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Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatocellular carcinoma

Authors: Yan Huang, Shaoli Liu, Xiaoju Zhang, Bingxu Zhang, Feng Shi, Jia Zhang, Shuaibo Shao, Hongya Han, Xiaoyun Ma, Jing Xie, Jianqi Zhang, Hongxiaoying Yu, Yongchao Zhao, Jiazheng Jin, Dong Xu, Liang Liu, Jianing Wang, Yu Tan, Kelu Xu, Lushuai Jin, Quanjun Du, Yifeng Geng, Andong Liu, Wei Xu

Journal: Nature Communications

PubMed ID: 41397962

Doi: 10.1038/s41467-025-66087-y

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β-sheet stabilization of the island domain underlies ligand-induced LRR-RP activation of plant immune signaling

Authors: Simon Snoeck, Lisha Zhang, Valentin Studer, Gijeong Kim, Álvaro D Fernández-Fernández, Thorsten Nürnberger, Cyril Zipfel

Journal: Nature Communications

PubMed ID: 41361182

Doi: 10.1038/s41467-025-66119-7

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SLC45A4 encodes a peroxisomal putrescine transporter that promotes GABA de novo synthesis

Authors: Cecilia Colson, Yujue Wang, James Atherton, Nisha Rani Dahiya, Davood Kharaghani, Xiaoyang Su

Journal: Nature Communications

PubMed ID: 41266324

Doi: 10.1038/s41467-025-62721-x.

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UDP-glucose Activation of a G-protein/Sucrose Synthase 1 Signaling Supercomplex

Authors: Haiyan Jia, Fei Lou, Justin Watkins, Celio Cabral Oliveira, Christopher G. Tate and Alan M. Jones

Journal: bioRxiv

Doi: doi.org/10.1101/2025.09.10.672744

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Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states

Authors: Tomasz Włodarczyk, Aaron Lun, Diana Wu, Minyi Shi, Xiaofen Ye, Shreya Menon, Shushan Toneyan, Kerstin Seidel, Liang Wang, Jenille Tan, Shang-Yang Chen, Timothy Keyes, Aleksander Chlebowski, Adrian Waddell, Wei Zhou, Yangmeng Wang, Qiuyue Yuan, Yu Guo, Liang-Fu Chen, Bence Daniel, Antonina Hafner, Meng He, Alejandro Chibly, Yuxin Liang, Zhana Duren, Ciara Metcalfe, Marc Hafner, Christian W Siebel, M Ryan Corces, Robert Yauch, Shiqi Xie, Xiaosai Yao

Journal: Nature Communications

PubMed ID: 40753156

Doi: 10.1038/s41467-025-62252-5.

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Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH

Authors: Dhanya Thamaraparambil Jayaram, Pranav Sivaram, Pranjal Biswas, Yue Dai, Elizabeth A Sweeny, Dennis J Stuehr

Journal: Nature Communications

PubMed ID: 40858607

Doi: 10.1038/s41467-025-62819-2.

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Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis

Authors: Susovan Sarkar, Hao-Yang Liu, Feng Yuan, Brandon T Malady, Liping Wang, Eileen M Lafer, Jessica Perez, Jon M Huibregtse, Jeanne C Stachowiak

Journal: Nature Communications

PubMed ID: 40854908

Doi: 10.1038/s41467-025-63238-z.

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Genetic architecture of a light-temperature coincidence detector

Authors: Adam Seluzicki , Joanne Chory

Journal: Nature Communications

PubMed ID: 40858539

Doi: 10.1038/s41467-025-62194-y.

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LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation

Authors: Dhanusha A Nalawansha, Georgios Mazis, Gitte Husemoen, Kate S Ashton, Weixian Deng, Ryan P Wurz, Anh T Tran, Brian A Lanman, Jiansong Xie, Robert G Guenette, Shiqian Li, Christopher E Smith, Suresh Archunan, Manoj K Agnihotram, Arghya Sadhukhan, Rajiv Kapoor, Chris Wilde, Sajjan Koirala, Felipe De Sousa E Melo, Patrick Ryan Potts

Journal: Nature Communications

PubMed ID: 40841368

Doi: 10.1038/s41467-025-63128-4.

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Internal ribosome entry sites enhance translation in trans in antisense non-coding SINEUP and circular RNAs

Authors: Sabrina D'Agostino, Abraham Tettey-Matey, Massimiliano Volpe, Bianca Pierattini, Mattia D'Agostino, Denisa Smělá, Federico Ansaloni, Laura Broglia, Pierre Lau, Omar Peruzzo, Clarissa Braccia, Andrea Armirotti, Margherita Scarpato, Devid Damiani, Gloria Ros, Valerio Di Carlo, Federica Maniscalco, Elias Bechara, Gian Gaetano Tartaglia, Piero Carninci, Claudio Santoro, Francesca Persichetti, Luca Pandolfini, Angelita Simonetti, Stefano Espinoza, Silvia Zucchelli, Remo Sanges, Carlotta Bon, Stefano Gustincich

Journal: Nucleic Acids Research

PubMed ID: 40823812

Doi: 10.1093/nar/gkaf788

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