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Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe

Authors: Pedro Ortega, Elodie Bournique, Junyi Li, Ambrocio Sanchez, Gisselle Santiago, Brooke R Harris, Josefine Striepen, John Maciejowski, Abby M Green, Rémi Buisson

Journal: SCIENCE ADVANCES

PubMed ID: 40238882

Doi: 10.1126/sciadv.adu0437

Products & Services: Gene Synthesis

Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1

Authors: Vincent Villeret

Journal: Nature Communications

PubMed ID: 40263353

Doi: 10.1038/s41467-025-59014-8

Products & Services: Gene Synthesis

Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine

Authors: Kalvis Brangulis, Jill Malfetano, Ashley L. Marcinkiewicz, Alan Wang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Xiuli Yang, Ulrich Strych, Dagnija Tupina, Inara Akopjana, Maria-Elena Bottazzi, Utpal Pal, Ching-Lin Hsieh, Wen-Hsiang Chen & Yi-Pin Lin

Journal: Nature Communications

PubMed ID: 40189575

Doi: 10.1038/s41467-025-58182-x

Products & Services: Gene Synthesis

Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5

Authors: Zhefan Stephen Chen, Shaohong Isaac Peng, Lok I Leong, Terence Gall-Duncan, Nathan Siu Jun Wong, Tsz Ho Li, Xiao Lin, Yuming Wei, Alex Chun Koon, Junzhe Huang, Jacquelyne Ka-Li Sun, Clinton Turner, Lynette Tippett, Maurice A. Curtis, Richard L. M. Faull, Kin Ming Kwan, Hei-Man Chow, Ho Ko, Ting-Fung Chan, Kevin Talbot, Christopher E. Pearson & Ho Yin Edwin Chan

Journal: Nature Communications

PubMed ID: 40204699

Doi: 10.1038/s41467-025-58618-4

Products & Services: Gene Synthesis

Modified pegRNAs mitigate scaffold-derived prime editing by-products

Authors: Panagiotis Antoniou, Louis Dacquay, Hanna Mårtensson, Katja Madeyski-Bengtson, Anna-Lena Loyd, Anna Shiriaeva, Euan Gordon, Salman Mustfa, George Thom, Pei-Pei Hsieh, Saša Šviković, Mike Firth, Nina Akrap, Marcello Maresca & Martin Peterka

Journal: Nature Communications

PubMed ID: 40204736

Doi: 10.1038/s41467-025-58653-1

Products & Services: Gene Synthesis

Architecture and conformational dynamics of the BAM-SurA holo insertase complex

Authors: Philippe A Lehner, Morris Degen, Roman P Jakob, Seyed Majed Modaresi, Morgane Callon, Björn M Burmann, Timm Maier, Sebastian Hiller

Journal: SCIENCE ADVANCES

PubMed ID: 40184469

Doi: 10.1126/sciadv.ads6094

Products & Services: Gene Synthesis

Unexpected enzymatic function of an ancient nucleic acid-binding fold

Authors: Rylan R Watkins, Stella Bockelman, Anna Vradi, Kaylee Grabarkewitz, Alexa Pyun, Josephine Stark, Vicki H Wysocki, Juan D Alfonzo, Karin Musier-Forsyth

Journal: Nucleic Acids Research

PubMed ID: 40274265

Doi: 10.1093/nar/gkaf328

Products & Services: Gene Synthesis

DNA-guided transcription factor interactions extend human gene regulatory code

Authors: Zhiyuan Xie, Ilya Sokolov, Maria Osmala, Xue Yue, Grace Bower, J. Patrick Pett, Yinan Chen, Kai Wang, Ayse Derya Cavga, Alexander Popov, Sarah A. Teichmann, Ekaterina Morgunova, Evgeny Z. Kvon, Yimeng Yin & Jussi Taipale

Journal: Nature

PubMed ID: 40205063

Doi: 10.1038/s41586-025-08844-z

Products & Services: Gene Synthesis

Enzymatic oxidation of galacturonides from pectin breakdown contributes to stealth infection by Oomycota phytopathogens

Authors: Simone Turella, Cheng He, Lin Zhao, Sanchari Banerjee, Lauriane Plouhinec, Roseline Assiah Yao, Mette Christine Nørgaard Kejlstrup, Sacha Grisel, Yunjeong So, Bastien Annic, Mathieu Fanuel, Majid Haddad Momeni, Bastien Bissaro, Sebastian Meier, Jens Preben Morth, Suomeng Dong, Jean-Guy Berrin & Maher Abou Hachem

Journal: Nature Communications

PubMed ID: 40216756

Doi: 10.1038/s41467-025-58668-8

Products & Services: Gene Synthesis

Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation

Authors: Ryan P McGlinchey, Sashary Ramos, Emilios K Dimitriadis, C Blake Wilson, Jennifer C Lee

Journal: Nature Communications

PubMed ID: 40268916

Doi: 10.1038/s41467-025-58899-9

Products & Services: Gene Synthesis