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A powerful and highly efficient PAI-mediated transgenesis approach in Drosophila

Authors: Wangfei Shi, Xuedi Zhang, Angyang Sun, Jie Zheng, Kailong Zhuang, Ziheng Chen, Ju Peng, Pengchong Fu, Guanjun Gao

Journal: Nucleic Acids Research

PubMed ID: 40266685

Doi: 10.1093/nar/gkaf317

Products & Services: Gene Synthesis

Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel

Authors: Young-Woo Nam, Dohyun Im, Ana Santa Cruz Garcia, Marios L Tringides, Hai Minh Nguyen, Yan Liu, Razan Orfali, Alena Ramanishka, Grigore Pintilie, Chih-Chia Su, Meng Cui, Diomedes E Logothetis, Edward W Yu, Heike Wulff, K George Chandy, Miao Zhang

Journal: Nat Commun

PubMed ID: 40246884

Doi: /10.1038/s41467-025-59061-1

Products & Services: Gene Synthesis

Discovery of diverse and high-quality mRNA capping enzymes through a language model–enabled platform

Authors: Tianze Wang, Bowen R Qin, Sihong Li, Zimo Wang, Xuejian Li, Yuanxu Jiang, Chenrui Qin, Qi Ouyang, Chunbo Lou, Long Qian

Journal: SCIENCE ADVANCES

PubMed ID: 40203090

Doi: 10.1126/sciadv.adt0402

Products & Services: Gene Synthesis

Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair

Authors: Marianna Genta, Giulia Ferrara, Riccardo Capelli, Diego Rondelli, Sarah Sertic, Martino Bolognesi, Menico Rizzi, Franca Rossi, David Jeruzalmi, Antonio Chaves-Sanjuan & Riccardo Miggiano

Journal: Nature Communications

PubMed ID: 40210888

Doi: 10.1038/s41467-025-58670-0

Products & Services: Gene Synthesis

Molecular basis of human GABA transporter 3 inhibition

Authors: Ravi Yadav, Gye Won Han, Cornelius Gati

Journal: Nature Communications

PubMed ID: 40268946

Doi: 10.1038/s41467-025-59066-w

Products & Services: Gene Synthesis

The structure and function of the ghrelin receptor coding for drug actions

Authors: Yuki Shiimura, Dohyun Im, Ryosuke Tany, Hidetsugu Asada, Ryoji Kise, Eon Kurumiya, Hideko Wakasugi-Masuho, Satoshi Yasuda, Kazuma Matsui, Jun-Ichi Kishikawa, Takayuki Kato, Takeshi Murata, Masayasu Kojima, So Iwata, Ikuo Masuho

Journal: Nat Struct Mol Biol

PubMed ID: 39833471

Doi: 39833471

Products & Services: Gene Synthesis

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

Authors: Wenyang Li, Robert P Sparks, Cheng Sun, Yang Yang, Lorena Pantano, Rory Kirchner, Nahid Arghiani, Arden Weilheimer, Benjamin J Toles, Jennifer Y Chen, Sean P Moran, Victor Barrera, Zixiu Li, Peng Zhou, Meghan L Brassil, David Wrobel, Shannan J Ho Sui, Gary Aspnes, Michael Schuler, Jennifer Smith, Benjamin D Medoff, Chan Zhou, Carine M Boustany-Kari, Jörg F Rippmann, Daniela M Santos, Julia F Doerner, Alan C Mullen

Journal: Nature Communications

PubMed ID: 40025044

Doi: 10.1038/s41467-025-56900-z

Products & Services: Gene Synthesis

Jumbo phage killer immune system targets early infection of nucleus-forming phages

Authors: Li Yuping, Linlin Guan, Isabelle Becher, Kira S Makarova, Xueli Cao, Surabhi Hareendranath, Jingwen Guan, Frank Stein, Siqi Yang, Arne Boergel, Karine Lapouge, Kim Remans, David Agard, Mikhail Savitski, Athanasios Typas, Eugene V Koonin, Yue Feng, Joseph Bondy-Denomy

Journal: Cell

PubMed ID: 40112800

Doi: 10.1016/j.cell.2025.02.016

Products & Services: Gene Synthesis

Enhancing the Anticancer Activity of a Carcinoma-Directed Peptide–HLA-I Fusion Protein by Armoring with Mutein IFNα

Authors: Douwe Freerk Samplonius , Anne Paulien van Wijngaarden , Lisanne Koll , Xiurong Ke , Wijnand Helfrich

Journal: Int J Mol Sci

PubMed ID: 40243928

Doi: ijms26073178

Products & Services: Gene Synthesis

The conductance of KCNQ2 and its pathogenic variants is determined by individual subunit gating

Authors: Andy Hinojo-Perez, Jodene Eldstrom, Ying Dou, Allan Marinho-Alcara, Michaela A Edmond, Alicia de la Cruz, Marta E Perez Rodriguez, Maykelis Diaz-Solares, Derek M Dykxhoorn, David Fedida, Rene Barro-Soria

Journal: SCIENCE ADVANCES

PubMed ID: 40043113

Doi: 10.1126/sciadv.adr7012

Products & Services: Gene Synthesis