ruth Geiss-Friedlander

Journal: EMBO Reports

Doi: 10.15252/embr.202154136

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Available online 28 June 2022 0925-4005/© 2022 Elsevier B.V. All rights reserved. A universal CRISPR/Cas12a-mediated AuNPs aggregation-based surface-enhanced Raman scattering (CRISPR/Cas-SERS) platform for virus gene detection

Authors: Ailing Su ， Yuan Liu , Xiumian Cao , Weiqing Xu , Chongyang Liang , Shuping Xu

Journal: Sensors and Actuators B: Chemical

Doi: 10.1016/j.snb.2022.132295

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A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin

Authors: Qiyao Chai , Shanshan Yu, Yanzhao Zhong , Zhe Lu , Changgen Qiu, Yang Yu , Xinwen Zhang , Yong Zhang, Zehui Lei, Lihua Qiang, Bing-Xi Li, Yu Pang, Xiao-Bo Qiu, Jing Wang , Cui Hua Liu

Journal: Science .

PubMed ID: 36227980

Doi: 10.1126/science.abq0132

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Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

Authors: Phillip Pymm, Samuel J Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P Cooney, Kathryn C Davidson, Ebene R Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L Grimley, Damian F J Purcell, Stephen J Kent, Adam K Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W Chung, Kanta Subbarao, Adam P Uldrich, Wai-Hong Tham, Dale I Godfrey, Nicholas A Gherardin

Journal: iScience

PubMed ID: 36213007

Doi: 10.1016/j.isci.2022.105259

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SARS-CoV-2 Transmission from Human to Pet and Suspected Transmission from Pet to Human, Thailand

Authors: Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Sabrina Wahyu Wardhani, Wichan Dankaona, Jiratchaya Puenpa, Yong Poovorawan, Somporn Techangamsuwan

Journal: J Clin Microbiol

PubMed ID: 36314788

Doi: 10.1128/jcm.01058-22

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Divergent SARS-CoV-2-specific T cell responses in intensive care unit workers following mRNA COVID-19 vaccination

Authors: Estefanía Salgado Del Riego, María Laura Saiz, Viviana Corte-Iglesias, Blanca Leoz Gordillo, Cristina Martin-Martin, Mercedes Rodríguez-Pérez, Dolores Escudero, Carlos Lopez-Larrea, Beatriz Suarez-Alvarez

Journal: Front Immunol

PubMed ID: 36275696

Doi: 10.3389/fimmu.2022.942192

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Antibody Response to Rotavirus C Pre-Farrow Natural Planned Exposure to Gilts and Their Piglets

Authors: Deepak Kumar, Amanda V Anderson, Jeremy Pittman, Nora L Springer, Douglas G Marthaler, Waithaka Mwangi

Journal: Viruses

PubMed ID: 36298806

Doi: 10.3390/v14102250

Products & Services: Mammalian Expression

The Therapeutic Effects of a PEDF-Derived Short Peptide on Murine Experimental Dry Eye Involves Suppression of MMP-9 and Inflammation

Authors: Tsung-Chuan Ho, Nai-Wen Fan, Shu-I Yeh, Show-Li Chen, Yeou-Ping Tsao

Journal: Transl Vis Sci Technol

PubMed ID: 36201200

Doi: 10.1167/tvst.11.10.12

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Focused B cell response to recurring gluten motif with implications for epitope spreading in celiac disease

Authors: Chunyan Zhou, Thomas Østerbye, Emil Bach, Shiva Dahal-Koirala, Lene S Høydahl, Øyvind Steinsbø, Jørgen Jahnsen, Knut E A Lundin, Søren Buus, Ludvig M Sollid, Rasmus Iversen

Journal: Cell Rep

PubMed ID: 36288703

Doi: 10.1016/j.celrep.2022.111541

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Deciphering the Key Regulatory Roles of KLF6 and Bta-miR-148a on Milk Fat Metabolism in Bovine Mammary Epithelial Cells

Authors: Ambreen Iqbal, Haibin Yu, Ping Jiang, Zhihui Zhao

Journal: Genes (Basel)

PubMed ID: 36292712

Doi: 10.3390/genes13101828

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Investigating the Role of African Horse Sickness Virus VP7 Protein Crystalline Particles on Virus Replication and Release

Authors: Shani Bekker, Christiaan A Potgieter, Vida van Staden, Jacques Theron

Journal: Viruses

PubMed ID: 36298748

Doi: 10.3390/v14102193

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Glycoside hydrolase subfamily GH5_57 features a highly redesigned catalytic interface to process complex hetero-β-mannans

Authors: Marcele P Martins, Mariana A B Morais, Gabriela F Persinoti, Rafael H Galinari, Li Yu, Yoshihisa Yoshimi, Fernanda B Passos Nunes, Tatiani B Lima, Shayla F Barbieri, Joana L M Silveira, Vincent Lombard, Nicolas Terrapon, Paul Dupree, Bernard Henrissat, Mário T Murakami

