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Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain

Authors: Airah Javorsky, Patrick O Humbert , Marc Kvansakul

Journal: Commun Biol

PubMed ID: 34117354

Doi: 10.1038/s42003-021-02250-7

Products & Services: Codon Optimization

LcCCL28-25, Derived from Piscine Chemokine, Exhibits Antimicrobial Activity against Gram-Negative and Gram-Positive Bacteria In Vitro and In Vivo

Authors: Juanjuan Su , Haimeng Li , Jingyang Hu , Danni Wang , Fengchao Zhang , Zheng Fu , Feng Han

Journal: Microbiol Spectr

PubMed ID: 35616397

Doi: 10.1128/spectrum.02515-21

Products & Services: Peptide Synthesis

Umami polypeptide detection system targeting the human T1R1 receptor and its taste-presenting mechanism

Authors: Chuanxi Zhang , Yulu Miao , Yinghui Feng , Jiawei Wang , Zhuoli Tian , Juan Dong , Bei Gao , Lujia Zhang

Journal: Biomaterials

PubMed ID: 35792387

Doi: doi.org/10.1016/j.biomaterials.2022.121660

Products & Services: Gene Synthesis

Staphylococcal saoABC operon codes for a DNA-binding protein SaoC implicated in the response to nutrient deficit

Authors: Michal Bukowski , Maja Kosecka-Strojek , Anna Madry , Rafal Zagorski-Przybylo , Tomasz Zadlo , Katarzyna Gawron , Benedykt Wladyka

Journal: Int J Mol Sci

PubMed ID: 35742885

Doi: 10.3390/ijms23126443

Products & Services: Gene Synthesis

3D structure and in situ arrangements of CatSper channel in the sperm flagellum

Authors: Yanhe Zhao , Huafeng Wang , Caroline Wiesehoefer , Naman B Shah , Evan Reetz , Jae Yeon Hwang , Xiaofang Huang , Tse-En Wang , Polina V Lishko , Karen M Davies , Gunther Wennemuth , Daniela Nicastro , Jean-Ju Chung

Journal: Nat Commun

PubMed ID: 35715406

Doi: 10.1038/s41467-022-31050-8

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A Five Year Randomized Controlled Trial to Assess the Efficacy and Antibody Responses to a Commercial and Autogenous Vaccine for the Prevention of Infectious Bovine Keratoconjunctivitis

Authors: Matthew M Hille, Matthew L Spangler, Michael L Clawson, Kelly D Heath, Hiep L X Vu, Rachel E S Rogers, John Dustin Loy

Journal: Vaccines (Basel)

PubMed ID: 35746524

Doi: 10.3390/vaccines10060916

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A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis

Authors: Monir Ejemel, Todd G Smith, Lauren Greenberg, William C Carson, David Lowe, Yong Yang, Felix R Jackson, Clint N Morgan, Brock E Martin, Chantal Kling, Christina L Hutson, Nadia Gallardo-Romero, James A Ellison, Susan Moore, Adam Buzby, John Sullivan-Bolyai, Mark Klempner, Yang Wang

Journal: Sci Rep

PubMed ID: 35672343

Doi: 10.1038/s41598-022-13527-0

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Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice

Authors: Mingqing Lu, Kunpeng Liu, Yun Peng, Zhe Ding, Yingwen Li, Alexander Tendu, Xue Hu, Ge Gao, Weiwei Guo, Hang Liu, Juhong Rao, Jiaxuan Zhao, Miaoyu Chen, Zhiming Yuan, Gary Wong, Chao Shan, Yanfeng Yao, Jiaming Lan

Journal: Virol Sin

PubMed ID: 35659605

Doi: 10.1016/j.virs.2022.05.006

Products & Services: Peptide Library Services

The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of Li01 and Resveratrol in Ameliorating Colitis in Mice

Authors: Yiqiu Fei, Shuobo Zhang, Shengyi Han, Bo Qiu, Yanmeng Lu, Weixing Huang, Fang Li, Deying Chen, Björn Berglund, Hang Xiao, Lanjuan Li, Mingfei Yao

Journal: Research (Wash D C)

PubMed ID: 35935130

Doi: 10.34133/2022/9863845

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Excessive Immune Activation and the Correlation with Decreased Expression of PD-1 at the Maternal-Fetal Interface in Preeclampsia

Authors: Shan Wang, Yining Liu, Yue Liang, Lina Sun, Xiaoxiao Du, Yueyang Shi, Jinlai Meng

Journal: Reprod Sci

PubMed ID: 35708884

Doi: 10.1007/s43032-022-01003-z

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Patulin Detoxification by Recombinant Manganese Peroxidase from Expressed by

