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HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people

Authors: Jennifer R Habel, Andrea T Nguyen, Louise C Rowntree, Christopher Szeto, Nicole A Mifsud, E Bridie Clemens, Liyen Loh, Weisan Chen, Steve Rockman, Jane Nelson, Jane Davies, Adrian Miller, Steven Y C Tong, Jamie Rossjohn, Stephanie Gras, Anthony W Purcell, Luca Hensen, Katherine Kedzierska, Patricia T Illing

Journal: PLoS Pathog

PubMed ID: 35255101

Doi: 10.1371/journal.ppat.1010337

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Physical Interaction between Cyclin-Dependent Kinase 5 (CDK5) and Clock Factors Affects the Circadian Rhythmicity in Peripheral Oscillators

Authors: Jürgen A Ripperger, Rohit Chavan, Urs Albrecht, Andrea Brenna

Journal: Clocks Sleep

PubMed ID: 35323171

Doi: 10.3390/clockssleep4010017

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RNA chain length and stoichiometry govern surface tension and stability of protein-RNA condensates

Authors: Rabia Laghmach, Ibraheem Alshareedah, Matthew Pham, Muralikrishna Raju, Priya R Banerjee, Davit A Potoyan

Journal: iScience

PubMed ID: 35378855

Doi: 10.1016/j.isci.2022.104105

Products & Services: Proteins, Expression, Isolation and Analysis

Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue

Authors: Federico Cerullo, Sebastian Filbeck, Pratik Rajendra Patil, Hao-Chih Hung, Haifei Xu, Julia Vornberger, Florian W Hofer, Jaro Schmitt, Guenter Kramer, Bernd Bukau, Kay Hofmann, Stefan Pfeffer, Claudio A P Joazeiro

Journal: Nature

PubMed ID: 35264791

Doi: 10.1038/s41586-022-04487-6

Products & Services: Proteins, Expression, Isolation and Analysis

Peptide-based simple detection of SARS-CoV-2 with electrochemical readout

Authors: Dayana Soto, Jahir Orozco

Journal: Anal Chim Acta

PubMed ID: 35414399

Doi: 10.1016/j.aca.2022.339739

Products & Services: Recombinant Antibody Expression

Combined Subcutaneous-Intranasal Immunization With Epitope-Based Antigens Elicits Binding and Neutralizing Antibody Responses in Serum and Mucosae Against PRRSV-2 and SARS-CoV-2

Authors: Mario Fragoso-Saavedra, Carmen Ramírez-Estudillo, Diana L Peláez-González, Jorge O Ramos-Flores, Gustavo Torres-Franco, Leandro Núñez-Muñoz, Gabriel Marcelino-Pérez, María G Segura-Covarrubias, Rogelio González-González, Roberto Ruiz-Medrano, Beatriz Xoconostle-Cázares, Amanda Gayosso-Vázquez, Silvia Reyes-Maya, Vianey Ramírez-Andoney, Rogelio A Alonso-Morales, Marco A Vega-López

Journal: Front Immunol

PubMed ID: 35432364

Doi: 10.3389/fimmu.2022.848054

Protein chain collapse modulation and folding stimulation by GroEL-ES

Authors: Mohsin M Naqvi, Mario J Avellaneda, Andrew Roth, Eline J Koers, Antoine Roland, Vanda Sunderlikova, Günter Kramer, Hays S Rye, Sander J Tans

Journal: Sci Adv

PubMed ID: 35245117

Doi: 10.1126/sciadv.abl6293

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CTNNBL1 restricts HIV-1 replication by suppressing viral DNA integration into the cell genome

Authors: Guoxin Liang, Yang He, Li Zhao, Jiayue Ouyang, Wenqing Geng, Xiaowei Zhang, Xiaoxu Han, Yongjun Jiang, Haibo Ding, Ying Xiong, Jinxiu Dong, Mei Liu, Hong Shang

Journal: Cell Rep

PubMed ID: 35294870

Doi: 10.1016/j.celrep.2022.110533

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Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

Authors: Rachid Essalmani, Jaspreet Jain, Delia Susan-Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David N Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Etienne Decroly, Tram Nq Pham, Éric A Cohen, Nabil G Seidah

Journal: J Virol

PubMed ID: 35343766

Doi: 10.1128/jvi.00128-22

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CD4+ T cells from COVID-19 mRNA vaccine recipients recognize a conserved epitope present in diverse coronaviruses

Authors: Bezawit A Woldemeskel, Arbor G Dykema, Caroline C Garliss, Saphira Cherfils, Kellie N Smith, Joel N Blankson

Journal: J Clin Invest

PubMed ID: 35061630

Doi: 10.1172/JCI156083

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KIR3DL05 and KIR3DS02 Recognition of a Nonclassical MHC Class I Molecule in the Rhesus Macaque Implicated in Pregnancy Success

Authors: Rachel E Nicholas, Kjell Sandstrom, Jennifer L Anderson, Willow R Smith, Molly Wetzel, Priyankana Banerjee, Sanath Kumar Janaka, David T Evans

Journal: Front Immunol

PubMed ID: 35401580

Doi: 10.3389/fimmu.2022.841136

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ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma

