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Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation

Authors: Jun Nagai, Madeline M Hastings, Airi Nishida, Sreyashi Majumdar, Kendall Zaleski, Sofia A Marshall, Junrui Lin, Mira A S Saliman, Yumi Tani, Yamato Murakami, Chunli Feng, Alexander Perniss, Caitlin Wong, Lora G Bankova, Asuka Inoue, Nora A Barrett, Joshua A Boyce

Journal: Cell Reports

PubMed ID: 41422505

Doi: 10.1016/j.celrep.2025.116758

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Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Authors: Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong-Hui Zheng

Journal: Advanced Science

PubMed ID: 41324484

Doi: 10.1002/advs.202519256

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Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatocellular carcinoma

Authors: Yan Huang, Shaoli Liu, Xiaoju Zhang, Bingxu Zhang, Feng Shi, Jia Zhang, Shuaibo Shao, Hongya Han, Xiaoyun Ma, Jing Xie, Jianqi Zhang, Hongxiaoying Yu, Yongchao Zhao, Jiazheng Jin, Dong Xu, Liang Liu, Jianing Wang, Yu Tan, Kelu Xu, Lushuai Jin, Quanjun Du, Yifeng Geng, Andong Liu, Wei Xu

Journal: Nature Communications

PubMed ID: 41397962

Doi: 10.1038/s41467-025-66087-y

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β-sheet stabilization of the island domain underlies ligand-induced LRR-RP activation of plant immune signaling

Authors: Simon Snoeck, Lisha Zhang, Valentin Studer, Gijeong Kim, Álvaro D Fernández-Fernández, Thorsten Nürnberger, Cyril Zipfel

Journal: Nature Communications

PubMed ID: 41361182

Doi: 10.1038/s41467-025-66119-7

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SLC45A4 encodes a peroxisomal putrescine transporter that promotes GABA de novo synthesis

Authors: Cecilia Colson, Yujue Wang, James Atherton, Nisha Rani Dahiya, Davood Kharaghani, Xiaoyang Su

Journal: Nature Communications

PubMed ID: 41266324

Doi: 10.1038/s41467-025-62721-x.

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UDP-glucose Activation of a G-protein/Sucrose Synthase 1 Signaling Supercomplex

Authors: Haiyan Jia, Fei Lou, Justin Watkins, Celio Cabral Oliveira, Christopher G. Tate and Alan M. Jones

Journal: biorxiv

Doi: doi.org/10.1101/2025.09.10.672744

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Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states

Authors: Tomasz Włodarczyk, Aaron Lun, Diana Wu, Minyi Shi, Xiaofen Ye, Shreya Menon, Shushan Toneyan, Kerstin Seidel, Liang Wang, Jenille Tan, Shang-Yang Chen, Timothy Keyes, Aleksander Chlebowski, Adrian Waddell, Wei Zhou, Yangmeng Wang, Qiuyue Yuan, Yu Guo, Liang-Fu Chen, Bence Daniel, Antonina Hafner, Meng He, Alejandro Chibly, Yuxin Liang, Zhana Duren, Ciara Metcalfe, Marc Hafner, Christian W Siebel, M Ryan Corces, Robert Yauch, Shiqi Xie, Xiaosai Yao

Journal: Nature Communications

PubMed ID: 40753156

Doi: 10.1038/s41467-025-62252-5.

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Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis

Authors: Susovan Sarkar, Hao-Yang Liu, Feng Yuan, Brandon T Malady, Liping Wang, Eileen M Lafer, Jessica Perez, Jon M Huibregtse, Jeanne C Stachowiak

Journal: Nature Communications

PubMed ID: 40854908

Doi: 10.1038/s41467-025-63238-z.

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Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH

Authors: Dhanya Thamaraparambil Jayaram, Pranav Sivaram, Pranjal Biswas, Yue Dai, Elizabeth A Sweeny, Dennis J Stuehr

Journal: Nature Communications

PubMed ID: 40858607

Doi: 10.1038/s41467-025-62819-2.

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Genetic architecture of a light-temperature coincidence detector

Authors: Adam Seluzicki , Joanne Chory

Journal: Nature Communications

PubMed ID: 40858539

Doi: 10.1038/s41467-025-62194-y.

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