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Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19
Authors: Brian J Ward, Philipe Gobeil, Annie Séguin, Judith Atkins, Iohann Boulay, Pierre-Yves Charbonneau, Manon Couture, Marc-André D'Aoust, Jiwanjeet Dhaliwall, Carolyn Finkle, Karen Hager, Asif Mahmood, Alexander Makarkov, Matthew P Cheng, Stéphane Pillet, Patricia Schimke, Sylvie St-Martin, Sonia Trépanier, Nathalie Landry
Journal: Nat Med
PubMed ID: 34007070
Doi: 10.1038/s41591-021-01370-1
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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
Authors: Silvia Vaena, Paramita Chakraborty, Han Gyul Lee, Alhaji H Janneh, Mohamed Faisal Kassir, Gyda Beeson, Zachariah Hedley, Ahmet Yalcinkaya, M Hanief Sofi, Hong Li, Monica L Husby, Robert V Stahelin, Xue-Zhong Yu, Shikhar Mehrotra, Besim Ogretmen
Journal: Cell Rep
PubMed ID: 33951438
Doi: 10.1016/j.celrep.2021.109076
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Drp1-dependent peptide reverse mitochondrial fragmentation, a homeostatic response in Friedreich ataxia
Authors: Joseph Johnson, Elizabeth Mercado-Ayón, Elisia Clark, David Lynch, Hong Lin
Journal: Pharmacol Res Perspect
PubMed ID: 33951329
Doi: 10.1002/prp2.755
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BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated G activation at early endosomes
Authors: Shane C Wright, Viktoriya Lukasheva, Christian Le Gouill, Hiroyuki Kobayashi, Billy Breton, Samuel Mailhot-Larouche, Élodie Blondel-Tepaz, Nichelle Antunes Vieira, Claudio Costa-Neto, Madeleine Héroux, Nevin A Lambert, Lucas Tabajara Parreiras-E-Silva, Michel Bouvier
Journal: Proc Natl Acad Sci U S A
PubMed ID: 33990469
Doi: 10.1073/pnas.2025846118
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Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities
Authors: Nakamura-Bencomo S, Gutierrez DA, Robles-Escajeda E, Iglesias-Figueroa B, Siqueiros-Cendón TS, Espinoza-Sánchez EA, Arévalo-Gallegos S, Aguilera RJ, Rascón-Cruz Q, Varela-Ramirez A
Journal: Investigational new drugs
PubMed ID: 33063290
Doi: 10.1007/s10637-020-01020-2
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Natural killer cell receptors regulate responses of HLA-E-restricted T cells
Authors: Lucy C Sullivan, Thi H O Nguyen, Christopher M Harpur, Sanda Stankovic, Abbie R Kanagarajah, Marios Koutsakos, Philippa M Saunders, Zhangying Cai, James A Gray, Jacqueline M L Widjaja, Jie Lin, Gabriella Pietra, Maria Cristina Mingari, Lorenzo Moretta, Jerome Samir, Fabio Luciani, Glen P Westall, Karl J Malmberg, Katherine Kedzierska, Andrew G Brooks
Journal: Sci Immunol
PubMed ID: 33893172
Doi: 10.1126/sciimmunol.abe9057
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Ultrasound-responsive nutlin-loaded nanoparticles for combined chemotherapy and piezoelectric treatment of glioblastoma cells
Authors: Carlotta Pucci, Attilio Marino, Özlem Şen, Daniele De Pasquale, Martina Bartolucci, Nerea Iturrioz-Rodríguez, Nicoletta di Leo, Giuseppe de Vito, Doriana Debellis, Andrea Petretto, Gianni Ciofani
Journal: Acta Biomater
PubMed ID: 33894347
Doi: 10.1016/j.actbio.2021.04.005
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Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7
Authors: Akihiro Nakamura, Yoshiyuki Suzuki, Yasumitsu Sakamoto, Saori Roppongi, Chisato Kushibiki, Natsuri Yonezawa, Masato Takahashi, Yosuke Shida, Hiroaki Gouda, Takamasa Nonaka, Nobutada Tanaka, Wataru Ogasawara
Journal: Sci Rep
PubMed ID: 33846449
Doi: 10.1038/s41598-021-86965-x
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Reduced Nucleoprotein Availability Impairs Negative-Sense RNA Virus Replication and Promotes Host Recognition
Authors: Benjamin E Nilsson-Payant, Daniel Blanco-Melo, Skyler Uhl, Beatriz Escudero-Pérez, Silke Olschewski, Patricia Thibault, Maryline Panis, Maria Rosenthal, César Muñoz-Fontela, Benhur Lee, Benjamin R tenOever
Journal: J Virol
PubMed ID: 33568513
Doi: 10.1128/JVI.02274-20
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Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine
Authors: Junhua Mai, Zhaoqi Li, Xiaojun Xia, Jingxin Zhang, Jun Li, Haoran Liu, Jianliang Shen, Maricela Ramirez, Feng Li, Zheng Li, Kenji Yokoi, Xuewu Liu, Elizabeth A Mittendorf, Mauro Ferrari, Haifa Shen
Journal: Adv Sci (Weinh)
PubMed ID: 34194942
Doi: 10.1002/advs.202100166
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