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Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits
Authors: Loϊc Binan, Aiping Jiang, Serwah A Danquah, Vera Valakh, Brooke Simonton, Jon Bezney, Robert T Manguso, Kathleen B Yates, Ralda Nehme, Brian Cleary, Samouil L Farhi
Journal: Cell
PubMed ID: 40081369
Doi: 10.1016/j.cell.2025.02.012
Products & Services: Custom Vector Construction   
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity
Authors: Liora S Katz, Emira J Visser, Kathrin F Plitzko, Marloes A M Pennings, Peter J Cossar, Isabelle L Tse, Markus Kaiser, Luc Brunsveld, Christian Ottmann, Donald K Scott
Journal: Nature Communications
PubMed ID: 40025013
Doi: 10.1038/s41467-025-57241-7
Products & Services: Peptide Services   
Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodeling
Authors: Charles Bou-Nader, Katie A Link, Krishna C Suddala, Jay R Knutson, Jinwei Zhang
Journal: Nature Communications
PubMed ID: 40050622
Doi: 10.1038/s41467-025-57519-w
Products & Services: Peptide Synthesis   
Blockade of ZMIZ1-GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage
Authors: Jiho Nam, Hyunmin Woo, Jihye Yang, Seok Jung Kim, Kwang Pyo Lee, Ji Hoon Yu, Tae Joo Park, Seong-Il Eyun, Siyoung Yang
Journal: Advanced Science
PubMed ID: 40040621
Doi: 10.1002/advs.202404311
Products & Services: Chemicals   
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
Authors: Yansi Xian, Bin Liu, Tao Shen, Lin Yang, Rui Peng, Hongdou Shen, Xueying An, Yutian Wang, Yu Ben, Qing Jiang, Baosheng Guo
Journal: Bone Res
PubMed ID: 40025004
Doi: 10.1038/s41413-024-00399-5
Products & Services: Protein and Antibody Isolation   
Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs
Authors: Jibin Cui , Qingyun Zheng , Yicheng Weng , Xiaoguo Zhai , Zhen Su , Yunxiang Du , Xiaoxiong Wei , Yuanyuan Yu , Qian Qu , Man Pan
Journal: Analytical Chemistry
PubMed ID: 40000409
Doi: doi.org/10.1002/anie.202501488
Products & Services: Codon Optimization   Gene Synthesis   
Rational Design Assisted by Evolutionary Engineering Allows (De)Construction and Optimization of Complex Phenotypes in Pseudomonas putida KT2440
Authors: Blas Blázquez, Juan Nogales
Journal: Microbial biotechnology
PubMed ID: 40126873
Doi: 10.1111/1751-7915.70132
Products & Services: Gene Synthesis   
Immunomodulatory role of the stem cell circadian clock in muscle repair
Authors: Pei Zhu, Eric M Pfrender, Adam W T Steffeck, Colleen R Reczek, Yalu Zhou, Abhishek Vijay Thakkar, Neha R Gupta, Ariana Kupai, Amber Willbanks, Richard L Lieber, Ishan Roy, Navdeep S Chandel, Clara B Peek
Journal: SCIENCE ADVANCES
PubMed ID: 40043110
Doi: 10.1126/sciadv.adq8538
Products & Services: Gene Synthesis   
Integration of multi-omics data accelerates molecular analysis of common wheat traits
Authors: Ning Zhang, Li Tang, Songgang Li, Lu Liu, Mengjuan Gao, Sisheng Wang, Daiying Chen, Yichao Zhao, Ruiqing Zheng, Armin Soleymaniniya, Lingran Zhang, Wenkang Wang, Xia Yang, Yan Ren, Congwei Sun, Mathias Wilhelm, Daowen Wang, Min Li, Feng Chen
Journal: Nature Communications
PubMed ID: 40038279
Doi: 10.1038/s41467-025-57550-x
Products & Services: Molecular Biology Tools   
Structural basis for the allosteric activation of Lon by the heat shock protein LarA
Authors: Hsiu-Jung Wang, Yun-Erh Kuan, Meng-Ru Ho, Chung-I Chang
Journal: Nature Communications
PubMed ID: 40044692
Doi: 10.1038/s41467-025-57482-6
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