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Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis

Authors: Austin Tedman; Muskan Goel; Sohan Shah; Mathew K. Howard; Laura M. Chamness; Antonio Bonifasi; Ismalia Adams; Jacklyn M. Gallagher; Wesley D. Penn; Katarina Nemec; Eli F. McDonald; Brianna N. Corman; J. Paul Robinson; Carol Beth Post; Patricia L. Clark; M. Madan Babu; Aashish Manglik; Charles P. Kuntz; Willow Coyote-Maestas; Jonathan P. Schlebach

Journal: biorxiv

PubMed ID: 41000614

Doi: 10.1101/2025.09.19.677468

Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system

Authors: Dapeng Li; Yuanfan Li; Jie Cang; Xianwen Yan; Feipeng Wu; Xuan Sun; Wenchao Zhang

Journal: Frontiers in pharmacology

PubMed ID: 40264674

Doi: 10.3389/fphar.2025.1584245

Products & Services: Peptide Synthesis

Resistance to oxyimino-cephalosporins conferred by an alternative mechanism of hydrolysis by the Acinetobacter -derived cephalosporinase-33 (ADC-33), a class C -lactamase present in carbapenem-resistant Acinetobacter baumannii (CR Ab )

Authors: Rachel A. Powers; Bradley J. Wallar; Hannah R. Jarvis; Zoe X. Ziegler; Cynthia M. June; Christopher R. Bethel; Andrea M. Hujer; Magdalena A. Taracila; Susan D. Rudin; Kristine M. Hujer; Fabio Prati; Emilia Caselli; Robert A. Bonomo

Journal: MBio

PubMed ID: 40377322

Doi: 10.1128/mbio.00287-25

Co‑treatment with triptolide and RSL3 induces hepatocellular carcinoma cell apoptosis and ferroptosis

Authors: Weixia Liu , Guodi Wu , Jing Wang , Shanshan Wu , Zhi Chen

Journal: Molecular Medicine Reports

PubMed ID: 40376993

Doi: 10.3892/mmr.2025.13567

Products & Services: Protein Electrophoresis and Western

The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies

Authors: Zhuoqian Zhao, Qi Yang, Xiaoce Liu, Mengfei Li, Yinkai Duan, Mingjuan Du, Anqi Zhou, Huanzhen Liu, Yujia He, Wei Wang, Yuchi Lu, Xiaoyu Zhang, Haofeng Wang, Xiuna Yang, Hongkai Zhang, Xinwen Chen, Zihe Rao, Haitao Yang

Journal: nature COMMUNICATION

PubMed ID: 40681508

Doi: 10.1038/s41467-025-62023-2

Products & Services: Protein and Antibody Isolation

Staphylococcus aureus LukMF' targets neutrophils to promote skin and soft tissue infection

Authors: Daiane Boff, Ravishankar Chandrasekaran, Gregory Putzel, Rachel M Kratofil, Xuhui Zheng, Ashley Castellaw, Kody Mansfield, Ikjot Sidhu, Avantika Dhabaria, Keenan A Lacey, Sandra Gonzalez, Filadelfia Tadjibaeva, Beatrix Ueberheide, Cynthia Loomis, Alejandro Pironti, Silva Holtfreter, Shruti Naik, Victor J Torres

Journal: SCIENCE ADVANCES

PubMed ID: 40614206

Doi: 10.1126/sciadv.adr5240

Products & Services: Endotoxin Detection & Removal System

The haplotype-resolved telomere-to-telomere genome and OMICS analyses reveal genetic responses to tapping in rubber tree

Authors: Chaochao Li, Yuan Yuan, Zhiyi Nie, Tingkai Wu, Zhiyuan Wang, Jiangxia Qiao, Zhi Deng, Xiaobo Wang, Dong Xu, Xu Wang, Shuo Cao, Bingqin Li, Zewei An, Wenguan Wu, Zhongxin Jin, Huasun Huang, Wei Hu, Yongfeng Zhou, Han Cheng

Journal: Nature Communications

PubMed ID: 40624070

Doi: 10.1038/s41467-025-61527-1

Products & Services: Protein and Antibody Isolation

Structural basis for engagement of Western Equine Encephalitis Virus with the PCDH10 receptor

Authors: Shengjian Liang, Yan Yang, Yixiao Liu, Zhili Xu, Jichao Hou, Donghan Li, Lixin Zhao, Chuyu Hu, Xiaoke Liu, Zihe Rao, Yanyi Wang, Zhiyong Lou

Journal: Nature Communications

PubMed ID: 40628733

Doi: 10.1038/s41467-025-61659-4

Products & Services: Protein and Antibody Isolation

The mitotic chromosome periphery modulates chromosome mechanics

Authors: Tania Mendonca, Roman Urban, Kellie Lucken, George Coney, Neil M Kad, Manlio Tassieri, Amanda J Wright, Daniel G Booth