Authors: Ji-Ye Kim, Entaz Bahar, Jung-Yun Lee, Sunhee Chang, Se Hoon Kim, Eun Young Park, Sung-Im Do, Hyonok Yoon, Hyun-Soo Kim

Journal: Cell Death Dis

PubMed ID: 35293383

Doi: 10.1038/s41419-022-04568-4

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A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis

Authors: Yun Ji Park, Richard J Jodts, Jeffrey W Slater, Reyvin M Reyes, Valerie J Winton, Rana A Montaser, Paul M Thomas, William B Dowdle, Anahi Ruiz, Neil L Kelleher, J Martin Bollinger, Carsten Krebs, Brian M Hoffman, Amy C Rosenzweig

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35320042

Doi: 10.1073/pnas.2123566119

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AcrIF5 specifically targets DNA-bound CRISPR-Cas surveillance complex for inhibition

Authors: Yongchao Xie, Laixing Zhang, Zhengyu Gao, Peipei Yin, Hao Wang, Hang Li, Zeliang Chen, Yi Zhang, Maojun Yang, Yue Feng

Journal: Nat Chem Biol

PubMed ID: 35301482

Doi: 10.1038/s41589-022-00995-8

Products & Services: PCR and Cloning

RACK1 Associates with RNA-Binding Proteins Vigilin and SERBP1 to Facilitate Dengue Virus Replication

Authors: Alexis Brugier, Mohamed Lamine Hafirrassou, Marie Pourcelot, Morgane Baldaccini, Vasiliya Kril, Laurine Couture, Beate M Kümmerer, Sarah Gallois-Montbrun, Lucie Bonnet-Madin, Pierre-Olivier Vidalain, Constance Delaugerre, Sébastien Pfeffer, Laurent Meertens, Ali Amara

Journal: J Virol

PubMed ID: 35266803

Doi: 10.1128/jvi.01962-21

Products & Services: Mammalian Expression

OvoA from ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities

Authors: Ronghai Cheng, Andrew C Weitz, Jared Paris, Yijie Tang, Jingyu Zhang, Heng Song, Nathchar Naowarojna, Kelin Li, Lu Qiao, Juan Lopez, Mark W Grinstaff, Lixin Zhang, Yisong Guo, Sean Elliott, Pinghua Liu

Journal: Chem Sci

PubMed ID: 35432880

Doi: 10.1039/d1sc05479a

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miR-2055 regulates lipid metabolism via fatty acid synthase expression

Authors: Yang Cheng, Tengfei Lu, Junliang Guo, Zhe Lin, Qiao Jin, Xiaoming Zhang, Zhen Zou

Journal: Open Biol

PubMed ID: 35232249

Doi: 10.1098/rsob.210307

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Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Authors: Moyad Shahwan, Fahad Alhumaydhi, Ghulam Md Ashraf, Prince M Z Hasan, Anas Shamsi

Journal: Int J Biol Macromol

PubMed ID: 35247420

Doi: 10.1016/j.ijbiomac.2022.03.004

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Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Authors: Moyad Shahwan, Fahad Alhumaydhi, Ghulam Md Ashraf, Prince M Z Hasan, Anas Shamsi

Journal: Int J Biol Macromol

PubMed ID: 35247420

Doi: 10.1016/j.ijbiomac.2022.03.004

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Therapeutic Effect of Extracellular Vesicles Derived from HIF Prolyl Hydroxylase Domain Enzyme Inhibitor-Treated Cells on Renal Ischemia/Reperfusion Injury

Authors: Zhao-Ying Ding, Tao-Tao Tang, Zuo-Lin Li, Jing-Yuan Cao, Lin-Li Lv, Yi Wen, Bin Wang, Bi-Cheng Liu

Journal: Kidney Dis (Basel)

PubMed ID: 35702708

Doi: 10.1159/000522584

Products & Services: Proteins, Expression, Isolation and Analysis

Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion

Authors: Nian Jiang, Bowen Xie, Wenwu Xiao, Ming Fan, Shanxiu Xu, Yixin Duan, Yamah Hamsafar, Angela C Evans, Jie Huang, Weibing Zhou, Xuelei Lin, Ningrong Ye, Siyi Wanggou, Wen Chen, Di Jing, Ruben C Fragoso, Brittany N Dugger, Paul F Wilson, Matthew A Coleman, Shuli Xia, Xuejun Li, Lun-Quan Sun, Arta M Monjazeb, Aijun Wang, William J Murphy, Hsing-Jien Kung, Kit S Lam, Hong-Wu Chen, Jian Jian Li

Journal: Nat Commun

PubMed ID: 35314680

Doi: 10.1038/s41467-022-29137-3

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Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria

Authors: Huan Yang, Caroline Sibilla, Raymond Liu, Jina Yun, Bruce A Hay, Craig Blackstone, David C Chan, Robert J Harvey, Ming Guo

Journal: Nat Commun

PubMed ID: 35332133

Doi: 10.1038/s41467-022-29071-4

Products & Services: Proteins, Expression, Isolation and Analysis

Structure of BrxA from Staphylococcus aureus, a bacilliredoxin involved in redox homeostasis in Firmicutes

