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The antiviral enzyme viperin inhibits cholesterol biosynthesis

Authors: Timothy J Grunkemeyer, Soumi Ghosh, Ayesha M Patel, Keerthi Sajja, James Windak, Venkatesha Basrur, Youngsoo Kim, Alexey I Nesvizhskii, Robert T Kennedy, E Neil G Marsh

Journal: J Biol Chem

PubMed ID: 34029588

Doi: 10.1016/j.jbc.2021.100824

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Structural basis of tetanus toxin neutralization by native human monoclonal antibodies

Authors: Yueming Wang, Changwen Wu, Jinfang Yu, Shujian Lin, Tong Liu, Lipeng Zan, Nan Li, Po Hong, Xiaoli Wang, Zhenxing Jia, Jason Li, Yao Wang, Ming Zhang, Xiaohui Yuan, Chengming Li, Wenwen Xu, Weihong Zheng, Xinquan Wang, Hua-Xin Liao

Journal: Cell Rep

PubMed ID: 33951441

Doi: 10.1016/j.celrep.2021.109070

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ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-β1

Authors: Masataka Umeda, Nobuya Yoshida, Ryo Hisada, Catalina Burbano, Seo Yeon K Orite, Michihito Kono, Vasileios C Kyttaris, Suzanne Krishfield, Caroline A Owen, George C Tsokos

Journal: Proc Natl Acad Sci U S A

PubMed ID: 33911034

Doi: 10.1073/pnas.2023230118

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Enhanced dengue vaccine virus replication and neutralizing antibody responses in immune primed rhesus macaques

Authors: Michael K McCracken, Caitlin H Kuklis, Chandrika B Kannadka, David A Barvir, Mark A Sanborn, Adam T Waickman, Hayden C Siegfried, Kaitlin A Victor, Kristin L Hatch, Rafael De La Barrera, Shannon D Walls, Wiriya Rutvisuttinunt, Jeffrey R Currier, Heather Friberg, Richard G Jarman, Gregory D Gromowski

Journal: npj Vaccines

PubMed ID: 34021159

Doi: 10.1038/s41541-021-00339-y

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Knockdown of ANXA10 inhibits proliferation and promotes apoptosis of papillary thyroid carcinoma cells by down-regulating TSG101 thereby inactivating the MAPK/ERK signaling pathway

Authors: Tianjun Wei, Xiangming Zhu

Journal: J Bioenerg Biomembr

PubMed ID: 34032966

Doi: 10.1007/s10863-021-09902-7

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Circular RNA ITCH promotes extracellular matrix degradation via activating Wnt/β-catenin signaling in intervertebral disc degeneration

Authors: Feng Zhang, Feili Lin, Zhiwen Xu, Zheng Huang

Journal: Aging (Albany NY)

PubMed ID: 34015763

Doi: 10.18632/aging.203036

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Structural characterization of NORAD reveals a stabilizing role of spacers and two new repeat units

Authors: Uciel Chorostecki, Ester Saus, Toni Gabaldón

Journal: Comput Struct Biotechnol J

PubMed ID: 34141143

Doi: 10.1016/j.csbj.2021.05.045

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Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation

Authors: Ying Xu, Yunxia Dong, Cong Wang, Qian Jiang, Haichao Chu, Yue Tian

Journal: Neurochem Int

PubMed ID: 34048842

Doi: 10.1016/j.neuint.2021.105078

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Extracellular vesicles-encapsulated microRNA-10a-5p shed from cancer-associated fibroblast facilitates cervical squamous cell carcinoma cell angiogenesis and tumorigenicity via Hedgehog signaling pathway

Authors: Zhang X, Wang Y, Wang X, Zou B, Mei J, Peng X, Wu Z

Journal: Cancer gene therapy

PubMed ID: 33235271

Doi: 10.1038/s41417-020-00238-9

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Dopaminergic signalling limits suppressive activity and gut homing of regulatory T cells upon intestinal inflammation

Authors: Ugalde V, Contreras F, Prado C, Chovar O, Espinoza A, Pacheco R

Journal: Mucosal Immunology

PubMed ID: 33184477

Doi: 10.1038/s41385-020-00354-7

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