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Dynamic U2AF cycling defines two phases of cotranscriptional pre-mRNA splicing

Authors: Changwei Shao, Yajing Hao, Li Jiang, Dong Wang, Rui Wang, Yuanjun Li, Hui Wang, Yaping Ge, Rui Bai, Xiangjuan Du, Xizi Chen, Tan Wu, Lan-Tao Gou, Ruixue Wan, Yanhui Xu, Xiong Ji, Xiang-Dong Fu

Journal: Science

PubMed ID: 40997183

Doi: 10.1126/science.adj9141

Products & Services: Protein Electrophoresis and Western

De novo design of potent inhibitors of clostridial family toxins

Authors: Robert J. Ragotte; Huazhu Liang; John Tam; Sean Miletic; Jacob M. Berman; Roger Palou; Connor Weidle; Zhijie Li; Matthias Gl gl; Greg L. Beilhartz; Kenneth D. Carr; Andrew J. Borst; Brian Coventry; Xinru Wang; John L. Rubinstein; Mike Tyers; Daniel Schramek; Roman A. Melnyk; David Baker

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 40982695

Doi: 10.1073/pnas.2509329122

Products & Services: Plasmid DNA Preparation

Functional characterisation of missense ceruloplasmin variants and real-world prevalence assessment of Aceruloplasminemia using population data

Authors: Nicole Ziliotto; Sara Lencioni; Martina Cirinciani; Alan Zanardi; Massimo Alessio; Giulia Sold ; Eleonora Da Pozzo; Rosanna Asselta; Andrea Caricasole

Journal: EBioMedicine

PubMed ID: 40043514

Doi: 10.1016/j.ebiom.2025.105625

Onametostat, a PfPRMT5 inhibitor, exhibits antimalarial activity to Plasmodium falciparum

Authors: Hui Min; Amuza Byaruhanga Lucky; Jesper J. Madsen; Anongruk Chim-Ong; Xiaolian Li; Liwang Cui; Jun Miao

Journal: Antimicrobial Agents and Chemotherapy

PubMed ID: 39194263

Doi: 10.1128/aac.00176-24

Products & Services: Catalog Antibodies

Onametostat, a PfPRMT5 inhibitor, exhibits antimalarial activity to Plasmodium falciparum

Authors: Hui Min; Amuza Byaruhanga Lucky; Jesper J. Madsen; Anongruk Chim-Ong; Xiaolian Li; Liwang Cui; Jun Miao

Journal: Antimicrobial Agents and Chemotherapy

PubMed ID: 39194263

Doi: 10.1128/aac.00176-24

Products & Services: Catalog Antibodies

Onametostat, a PfPRMT5 inhibitor, exhibits antimalarial activity to Plasmodium falciparum

Authors: Hui Min; Amuza Byaruhanga Lucky; Jesper J. Madsen; Anongruk Chim-Ong; Xiaolian Li; Liwang Cui; Jun Miao

Journal: Antimicrobial Agents and Chemotherapy

PubMed ID: 39194263

Doi: 10.1128/aac.00176-24

Products & Services: Catalog Antibodies

The TaCEP15 peptide signaling cascade modulates primary root length and drought tolerance in wheat

Authors: Wen Yang, Renhan Li, Man Feng, Zhen Qin, Yumei Zhang, Huiru Peng, Yingyin Yao, Zhaorong Hu, Zhongfu Ni, Wen Song, Feng Qin, Fuminori Takahashi, Qixin Sun, Mingming Xin

Journal: SCIENCE ADVANCES

PubMed ID: 40901958

Doi: 10.1126/sciadv.ady1949

Products & Services: Peptide Services

PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunity

Authors: Shen Yang, Eugenio Santelli, Carlos G Gonzalez, Wade T Johnson, Irene V Choi, Chuling Zhuang, Myungja Ro, Leigh-Ana M Rossitto, I-Shing Yu, Shu-Wha Lin, Yuan Zhan, Qinwei Chen, Jonathan D Yoshihara, Daniel J Wallace, Caroline A Jefferies, Michifumi Yamashita, David J Gonzalez, Richard I Ainsworth, Nisarg J Shah, Stephanie M Stanford, Nunzio Bottini

Journal: SCIENCE ADVANCES

PubMed ID: 40911684

Doi: 10.1126/sciadv.adw2568

Products & Services: Gene Services

Molecular Chain Elongation Mechanism for n-Caproate Biosynthesis by Megasphaera Hexanoica

Authors: Byoung Seung Jeon, Eun-Jung Kim, Hogyun Seo, Hyunjin Kim, Seungjin Shin, Caroline Schlaiß, Largus T Angenent, Kyung-Jin Kim, Byoung-In Sang

Journal: Advanced Science

PubMed ID: 40932660

Doi: 10.1002/advs.202506069

Controllable Generation of Pathogen-Specific Antimicrobial Peptides Through Knowledge-Aware Prompt Diffusion Model

Authors: Yongkang Wang, Menglu Li, Feng Huang, Minyao Qiu, Wen Zhang

Journal: Advanced Science

PubMed ID: 40953451

Doi: 10.1002/advs.202507457

Products & Services: Peptide Services