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Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors

Authors: Nicolas Çuburu, Lukasz Bialkowski, Sergio M Pontejo, Shiv K Sethi, Alexander T F Bell, Rina Kim, Cynthia D Thompson, Douglas R Lowy, John T Schiller

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35749366

Doi: 10.1073/pnas.2116738119

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Recapitulating early human development with 8C-like cells

Authors: Xiu Yu, Shiqi Liang, Manqi Chen, Hanwen Yu, Ruiqi Li, Yuliang Qu, Xuhui Kong, Ruirui Guo, Rongyan Zheng, Zsuzsanna Izsvák, Chuanbo Sun, Mingzhu Yang, Jichang Wang

Journal: Cell Rep

PubMed ID: 35732112

Doi: 10.1016/j.celrep.2022.110994

Products & Services: Proteins, Expression, Isolation and Analysis

Insights Into the Effect of Rice Stripe Virus P2 on Rice Defense by Comparative Proteomic Analysis

Authors: Zihang Yang, Hehong Zhang, Xiaoxiang Tan, Zhongyan Wei, Caiyi Wen, Zongtao Sun, Bingjian Sun, Jianping Chen

Journal: Front Microbiol

PubMed ID: 35747367

Doi: 10.3389/fmicb.2022.897589

Products & Services: Gene Synthesis

Construction of a synthetic Saccharomyces cerevisiae pan-genome neo-chromosome

Authors: Dariusz R Kutyna, Cristobal A Onetto, Thomas C Williams, Hugh D Goold, Ian T Paulsen, Isak S Pretorius, Daniel L Johnson, Anthony R Borneman

Journal: Nat Commun

PubMed ID: 35750675

Doi: 10.1038/s41467-022-31305-4

Products & Services: Plasmid DNA Preparation

Pore-Forming Cardiotoxin VVA2 (Volvatoxin A2) Variant I82E/L86K Is an Atypical Duplex-Specific Nuclease

Authors: Jia-Qi Lu, Jia-Wen Shou, Ka-Ching Lo, Yun-Sang Tang, Wei-Wei Shi, Pang-Chui Shaw

Journal: Toxins (Basel)

PubMed ID: 35737053

Doi: 10.3390/toxins14060392

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Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity

Authors: Dipika Sharma, Mandeep Singh, Punit Kaur, Uddipan Das

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35775983

Doi: 10.1107/S2059798322005290

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Disease-linked mutations cause exposure of a protein quality control degron

Authors: Caroline Kampmeyer, Sven Larsen-Ledet, Morten Rose Wagnkilde, Mathias Michelsen, Henriette K M Iversen, Sofie V Nielsen, Søren Lindemose, Alberto Caregnato, Tommer Ravid, Amelie Stein, Kaare Teilum, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

Journal: Structure

PubMed ID: 35700725

Doi: 10.1016/j.str.2022.05.016

Products & Services: Gene Synthesis

Duplication of horizontally acquired GH5_2 enzymes played a central role in the evolution of longhorned beetles

Authors: Na Ra Shin, Daniel Doucet, Yannick Pauchet

Journal: Mol Biol Evol

PubMed ID: 35763818

Doi: 10.1093/molbev/msac128

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DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism

Authors: Diti Chatterjee Bhowmick, Arianne Aslamy, Supriyo Bhattacharya, Eunjin Oh, Miwon Ahn, Debbie C Thurmond

Journal: Diabetes

PubMed ID: 35377441

Doi: 10.2337/db21-0681

Products & Services: Mutagenesis Services

A novel dual-targeting delivery system for specific delivery of CRISPR/Cas9 using hyaluronic acid, chitosan and AS1411

Authors: Zahra Khademi, Mohammad Ramezani, Mona Alibolandi, Mohammad Reza Zirak, Zahra Salmasi, Khalil Abnous, Seyed Mohammad Taghdisi