Authors: Colin S McHugh, Paul D Cook

Journal: Acta Crystallogr F Struct Biol Commun

PubMed ID: 35400666

Doi: 10.1107/S2053230X22002400

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MicroRNA-378 contributes to osteoarthritis by regulating chondrocyte autophagy and bone marrow mesenchymal stem cell chondrogenesis

Authors: Lu Feng, Zhengmeng Yang, Yucong Li, Qi Pan, Xiaoting Zhang, Xiaomin Wu, Jessica Hiu Tung Lo, Haixing Wang, Shanshan Bai, Xuan Lu, Ming Wang, Sien Lin, Xiaohua Pan, Gang Li

Journal: Mol Ther Nucleic Acids

PubMed ID: 35474736

Doi: 10.1016/j.omtn.2022.03.016

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Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury

Authors: Kurt Bachmaier, Andrew Stuart, Abhalaxmi Singh, Amitabha Mukhopadhyay, Sreeparna Chakraborty, Zhigang Hong, Li Wang, Yoshikazu Tsukasaki, Mark Maienschein-Cline, Balaji B Ganesh, Prasad Kanteti, Jalees Rehman, Asrar B Malik

Journal: ACS Nano

PubMed ID: 35230826

Doi: 10.1021/acsnano.1c09762

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Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels

Authors: Neha Singh, András Zeke, Attila Reményi

Journal: Int J Mol Sci

PubMed ID: 35328741

Doi: 10.3390/ijms23063320

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Method for quantification of porcine type I interferon activity using luminescence, by direct and indirect means

Authors: Michael Puckette, J Barrera, M Schwarz, M Rasmussen

Journal: BMC Biotechnol

PubMed ID: 35351081

Doi: 10.1186/s12896-022-00743-9

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Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice

Authors: Saurav S Rout, Yunyun Di, Ulf Dittmer, Kathrin Sutter, Kerry J Lavender

Journal: AIDS

PubMed ID: 35084382

Doi: 10.1097/QAD.0000000000003111

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Inhibition of avian influenza virus H9N2 infection by antiviral hexapeptides that target viral attachment to epithelial cells

Authors: Marwa Arbi, Imen Larbi, Jihen Nsiri, Imen El Behi, Ahmed Rejeb, Khaled Miled, Adeljelil Ghram, Mehdi Houimel

Journal: Virus Res

PubMed ID: 35306102

Doi: 10.1016/j.virusres.2022.198745

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RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants

Authors: Qingtai Liang, Yifeng Wang, Shuyuan Zhang, Jing Sun, Wenbo Sun, Jizhou Li, Yaping Liu, Mingxi Li, Lin Cheng, Yuhang Jiang, Ruoke Wang, Rui Zhang, Zihan Yang, Yifei Ren, Peng Chen, Peng Gao, Huayuan Yan, Zheng Zhang, Qi Zhang, Xuanling Shi, Jianbin Wang, Wanli Liu, Xinquan Wang, Bo Ying, Jincun Zhao, Hai Qi, Linqi Zhang

Journal: iScience

PubMed ID: 35291264

Doi: 10.1016/j.isci.2022.104043

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DNA methylation in Friedreich ataxia silences expression of frataxin isoform E

Authors: Layne N Rodden, Kaitlyn M Gilliam, Christina Lam, Teerapat Rojsajjakul, Clementina Mesaros, Chiara Dionisi, Mark Pook, Massimo Pandolfo, David R Lynch, Ian A Blair, Sanjay I Bidichandani

Journal: Sci Rep

PubMed ID: 35322126

Doi: 10.1038/s41598-022-09002-5

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FSH blockade improves cognition in mice with Alzheimer's disease

Authors: Jing Xiong, Seong Su Kang, Zhihao Wang, Xia Liu, Tan-Chun Kuo, Funda Korkmaz, Ashley Padilla, Sari Miyashita, Pokman Chan, Zhaohui Zhang, Pavel Katsel, Jocoll Burgess, Anisa Gumerova, Kseniia Ievleva, Damini Sant, Shan-Ping Yu, Valeriia Muradova, Tal Frolinger, Daria Lizneva, Jameel Iqbal, Ki A Goosens, Sakshi Gera, Clifford J Rosen, Vahram Haroutunian, Vitaly Ryu, Tony Yuen, Mone Zaidi, Keqiang Ye

Journal: Nature

PubMed ID: 35236988

Doi: 10.1038/s41586-022-04463-0

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Protein Electrostatics Investigated through Paramagnetic NMR for Nonpolar Groups

Authors: Binhan Yu, Channing C Pletka, Junji Iwahara

Journal: J Phys Chem B

PubMed ID: 35266708

Doi: 10.1021/acs.jpcb.1c10930

Products & Services: Mammalian Expression

Identifying Function Determining Residues in Neuroimmune Semaphorin 4A

Authors: Svetlana P Chapoval, Mariah Lee, Aaron Lemmer, Oluwaseyi Ajayi, Xiulan Qi, Andrew F Neuwald, Achsah D Keegan

