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Modular deregulation of central carbon metabolism for efficient xylose utilization in Saccharomyces

Authors: Xiaowei Li, Yanyan Wang, Xin Chen, Leon Eisentraut, Chunjun Zhan, Jens Nielsen, Yun Chen

Journal: Nature Communications

PubMed ID: 40379631

Doi: 10.1038/s41467-025-59966-x

Products & Services: Gene Synthesis

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site

Authors: Leslie A Dakin, Li Xing, Justin Hall, Weidong Ding, Felix F Vajdos, Jeffrey W Pelker, Simeon Ramsey, Paul Balbo, Parag V Sahasrabudhe, Mary Ellen Banker, Won Young Choi, Stephen W Wright, Jeanne S Chang, John M Curto, Jennifer E Davoren, Susan E Drozda, Kimberly F Fennell, Kentaro Futatsugi, Steve Kortum, Katherine L Lee, Shenping Liu, Frank Lovering, Jennifer A Nicki, John I Trujillo, Fabien Vincent, Mark E Schnute

Journal: Nature Communications

PubMed ID: 40379660

Doi: 10.1038/s41467-025-59919-4

Products & Services: Gene Synthesis

Interaction networks of SIM-binding groove mutants reveal alternate modes of SUMO binding and profound impact on SUMO conjugation

Authors: Laura A Claessens, Matty Verlaan-de Vries, Nienke Broekman, Martijn S Luijsterburg, Alfred C O Vertegaal

Journal: SCIENCE ADVANCES

PubMed ID: 40367183

Doi: 10.1126/sciadv.adp2643

Products & Services: Gene Synthesis

An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element

Authors: Hengxia Jia, Shunli Liu, Guibo Rao, Qiaojie Liu, Jiqin Wu, Sheng Cao, Peng Gong

Journal: Sci Adv

PubMed ID: 40249801

Doi: 10.1126/sciadv.adv9640

Products & Services: Gene Synthesis Custom Vector Construction

Stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids

Authors: Jennifer M. Podgorski, Joshua Podgorski, Lawrence Abad, Deborah Jacobs-Sera, Krista G. Freeman, Colin Brown, Graham F. Hatfull, Antoni Luque & Simon J. White

Journal: Nature Communications

PubMed ID: 40175362

Doi: 10.1038/s41467-025-58298-0

Products & Services: Gene Synthesis

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment

Authors: Zhuoyao Chen, Gamma Chi, Timea Balo, Xiangrong Chen, Beatriz Ralsi Montes, Steven C. Clifford, Vincenzo D’Angiolella, Timea Szabo, Arpad Kiss, Tibor Novak, András Herner, András Kotschy & Alex N. Bullock

Journal: Nature Communications

PubMed ID: 40175372

Doi: 10.1038/s41467-025-58350-z

Products & Services: Gene Synthesis

Enhanced the Trans-Cleavage Activity of CRISPR-Cas12a Using Metal-Organic Frameworks as Stimulants for Efficient Electrochemical Sensing of Circulating Tumor DNA

Authors: Shuai Wu, Yincheng Liu, Tianyu Zeng, Tianci Zhou, Yanting Sun, Ying Deng, Juan Zhang, Genxi Li, Yongmei Yin

Journal: Advanced Science

PubMed ID: 40184611

Doi: 10.1002/advs.202417206

Products & Services: Gene Synthesis

CD22 TCR-engineered T cells exert antileukemia cytotoxicity without causing inflammatory responses

Authors: Kilyna A Nguyen, Zhihui Liu, John S Davies, Crystal P McIntosh, Lindsey M Draper, Scott M Norberg, Zachary Rae, Sooraj R Achar, Gregoire Altan-Bonnet, Ling Zhang, Xiaolin Wu, Thomas J Meyer, Michael C Kelly, Naomi Taylor, Christian S Hinrichs, Kazusa Ishii

Journal: SCIENCE ADVANCES

PubMed ID: 40203088

Doi: 10.1126/sciadv.adq4297

Products & Services: Gene Synthesis

Chromosome end protection by RAP1-mediated inhibition of DNA-PK

Authors: Patrik Eickhoff, Ceylan Sonmez, Charlotte E. L. Fisher, Oviya Inian, Theodoros I. Roumeliotis, Angela dello Stritto, Jörg Mansfeld, Jyoti S. Choudhary, Sebastian Guettler, Francisca Lottersberger & Max E. Douglas

Journal: Nature

PubMed ID: 40240611

Doi: 10.1038/s41586-025-08896-1

Products & Services: Gene Synthesis

Mechanism of small heat shock protein client sequestration and induced polydispersity

Authors: Adam P. Miller & Steve L. Reichow

Journal: Nature Communications

PubMed ID: 40240363

Doi: 10.1038/s41467-025-58964-3

Products & Services: Gene Synthesis