Journal: Carbohydr Polym

PubMed ID: 35725215

Doi: 10.1016/j.carbpol.2022.119691

Products & Services: Plasmid DNA Preparation

A Novel Flavi-like Virus in Alfalfa ( L) Crops along the Snake River Valley

Authors: Jennifer Dahan, Yuri I Wolf, Gardenia E Orellana, Erik J Wenninger, Eugene V Koonin, Alexander V Karasev

Journal: Viruses

PubMed ID: 35746792

Doi: 10.3390/v14061320

Products & Services: PCR and Cloning

Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1

Authors: Jianxiu Zhang, Ying-Ying Wang, Zhao-Qian Pan, Yulu Li, Jianhua Sui, Li-Lin Du, Keqiong Ye

Journal: Nat Commun

PubMed ID: 35752625

Doi: 10.1038/s41467-022-31439-5

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SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebraﬁsh

Authors: Fang Liang, Yu Zhang, Lin Li, Yexin Yang, Ji-Feng Fei, Yanmei Liu, Wei Qin

Journal: Nat Commun

PubMed ID: 35701400

Doi: 10.1038/s41467-022-31034-8

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Structure−Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification

Authors: Hua Yang , Ruxue Yan , Yue Li , Zhaoxin Lu , Xiaomei Bie , Haizhen Zhao , Fengxia Lu , Meirong Chen

Journal: J Agric Food Chem

PubMed ID: 35613468

Doi: 10.1021/acs.jafc.2c01083

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The Pre-Existing Human Antibody Repertoire to Computationally Optimized Influenza H1 Hemagglutinin Vaccines

Authors: Kaito Nagashima, John V Dzimianski, Julianna Han, Nada Abbadi, Aaron D Gingerich, Fredejah Royer, Sara O'Rourke, Giuseppe A Sautto, Ted M Ross, Andrew B Ward, Rebecca M DuBois, Jarrod J Mousa

Journal: J Immunol

PubMed ID: 35697384

Doi: 10.4049/jimmunol.2101171

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Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx

Authors: Tae Gun Kang, Kee Woong Kwon, Kyungsoo Kim, Insuk Lee, Myeong Joon Kim, Sang-Jun Ha, Sung Jae Shin

Journal: Nat Commun

PubMed ID: 35672321

Doi: 10.1038/s41467-022-30914-3

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Senescent cells limit p53 activity via multiple mechanisms to remain viable

Authors: Ines Sturmlechner, Chance C Sine, Karthik B Jeganathan, Cheng Zhang, Raul O Fierro Velasco, Darren J Baker, Hu Li, Jan M van Deursen

Journal: Nat Commun

PubMed ID: 35764649

Doi: 10.1038/s41467-022-31239-x

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of inositol lipid metabolism in gut-associated Bacteroidetes

Authors: Stacey L Heaver, Henry H Le, Peijun Tang, Arnaud Baslé, Claudia Mirretta Barone, Dai Long Vu, Jillian L Waters, Jon Marles-Wright, Elizabeth L Johnson, Dominic J Campopiano, Ruth E Ley

Journal: Nat Microbiol

PubMed ID: 35725777

Doi: 10.1038/s41564-022-01152-6

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Production of Plant Sesquiterpene Lactone Parthenolide in the Yeast Cell Factory

Authors: Yiting Shi, Tianyu Dong, Boxuan Zeng, Mingdong Yao, Ying Wang, Zexiong Xie, Wenhai Xiao, Yingjin Yuan

Journal: ACS Synth Biol

PubMed ID: 35723427

Doi: 10.1021/acssynbio.2c00132

Products & Services: Recombinant Antibody Expression

Human Superantibodies to 3CL Inhibit Replication of SARS-CoV-2 across Variants

Authors: Kittirat Glab-Ampai, Kanasap Kaewchim, Thanatsaran Saenlom, Watayagorn Thepsawat, Kodchakorn Mahasongkram, Nitat Sookrung, Wanpen Chaicumpa, Monrat Chulanetra