Journal: Int J Mol Sci

PubMed ID: 35328445

Doi: 10.3390/ijms23063024

Products & Services: Mutant Libraries

Melatonin Regulates Lipid Metabolism in Porcine Cumulus-Oocyte Complexes via the Melatonin Receptor 2

Authors: Jun-Xue Jin, Jing-Tao Sun, Chao-Qian Jiang, Hong-Di Cui, Ya Bian, Sanghoon Lee, Lianjin Zhang, Byeong Chun Lee, Zhong-Hua Liu

Journal: Antioxidants (Basel)

PubMed ID: 35453372

Doi: 10.3390/antiox11040687

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Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

Authors: Zi-Wei Ye, Chon Phin Ong, Kaiming Tang, Yilan Fan, Cuiting Luo, Runhong Zhou, Peng Luo, Yun Cheng, Victor Sebastien Gray, Pui Wang, Hin Chu, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Honglin Chen, Zhiwei Chen, Kwok-Yung Yuen, Guang Sheng Ling, Shuofeng Yuan, Dong-Yan Jin

Journal: Cell Mol Immunol

PubMed ID: 35352010

Doi: 10.1038/s41423-022-00855-4

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Use of a Novel Detection Tool to Survey Orthohantaviruses in Wild-Caught Rodent Populations

Authors: Samuel M Goodfellow, Robert A Nofchissey, Chunyan Ye, Jonathan L Dunnum, Joseph A Cook, Steven B Bradfute

Journal: Viruses

PubMed ID: 35458412

Doi: 10.3390/v14040682

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Monomodular Pseudomonas aeruginosa phage JG004 lysozyme (Pae87) contains a bacterial surface-active antimicrobial peptide-like region and a possible substrate-binding subdomain

Authors: Roberto Vázquez, Mateo Seoane-Blanco, Virginia Rivero-Buceta, Susana Ruiz, Mark J van Raaij, Pedro García

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35362467

Doi: 10.1107/S2059798322000936

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Neddylation is essential for β-catenin degradation in Wnt signaling pathway

Authors: Bojun Wang, Tiantian Wang, Huimin Zhu, Rong Yan, Xinru Li, Chengqian Zhang, Wanyu Tao, Xisong Ke, Piliang Hao, Yi Qu

Journal: Cell Rep

PubMed ID: 35320710

Doi: 10.1016/j.celrep.2022.110538

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An ArsRC fusion protein enhances arsenate sensing and detoxification

Authors: Jian Chen, Adriana E Galván, Venkadesh Sarkarai Nadar, Masafumi Yoshinaga, Barry P Rosen

Journal: Environ Microbiol

PubMed ID: 35229439

Doi: 10.1111/1462-2920.15957

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Resveratrol Blunts Mitochondrial Loss in Slow and Mixed Skeletal Muscle Phenotypes of Non-Human Primates following a Long-Term High Fat/Sugar Diet

Authors: Jon-Philippe K Hyatt, Rafael de Cabo, Julie A Mattison

Journal: J Diet Suppl

PubMed ID: 35229700

Doi: 10.1080/19390211.2022.2039340

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The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV15 and ranolazine reverses the phenotype

Authors: Maria Vitoria da Silva, Artur Santos-Miranda, Julliane V Joviano-Santos, Diego Santos Souza, Leisiane Pereira Marques, Jaqueline Oliveira Sarmento, Samuel Santos Beserra, Danilo Roman-Campos

Journal: Clin Sci (Lond)

PubMed ID: 35190819

Doi: 10.1042/CS20211151

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Osteopontin aggravates acute lung injury in influenza virus infection by promoting macrophages necroptosis

Authors: Jinping Wang, Xuehui Li, Yuchong Wang, Yuyu Li, Fan Shi, Hongyan Diao

Journal: Cell Death Discov

PubMed ID: 35246529

Doi: 10.1038/s41420-022-00904-x

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Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-b1Induced OCT4/Nanog Pathway

Authors: Wenting Li, Xiaoqiong Duan, Chuanlong Zhu, Xiao Liu, Andre J Jeyarajan, Min Xu, Zeng Tu, Qiuju Sheng, Dong Chen, Chuanwu Zhu, Tuo Shao, Zhimeng Cheng, Shadi Salloum, Esperance A Schaefer, Annie J Kruger, Jacinta A Holmes, Raymond T Chung, Wenyu Lin

Journal: J Immunol

PubMed ID: 35022275

Doi: doi/10.4049/jimmunol.2001453

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CD137 Agonists Targeting CD137-Mediated Negative Regulation Show Enhanced Antitumor Efficacy in Lung Cancer

Authors: Ling Yi , Xin Jin , Jinghui Wang , Zhuohong Yan , Xu Cheng , Tao Wen , Bin Yang , Xiaojue Wang , Nanying Che , Zhidong Liu and Hongtao Zhang

Journal: Frontiers in Immunology

Doi: 10.3389/fimmu.2022.771809

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Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family

Authors: Jianmei Hou , Elizabeth V Nguyen , Minglyanna Surudoi , Michael J Roy , Onisha Patel , Isabelle S Lucet , Xiuquan Ma , Roger J Daly

