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Low pH structure of heliorhodopsin reveals chloride binding site and intramolecular signaling pathway

Authors: Jessica E Besaw, Jörg Reichenwallner, Paolo De Guzman, Andrejs Tucs, Anling Kuo, Takefumi Morizumi, Koji Tsuda, Adnan Sljoka, R J Dwayne Miller, Oliver P Ernst

Journal: Sci Rep

PubMed ID: 35977989

Doi: 10.1038/s41598-022-17716-9

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Case report: A novel loss-of-function pathogenic variant in the KCNA1 cytoplasmic N-terminus causing carbamazepine-responsive type 1 episodic ataxia

Authors: Rían W Manville, Richard Sidlow, Geoffrey W Abbott

Journal: Front Neurol

PubMed ID: 36016548

Doi: 10.3389/fneur.2022.975849

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Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

Authors: Torleif Tollefsrud Gjølberg, Rahel Frick, Simone Mester, Stian Foss, Algirdas Grevys, Lene Støkken Høydahl, Øystein Kalsnes Jørstad, Tilman Schlothauer, Inger Sandlie, Morten C Moe, Jan Terje Andersen

Journal: Commun Biol

PubMed ID: 35982144

Doi: 10.1038/s42003-022-03787-x

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Exfoliative Toxin E, Oligomeric State and Flip of P186: Implications for Its Action Mechanism

Authors: Carolina Gismene, Jorge Enrique Hernández González, Angela Rocio Niño Santisteban, Andrey Fabricio Ziem Nascimento, Lucas Dos Santos Cunha, Fábio Rogério de Moraes, Cristiano Luis Pinto de Oliveira, Caio C Oliveira, Paola Jocelan Scarin Provazzi, Pedro Geraldo Pascutti, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti

Journal: Int J Mol Sci

PubMed ID: 36077258

Doi: 10.3390/ijms23179857

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Efﬁcacy of glucose transporter inhibitors for the treatment of ERRα-overexpressed colorectal cancer

Authors: Miao Zhao, Cairong Xu, Hui Zhu

Journal: Acta Biochim Pol

PubMed ID: 36026615

Doi: 10.18388/abp.2020_5852

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T cells use distinct topographical and membrane receptor scanning strategies that individually coalesce during receptor recognition

Authors: En Cai, Casey Beppler, John Eichorst, Kyle Marchuk, Scott W Eastman, Matthew F Krummel

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35914144

Doi: 10.1073/pnas.2203247119

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The neurodevelopmental gene MSANTD2 belongs to a gene family formed by recurrent molecular domestication of Harbinger transposons at the base of vertebrates

Authors: Ema Etchegaray, Dominique Baas, Magali Naville, Zofia Haftek-Terreau, Jean Nicolas Volff

Journal: Mol Biol Evol

PubMed ID: 35980103

Doi: 10.1093/molbev/msac173

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Immunoprophylaxis using polypeptide chimera vaccines plus adjuvant system promote Th1 response controlling the spleen parasitism in hamster model of visceral leishmaniasis

Authors: Miriã Rodrigues Gusmão, Thaís Lopes Valentim Di Paschoali Ostolin, Lívia Mendes Carvalho, Ana Flávia Pereira Costa, Gabriel José Lucas Moreira, Jamille Mirelle de Oliveira Cardoso, Rodrigo Dian de Oliveira Aguiar-Soares, Alexandre Barbosa Reis, Rory Cristiane Fortes de Brito, Bruno Mendes Roatt

Journal: Vaccine

PubMed ID: 35963820

Doi: 10.1016/j.vaccine.2022.08.005

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Second-Generation SuptoxR Strains for High-Level Recombinant Membrane Protein Production

Authors: Eleni Vasilopoulou, Artemis Giannakopoulou, Charalampos Kapsalis, Myrsini Michou, Aristeidis Michoglou-Sergiou, Fragiskos N Kolisis, Georgios Skretas

Journal: ACS Synth Biol

PubMed ID: 35922033

Doi: 10.1021/acssynbio.1c00598

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TCR extracellular domain genetically linked to CD28, 2B4/41BB and DAP10/CD3ζ -engineered NK cells mediates antitumor effects

Authors: Shance Li, Chaoting Zhang, Luyan Shen, Xia Teng, Yefei Xiao, Bentong Yu, Zheming Lu

Journal: Cancer Immunol Immunother

PubMed ID: 35988132

Doi: 10.1007/s00262-022-03275-5

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