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Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation
Authors: Rajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, Tomas Smutny, Kryštof Škach, Klara Dohnalova, Lucie Smutna, Dharani Sai Sreekanth Nellore, Jan Dusek, Karel Chalupsky, Jana Hricová, Thales Kronenberger, Aaron Stahl, Markus Templin, Albert Braeuning, Radim Nencka, Petr Pavek
Journal: Journal of Medicinal Chemistry
PubMed ID: 40650588
Doi: 10.1021/acs.jmedchem.4c03134
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An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element
Authors: Hengxia Jia, Shunli Liu, Guibo Rao, Qiaojie Liu, Jiqin Wu, Sheng Cao, Peng Gong
Journal: Sci Adv
PubMed ID: 40249801
Doi: 10.1126/sciadv.adv9640
Products & Services: Gene Synthesis   Custom Vector Construction   
Immunoaffinity Intact Top-Down Mass Spectrometry for Quantification of Neuron-Specific Enolase Gamma, a Low-Abundance Protein Biomarker
Authors: Sebastian A H van den Wildenberg , Sylvia A A M Genet , Maarten A C Broeren , Joost L J van Dongen , Maxime C M van den Oetelaar , Luc Brunsveld , Volkher Scharnhorst , Daan van de Kerkhof
Journal: Anal Chem
PubMed ID: 39710932
Doi: 10.1021/acs.analchem.4c04677
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5′-tRNAGly(GCC) halves generated by IRE1α are linked to the ER stress response
Authors: Hanyong Jin , Ji-Hyun Yeom , Eunkyoung Shin , Yoonjie Ha , Haifeng Liu , Daeyoung Kim , Minju Joo , Yong-Hak Kim , Hak Kyun Kim , Minkyung Ryu, Hong-Man Kim , Jeongkyu Kim , Keun P Kim , Yoonsoo Hahn , Jeehyeon Bae , Kangseok Lee
Journal: Nature Communications
PubMed ID: 39468069
Doi: 10.1038/s41467-024-53624-4
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Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression
Authors: Haley E Adcox , Jason R Hunt , Paige E Allen , Thomas E Siff , Kyle G Rodino , Andrew K Ottens , Jason A Carlyon
Journal: Nature Communications
PubMed ID: 39277599
Doi: 10.1038/s41467-024-52119-6
Products & Services: Custom Vector Construction   Codon Optimization   
Translation of Overlapping Open Reading Frames Promoted by Type 2 IRESs in Avian Calicivirus Genomes
Authors: Yani Arhab , Tatyana V Pestova , Christopher U T Hellen
Journal: Viruses
PubMed ID: 39339889
Doi: 10.3390/v16091413
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Andrographolide influences IDD cell autophagy and oxidative stress under mechanical pressure via miR-9/FoxO3/PINK1/Parkin molecular axis
Authors: Jianwei Liu, Dixing Lin, Jiadong Lu
Journal: Cell Mol Biol (Noisy-le-grand)
PubMed ID: 38836662
Doi: 10.14715/cmb/2024.70.6.29
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One-shot design elevates functional expression levels of a voltage-gated potassium channel
Authors: Jonathan Jacob Weinstein, Chandamita Saikia, Izhar Karbat, Adi Goldenzweig, Eitan Reuveny, Sarel Jacob Fleishman
Journal: Protein Sci
PubMed ID: 38747377
Doi: 10.1002/pro.4995
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Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design
Authors: Manjeet Mukherjee, Philip J Day, Duncan Laverty, Juan A Bueren-Calabuig, Andrew J Woodhead, Charlotte Griffiths-Jones, Steve Hiscock, Charlotte East, Susan Boyd, Marc O'Reilly
Journal: Structure
PubMed ID: 38870939
Doi: 10.1016/j.str.2024.05.011
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