Journal: Sci Signal

PubMed ID: 35192416

Doi: 10.1126/scisignal.abj3

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Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells

Authors: Shenglong Zhu , Wei Wang , Jingwei Zhang , Siyu Ji , Zhe Jing , Yong Q Chen

Journal: Cell Mol Biol Lett

PubMed ID: 35109789

Doi: 10.1186/s11658-022-00314-y

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Structural characterization of the Myxococcus xanthus encapsulin and ferritin-like cargo system gives insight into its iron storage mechanism

Authors: Elif Eren, Bing Wang, Dennis C Winkler, Norman R Watts, Alasdair C Steven, Paul T Wingfield

Journal: Structure

PubMed ID: 35150605

Doi: 10.1016/j.str.2022.01.008

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Optical Sensors and Actuators for Probing Proximity-Dependent Biotinylation in Living Cells

Authors: Rui Chen, Ningxia Zhang, Yubin Zhou, Ji Jing

Journal: Front Cell Neurosci

PubMed ID: 35250484

Doi: 10.3389/fncel.2022.801644

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Robust and Functional Immune Memory Up to 9 Months After SARS-CoV-2 Infection: A Southeast Asian Longitudinal Cohort

Authors: Hoa Thi My Vo, Alvino Maestri, Heidi Auerswald, Sopheak Sorn, Sokchea Lay, Heng Seng, Sotheary Sann, Nisa Ya, Polidy Pean, Philippe Dussart, Olivier Schwartz, Sovann Ly, Timothée Bruel, Sowath Ly, Veasna Duong, Erik A Karlsson, Tineke Cantaert

Journal: Front Immunol

PubMed ID: 35185909

Doi: 10.3389/fimmu.2022.817905

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Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

Authors: Remkes A Scheele, Laurens H Lindenburg, Maya Petek, Markus Schober, Kevin N Dalby, Florian Hollfelder

Journal: Nat Commun

PubMed ID: 35149678

Doi: 10.1038/s41467-022-28396-4

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Defining molecular glues with a dual-nanobody cannabidiol sensor

Authors: Shiyun Cao, Shoukai Kang, Haibin Mao, Jiayu Yao, Liangcai Gu, Ning Zheng

Journal: Nat Commun

PubMed ID: 35145136

Doi: 10.1038/s41467-022-28507-1

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Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions

Authors: Fin J Milder, Mandy Jongeneelen, Tina Ritschel, Pascale Bouchier, Ilona J M Bisschop, Martijn de Man, Daniel Veldman, Lam Le, Baerbel Kaufmann, Mark J G Bakkers, Jarek Juraszek, Boerries Brandenburg, Johannes P M Langedijk

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35131851

Doi: 10.1073/pnas.2115379119

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T cell receptors employ diverse strategies to target a p53 cancer neoantigen

Authors: Daichao Wu, Ragul Gowathaman, Brian G Pierce, Roy A Mariuzza

Journal: J Biol Chem

PubMed ID: 35124005

Doi: 10.1016/j.jbc.2022.101684

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Evolution and conserved functionality of organ size and shape regulator PEAPOD

Authors: Ruth Cookson, Somrutai Winichayakul, Hong Xue, Kim Richardson, Roger Moraga, Aurelie Laugraud, Ambarish Biswas, Greg Bryan, Nick Roberts

Journal: PLoS ONE

PubMed ID: 35148336

Doi: 10.1371/journal.pone.0263928

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Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trial

Authors: Carlo Scognamiglio Renner Araujo, Ana Cristina Medeiros-Ribeiro, Carla G S Saad, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Matheus Santos Rodrigues Silva, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Tatiana Pedrosa, Leonard de Vinci Kanda Kupa, Gioanna Zou, Rosa M R Pereira, Clóvis Artur Silva, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Ann Rheum Dis

PubMed ID: 35193873

Doi: 10.1136/annrheumdis-2021-221916

Products & Services: Proteins, Expression, Isolation and Analysis

Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events

Authors: Siew C Ng, Ye Peng, Lin Zhang, Chris Kp Mok, Shilin Zhao, Amy Li, Jessica Yl Ching, Yingzhi Liu, Shuai Yan, Dream L S Chan, Jie Zhu, Chunke Chen, Adrian Ch Fung, Kenneth Ky Wong, David Sc Hui, Francis Kl Chan, Hein M Tun

Journal: Gut

PubMed ID: 35140064

Doi: 10.1136/gutjnl-2021-326563

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Inhibition of base editors with anti-deaminases derived from viruses

Authors: Zhiquan Liu, Siyu Chen, Liangxue Lai, Zhanjun Li

Journal: Nat Commun

PubMed ID: 35105899

Doi: 10.1038/s41467-022-28300-0

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Differences in mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine immunogenicity among patients undergoing dialysis

Authors: Kevin Yau, Christopher T Chan, Kento T Abe, Yidi Jiang, Mohammad Atiquzzaman, Sarah I Mullin, Ellen Shadowitz, Lisa Liu, Ema Kostadinovic, Tatjana Sukovic, Anny Gonzalez, Margaret E McGrath-Chong, Matthew J Oliver, Jeffrey Perl, Jerome A Leis, Shelly Bolotin, Vanessa Tran, Adeera Levin, Peter G Blake, Karen Colwill, Anne-Claude Gingras, Michelle A Hladunewich

