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The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist

Authors: Christian Berg, Michael J Wedemeyer, Motiejus Melynis, Roman R Schlimgen, Lasse H Hansen, Jon Våbenø, Francis C Peterson, Brian F Volkman, Mette M Rosenkilde, Hans R Lüttichau

Journal: PLoS Pathog

PubMed ID: 35271688

Doi: 10.1371/journal.ppat.1010355

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Rapid Exchange of Stably Bound Protein and DNA Cargo on a DNA Origami Receptor

Authors: James W P Brown, Rokiah G Alford, James C Walsh, Richard E Spinney, Stephanie Y Xu, Sophie Hertel, Jonathan F Berengut, Lisanne M Spenkelink, Antoine M van Oijen, Till Böcking, Richard G Morris, Lawrence K Lee

Journal: ACS Nano

PubMed ID: 35316035

Doi: 10.1021/acsnano.2c00699

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Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT

Authors: Bin Li, Minshik Jo, Jianxin Liu, Jiayi Tian, Robert Canfield, Jennifer Bridwell-Rabb

Journal: Commun Biol

PubMed ID: 35347217

Doi: 10.1038/s42003-022-03226-x

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Generation of Gal-enhanced bifunctional tumor vaccine

Authors: Jian He, Yu Huo, Zhikun Zhang, Yiqun Luo, Xiuli Liu, Qiaoying Chen, Pan Wu, Wei Shi, Tao Wu, Chao Tang, Huixue Wang, Lan Li, Xiyu Liu, Yong Huang, Yongxiang Zhao, Lu Gan, Bing Wang, Liping Zhong

Journal: Acta Pharm Sin B

PubMed ID: 35865091

Doi: 10.1016/j.apsb.2022.03.002

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Characterization of SARS-CoV-2 Variants B16171 (Kappa), B16172 (Delta), and B1618 by Cell Entry and Immune Evasion

Authors: Wenlin Ren, Xiaohui Ju, Mingli Gong, Jun Lan, Yanying Yu, Quanxin Long, Devin J Kenney, Aoife K O'Connell, Yu Zhang, Jin Zhong, Guocai Zhong, Florian Douam, Xinquan Wang, Ailong Huang, Rong Zhang, Qiang Ding

Journal: MBio

PubMed ID: 35266815

Doi: 10.1128/mbio.00099-22

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Accurate positioning of functional residues with robotics-inspired computational protein design

Authors: Cody Krivacic, Kale Kundert, Xingjie Pan, Roland A Pache, Lin Liu, Shane O Conchúir, Jeliazko R Jeliazkov, Jeffrey J Gray, Michael C Thompson, James S Fraser, Tanja Kortemme

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35254891

Doi: 10.1073/pnas.2115480119

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Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion

Authors: Chia-Jung Li, Tai-Ling Chao, Ting-Yu Chang, Chia-Chun Hsiao, De-Chao Lu, Yi-Wei Chiang, Guan-Chun Lai, Ya-Min Tsai, Jun-Tung Fang, Siman Ieong, Jann-Tay Wang, Sui-Yuan Chang, Shih-Chung Chang

Journal: Microbiol Spectr

PubMed ID: 35293796

Doi: 10.1128/spectrum.01814-21

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Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host

Authors: Francesca D'Angelo, Elena Fernández-Fueyo, Pierre Simon Garcia, Helena Shomar, Martin Pelosse, Rita Rebelo Manuel, Ferhat Büke, Siyi Liu, Niels van den Broek, Nicolas Duraffourg, Carol de Ram, Martin Pabst, Emmanuelle Bouveret, Simonetta Gribaldo, Béatrice Py, Sandrine Ollagnier de Choudens, Frédéric Barras, Gregory Bokinsky

Journal: Elife

PubMed ID: 35244541

Doi: 10.7554/eLife.70936

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CRISPR/Cas9-Based Mutagenesis of Histone H31 in Spinal Dynorphinergic Neurons Attenuates Thermal Sensitivity in Mice

Authors: Zoltán Mészár, Éva Kókai, Rita Varga, László Ducza, Tamás Papp, Monika Béresová, Marianna Nagy, Péter Szücs, Angelika Varga

Journal: Int J Mol Sci

PubMed ID: 35328599

Doi: 10.3390/ijms23063178

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Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities

Authors: Suhail Khoja, Jenna Lambert, Matthew Nitzahn, Adam Eliav, YuChen Zhang, Mikayla Tamboline, Colleen T Le, Eram Nasser, Yunfeng Li, Puja Patel, Irina Zhuravka, Lindsay M Lueptow, Ilona Tkachyova, Shili Xu, Itzhak Nissim, Andreas Schulze, Gerald S Lipshutz

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35505663

Doi: 10.1016/j.omtm.2022.03.015

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