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Internal ribosome entry sites enhance translation in trans in antisense non-coding SINEUP and circular RNAs

Authors: Sabrina D'Agostino, Abraham Tettey-Matey, Massimiliano Volpe, Bianca Pierattini, Mattia D'Agostino, Denisa Smělá, Federico Ansaloni, Laura Broglia, Pierre Lau, Omar Peruzzo, Clarissa Braccia, Andrea Armirotti, Margherita Scarpato, Devid Damiani, Gloria Ros, Valerio Di Carlo, Federica Maniscalco, Elias Bechara, Gian Gaetano Tartaglia, Piero Carninci, Claudio Santoro, Francesca Persichetti, Luca Pandolfini, Angelita Simonetti, Stefano Espinoza, Silvia Zucchelli, Remo Sanges, Carlotta Bon, Stefano Gustincich

Journal: Nucleic Acids Research

PubMed ID: 40823812

Doi: 10.1093/nar/gkaf788

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POSTN-Mediated Interplay of M1 Polarized Macrophage with Tendon-Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?

Authors: Hang Liu, Xinyue Li, Mengyi Li, Ziyang Sun, Xu Wang, Juehong Li, Binbin Xu, Qian Chen, Cunyi Fan, Hongjiang Ruan

Journal: Advanced Science

PubMed ID: 40823759

Doi: 10.1002/advs.202507951

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Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies

Authors: Julia Lederhofer, Andrew J Borst, Lam Nguyen, Rebecca A Gillespie, Connor J Williams, Emma L Walker, Julie E Raab, Christina Yap, Daniel Ellis, Adrian Creanga, Hyon-Xhi Tan, Thi H T Do, Michelle Ravichandran, Adrian B McDermott, Valerie Le Sage, Sarah F Andrews, Barney S Graham, Adam K Wheatley, Douglas S Reed, Neil P King, Masaru Kanekiyo

Journal: Nature Communications

PubMed ID: 40750617

Doi: 10.1038/s41467-025-62339-z.

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Identification of distinct epitopes in dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid

Authors: Shoko Mai https://orcid.org/0000-0001-5468-6851, Yosuke Mai https://orcid.org/0000-0001-6356-7192, Inkin Ujiie https://orcid.org/0000-0002-7931-949X, Kentaro Izumi https://orcid.org/0000-0001-8221-9644, Ken Natsuga https://orcid.org/0000-0003-3865-6366, Wataru Nishie https://orcid.org/0000-0002-0486-9112, and Hideyuki Ujiie

Journal: SCIENCE ADVANCES

PubMed ID: 40749047

Doi: 10.1126/sciadv.adv9423

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Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis

Authors: Emma Schuster, Nurmaa K Dashzeveg, Fangjia Tong, Yuzhi Jia, Lamiaa El-Shennawy, Tong Zhang, Andrew D Hoffman, Reta Birhanu Kitata, Golam Kibria, Youbin Zhang, Joshua R Squires, Chunlei Zheng, Erika Ramos, Rokana Taftaf, David Scholten, Hannah F Almubarak, Valery Adorno-Cruz, David P Sullivan, Carolina Reduzzi, Allegra C Minor, William Purev-Ochir, Sabina Spahija, Rong Xu, Kalliopi P Siziopikou, Leonidas C Platanias, Ami Shah, William A Muller, William J Gradishar, Massimo Cristofanilli, Chia-Feng Tsai, Tujin Shi, Huiping Liu

Journal: Nature Communications

PubMed ID: 40818975

Doi: 10.1038/s41467-025-62862-z

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Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

Authors: Martin Steger, Gisele Nishiguchi, Qiong Wu, Bjoern Schwalb, Bachuki Shashikadze, Kevin McGowan, Marisa Actis, Anup Aggarwal, Zhe Shi, Jeanine Price, Anand Mayasundari, Lei Yang, Anastasia H Bednarz, Sophie Machata, Tobias Graef, Denis Bartoschek, Vadim Demichev, Uli Ohmayer, Jun Yang, Henrik Daub, Zoran Rankovic

Journal: Nature Communications

PubMed ID: 40835825

Doi: 10.1038/s41467-025-62829-0.

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The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress

Authors: Qianqian Dong, Matthew Day, Yuichiro Saito, Emma Parker, Lotte P Watts, Masato T Kanemaki, Antony W Oliver, Laurence H Pearl, Shin-Ichiro Hiraga, Anne D Donaldson

Journal: Nature Communications

PubMed ID: 40595496

Doi: 10.1038/s41467-025-60817-y

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Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation

Authors: Rajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, Tomas Smutny, Kryštof Škach, Klara Dohnalova, Lucie Smutna, Dharani Sai Sreekanth Nellore, Jan Dusek, Karel Chalupsky, Jana Hricová, Thales Kronenberger, Aaron Stahl, Markus Templin, Albert Braeuning, Radim Nencka, Petr Pavek

Journal: Journal of Medicinal Chemistry

PubMed ID: 40650588

Doi: 10.1021/acs.jmedchem.4c03134

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Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma

Authors: Bartimée Galvan, Loïc Ongena, Jonathan Bruyr, Gregory Fettweis, Eva Lucarelli, Arnaud Lavergne, Emeline Mariavelle, Tina M O'Grady, Zahrat El Oula Hassoun, Margaux Claes, Laurence Dubois, Kevin A W Lee, Véronique Kruys, Cyril Gueydan, Jules Durand, Eric Hervouet, Florian H Geyer, Ana Banito, Roland Imle, Lianghao Mao, Ashok K Jayavelu, Thomas G P Grünewald, Florencia Cidre-Aranaz, Jean-Claude Twizere, Franck Dequiedt

Journal: Nature Communications

PubMed ID: 40664627

Doi: 10.1038/s41467-025-61725-x

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Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation

Authors: Xiaoman Ju, Eva Maria Putz, Yaqi Liu, Dongchen Yuan, Guowei Sun, Stephane Koda, Zhuo Fu, Simin Shao, Chunrong Tong, Biping Deng, Jing Hu, Juming Yan

Journal: Nature Communications

PubMed ID: 40593670

Doi: 10.1038/s41467-025-60922-y.

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