Journal: CMAJ

PubMed ID: 35115375

Doi: 10.1503/cmaj.211881

Products & Services: Mammalian Expression

The nsp15 Nuclease as a Good Target to Combat SARS-CoV-2: Mechanism of Action and Its Inactivation with FDA-Approved Drugs

Authors: Margarida Saramago, Vanessa G Costa, Caio S Souza, Cátia Bárria, Susana Domingues, Sandra C Viegas, Diana Lousa, Cláudio M Soares, Cecília M Arraiano, Rute G Matos

Journal: Microorganisms

PubMed ID: 35208797

Doi: 10.3390/microorganisms10020342

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Intensity and Dynamics of Anti-SARS-CoV-2 Immune Responses after BNT162b2 mRNA Vaccination: Implications for Public Health Vaccination Strategies

Authors: Matthaios Speletas, Ioanna Voulgaridi, Styliani Sarrou, Aikaterini Dadouli, Varvara A Mouchtouri, Dimitrios J Nikoulis, Maria Tsakona, Maria A Kyritsi, Athanasia-Marina Peristeri, Ioanna Avakian, Asimina Nasika, Paraskevi C Fragkou, Charalampos D Moschopoulos, Stamatia Zoubouneli, Ilias Onoufriadis, Lemonia Anagnostopoulos, Alexia Matziri, Georgia Papadamou, Aikaterini Theodoridou, Sotirios Tsiodras, Christos Hadjichristodoulou

Journal: Vaccines (Basel)

PubMed ID: 35214774

Doi: 10.3390/vaccines10020316

The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

Authors: Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F Markmann, Emanuela Orsi, Jan Škrha, Maria Gabriella Camboni, Reza Abdi, A M James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zuccotti, Paolo Fiorina

Journal: Nat Commun

PubMed ID: 35115561

Doi: 10.1038/s41467-022-28360-2

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Sensitivity of eight types of ALK fusion variant to alectinib in ALK-transformed cells

Authors: Koh Furugaki, Naoki Harada, Yasushi Yoshimura

Journal: Anticancer Drugs

PubMed ID: 34520436

Doi: 10.1097/CAD.0000000000001249

Products & Services: Mammalian Expression

Chloroplast translational regulation uncovers nonessential photosynthesis genes as key players in plant cold acclimation

Authors: Yang Gao, Wolfram Thiele, Omar Saleh, Federico Scossa, Fayezeh Arabi, Hongmou Zhang, Arun Sampathkumar, Kristina Kühn, Alisdair Fernie, Ralph Bock, Mark A Schöttler, Reimo Zoschke

Journal: Plant Cell

PubMed ID: 35171295

Doi: 10.1093/plcell/koac056

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Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination

Authors: Christina Strauch, Thu-Huong Hoang, Frank Angenstein, Denise Manahan-Vaughan

Journal: Cereb Cortex

PubMed ID: 34379749

Doi: 10.1093/cercor/bhab226

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Vaccine Candidate Double Mutant Variants of Enterotoxigenic Heat-Stable Toxin

Authors: Ephrem Debebe Zegeye, Yuleima Diaz, Pål Puntervoll

Journal: Vaccines (Basel)

PubMed ID: 35214698

Doi: 10.3390/vaccines10020241

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Structural characterization of a new subclass of panicum mosaic virus-like 3' cap-independent translation enhancer

Authors: Philip Z Johnson, Wojciech K Kasprzak, Bruce A Shapiro, Anne E Simon

Journal: Nucleic Acids Res

PubMed ID: 35104872

Doi: 10.1093/nar/gkac007

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Performance evaluation of four surrogate Virus Neutralization Tests (sVNTs) in comparison to the gold standard test

Authors: Massimo Pieri, Maria Infantino, Mariangela Manfredi, Marzia Nuccetelli, Valentina Grossi, Barbara Lari, Flaminia Tomassetti, Serena Sarubbi, Edda Russo, Amedeo Amedei, Maurizio Benucci, Patrizia Casprini, Lorenzo Stacchini, Concetta Castilletti, Sergio Bernardini

Journal: Front Biosci (Landmark Ed)

PubMed ID: 35227017

Doi: 10.31083/j.fbl2702074

IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy

Authors: Pengsen Wu, Bingying Lin, Siyu Huang, Jie Meng, Fan Zhang, Min Zhou, Xiangqing Hei, Yu Ke, Huasheng Yang, Danping Huang

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35273577

Doi: 10.3389/fendo.2022.846106

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Nonswelling and Hydrolytically Stable Hydrogels Uncover Cellular Mechanosensing in 3D

Authors: Hongyan Long, Bart E Vos, Timo Betz, Brendon M Baker, Britta Trappmann

Journal: Adv Sci (Weinh)

PubMed ID: 35187856

Doi: 10.1002/advs.202105325

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The Cdc42 GTPase-activating protein Rga6 promotes the cortical localization of septin