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 36322419

Doi: 10.1107/S2059798322009561

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MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases

Authors: Zahra Mohtashami, Mithalesh K Singh, Nasim Salimiaghdam, Mustafa Ozgul, M Cristina Kenney

Journal: Int J Mol Sci

PubMed ID: 36233287

Doi: 10.3390/ijms231911991

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Ablation of CD8 T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA1, BA2 and BA3

Authors: Srividhya Swaminathan, Katie E Lineburg, Archana Panikkar, Jyothy Raju, Lawton D Murdolo, Christopher Szeto, Pauline Crooks, Laetitia Le Texier, Sweera Rehan, Michael J Dewar-Oldis, Peter J Barnard, George R Ambalathingal, Michelle A Neller, Kirsty R Short, Stephanie Gras, Rajiv Khanna, Corey Smith

Journal: Nat Commun

PubMed ID: 36302758

Doi: 10.1038/s41467-022-34180-1

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The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

Authors: Lavanya Moparthi, Viktor Sinica, Vamsi K Moparthi, Mohamed Kreir, Thibaut Vignane, Milos R Filipovic, Viktorie Vlachova, Peter M Zygmunt

Journal: Nat Commun

PubMed ID: 36253390

Doi: 10.1038/s41467-022-33876-8

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Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology

Authors: Anika Heinze, Cara Schuldt, Sharof Khudayberdiev, Bas van Bommel, Daniela Hacker, Toni G Schulz, Ramona Stringhi, Elena Marcello, Marina Mikhaylova, Marco B Rust

Journal: Cell Mol Life Sci

PubMed ID: 36264429

Doi: 10.1007/s00018-022-04593-8

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The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs

Authors: Yuji Kashiwakura, Nemekhbayar Baatartsogt, Shoji Yamazaki, Azusa Nagao, Kagehiro Amano, Nobuaki Suzuki, Tadashi Matsushita, Akihiro Sawada, Satoshi Higasa, Naoya Yamasaki, Teruhisa Fujii, Taemi Ogura, Hideyuki Takedani, Masashi Taki, Takeshi Matsumoto, Jun Yamanouchi, Michio Sakai, Masako Nishikawa, Yutaka Yatomi, Koji Yada, Keiji Nogami, Ryota Watano, Takafumi Hiramoto, Morisada Hayakawa, Nobuhiko Kamoshita, Akihiro Kume, Hiroaki Mizukami, Shizukiyo Ishikawa, Yoichi Sakata, Tsukasa Ohmori

Journal: Mol Ther Methods Clin Dev

PubMed ID: 36381300

Doi: 10.1016/j.omtm.2022.10.014

Products & Services: Plasmid DNA Preparation

Development of a Factor VII Activating Protease (FSAP) generation assay and its application in studying FSAP in venous thrombosis

Authors: Michael Etscheid, Kay-Martin Hanschmann, Per Morten Sandset, Sandip M Kanse

Journal: Thromb Res

PubMed ID: 36265411

Doi: 10.1016/j.thromres.2022.09.027

Products & Services: Gene Synthesis

High-throughput genome editing in rice with a virus-based surrogate system

Authors: Yifu Tian, Dating Zhong, Xinbo Li, Rundong Shen, Han Han, Yuqin Dai, Qi Yao, Xuening Zhang, Qi Deng, Xuesong Cao, Jian-Kang Zhu, Yuming Lu

Journal: J Integr Plant Biol

PubMed ID: 36218268

Doi: 10.1111/jipb.13381

Products & Services: Protein and Antibody Isolation

Immunogenicity and reactogenicity of a third dose of BNT162b2 vaccine for COVID-19 after a primary regimen with BBIBP-CorV or BNT162b2 vaccines in Lima, Peru

Authors: Natalia Vargas-Herrera, Manuel Fernández-Navarro, Nestor E Cabezudo, Percy Soto-Becerra, Gilmer Solís-Sánchez, Stefan Escobar-Agreda, Javier Silva-Valencia, Luis Pampa-Espinoza, Ricardo Bado-Pérez, Lely Solari, Roger V Araujo-Castillo

Journal: PLoS ONE

PubMed ID: 36251630

Doi: 10.1371/journal.pone.0268419

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Bioelectrocatalytic CO Reduction by Redox Polymer-Wired Carbon Monoxide Dehydrogenase Gas Diffusion Electrodes

Authors: Jana M Becker, Anna Lielpetere, Julian Szczesny, João R C Junqueira, Patricia Rodríguez-Maciá, James A Birrell, Felipe Conzuelo, Wolfgang Schuhmann

