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The study of immunogenicity of the antigenic protein of high risk oncogenic type of the human papillomavirus HPV16 L1 produced in the plant expression system on the base of transgenic tomato.

Dokl Biochem Biophys. 2017;

Salyaev RK, Rekoslavskaya NI,, Stolbikov AS, Tretyakova AV.

Products/Services Used	Details	Operation
Gene Synthesis	… pBINHPV16 L1 Ω- 5'-UTR TMV The pBINHPV16 L1 Ω-5'-UTR TMV genetic construct, synthesized by the Genscript Com- pany (United States), was inserted into the pUC57 plasmid for cloning pBIN-plasmids were then trans …	Get A Quote

摘要

The immunogenicity of plant-made peroral vaccine against cervical cancer was studied in mice during 342 days after vaccination with the material of tomato fruits genetically transformed with HPV16 L1 Ώ 5'UTR TMV. The immune response was found on day 4 after vaccination in blood serum of vaccinated mice. On days 90-100, the rise to maximum value of the level of antibodies to HPV16 L1 was in the range of 500 ng of the standard antibodies to HPV16 L1 (Santa Cruz Biotechnology, United States). This level of antibodies was retained until the end of the study.