Journal: Int J Mol Sci

PubMed ID: 35743031

Doi: 10.3390/ijms23126587

Products & Services: Plasmid DNA Preparation

Development of a biosensor based on a new marine luciferase fused to an affibody to assess Her2 expression in living cells

Authors: Laura Rodríguez de la Fuente, Irene Golán Cancela, Ánxela M Estévez-Salguero, Pablo Iglesias, José A Costoya

Journal: Anal Chim Acta

PubMed ID: 35934341

Doi: 10.1016/j.aca.2022.340084

Products & Services: PCR Cloning and Subcloning

A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly

Authors: Francisco Figueiredo, Mónica Lopes-Marques, Bruno Almeida, Nena Matscheko, Pedro M Martins, Alexandra Silva, Sandra Macedo-Ribeiro

Journal: Cells

PubMed ID: 35741099

Doi: 10.3390/cells11121969

Products & Services: Proteins, Expression, Isolation and Analysis

Longitudinal profile of neutralizing and binding antibodies in vaccinated and convalescent COVID-19 cohorts by chemiluminescent immunoassays

Authors: Xiaowen Dou, Enyun Wang, Ruiwei Jiang, Min Li, Dan Xiong, Baoqing Sun, Xiuming Zhang

Journal: Immun Inflamm Dis

PubMed ID: 35634960

Doi: 10.1002/iid3.612

L and L Improve Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats through Suppression of Oxidative Stress

Authors: Shujun Jiang, Quanyan Cai, Yang Gao, Hui Dong, Yan Zhao, Fan Wu, Xin Ba, Yang Luan, Xin Zou, Lijun Xu, Fuer Lu

Journal: Evid Based Complement Alternat Med

PubMed ID: 35707467

Doi: 10.1155/2022/4187359

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The Cross-Protective Immunity Landscape Among Different SARS-CoV-2 Variant RBDs

Authors: Wenqiang Sun, Lihong He, Huicong Lou, Wenhui Fan, Limin Yang, Gong Cheng, Wenjun Liu, Lei Sun

Journal: Front Immunol

PubMed ID: 35757743

Doi: 10.3389/fimmu.2022.898520

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Activated Stellate Cell Paracrine HGF Exacerbated Pancreatic Cancer Cell Ferroptosis Resistance

Authors: Qiwei Wu, Lian Song, Yaxin Guo, Sai Liu, Wenyao Wang, Huli Liu, Aihua Gong, Xiang Liao, Haitao Zhu, Dongqing Wang

Journal: Oxid Med Cell Longev

PubMed ID: 35693705

Doi: 10.1155/2022/2985249

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Preclinical evaluation of a plant-derived SARS-CoV-2 subunit vaccine: Protective efficacy, immunogenicity, safety, and toxicity

Authors: Balamurugan Shanmugaraj, Narach Khorattanakulchai, Chalisa Panapitakkul, Ashwini Malla, Rawiwan Im-Erbsin, Manutsanun Inthawong, Piyanate Sunyakumthorn, Taweewun Hunsawong, Chonticha Klungthong, Matthew C Reed, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Passaraporn Srimangkornkaew, Aekkarin Klinkhamhom, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Suthira Taychakhoonavudh, Waranyoo Phoolcharoen

Journal: Vaccine

PubMed ID: 35697573

Doi: 10.1016/j.vaccine.2022.05.087

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Uricase sensitizes hepatocellular carcinoma cells to 5-fluorouracil through uricase-uric acid-UMP synthase axis

Authors: Saihong Yu, Zhuduo Li, Linglan Tu, Yiyi Pu, Dongmei Yan, Xiaoju Wang, Xiaoliang Zheng, Jie Yu

