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The conductance of KCNQ2 and its pathogenic variants is determined by individual subunit gating

Authors: Andy Hinojo-Perez, Jodene Eldstrom, Ying Dou, Allan Marinho-Alcara, Michaela A Edmond, Alicia de la Cruz, Marta E Perez Rodriguez, Maykelis Diaz-Solares, Derek M Dykxhoorn, David Fedida, Rene Barro-Soria

Journal: SCIENCE ADVANCES

PubMed ID: 40043113

Doi: 10.1126/sciadv.adr7012

Products & Services: Gene Synthesis

Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy

Authors: Lanfang Ren, Zeda Zhao, Yuqing Chao, Panting Yu, Zhoufang Mei, Bing Du, Yiyun Cheng

Journal: Advanced Science

PubMed ID: 40056044

Doi: 10.1002/advs.202500844

Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma

Authors: Hao Shi, Yajie Yang, Jiwei Gao, Satendra Kumar, Hong Xie, Ziqing Chen, Jiawen Lyu, Harri Sihto, Virve Koljonen, Silvia Vega-Rubin-de-Celis, Vladana Vukojevic, Filip Farnebo, Viveca Björnhagen, Anders Höög, C Christofer Juhlin, Linkiat Lee, Malin Wickström, Jürgen C Becker, John Inge Johnsen, Catharina Larsson, Weng-Onn Lui

Journal: Nature Communications

PubMed ID: 40108758

Doi: 10.1080/15548627.2025.2477385

Products & Services: Peptide Synthesis

Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome

Authors: Jessica C Hargarten, Kenneth Ssebambulidde, Seher H Anjum, Malcolm J Vaughan, Jintao Xu, Anutosh Ganguly, Brittany Dulek, Francisco Otaizo-Carrasquero, Brian Song, Sijia Tao, Yoon-Dong Park, Terri L Scott, Tracey-Ann Höltermann, Raymond F Schinazi, Prashant Chittiboina, Bridgette Jeanne Billioux, Dima A Hammoud, Michal A Olszewski, Peter R Williamson

Journal: SCIENCE ADVANCES

PubMed ID: 40117367

Doi: 10.1126/sciadv.adi9885

Products & Services: Protein Electrophoresis and Western

USP7 V517F mutation as a mechanism of inhibitor resistance

Authors: Yu-Ling Miao, Fengying Fan, Yong-Jun Cheng, Li Jia, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Jian Ding, Xuekui Yu, Jin-Xue He

Journal: Nature Communications

PubMed ID: 40087304

Doi: 10.1038/s41467-025-56981-w

Products & Services: CRISPR sgRNA library

Reprogramming yeast metabolism for customized starch-rich micro-grain through low-carbon microbial manufacturing

Authors: Zhihui Shi, Zhaoyu Xu, Weihe Rong, Hongbing Sun, Hongyi Zhou, Qianqian Yuan, Aixuan Xiao, Hongfei Ma, Tao Cai, Guokun Wang, Yanhe Ma

Journal: Nature Communications

PubMed ID: 40118900

Doi: 10.1038/s41467-025-58067-z

Products & Services: Custom Vector Construction

Acute diacylglycerol production activates critical membrane-shaping proteins leading to mitochondrial tubulation and fission

Authors: Joshua G Pemberton, Krishnendu Roy, Yeun Ju Kim, Tara D Fischer, Vijay Joshi, Elizabeth Ferrer, Richard J Youle, Thomas J Pucadyil, Tamas Balla

Journal: Nature Communications

PubMed ID: 40102394

Doi: 10.1038/s41467-025-57439-9

Products & Services: Custom Vector Construction

The structural basis for the human procollagen lysine hydroxylation and dual-glycosylation

Authors: Junjiang Peng, Wenguo Li, Deqiang Yao, Ying Xia, Qian Wang, Yan Cai, Shaobai Li, Mi Cao, Yafeng Shen, Peixiang Ma, Rijing Liao, Jie Zhao, An Qin, Yu Cao

Journal: Nature Communications

PubMed ID: 40069201

Doi: 10.1038/s41467-025-57768-9

Products & Services: Protein and Antibody Isolation

Monitoring mRNA vaccine antigen expression in vivo using PET/CT

Authors: Gabrielle S Blizard, Garima Dwivedi, Yi-Gen Pan, Catherine Hou, Jean M Etersque, Hooda Said, Anik Chevrier, Marc Lavertu, Houping Ni, Benjamin Davis, Ying Tam, Quy Cao, Robert H Mach, Drew Weissman, Mohamad-Gabriel Alameh, Mark A Sellmyer

Journal: Nature Communications

PubMed ID: 40044669

Doi: 10.1038/s41467-025-57446-w

Products & Services: Endotoxin Detection & Removal System

Machine Learning-Aided Identification of Fecal Extracellular Vesicle microRNA Signatures for Noninvasive Detection of Colorectal Cancer

Authors: Zhaowei Zhang, Xuyang Liu, Chuanyue Peng, Rui Du, Xiaoqin Hong, Jia Xu, Jiaming Chen, Xiaomin Li, Yujing Tang, Yuwei Li, Yang Liu, Chen Xu, Dingbin Liu

Journal: ACS Nano

PubMed ID: 40033785

Doi: 10.1021/acsnano.4c16698

Products & Services: Synthetic Guide RNA Catalog Gene Editing