Authors: Shuai Wang, Xiaolu Wang, Leena Penttinen, Huiying Luo, Yuhong Zhang, Bo Liu, Bin Yao, Nina Hakulinen, Wei Zhang, Xiaoyun Su

Journal: Toxins (Basel)

PubMed ID: 35878178

Doi: 10.3390/toxins14070440

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Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naïve CD8 T Cell Activation and Expansion by Promoting T Cell-APC Interactions

Authors: Monique M Waldman, Jeremy T Rahkola, Ashton L Sigler, Jeffrey W Chung, Benjamin A S Willett, Ross M Kedl, Rachel S Friedman, Jordan Jacobelli

Journal: Front Immunol

PubMed ID: 35757762

Doi: 10.3389/fimmu.2022.856977

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PD-L1 in gestational trophoblastic disease: an antibody evaluation

Authors: Yvonne M Hoeijmakers, Michiel Simons, Johan Bulten, Mark A J Gorris, Petronella B Ottevanger, I Jolanda M de Vries, Fred C G J Sweep

Journal: Acta Obstet Gynecol Scand

PubMed ID: 35689468

Doi: 10.1111/aogs.14404

Products & Services: Recombinant Proteins

The simultaneous perception of self- and non-self-danger signals potentiates plant innate immunity responses

Authors: Victoria Pastor, Raquel Cervero, Jordi Gamir

Journal: Planta

PubMed ID: 35697869

Doi: 10.1007/s00425-022-03918-y

Products & Services: Gene Synthesis

Genetic characterization of the cyclohexane carboxylate degradation pathway in the denitrifying bacterium Aromatoleum sp CIB

Authors: David Sanz, Eduardo Díaz

Journal: Environ Microbiol

PubMed ID: 35768954

Doi: 10.1111/1462-2920.16093

Products & Services: Gene Synthesis

A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis

Authors: Caroline De Souza Pereira, Helenita Costa Quadros, Samuel Yaw Aboagye, Diana Fontinha, Sarah D'Alessandro, Margaret Elizabeth Byrne, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Diogo Rodrigo M Moreira, Nicoletta Basilico, David L Williams, Miguel Prudêncio, Bruno Pradines, Maribel Navarro

Journal: Pharmaceutics

PubMed ID: 35745823

Doi: 10.3390/pharmaceutics14061251

Products & Services: Mammalian Expression

Engineering a highly sensitive biosensor for abscisic acid in mammalian cells

Authors: Seo Woo Kim, Kübra Alci, Femke Van Gaever, Yasmine Driege, Keylla Bicalho, Geert Goeminne, Claude Libert, Alain Goossens, Rudi Beyaert, Jens Staal

Journal: FEBS Lett

PubMed ID: 35727199

Doi: 10.1002/1873-3468.14431

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Mapping the deformability of natural and designed cellulosomes in solution

Authors: Jonathan Dorival, Sarah Moraïs, Aurore Labourel, Bartosz Rozycki, Pierre-Andre Cazade, Jérôme Dabin, Eva Setter-Lamed, Itzhak Mizrahi, Damien Thompson, Aurélien Thureau, Edward A Bayer, Mirjam Czjzek

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 35725490

Doi: 10.1186/s13068-022-02165-3

Products & Services: Plasmid DNA Preparation

The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication

Authors: Lucca R Policastro, Isabela Dolci, Andre S Godoy, José V J Silva Júnior, Uriel E A Ruiz, Igor A Santos, Ana C G Jardim, Kirandeep Samby, Jeremy N Burrows, Timothy N C Wells, Laura H V G Gil, Glaucius Oliva, Rafaela S Fernandes

Journal: Viruses

PubMed ID: 35891332

Doi: 10.3390/v14071351

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Gas5 inhibition promotes the axon regeneration in the adult mammalian nervous system

Authors: Xiaoxiao Han, Jiacheng Xu, Zixin Chen, Ping Li, Lili Zhao, Jincheng Tao, Yu Shen, Shengze Zhu, Bin Yu, Jianwei Zhu, Qianqian Cao, Songlin Zhou

Journal: Exp Neurol

PubMed ID: 35779613

Doi: 10.1016/j.expneurol.2022.114157

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ISCA2 deficiency leads to heme synthesis defects and impaired erythroid differentiation in K562 cells by indirect ROS-mediated IRP1 activation

Authors: Jing Wang, Mengyao Jiang, Guanru Yue, Lifei Zhu, Xueqing Wang, Mengxiang Liang, Xiaolin Wu, Beibei Li, Yilin Pang, Guoqiang Tan, Jianghui Li

