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Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP‑2 Signaling

Authors: Sarah Jane Rezzi, Andrea Butticè, Salvatore Villani, Gaia Lesca, Sofia Rossini, Eleonora Panfili, Daniele Mazzoletti, Elia Bari, Davide Violante, Marta Serafini, Alberto Massarotti, Ciriana Orabona, Maria Teresa Pallotta, Silvio Aprile, Silvia Fallarini, Erika Del Grosso, Rita Maria Concetta Di Martino, Riccardo Miggiano, Tracey Pirali

Journal: Journal of Medicinal Chemistr

PubMed ID: 42483959

Doi: 10.1021/acs.jmedchem.6c00759

Products & Services: Gene Synthesis

Photocatalytic Golgi Proteomics Reveals Palmitoylation-Regulated Golgiphagy

Authors: Yufei Di, Fuhu Guo, Ziqi Liu, Haotian Guo, Linghao Kong, Peng R Chen, Xinyuan Fan

Journal: Journal of the American Chemical Society

PubMed ID: 42619132

Doi: 10.1021/jacs.6c13532

Products & Services: Gene Synthesis

Description of the rate-limiting hydrogen tunneling mechanism for plant 9- and 13-lipoxygenases

Authors: Alex Kockler, Katherine Ray, Jordan King, Eric Anderson, Joi Walker, Nathaniel Gilbert, Patrick Horn, Adam R Offenbacher

Journal: Protein Science

PubMed ID: 42227275

Doi: 10.1002/pro.70647

Products & Services: Gene Synthesis

Efficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition

Authors: Junjie Zhu, Lin Ding, Kai-Ming Liu, Xingyu Zhu, Jifang Li, Buer Ha, Bao-Qing Gao, Xujiao Zhou, Chengfang Liu, Jia Wei, Shuangyu Ma, Wenchao Xu, Lingyun Kong, Jing Wu, Xiaodun Mou, Bei Yang, Lijie Wang, Jiaxu Hong, Li Yang & Jia Chen

Journal: Nature Biotechnology

Doi: 10.1038/s41587-026-03227-9

Products & Services: Gene Synthesis Synthetic Guide RNA

Beyond CAT, BSD, and URA: SUL, A novel selectable marker for Cyanidioschyzon merolae

Authors: Yissell Borges-Rodríguez, Martha R Stark, Elise Kerckhofs, Julie Mueller, Kyle J Lauersen, Daniel Schubert, Stephen D Rader

Journal: New biotechnology

PubMed ID: 41643937

Doi: 10.1016/j.nbt.2026.01.012

Products & Services: Gene Synthesis

Viral protease-initiated lytic cell death as a universal antiviral mRNA therapy

Authors: Lin Li, Xiu-Li Yan, Hao-Yang Wang, Hang-Yu Zhou, Yu-Yan Li, Wenlong Ma, Jian Li, Rong-Rong Zhang, Lu Lv, Xing-Yao Huang, Hao Du, Tian-Shu Cao, Qing Ye, Hui Zhao, Yan Fu, Byung-Ho Kang, Qiang Ding, Aiping Wu, Yi-Jiao Huang, Cheng-Feng Qin

Journal: Cell

PubMed ID: 42476130

Doi: 10.1016/j.cell.2026.06.031

Products & Services: Gene Synthesis

Genome-Wide Identification, Characterization, and Functional Analysis of the GSK3/Shaggy-like Gene Family in Melon (Cucumis melo L.)

Authors: Peng Tian, Bing Li, Jingjing Zhang, Xiurui Gao, Wei Liu, Bowen Liu, Zhaowei Li, Jing Yang, Mengyuan Su, Jige Dang, Yanrong Wu

Journal: Horticulturae

Doi: 10.3390

Products & Services: Gene Synthesis

Radiotherapy synergizes with an inducible AAVbased immunotherapy platform to program local and systemic antitumor immunity

Authors: Sonia Marco, Myriam Fernández, Beatriz Honorato, Nerea Juanarena, Cristina Sainz, Ainhoa Andueza, David J Gould, Seth Anderson, Carlos de Andrea, Paulo Pérez Domínguez, Paolo Wong, Carlos Vásquez, Irene Narinda, Carmen Unzu, Sergio Isola, Beatriz Tavira, Mikel Ariz, Gracián Camps, Miguel F Sanmamed, Julián Pardo, Sara Labiano, Marta M Alonso, Javier Marco-Sanz, Elizabeth Guruceaga, María Collantes, Jon Ander Simón, Iván Peñuelas, Joaquín Fernández-Irigoyen, Enrique Santamaría, Jesús Prieto, Juan Dubrot

Journal: Cancer Cell

PubMed ID: 41875889

Doi: doi.org/10.1016

Products & Services: Gene Synthesis

Structural basis for the subtype-selective activation of KCa3.1 channels

Authors: Alena Ramanishka, Joshua A. Nasburg, Yang Xu, Xinyi Ma, Reza Mehvar, Meng Cui, Young-Woo Nam, Heike Wulff, Miao Zhang

Journal: Structure

Doi: 10.1016/j.bpj.2025.11.2173

Products & Services: Gene Synthesis

Harnessing Microbial Bioremediation and Wastewater Valorization for Production of (Methyl)muconates via Engineered Metabolic Pathways in Aromatic Pollutant Mixtures

Authors: Siqing Fan, Xueni Fu, Xiaoyu Wang, Lvjing Wang, Hongyu Chen, Christopher E French, Hongzhi Tang, Hao Ren, Zhenmei Lu

Journal: Environmental science & technology

PubMed ID: 42049681

Doi: 10.1021/acs.est.5c11064

Products & Services: Gene Synthesis