Journal: J Physiol Biochem

PubMed ID: 35674867

Doi: 10.1007/s13105-022-00894-5

Products & Services: Plasmid DNA Preparation

Chemoproteomic identification of CO-dependent lysine carboxylation in proteins

Authors: Dustin T King, Sha Zhu, Darryl B Hardie, Jesús E Serrano-Negrón, Zarina Madden, Subramania Kolappan, David J Vocadlo

Journal: Nat Chem Biol

PubMed ID: 35710617

Doi: 10.1038/s41589-022-01043-1

Products & Services: Mutagenesis Services

Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA

Authors: Elena S Kim, Jun Zhou, Hu Zhang, Alexander Marchetti, Maarten van de Klundert, Dawei Cai, Xiaoyang Yu, Bidisha Mitra, Yuanjie Liu, Mu Wang, Ulrike Protzer, Haitao Guo

Journal: PLoS Pathog

PubMed ID: 35679251

Doi: 10.1371/journal.ppat.1010576

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Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors

Authors: Jiayue Su, Desheng Liu, Fan Yang, Mei-Qing Zuo, Chang Li, Meng-Qiu Dong, Shan Sun, Sen-Fang Sui

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35733257

Doi: 10.1073/pnas.2200158119

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Increased resistance of SARS-CoV-2 Lambda variant to antibody neutralization

Authors: Huimin Guo, Qing Fan, Shuo Song, Senlin Shen, Bing Zhou, Haiyan Wang, Lin Cheng, Xiangyang Ge, Bin Ju, Zheng Zhang

Journal: JOURNAL OF CLINICAL VIROLOGY

PubMed ID: 35461042

Doi: 10.1016/j.jcv.2022.105162

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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease

Authors: Nikhil Panicker, Tae-In Kam, Hu Wang, Stewart Neifert, Shih-Ching Chou, Manoj Kumar, Saurav Brahmachari, Aanishaa Jhaldiyal, Jared T Hinkle, Fatih Akkentli, Xiaobo Mao, Enquan Xu, Senthilkumar S Karuppagounder, Eric T Hsu, Sung-Ung Kang, Olga Pletnikova, Juan Troncoso, Valina L Dawson, Ted M Dawson

Journal: Neuron

PubMed ID: 35654037

Doi: 10.1016/j.neuron.2022.05.009

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Histidine Ligated Iron-Sulfur Peptides

Authors: Luca Valer, Daniele Rossetto, Taylor Parkkila, Lorenzo Sebastianelli, Graziano Guella, Amber L Hendricks, James A Cowan, Lingzi Sang, Sheref S Mansy

Journal: Chembiochem

PubMed ID: 35674331

Doi: 10.1002/cbic.202200202

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The Effects of Qinghao-Kushen and Its Active Compounds on the Biological Characteristics of Liver Cancer Cells

Authors: Jingmin Ji, Zhiqin Zhang, Qing Peng, Liyuan Hao, Yinglin Guo, Yu Xue, Yiwei Liu, Caige Li, Xinli Shi

Journal: Evid Based Complement Alternat Med

PubMed ID: 35722140

Doi: 10.1155/2022/8763510

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Towards a general approach for tailoring the hydrophobic binding site of phenylalanine ammonia-lyases

Authors: Souad Diana Tork, Mădălina Elena Moisă, Lilla Cserepes, Alina Filip, Levente Csaba Nagy, Florin Dan Irimie, László Csaba Bencze

Journal: Sci Rep

PubMed ID: 35739148

Doi: 10.1038/s41598-022-14585-0

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Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes

Authors: Lucy C Walters, Daniel Rozbesky, Karl Harlos, Max Quastel, Hong Sun, Sebastian Springer, Robert P Rambo, Fiyaz Mohammed, E Yvonne Jones, Andrew J McMichael, Geraldine M Gillespie

Journal: Cell Rep

PubMed ID: 35705051

Doi: 10.1016/j.celrep.2022.110959

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Microfluidic T Cell Selection by Cellular Avidity

