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Viruses inhibit TIR gcADPR signaling to overcome bacterial defense

Authors: Azita Leavitt, Erez Yirmiya, Gil Amitai, Allen Lu, Jeremy Garb, Ehud Herbst, Benjamin R Morehouse, Samuel J Hobbs, Sadie P Antine, Zhen-Yu J Sun, Philip J Kranzusch, Rotem Sorek

Journal: Nature

PubMed ID: 36174646

Doi: 10.1038/s41586-022-05375-9

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Effect of Foot-and-Mouth Disease Virus 2B Viroporin on Expression and Extraction of Mammalian Cell Culture Produced Foot-and-Mouth Disease Virus-like Particles

Authors: Victoria Primavera, Janine Simmons, Benjamin A Clark, John G Neilan, Michael Puckette

Journal: Vaccines (Basel)

PubMed ID: 36146583

Doi: 10.3390/vaccines10091506

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miR-3651 Participates in the Growth Cycle of Hepatocellular Carcinoma Cells and Promotes the Malignant Metastasis via the PI3K/AKT/mTOR Signalling Pathway

Authors: Yawei Liu, Litian Hu, Qinqiang Liu, Jing Ye, Jianping Zhang

Journal: J Oncol

PubMed ID: 36245984

Doi: 10.1155/2022/5744999

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Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

Authors: Callum Beach; David MacLean; Dominika Majorova; Stavros Melemenidis; Dhanya K. Nambiar; Ryan K. Kim; Gabriel N. Valbuena; Silvia Guglietta; Carsten Krieg; Mahnaz Darvish-Damavandi; Tatsuya Suwa; Alistair Easton; Lily V.S. Hillson; Ashley K. McCulloch; Ross K. McMahon; Kathryn Pennel; Joanne Edwards; Sean M. O Cathail; Campbell S. Roxburgh; Enric Domingo; Eui Jung Moon; Dadi Jiang; Yanyan Jiang; Qingyang Zhang; Albert C. Koong; Trent M. Woodruff; Edward E. Graves; Tim Maughan; Simon J.A. Buczacki; Manuel Stucki; Quynh-Thu Le; Simon J. Leedham; Amato J. Giaccia; Monica M. Olcina

Journal: The Journal of clinical investigation

PubMed ID: 37824211

Doi: 10.1172/JCI168277

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Proposal to Consider Chemical/Physical Microenvironment as a New Therapeutic Off-Target Approach

Authors: Alessandro Giuliani, Stefano Fais

Journal: Pharmaceutics

PubMed ID: 36297518

Doi: 10.3390/pharmaceutics14102084

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Protein Stabilization by Alginate Binding and Suppression of Thermal Aggregation

Authors: Roger Chang, Martin Gruebele, Deborah E Leckband

Journal: Biomacromolecules

PubMed ID: 36054903

Doi: 10.1021/acs.biomac.2c00297

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Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

Authors: Cathrine Scheepers, Prudence Kgagudi, Nonkululeko Mzindle, Elin S Gray, Thandeka Moyo-Gwete, Bronwen E Lambson, Brent Oosthuysen, Batsirai Mabvakure, Nigel J Garrett, Salim S Abdool Karim, Lynn Morris, Penny L Moore

Journal: PLoS Pathog

PubMed ID: 36054228

Doi: 10.1371/journal.ppat.1010450

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Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA275

Authors: Qian Wang, Sho Iketani, Zhiteng Li, Yicheng Guo, Andre Yanchen Yeh, Michael Liu, Jian Yu, Zizhang Sheng, Yaoxing Huang, Lihong Liu, David D Ho

Journal: Cell Host Microbe

PubMed ID: 36108630

Doi: 10.1016/j.chom.2022.09.002

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Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

Journal: The Journal of clinical investigation

PubMed ID: 37824211

Doi: 10.1172/JCI168277

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Evasion of neutralizing antibody responses by the SARS-CoV-2 BA275 variant

Authors: Panke Qu, John P Evans, Yi-Min Zheng, Claire Carlin, Linda J Saif, Eugene M Oltz, Kai Xu, Richard J Gumina, Shan-Lu Liu

Journal: Cell Host Microbe

PubMed ID: 36240764

Doi: 10.1016/j.chom.2022.09.015

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