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 35714932

Doi: 10.1016/j.bbamcr.2022.119307

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Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4

Authors: Hugh C Welles, Hannah A D King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A Schramm, Nicole A Doria-Rose, Adrienne E Swanstrom, James A Hoxie, Celia LaBranche, David C Montefiori, Daniel C Douek, Peter D Kwong, John R Mascola, Mario Roederer, Rosemarie D Mason

Journal: PLoS Pathog

PubMed ID: 35709309

Doi: 10.1371/journal.ppat.1010574

Products & Services: DNA Sequencing

A DNA vaccine candidate delivered by an electroacupuncture machine provides protective immunity against SARS-CoV-2 infection

Authors: Tsai-Teng Tzeng, Kit Man Chai, Kuan-Yin Shen, Chia-Yi Yu, Shiu-Ju Yang, Wan-Chun Huang, Hung-Chun Liao, Fang-Feng Chiu, Horng-Yunn Dou, Ching-Len Liao, Hsin-Wei Chen, Shih-Jen Liu

Journal: npj Vaccines

PubMed ID: 35662254

Doi: 10.1038/s41541-022-00482-0

Products & Services: Mammalian Expression

Immunoinformatics Design and Assessment of a Multiepitope Antigen (OvMCBL02) for Onchocerciasis Diagnosis and Monitoring

Authors: Bernis Neneyoh Yengo, Cabirou Mounchili Shintouo, An Hotterbeekx, Ntang Emmaculate Yaah, Robert Adamu Shey, Jusal Quanico, Geert Baggerman, Lawrence Ayong, Luc Vanhamme, Rose Njemini, Jacob Souopgui, Robert Colebunders, Stephen Mbigha Ghogomu

Journal: Diagnostics (Basel)

PubMed ID: 35741250

Doi: 10.3390/diagnostics12061440

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Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium

Authors: Aujan Mehregan, Sergio Pérez-Conesa, Yuxuan Zhuang, Ahmad Elbahnsi, Diletta Pasini, Erik Lindahl, Rebecca J Howard, Chris Ulens, Lucie Delemotte

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 35724739

Doi: 10.1016/j.bbamem.2022.183994

Products & Services: Recombinant Antibody Expression

RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer

Authors: Pola Olczak, Ken Matsui, Margaret Wong, Jade Alvarez, Paul Lambert, Neil D Christensen, Jiafen Hu, Bettina Huber, Reinhard Kirnbauer, Joshua W Wang, Richard B S Roden

Journal: J Virol

PubMed ID: 35703545

Doi: 10.1128/jvi.00566-22

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Snake Venom Hydrogels as a Rapid Hemostatic Agent for Uncontrolled Bleeding

Authors: Ramanathan Yegappan, Jan Lauko, Zhao Wang, Martin F Lavin, Amanda W Kijas, Alan E Rowan

Journal: Adv Healthc Mater

PubMed ID: 35652565

Doi: 10.1002/adhm.202200574

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Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms

Authors: Jia Li, Tingting Hong, Yue Wei, Lei Guo, Minjung Lee, Hui Yang, Caleb Class, Yaling Yang, Xiaoqiong Wang, Hua He, Stefan Siwko, M James You, Yubin Zhou, Guillermo Garcia-Manero, Yun Huang

Journal: Clin Epigenetics

PubMed ID: 35765052

Doi: 10.1186/s13148-022-01297-5

Products & Services: Proteins, Expression, Isolation and Analysis

Metabolic sensor O-GlcNAcylation regulates erythroid differentiation and globin production via BCL11A

Authors: Sudjit Luanpitpong, Xing Kang, Montira Janan, Kanjana Thumanu, Jingting Li, Pakpoom Kheolamai, Surapol Issaragrisil

Journal: Stem Cell Res Ther

PubMed ID: 35739577

Doi: 10.1186/s13287-022-02954-5

Products & Services: Plasmid DNA Preparation

The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression

Authors: Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen, Hai Rao

Journal: J Exp Clin Cancer Res

PubMed ID: 35655230

Doi: 10.1186/s13046-022-02400-7

Products & Services: Proteins, Expression, Isolation and Analysis

Location of the cross-β structure in prion fibrils: A search by seeding and electron spin resonance spectroscopy

Authors: Brett K-Y Chu, Ruei-Fong Tsai, Chien-Lun Hung, Yun-Hsuan Kuo, Eric H-L Chen, Yun-Wei Chiang, Sunney I Chan, Rita P-Y Chen

Journal: Protein Sci

PubMed ID: 35634767

Doi: 10.1002/pro.4326

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Laodelphax striatellus saliva mucin enables the formation of stylet sheathes to facilitate its feeding and rice stripe virus transmission

