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Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias

Authors: Won Jun Kim, Edie I Crosse, Emma De Neef, Inaki Etxeberria, Erich Y Sabio, Eric Wang, Jan Philipp Bewersdorf, Kuan-Ting Lin, Sydney X Lu, Andrea Belleville, Nina Fox, Cynthia Castro, Pu Zhang, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Beatrice Zhang, Jacob H Winick, Alexander M Lewis, Robert F Stanley, Susan DeWolf, Brigita Meškauskaitė Urben, Meril Takizawa, Tobias Krause, Henrik Molina, Ronan Chaligne, Priya Koppikar, Jeffrey Molldrem, Mathieu Gigoux, Taha Merghoub, Anthony Daniyan, Smita S Chandran, Benjamin D Greenbaum, Christopher A Klebanoff, Robert K Bradley, Omar Abdel-Wahab

Journal: Cell

PubMed ID: 40273911

Doi: 10.1016/j.cell.2025.03.047

Products & Services: Gene Synthesis

Enhanced the Trans-Cleavage Activity of CRISPR-Cas12a Using Metal-Organic Frameworks as Stimulants for Efficient Electrochemical Sensing of Circulating Tumor DNA

Authors: Shuai Wu, Yincheng Liu, Tianyu Zeng, Tianci Zhou, Yanting Sun, Ying Deng, Juan Zhang, Genxi Li, Yongmei Yin

Journal: Advanced Science

PubMed ID: 40184611

Doi: 10.1002/advs.202417206

Products & Services: Gene Synthesis

Chromosome end protection by RAP1-mediated inhibition of DNA-PK

Authors: Patrik Eickhoff, Ceylan Sonmez, Charlotte E. L. Fisher, Oviya Inian, Theodoros I. Roumeliotis, Angela dello Stritto, Jörg Mansfeld, Jyoti S. Choudhary, Sebastian Guettler, Francisca Lottersberger & Max E. Douglas

Journal: Nature

PubMed ID: 40240611

Doi: 10.1038/s41586-025-08896-1

Products & Services: Gene Synthesis

CD22 TCR-engineered T cells exert antileukemia cytotoxicity without causing inflammatory responses

Authors: Kilyna A Nguyen, Zhihui Liu, John S Davies, Crystal P McIntosh, Lindsey M Draper, Scott M Norberg, Zachary Rae, Sooraj R Achar, Gregoire Altan-Bonnet, Ling Zhang, Xiaolin Wu, Thomas J Meyer, Michael C Kelly, Naomi Taylor, Christian S Hinrichs, Kazusa Ishii

Journal: SCIENCE ADVANCES

PubMed ID: 40203088

Doi: 10.1126/sciadv.adq4297

Products & Services: Gene Synthesis

Mechanism of small heat shock protein client sequestration and induced polydispersity

Authors: Adam P. Miller & Steve L. Reichow

Journal: Nature Communications

PubMed ID: 40240363

Doi: 10.1038/s41467-025-58964-3

Products & Services: Gene Synthesis

Vesicular and non-vesicular extracellular small RNAs direct gene silencing in a plant-interacting bacterium

Authors: Antinéa Ravet, Jérôme Zervudacki, Meenu Singla-Rastogi, Magali Charvin, Odon Thiebeauld, Alvaro L. Perez-Quintero, Lucas Courgeon, Adrien Candat, Liam Lebeau, Antonio Emidio Fortunato, Venugopal Mendu & Lionel Navarro

Journal: Nature Communications

PubMed ID: 40229238

Doi: 10.1038/s41467-025-57908-1

Products & Services: Gene Synthesis

A predatory gene drive for targeted control of self-transmissible plasmids

Authors: Ryan Tsoi, Hye-In Son, Grayson S Hamrick, Katherine Tang, Jonathan H Bethke, Jia Lu, Rohan Maddamsetti, Lingchong You

Journal: SCIENCE ADVANCES

PubMed ID: 40173243

Doi: 10.1126/sciadv.ads4735

Products & Services: Gene Synthesis

Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species

Authors: He Wang, Yanjing Guo, Qing Liu, Jing Zhang, Qianlong Zhang, Mingying Yang, Qizhen Chen, Sheng Qiang, Bernal E Valverde, Shiguo Chen

Journal: Advanced Science

PubMed ID: 40278415

Doi: 10.1002/advs.202416188

Products & Services: Gene Synthesis

Synergistic impact of macrolide resistance and H3N2 infection on M. pneumoniae outbreak in children

Authors: Jiali Chen, Yingdan Wang, Juan Cheng, Yunping Ma, Xin Zhang, Xuezhou Bai, Palizhati Rehati, Huashun Cui, Fan Wu, Qiuhui Pan, Jinghe Huang

Journal: Microbiology Spectrum

PubMed ID: 39998323

Doi: 10.1128/spectrum.01844-24

Products & Services: Gene Synthesis

Multimeric transcription factor BCL11A utilizes two zinc-finger tandem arrays to bind clustered short sequence motifs

Authors: John R. Horton, Meigen Yu, Jujun Zhou, Melody Tran, Rithvi R. Anakal, Yue Lu, Robert M. Blumenthal, Xiaotian Zhang, Yun Huang, Xing Zhang & Xiaodong Cheng

Journal: Nature Communications

PubMed ID: 40246927

Doi: 10.1038/s41467-025-58998-7

Products & Services: Gene Synthesis