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USP7 V517F mutation as a mechanism of inhibitor resistance

Authors: Yu-Ling Miao, Fengying Fan, Yong-Jun Cheng, Li Jia, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Jian Ding, Xuekui Yu, Jin-Xue He

Journal: Nature Communications

PubMed ID: 40087304

Doi: 10.1038/s41467-025-56981-w

Products & Services: CRISPR sgRNA library

Authors: Jingjing Wang, Yong Ma, Zimu Li, Hang Yuan, Banghui Liu, Zexuan Li, Mengzhen Su, Gul Habib, Yutong Liu, Lutang Fu, Peiyi Wang, Mei Li, Jun He, Jing Chen, Peng Zhou, Zhengli Shi, Xinwen Chen, Xiaoli Xiong

Journal: SCIENCE ADVANCES

PubMed ID: 40085715

Doi: 10.1126/sciadv.adr8772

Products & Services: Codon Optimization

Developing Quorum Sensing-Based Collaborative Dynamic Control System in Halomonas TD01

Authors: Yi-Na Lin, Yu-Xi Li, Ye Zheng, Yi-Hao Deng, Kai-Xuan Liu, Yue Gan, Hao Li, Jun Wang, Jia-Wen Peng, Rui-Zhe Deng, Huai-Ming Wang, Hui Wang, Jian-Wen Ye

Journal: Advanced Science

PubMed ID: 40091435

Doi: 10.1002/advs.202408083

Products & Services: Protein Electrophoresis and Western

Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma

Authors: Hao Shi, Yajie Yang, Jiwei Gao, Satendra Kumar, Hong Xie, Ziqing Chen, Jiawen Lyu, Harri Sihto, Virve Koljonen, Silvia Vega-Rubin-de-Celis, Vladana Vukojevic, Filip Farnebo, Viveca Björnhagen, Anders Höög, C Christofer Juhlin, Linkiat Lee, Malin Wickström, Jürgen C Becker, John Inge Johnsen, Catharina Larsson, Weng-Onn Lui

Journal: Nature Communications

PubMed ID: 40108758

Doi: 10.1080/15548627.2025.2477385

Products & Services: Peptide Synthesis

Acute diacylglycerol production activates critical membrane-shaping proteins leading to mitochondrial tubulation and fission

Authors: Joshua G Pemberton, Krishnendu Roy, Yeun Ju Kim, Tara D Fischer, Vijay Joshi, Elizabeth Ferrer, Richard J Youle, Thomas J Pucadyil, Tamas Balla

Journal: Nature Communications

PubMed ID: 40102394

Doi: 10.1038/s41467-025-57439-9

Products & Services: Custom Vector Construction

Reprogramming yeast metabolism for customized starch-rich micro-grain through low-carbon microbial manufacturing

Authors: Zhihui Shi, Zhaoyu Xu, Weihe Rong, Hongbing Sun, Hongyi Zhou, Qianqian Yuan, Aixuan Xiao, Hongfei Ma, Tao Cai, Guokun Wang, Yanhe Ma

Journal: Nature Communications

PubMed ID: 40118900

Doi: 10.1038/s41467-025-58067-z

Products & Services: Custom Vector Construction

Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome

Authors: Jessica C Hargarten, Kenneth Ssebambulidde, Seher H Anjum, Malcolm J Vaughan, Jintao Xu, Anutosh Ganguly, Brittany Dulek, Francisco Otaizo-Carrasquero, Brian Song, Sijia Tao, Yoon-Dong Park, Terri L Scott, Tracey-Ann Höltermann, Raymond F Schinazi, Prashant Chittiboina, Bridgette Jeanne Billioux, Dima A Hammoud, Michal A Olszewski, Peter R Williamson

Journal: SCIENCE ADVANCES

PubMed ID: 40117367

Doi: 10.1126/sciadv.adi9885

Products & Services: Protein Electrophoresis and Western

Integrative in silico and biochemical analyses demonstrate direct Arl3-mediated ODA16 release from the intraflagellar transport machinery

Authors: Jiaolong Wang, Rune T Kidmose, Niels Boegholm, Nevin K Zacharia, Mads B Thomsen, Anni Christensen, Tara Malik, Karl Lechtreck, Esben Lorentzen

Journal: The Journal of Biological Chemistry

PubMed ID: 39880089

Doi: 10.1016/j.jbc.2025.108237

Products & Services: Gene Synthesis Codon Optimization

Cell-autonomous innate immunity by proteasome-derived defence peptides

Authors: Karin Goldberg, Arseniy Lobov, Paola Antonello, Merav D Shmueli, Idan Yakir, Tal Weizman, Adi Ulman, Daoud Sheban, Einav Laser, Matthias P Kramer, Ronen Shteinvil, Guoyun Chen, Angham Ibraheem, Vera Sysoeva, Vered Fishbain-Yoskovitz, Gayatree Mohapatra, Anat Abramov, Sandy Shimshi, Kseniia Ogneva, Madhurima Nandy, Sivan Amidror, Hadar Bootz-Maoz, Shanny H Kuo, Nili Dezorella, Assaf Kacen, Aaron Javitt, Gee W Lau, Nissan Yissachar, Zvi Hayouka, Yifat Merbl

Journal: Nature

PubMed ID: 40044870

Doi: 10.1038/s41586-025-08615-w

Products & Services: Peptide Synthesis

Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody

Authors: Susanne H D Ständer, Cyril F Reboul, Sarah N Le, Daniel E Williams, Peter G Chandler, Mauricio G S Costa, David E Hoke, John D T Jimma, James Fodor, Gustavo Fenalti, Stuart I Mannering, Benjamin T Porebski, Peter Schofield, Daniel Christ, Malcolm Buckle, Sheena McGowan, Dominika Elmlund, Kasper D Rand, Ashley M Buckle

Journal: Nature Communications

PubMed ID: 40055307

Doi: 10.1038/s41467-025-57492-4

Products & Services: Gene Synthesis