Authors: Shengnan Zheng, Biyu Zheng, Zhenbang Liu, Xiaopeng Ma, Xing Liu, Xuebiao Yao, Wenfan Wei, Chuanhai Fu

Journal: J Cell Sci

PubMed ID: 35048989

Doi: 10.1242/jcs.259228

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Fine mapping and cloning of the major seed protein quantitative trait loci on soybean chromosome 20

Authors: Christina E Fliege, Russell A Ward, Pamela Vogel, Hanh Nguyen, Truyen Quach, Ming Guo, João Paulo Gomes Viana, Lucas Borges Dos Santos, James E Specht, Tom E Clemente, Matthew E Hudson, Brian W Diers

Journal: Plant J

PubMed ID: 34978122

Doi: 10.1111/tpj.15658

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Induced ligno-suberin vascular coating and tyramine-derived hydroxycinnamic acid amides restrict Ralstonia solanacearum colonization in resistant tomato

Authors: Anurag Kashyap, Álvaro Luis Jiménez-Jiménez, Weiqi Zhang, Montserrat Capellades, Sumithra Srinivasan, Anna Laromaine, Olga Serra, Mercè Figueras, Jorge Rencoret, Ana Gutiérrez, Marc Valls, Nuria S Coll

Journal: New Phytol

PubMed ID: 35152435

Doi: 10.1111/nph.17982

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Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein

Authors: Oskar Staufer, Kapil Gupta, Jochen Estebano Hernandez Bücher, Fabian Kohler, Christian Sigl, Gunjita Singh, Kate Vasileiou, Ana Yagüe Relimpio, Meline Macher, Sebastian Fabritz, Hendrik Dietz, Elisabetta Ada Cavalcanti Adam, Christiane Schaffitzel, Alessia Ruggieri, Ilia Platzman, Imre Berger, Joachim P Spatz

Journal: Nat Commun

PubMed ID: 35165285

Doi: 10.1038/s41467-022-28446-x

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A Lateral Flow Immunoassay Coupled with a Spectrum-Based Reader for SARS-CoV-2 Neutralizing Antibody Detection

Authors: Rui-Lin Huang, Yi-Chen Fu, Yung-Chih Wang, Chitsung Hong, Wei-Chieh Yang, I-Jen Wang, Jun-Ren Sun, Yunching Chen, Ching-Fen Shen, Chao-Min Cheng

Journal: Vaccines (Basel)

PubMed ID: 35214731

Doi: 10.3390/vaccines10020271

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Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2

Authors: Youwen Zhuang, Lei Wang, Jia Guo, Dapeng Sun, Yue Wang, Weiyi Liu, H Eric Xu, Cheng Zhang

Journal: Nat Commun

PubMed ID: 35217703

Doi: 10.1038/s41467-022-28586-0

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N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum

Authors: Samuel Pazicky, Arne Alder, Haydyn Mertens, Dmitri Svergun, Tim Gilberger, Christian Löw

Journal: Biochem J

PubMed ID: 35023554

Doi: 10.1042/BCJ20210829

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Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly

Authors: Krishnendu Khan, Briana Long, Camelia Baleanu-Gogonea, Valentin Gogonea, Gauravi M Deshpande, Kommireddy Vasu, Paul L Fox

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35140182

Doi: 10.1073/pnas.2115799119

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Hot Hydrogen Atom Irradiation of Protonated/Deprotonated Peptide in an Ion Trap Facilitates Fragmentation through Heated Radical Formation

Authors: Daiki Asakawa, Hidenori Takahashi, Shinichi Iwamoto, Koichi Tanaka

Journal: J Am Chem Soc

PubMed ID: 35138819

Doi: 10.1021/jacs.1c11081

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Molecular Characterization and Gene Expression Analysis of Aquaporin in

Authors: Qingli Niu, Rongzeng Hao, Yuping Pan, Zhijie Liu, Jifei Yang, Guiquan Guan, Jianxun Luo, Hong Yin

Journal: Front Physiol

PubMed ID: 35250616

Doi: 10.3389/fphys.2022.811628

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Systemic and Lower Respiratory Tract Immunity to SARS-CoV-2 Omicron and Variants in Pediatric Severe COVID-19 and Mis-C

Authors: Juanjie Tang, Adrienne G Randolph, Tanya Novak, Tracie C Walker, Laura L Loftis, Matt S Zinter, Katherine Irby, Surender Khurana

Journal: Vaccines (Basel)

PubMed ID: 35214728

Doi: 10.3390/vaccines10020270

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Endothelial Phospholipase Cγ2 Improves Outcomes of Diabetic Ischemic Limb Rescue Following VEGF Therapy

Authors: Yashika Rustagi, Ahmed S Abouhashem, Priyanka Verma, Sumit S Verma, Edward Hernandez, Sheng Liu, Manishekhar Kumar, Poornachander R Guda, Rajneesh Srivastava, Sujit K Mohanty, Sedat Kacar, Sanskruti Mahajan, Kristen E Wanczyk, Savita Khanna, Michael P Murphy, Gayle M Gordillo, Sashwati Roy, Jun Wan, Chandan K Sen, Kanhaiya Singh