Authors: Yan Huo, Jing Zhao, Xiangyi Meng, Jie Yang, Ziyu Zhang, Zhiwei Liu, Rongxiang Fang, Lili Zhang

Journal: Pest Manag Sci

PubMed ID: 35604851

Doi: 10.1002/ps.6990

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Unbalanced regulation of Sec22b and Ykt6 blocks autophagosome axonal retrograde flux in neuronal ischemia-reperfusion injury

Authors: Haiying Li, Xiang Li, Zhongmou Xu, Jinxin Lu, Chang Cao, Wanchun You, Zhengquan Yu, Haitao Shen, Gang Chen

Journal: J Neurosci

PubMed ID: 35654605

Doi: 10.1523/JNEUROSCI.2030-21.2022

Products & Services: Proteins, Expression, Isolation and Analysis

CircFAT1 regulates retinal pigment epithelial cell pyroptosis and autophagy via mediating m6A reader protein YTHDF2 expression in diabetic retinopathy

Authors: Chengchi Huang, Peng Qi, Hao Cui, Qun Lu, Xue Gao

Journal: Exp Eye Res

PubMed ID: 35714699

Doi: 10.1016/j.exer.2022.109152

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Therapeutic use of α2-antiplasmin as an antifibrinolytic and hemostatic agent in surgery and regenerative medicine

Authors: Jialu Liu, Ani Solanki, Michael J V White, Jeffrey A Hubbell, Priscilla S Briquez

Journal: NPJ Regen Med

PubMed ID: 35773290

Doi: 10.1038/s41536-022-00230-x

Products & Services: Plasmid DNA Preparation

RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIa

Authors: Ashrafali M Ismail, Amrita Saha, Ji S Lee, David F Painter, Yinghua Chen, Gurdeep Singh, Gabriela N Condezo, James Chodosh, Carmen San Martín, Jaya Rajaiya

Journal: PLoS Pathog

PubMed ID: 35709296

Doi: 10.1371/journal.ppat.1010588

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Computational design and engineering of an strain producing the nonstandard amino acid -aminophenylalanine

Authors: Ali R Zomorrodi, Colin Hemez, Pol Arranz-Gibert, Terrence Wu, Farren J Isaacs, Daniel Segrè

Journal: iScience

PubMed ID: 35789833

Doi: 10.1016/j.isci.2022.104562

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Intranasal vaccination of hamsters with a Newcastle disease virus vector expressing the S1 subunit protects animals against SARS-CoV-2 disease

Authors: Manolo Fernández Díaz, Katherine Calderón, Aldo Rojas-Neyra, Vikram N Vakharia, Ricardo Choque-Guevara, Angela Montalvan-Avalos, Astrid Poma-Acevedo, Dora Rios-Matos, Andres Agurto-Arteaga, Maria de Grecia Cauti-Mendoza, Norma Perez-Martinez, Gisela Isasi-Rivas, Luis Tataje-Lavanda, Yacory Sernaque-Aguilar, Freddy Ygnacio, Manuel Criollo-Orozco, Edison Huaccachi-Gonzalez, Elmer Delgado-Ccancce, Doris Villanueva-Pérez, Ricardo Montesinos-Millán, Kristel Gutiérrez-Manchay, Katherinne Pauyac-Antezana, Ingrid Ramirez-Ortiz, Stefany Quiñones-Garcia, Yudith Cauna-Orocollo, Katherine Vallejos-Sánchez, Angela Rios-Angulo, Dennis Núñez-Fernández, Mario I Salguedo-Bohorquez, Julio Ticona, Manolo Fernández-Sánchez, Eliana Icochea, Luis A Guevara-Sarmiento, Mirko Zimic

Journal: Sci Rep

PubMed ID: 35725862

Doi: 10.1038/s41598-022-13560-z

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Targeted removal of mitochondrial DNA from mouse and human extrachromosomal circular DNA with CRISPR-Cas9

Authors: Weijia Feng, Gerard Arrey, Egija Zole, Wei Lv, Xue Liang, Peng Han, Marghoob Mohiyuddin, Henriette Pilegaard, Birgitte Regenberg

Journal: Comput Struct Biotechnol J

PubMed ID: 35782732

Doi: 10.1016/j.csbj.2022.06.028

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A group of CLE peptides regulates de novo shoot regeneration in Arabidopsis thaliana

