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Surface immune signaling unlocks NLR activation through mRNA alternative splicing

Authors: Chuyun Gao, Xi Meng, Xianchu Chen, Leiyun Yang, Tarhan Ibrahim, AmirAli Toghani, Enoch Lok Him Yuen, Nick Eilmann, Freddie King, Kangping Li, Luyao Wang, Biying Sun, Yuanchao Wang, Tolga Osman Bozkurt, Suomeng Dong

Journal: Science

PubMed ID: 42391383

Doi: 10.1126/science.adx9929

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DGAT1 Inhibition Induces Ferroptosis and Enhances Cancer Immunotherapy Efficacy

Authors: Dong Pan, Meng Jiao, Yanyan Zhu, Mengjie Hu, Fang Li, Jinming Yu, Chuan-Yuan Li

Journal: Cancer Research

PubMed ID: 41812065

Doi: 10.1158/0008-5472.CAN-25-0840

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Substituent-Based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides

Authors: Anirban Das, Ushasi Pramanik, Elise M Brown, Chih-Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E Jackrel, Mark A White, Jai S Rudra

Journal: Advanced Science

PubMed ID: 41560329

Doi: 10.1002/advs.202518567

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A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Authors: Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S L Parker, Yingying Guo, Dongming Zhou

Journal: Advanced Science

PubMed ID: 41431149

Doi: 10.1002/advs.202512262

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Structural snapshots capture nucleotide release at the μ-opioid receptor

Authors: Saif Khan, Aaliyah S Tyson, Mohsen Ranjbar, Zixin Zhang, Jaskaran Singh, Gye Won Han, Cornelius Gati

Journal: Nature

PubMed ID: 41193810

Doi: 10.1038/s41586-025-09677-6.

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A ternary switch model governing ERα ligand binding domain conformation

Authors: Daniel P McDougal, Jordan L Pederick, Scott J Novick, Blagojce Jovcevski, Annmaree K Warrender, Bruce D Pascal, Patrick R Griffin, John B Bruning

Journal: Nature Communications

PubMed ID: 41285747

Doi: 10.1038/s41467-025-65323-9.

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A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome

Authors: Louise Fairall, Kristupas Sirvydis, Robert E Turnbull, Suzan Jg Knottnerus, Oksana Gonchar, Frederick W Muskett, Rebekah Jukes-Jones, Lonneke van Brussel, Ellen van de Geer, Koen van Gassen, Paul Badenhorst, Diana Johnson, Paulien A Terhal, Peter M van Hasselt, Richard H van Jaarsveld, John Wr Schwabe

Journal: Nature Communications

PubMed ID: 41290615

Doi: 10.1038/s41467-025-65472-x.

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Neutrophil elastase-activatable ratiometric photoacoustic nanoprobes for imaging atherosclerotic plaque vulnerability

Authors: Hui Cao, Xin Meng, Yuan Ma, Zhe Li, Xinyu Xu, Jiaqi Fu, Qingpeng Zhang, Hanlin Wei, Peng Liang, Dingyou Lu, Jinyu Li, Baoli Yin, Shuangyan Huan, Xiao-Bing Zhang, Guosheng Song

Journal: Nature Communications

PubMed ID: 41173886

Doi: 10.1038/s41467-025-64633-2

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UDP-glucose Activation of a G-protein/Sucrose Synthase 1 Signaling Supercomplex

Authors: Haiyan Jia, Fei Lou, Justin Watkins, Celio Cabral Oliveira, Christopher G. Tate and Alan M. Jones

Journal: biorxiv

Doi: doi.org/10.1101/2025.09.10.672744

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Vortex-Generated Microdroplets Enable Simple, Rapid, and Low-Volume Measurement of Condensate Volume and Concentration

Authors: Feipeng Chen, Ho Cheung Shum

Journal: Advanced Science

PubMed ID: 40841927

Doi: 10.1002/advs.202511197

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