Journal: ACS Appl Mater Interfaces

PubMed ID: 36194638

Doi: 10.1021/acsami.2c09547

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Lysyl-tRNA synthetase, a target for urgently needed M tuberculosis drugs

Authors: Simon R Green, Susan H Davis, Sebastian Damerow, Curtis A Engelhart, Michael Mathieson, Beatriz Baragaña, David A Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K Tamaki, Kirsteen I Buchanan, John Post, Karen Dowers, Sharon M Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C Kim, James M Bean, Navid Nahiyaan, Kyu Y Rhee, Qinglan Wang, Vee Y Tan, Helena I M Boshoff, Paul J Converse, Si-Yang Li, Yong S Chang, Nader Fotouhi, Anna M Upton, Eric L Nuermberger, Dirk Schnappinger, Kevin D Read, Lourdes Encinas, Robert H Bates, Paul G Wyatt, Laura A T Cleghorn

Journal: Nat Commun

PubMed ID: 36220877

Doi: 10.1038/s41467-022-33736-5

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Characterization of a GH5 endoxylanase from Penicillium funiculosum and its synergism with GH16 endo-1,3(4)-glucanase in saccharification of sugarcane bagasse

Authors: Olusola A Ogunyewo, Omoaruemike E Okereke, Sandeep Kumar, Syed Shams Yazdani

Journal: Sci Rep

PubMed ID: 36241677

Doi: 10.1038/s41598-022-21529-1

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Nitric Oxide Negatively Regulates the Rapid Formation of Primordia by Inhibiting the Mitochondrial Gene

Authors: Ludan Hou, Chenyang Huang, Xiangli Wu, Jinxia Zhang, Mengran Zhao

Journal: J Fungi (Basel)

PubMed ID: 36294620

Doi: 10.3390/jof8101055

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A new family of CRISPR-type V nucleases with C-rich PAM recognition

Authors: Tomas Urbaitis, Giedrius Gasiunas, Joshua K Young, Zhenglin Hou, Sushmitha Paulraj, Egle Godliauskaite, Mantvyda M Juskeviciene, Migle Stitilyte, Monika Jasnauskaite, Megumu Mabuchi, G Brett Robb, Virginijus Siksnys

Journal: EMBO Rep

PubMed ID: 36268581

Doi: 10.15252/embr.202255481

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Author Correction: [C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease

Authors: Tharick A Pascoal, Mira Chamoun, Elad Lax, Hsiao-Ying Wey, Monica Shin, Kok Pin Ng, Min Su Kang, Sulantha Mathotaarachchi, Andrea L Benedet, Joseph Therriault, Firoza Z Lussier, Frederick A Schroeder, Jonathan M DuBois, Baileigh G Hightower, Tonya M Gilbert, Nicole R Zürcher, Changning Wang, Robert Hopewell, Mallar Chakravarty, Melissa Savard, Emilie Thomas, Sara Mohaddes, Sarah Farzin, Alyssa Salaciak, Stephanie Tullo, A Claudio Cuello, Jean-Paul Soucy, Gassan Massarweh, Heungsun Hwang, Eliane Kobayashi, Bradley T Hyman, Bradford C Dickerson, Marie-Christine Guiot, Moshe Szyf, Serge Gauthier, Jacob M Hooker, Pedro Rosa-Neto

Journal: Nat Commun

PubMed ID: 36192402

Doi: 10.1038/s41467-022-33668-0

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Molecular architecture of the glycogen- committed PP1/PTG holoenzyme

Authors: Marta Stefania Semrau, Gabriele Giachin, Sonia Covaceuszach, Alberto Cassetta, Nicola Demitri, Paola Storici, Graziano Lolli

Journal: Nat Commun

PubMed ID: 36261419

Doi: 10.1038/s41467-022-33693-z

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Regulation of PaRBOH1-mediated ROS production in Norway spruce by Ca binding and phosphorylation

Authors: Kaloian Nickolov, Adrien Gauthier, Kenji Hashimoto, Teresa Laitinen, Enni Väisänen, Tanja Paasela, Rabah Soliymani, Takamitsu Kurusu, Kristiina Himanen, Olga Blokhina, Kurt V Fagerstedt, Soile Jokipii-Lukkari, Hannele Tuominen, Hely Häggman, Gunnar Wingsle, Teemu H Teeri, Kazuyuki Kuchitsu, Anna Kärkönen

Journal: Front Plant Sci

PubMed ID: 36311083

Doi: 10.3389/fpls.2022.978586

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SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment

Authors: Wenbo Chen, Wuyang Zheng, Shixiao Liu, Qiang Su, Kangxi Ding, Ziguan Zhang, Ping Luo, Yong Zhang, Jianming Xu, Chundong Yu, Weihua Li, Zhengrong Huang