Authors: Jingke Kang, Xuening Wang, Takashi Ishida, Etienne Grienenberger, Qian Zheng, Jing Wang, Yonghong Zhang, Wenqiang Chen, Mengmeng Chen, Xiu-Fen Song, Chengyun Wu, Zhubing Hu, Lingyu Jia, Chen Li, Chun-Ming Liu, Jennifer C Fletcher, Shinichiro Sawa, Guodong Wang

Journal: New Phytol

PubMed ID: 35642449

Doi: 10.1111/nph.18291

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TCFL5 deficiency impairs the pachytene to diplotene transition during spermatogenesis in the mouse

Authors: Javier Galán-Martínez, Inés Berenguer, Ma Del Carmen Maza, Konstantinos Stamatakis, Núria Gironès, Manuel Fresno

Journal: Sci Rep

PubMed ID: 35768632

Doi: 10.1038/s41598-022-15167-w

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ZIC5 promotes human hepatocellular carcinoma cell proliferation through upregulating COL1A1

Authors: Wenping Song, Weijiang Yu, Ding Li, Cheng Cheng, Xuan Wu, Jinhua Chen, Wenzhou Zhang

Journal: J Gastrointest Oncol

PubMed ID: 35837163

Doi: 10.21037/jgo-22-335

Products & Services: Proteins, Expression, Isolation and Analysis

Mapping immunogenic epitopes of an adhesin-like protein from Methanobrevibacter ruminantium M1 and comparison of empirical data with in silico prediction methods

Authors: Sofia Khanum, Vincenzo Carbone, Sandeep K Gupta, Juliana Yeung, Dairu Shu, Tania Wilson, Natalie A Parlane, Eric Altermann, Silvia M Estein, Peter H Janssen, D Neil Wedlock, Axel Heiser

Journal: Sci Rep

PubMed ID: 35729277

Doi: 10.1038/s41598-022-14545-8

Products & Services: Proteins, Expression, Isolation and Analysis

CRISPR-mediated protein-tagging signal amplification systems for efficient transcriptional activation and repression in Saccharomyces cerevisiae

Authors: Haotian Zhai, Li Cui, Zhen Xiong, Qingsheng Qi, Jin Hou

Journal: Nucleic Acids Res

PubMed ID: 35641106

Doi: 10.1093/nar/gkac463

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Serological screening in wild ruminants in Germany, 2021/2022: No evidence of SARS-CoV-2, bluetongue virus or pestivirus spread but high seroprevalences against Schmallenberg virus

Authors: Kerstin Wernike, Luisa Fischer, Mark Holsteg, Andrea Aebischer, Anja Petrov, Katharina Marquart, Ulrich Schotte, Jacob Schön, Donata Hoffmann, Silke Hechinger, Antonie Neubauer-Juric, Julia Blicke, Thomas C Mettenleiter, Martin Beer

Journal: Transbound Emerg Dis

PubMed ID: 35585653

Doi: 10.1111/tbed.14600

Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum

Authors: Júlio Souza Dos-Santos, Luan Firmino-Cruz, Alessandra Marcia da Fonseca-Martins, Diogo Oliveira-Maciel, Gustavo Guadagnini Perez, Victor A Roncaglia-Pereira, Carlos H Dumard, Francisca H Guedes-da-Silva, Ana C Vicente Santos, Monique Dos Santos Leandro, Jesuino Rafael Machado Ferreira, Kamila Guimarães-Pinto, Luciana Conde, Danielle A S Rodrigues, Marcus Vinicius de Mattos Silva, Renata G F Alvim, Tulio M Lima, Federico F Marsili, Daniel P B Abreu, Orlando C Ferreira, Ronaldo da Silva Mohana Borges, Amilcar Tanuri, Thiago Moreno L Souza, Bartira Rossi-Bergmann, André M Vale, Jerson Lima Silva, Andréa Cheble de Oliveira, Alessandra D'Almeida Filardy, Andre M O Gomes, Herbert Leonel de Matos Guedes

Journal: Front Immunol

PubMed ID: 35844561

Doi: 10.3389/fimmu.2022.884760

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COVID-19 infection after two doses of SARS-CoV-2 mRNA vaccine in multiple sclerosis, AQP4-antibody NMOSD and MOGAD

Authors: Tianrong Yeo, Amy May Lin Quek, Kok Pin Yong, Janis Siew Noi Tye, Pavanni Ratnagopal, Derek Tuck Loong Soon, Kevin Tan

Journal: Mult Scler Relat Disord

PubMed ID: 35803084

Doi: 10.1016/j.msard.2022.104003

Megaviruses contain various genes encoding for eukaryotic vesicle trafficking factors

Authors: Dany Khalifeh, Emilie Neveu, Dirk Fasshauer

Journal: Traffic