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A tick saliva serpin, Ixs S17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent

Authors: Thu-Thuy Nguyen; Tae Heung Kim; Emily Bencosme-Cuevas; Jacquie Berry; Alex Samuel Kiarie Gaithuma; Moiz Ashraf Ansari; Tae Kwon Kim; Lucas Tirloni; Zeljko Radulovic; James J. Moresco; John R. Yates; Albert Mulenga

Journal: PLOS Pathogens

PubMed ID: 38394332

Doi: 10.1371/journal.ppat.1012032

Products & Services: Monoclonal Antibody Services

Structure-based lead optimization of enterovirus D68 2A protease inhibitors

Authors: Bin Tan; Chang Liu; Kan Li; Prakash Jadhav; George Lambrinidis; Lan Zhu; Linda Olson; Haozhou Tan; Yu Wen; Antonios Kolocouris; Wei Liu; Jun Wang

Journal: Journal of Medicinal Chemistry

PubMed ID: 37857371

Doi: 10.1021/acs.jmedchem.3c00995

De novo design of potent inhibitors of clostridial family toxins

Authors: Robert J. Ragotte; Huazhu Liang; John Tam; Sean Miletic; Jacob M. Berman; Roger Palou; Connor Weidle; Zhijie Li; Matthias Gl gl; Greg L. Beilhartz; Kenneth D. Carr; Andrew J. Borst; Brian Coventry; Xinru Wang; John L. Rubinstein; Mike Tyers; Daniel Schramek; Roman A. Melnyk; David Baker

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 40982695

Doi: 10.1073/pnas.2509329122

Products & Services: Plasmid DNA Preparation

Functional characterisation of missense ceruloplasmin variants and real-world prevalence assessment of Aceruloplasminemia using population data

Authors: Nicole Ziliotto; Sara Lencioni; Martina Cirinciani; Alan Zanardi; Massimo Alessio; Giulia Sold ; Eleonora Da Pozzo; Rosanna Asselta; Andrea Caricasole

Journal: EBioMedicine

PubMed ID: 40043514

Doi: 10.1016/j.ebiom.2025.105625

Onametostat, a PfPRMT5 inhibitor, exhibits antimalarial activity to Plasmodium falciparum

Authors: Hui Min; Amuza Byaruhanga Lucky; Jesper J. Madsen; Anongruk Chim-Ong; Xiaolian Li; Liwang Cui; Jun Miao

Journal: Antimicrobial Agents and Chemotherapy

PubMed ID: 39194263

Doi: 10.1128/aac.00176-24

Products & Services: Catalog Antibodies

Onametostat, a PfPRMT5 inhibitor, exhibits antimalarial activity to Plasmodium falciparum

Authors: Hui Min; Amuza Byaruhanga Lucky; Jesper J. Madsen; Anongruk Chim-Ong; Xiaolian Li; Liwang Cui; Jun Miao

Journal: Antimicrobial Agents and Chemotherapy

PubMed ID: 39194263

Doi: 10.1128/aac.00176-24

Products & Services: Catalog Antibodies

Onametostat, a PfPRMT5 inhibitor, exhibits antimalarial activity to Plasmodium falciparum

Authors: Hui Min; Amuza Byaruhanga Lucky; Jesper J. Madsen; Anongruk Chim-Ong; Xiaolian Li; Liwang Cui; Jun Miao

Journal: Antimicrobial Agents and Chemotherapy

PubMed ID: 39194263

Doi: 10.1128/aac.00176-24

Products & Services: Catalog Antibodies

SMAD3 and p300 complex scaffolding by long non-coding RNA LIMD1-AS1 promotes TGF-β-induced breast cancer cell plasticity

Authors: Chuannan Fan， Davy Cats， Miriam Selle， Olga Khorosjutina， Soniya Dhanjal， Bernhard Schmierer， Hailiang Mei， Peter Ten Dijke， Qian Wang

Journal: Nucleic Acids Research

PubMed ID: 40889156

Doi: 10.1093/nar/gkaf841

Products & Services: CRISPR Services

Translesion DNA polymerases Rev1 and PolH promote LTR-retrotransposon transcription by safeguarding Pol II occupancy in both germline and somatic tissues of Drosophila

Authors: Chongyang Li, Zhe Meng, Qiuju Wen, Wenjuan Yang, Yaqian Xu, Yuening Lyu, Yile Guo, Tong Lyu, Dan Shen, Kun Dou

Journal: Nucleic Acids Research

PubMed ID: 40966519

Doi: 10.1093/nar/gkaf903

OLD amputates the anticodon arm of tRNAs during P2–Lambda interference

Authors: Apurva A Govande, Brian D Matibag, Irem Ünlü, Eric J Wolf, Molly R Sargen, Brooke Ramsey, Sangjin Kim, Sophie Helaine, Ivan R Corrêa Jr, Hoong Chuin Lim

Journal: Nucleic Acids Research

PubMed ID: 40966496

Doi: 10.1093/nar/gkaf874

Products & Services: Gene Services