Journal: Int J Biol Sci

PubMed ID: 36263184

Doi: 10.7150/ijbs.74864

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Characterization of proteases from Irpex lacteus grown on minimally denatured soybean meals

Authors: Xiaoxu Zhu, Yufei Hua, Xiangzhen Kong, Xingfei Li, Yeming Chen, Caimeng Zhang

Journal: J Sci Food Agric

PubMed ID: 36317244

Doi: 10.1002/jsfa.12301

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Crystal Structures of Epstein-Barr Virus Bcl-2 Homolog BHRF1 Bound to Bid and Puma BH3 Motif Peptides

Authors: Chathura D Suraweera, Mark G Hinds, Marc Kvansakul

Journal: Viruses

PubMed ID: 36298777

Doi: 10.3390/v14102222

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Greater Phosphorylation of AMPK and Multiple AMPK Substrates in the Skeletal Muscle of 24 Month-old Calorie Restricted Compared to Ad Libitum Fed Male Rats

Authors: Amy Zheng, Seong Eun Kwak, Jesper B Birk, Edward B Arias, Dominic Thorley, Jørgen F P Wojtaszewski, Gregory D Cartee

Journal: J Gerontol A Biol Sci Med Sci

PubMed ID: 36269629

Doi: 10.1093/gerona/glac218

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Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum

Authors: Ajit Kumar Singh, Margaret Phillips, Saleh Alkrimi, Marco Tonelli, Samuel P Boyson, Kiera L Malone, Jay C Nix, Karen C Glass

Journal: Int J Biol Macromol

PubMed ID: 36328269

Doi: 10.1016/j.ijbiomac.2022.10.247

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Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry

Authors: Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab R Shrestha, Rafal Wiewiora, Zachary A McDargh, Fen Pei, Rajat Pal, João V Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar M Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Wenchang Zhou, Jagat Adhikari, Benjamin Ruprecht, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus A Izaguirre

Journal: Nat Commun

PubMed ID: 36202813

Doi: 10.1038/s41467-022-33575-4

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G3BP/Rin-Binding Motifs Inserted into Flexible Regions of nsP2 Support RNA Replication of Chikungunya Virus

Authors: Sainan Wang, Andres Merits

Journal: J Virol

PubMed ID: 36226983

Doi: 10.1128/jvi.01278-22

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Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif

Authors: Wenwen Ru, Tomoyuki Koga, Xiaoyang Wang, Qiong Guo, Micah D Gearhart, Shidong Zhao, Mark Murphy, Hiroko Kawakami, Dylan Corcoran, Jiahai Zhang, Zhongliang Zhu, Xuebiao Yao, Yasuhiko Kawakami, Chao Xu

Journal: J Biol Chem

PubMed ID: 36257403

Doi: 10.1016/j.jbc.2022.102607

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Tannin Reduces the Incidence of Polyspermic Penetration in Porcine Oocytes

Authors: Jing-Tao Sun, Jia-Hui Liu, Xi-Qing Jiang, Xin Luo, Jin-Dong Yuan, Qi Zhang, Xin-Yue Qi, Sanghoon Lee, Zhong-Hua Liu, Jun-Xue Jin

Journal: Antioxidants (Basel)

PubMed ID: 36290750

Doi: 10.3390/antiox11102027

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Immunization with CRT-Induced Protective Immunity against Infection in BALB/c Mice

Authors: Lujuan Chen, Zhe Cheng, Siqi Xian, Bin Zhan, Zhijian Xu, Yan Yan, Jianfang Chen, Yanhai Wang, Limei Zhao

Journal: Trop Med Infect Dis

PubMed ID: 36288020

Doi: 10.3390/tropicalmed7100279

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Genetic variation in gene linked to predisposition of T2DM: A case control study

Authors: Archna Bhargave, Kiran Devi, Imteyaz Ahmad, Anita Yadav, Ranjan Gupta

Journal: J Diabetes Metab Disord

PubMed ID: 36249912

Doi: 10.1007/s40200-022-01131-y

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Molecular cloning and characterization of a novel bifunctional cellobiohydrolase/β-xylosidase from a metagenomic library of mangrove soil

Authors: Yi-De Liu, Ge Yuan, Yu-Ting An, Zi-Ran Zhu, Gang Li

Journal: Enzyme Microb Technol

PubMed ID: 36265247

Doi: 10.1016/j.enzmictec.2022.110141

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Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice

Authors: Weijun Ou, Yuu Ohno, Joshua Yang, Devaraj V Chandrashekar, Tamara Abdullah, Jiahong Sun, Riley Murphy, Chuli Roules, Nataraj Jagadeesan, David H Cribbs, Rachita K Sumbria

Journal: Pharmaceutics

PubMed ID: 36297637

Doi: 10.3390/pharmaceutics14102200

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