Authors: Julian F Ashby, Julien Schmidt, Neelima Kc, Armand Kurum, Caroline Koch, Alexandre Harari, Li Tang, Sam H Au

Journal: Adv Healthc Mater

PubMed ID: 35657072

Doi: 10.1002/adhm.202200169

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Successful Preservation of Native BCR::ABL1 in Chronic Myeloid Leukemia Primary Leukocytes Reveals a Reduced Kinase Activity

Authors: Christian Boni, Massimiliano Bonifacio, Marzia Vezzalini, Luigi Scaffidi, Luisa Tomasello, Laurie L Parker, Diego Boscarino, Dino Paladin, Mauro Krampera, Claudio Sorio

Journal: Front Oncol

PubMed ID: 35756686

Doi: 10.3389/fonc.2022.904510

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Comparative Characterization of Different Molecular Formats of Bispecific Antibodies Targeting EGFR and PD-L1

Authors: Nishant Mohan, Atul Agrawal, Yi Shen, Katie L Winarski, Yukinori Endo, Milos Dokmanovic, Deborah Schmiel, Jiwen Zheng, David S Rotstein, Lorraine C Pelosof, Wen Jin Wu

Journal: Pharmaceutics

PubMed ID: 35890277

Doi: 10.3390/pharmaceutics14071381

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The Use of Endo-Cellulase and Endo-Xylanase for the Extraction of Apple Pectins as Factors Modifying Their Anticancer Properties and Affecting Their Synergy with the Active Form of Irinotecan

Authors: Jerzy Maksymowicz, Anna Palko-Łabuz, Beata Sobieszczańska, Mateusz Chmielarz, Mirosława Ferens-Sieczkowska, Magdalena Skonieczna, Agnieszka Wikiera, Olga Wesołowska, Kamila Środa-Pomianek

Journal: Pharmaceuticals (Basel)

PubMed ID: 35745651

Doi: 10.3390/ph15060732

Products & Services: Recombinant Proteins

Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides

Authors: Chulbul M Ahmed, Tristan R Grams, David C Bloom, Howard M Johnson, Alfred S Lewin

Journal: Front Immunol

PubMed ID: 35799776

Doi: 10.3389/fimmu.2022.902956

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SASH1 knockdown suppresses TRAF6 ubiquitination to regulate hemangioma progression by mediating EZH2 degradation

Authors: Xueyuan Yu, Nuonuo Cong, Xiangyu Liu, Rui Wang, Daxu Li

Journal: Exp Cell Res

PubMed ID: 35772492

Doi: 10.1016/j.yexcr.2022.113270

Products & Services: Proteins, Expression, Isolation and Analysis

Inhibition of histone acetyltransferase GCN5 by a transcription factor FgPacC controls fungal adaption to host-derived iron stress

Authors: Qin Gu, Yujie Wang, Xiaozhen Zhao, Bingqin Yuan, Mengxuan Zhang, Zheng Tan, Xinyue Zhang, Yun Chen, Huijun Wu, Yuming Luo, Nancy P Keller, Xuewen Gao, Zhonghua Ma

Journal: Nucleic Acids Res

PubMed ID: 35687128

Doi: 10.1093/nar/gkac498

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Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice

Authors: Jie Liu, Junyang Lin, Linjun Cai, Jie Sun, Xue Ding, Cenrong Wang, Yanchun Wu, Xiaoling Gao, Weiheng Su, Chunlai Jiang

Journal: Viruses

PubMed ID: 35746685

Doi: 10.3390/v14061214

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LncRNA RAD51-AS1 Regulates Human Bone Marrow Mesenchymal Stem Cells via Interaction with YBX1 to Ameliorate Osteoporosis

Authors: Beichen Li, Jing Wang, Fangrong Xu, Qinjue Wang, Quan Liu, Guantong Wang, Dengshun Miao, Qiang Sun