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Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC)

Authors: Raghuvir Viswanatha, Samuel Entwisle, Yanhui Hu, Ah-Ram Kim, Kelly Reap, Matthew Butnaru, Mujeeb Qadiri, Stephanie E Mohr, Norbert Perrimon

Journal: Nature Communications

PubMed ID: 40659672

Doi: 10.1038/s41467-025-61692-3

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Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Authors: Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S Yarla, Lu Wang, Jindan Yu, Jonathan C Zhao, Ivet Bahar, Yong Wan

Journal: Advanced Science

PubMed ID: 40671262

Doi: 10.1002/advs.202415585

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O-GalNAc Glycosylation Activates MBL-Mediated Complement and Coagulation Cascades to Drive Organotropic Metastasis

Authors: Xinyu Chen, Wei Bao, Kaiyuan Liu, Na Jing, Genyu Du, Luyao Jiang, Qian You, Yingchao Zhang, Penghui Xu, Chaping Cheng, Nan Wang, Xialian Xi, Mingyue Wang, Yiyun Liu, Jinming Wang, Huifang Zhao, Shilei Zhang, Dinglan Wu, Chi-Fai Ng, Jiahua Pan, Wei Xue, Wei-Qiang Gao, Pengcheng Zhang, Kai Zhang, Helen He Zhu

Journal: Advanced Science

PubMed ID: 40492591

Doi: 10.1002/advs.202504809

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Structure of bifunctional variediene synthase yields unique insight on biosynthetic diterpene assembly and cyclization

Authors: Eliott S Wenger, David W Christianson

Journal: Nature Communications

PubMed ID: 39677668

Doi: 10.1101/2024.12.03.626647

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Large-scale experimental assessment of variant effects on the structure and function of the citrate transporter SLC13A5

Authors: Wen-An Wang, Evandro Ferrada, Christoph Klimek, Tanja Osthushenrich, Aidan MacNamara, Tabea Wiedmer, Giulio Superti-Furga

Journal: SCIENCE ADVANCES

PubMed ID: 40577459

Doi: 10.1126/sciadv.adx3011

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Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI

Authors: Edward D B Lopatto, Jesús M Santiago-Borges, Denise A Sanick, Sameer Kumar Malladi, Philippe N Azimzadeh, Morgan W Timm, Isabella F Fox, Aaron J Schmitz, Jackson S Turner, Shaza M Sayed Ahmed, Lillian Ortinau, Nathaniel C Gualberto, Jerome S Pinkner, Karen W Dodson, Ali H Ellebedy, Andrew L Kau, Scott J Hultgren

Journal: SCIENCE ADVANCES

PubMed ID: 40540557

Doi: 10.1126/sciadv.adw0698

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Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Authors: Alexandra Teslenko , Beat Fierz

Journal: SCIENCE ADVANCES

PubMed ID: 40397729

Doi: 10.1126/sciadv.adt7013

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Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3

Authors: Qishun Zhou, Theo Sagmeister, Saskia Hutten, Benjamin Bourgeois, Tea Pavkov-Keller, Dorothee Dormann, Tobias Madl

Journal: Nature Communications

PubMed ID: 40360518

Doi: 10.1038/s41467-025-59802-2

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LLPS REDIFINE allows the biophysical characterization of multicomponent condensates without tags or labels

Authors: Mihajlo Novakovic, Yaning Han, Nina C Kathe, Yinan Ni, Leonidas Emmanouilidis, Frédéric H-T Allain

Journal: Nature Communications

PubMed ID: 40389460

Doi: 10.1038/s41467-025-59759-2

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The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin

Authors: Irina S Abaeva, Alexander G Bulakhov, Christopher U T Hellen, Tatyana V Pestova

Journal: Genes Dev

PubMed ID: 40169231

Doi: 10.1101/gad.352389.124

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