Journal: Diabetes

PubMed ID: 35192691

Doi: 10.2337/db21-0830

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Ratiometric Imaging of Mitochondrial Hydrogen Peroxide in Aβ-Mediated Neurotoxicity

Authors: Xinyu Li, Yiyu Zhang, Hui-Wang Ai

Journal: ACS Sens

PubMed ID: 35226474

Doi: 10.1021/acssensors.1c01381

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Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1

Authors: Yu-Syuan Wei, Wan-Zhen Lin, Tse-En Wang, Wei-Yun Lee, Sheng-Hsiang Li, Fu-Jung Lin, Brett Nixon, Petra Sipilä, Pei-Shiue Tsai

Journal: J Reprod Dev

PubMed ID: 35228412

Doi: 10.1262/jrd.2021-128

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Hsa_circ_0007059 promotes apoptosis and inflammation in cardiomyocytes during ischemia by targeting microRNA-378 and microRNA-383

Authors: Chaorui Xu, Zhuowen Jia, Xuefei Cao, Sha Wang, Jipeng Wang, Liping An

Journal: Cell Cycle

PubMed ID: 35192424

Doi: 10.1080/15384101.2022.2040122

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Rapid colloidal gold immunochromatographic assay for the detection of SARS-CoV-2 total antibodies after vaccination

Authors: Liya Ye, Xinxin Xu, Shanshan Song, Liguang Xu, Hua Kuang, Chuanlai Xu

Journal: J Mater Chem B

PubMed ID: 35212337

Doi: 10.1039/d1tb02521j

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Adaptive evolution of Methylotuvimicrobium alcaliphilum to grow in the presence of rhamnolipids improves fatty acid and rhamnolipid production from CH4

Authors: Deepika Awasthi, Yung-Hsu Tang, Bashar Amer, Edward E K Baidoo, Jennifer Gin, Yan Chen, Christopher J Petzold, Marina Kalyuzhnaya, Steven W Singer

Journal: J Ind Microbiol Biotechnol

PubMed ID: 35134957

Doi: 10.1093/jimb/kuac002

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PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy

Authors: Ruhul H Choudhury, Peter Symonds, Samantha J Paston, Ian Daniels, Katherine W Cook, Mohamed Gijon, Rachael L Metheringham, Victoria A Brentville, Lindy G Durrant

Journal: J Immunother Cancer

PubMed ID: 35140112

Doi: 10.1136/jitc-2021-003526

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Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET

Authors: Rhye-Samuel Kanassatega, Thomas A Bunch, Victoria C Lepak, Christopher Wang, Brett A Colson

Journal: J Mol Cell Cardiol

PubMed ID: 35227736

Doi: 10.1016/j.yjmcc.2022.02.005

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Highly Stable Buffer-Based Zinc Oxide/Reduced Graphene Oxide Nanosurface Chemistry for Rapid Immunosensing of SARS-CoV-2 Antigens

Authors: Fatemeh Haghayegh, Razieh Salahandish, Mohsen Hassani, Amir Sanati-Nezhad

Journal: ACS Appl Mater Interfaces

PubMed ID: 35172574

Doi: 10.1021/acsami.1c24475

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Identification and mapping of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells

Authors: Mariana Estevez, Rui Li, Biplab Paul, Kaveh Daneshvar, Alan C Mullen, Fabio Romerio, Balasubrahmanyam Addepalli

Journal: RNA

PubMed ID: 35168996

Doi: 10.1261/rna.079043.121

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APLNR Regulates IFN-γ signaling via β-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells

Authors: Yingying Liu, Xiaochuan Ma, Hui Yang, Xun Li, Yingli Ma, Brandon Ason, Suling Liu, Liaoyuan A Hu

Journal: Biochem J

PubMed ID: 35084016

Doi: 10.1042/BCJ20210813

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Genome-wide identification and functional characterization of gene family reveal their involvement in response to drought stress in

Authors: Guangzhen Shi, Xinxia Zhu

Journal: PeerJ

PubMed ID: 35186477

Doi: 10.7717/peerj.12883

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CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling

Authors: Dan Chen, Yi Zhang, Lian Ji, Yubin Wu

Journal: Cell Biol Int

PubMed ID: 35143104

Doi: 10.1002/cbin.11777

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CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling

Authors: Dan Chen, Yi Zhang, Lian Ji, Yubin Wu

Journal: Cell Biol Int

PubMed ID: 35143104

Doi: 10.1002/cbin.11777

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Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance

Authors: Xiaorong Chen, Noah P Bradley, Wei Lu, Katherine L Wahl, Mei Zhang, Hua Yuan, Xian-Feng Hou, Brandt F Eichman, Gong-Li Tang

Journal: Nucleic Acids Res

PubMed ID: 35191495

Doi: 10.1093/nar/gkac085

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Cathepsin B inhibitor alleviates Th1, Th17, and Th22 transcription factor signaling dysregulation in experimental autoimmune encephalomyelitis

Authors: Mushtaq A Ansari, Ahmed Nadeem, Musaad A Alshammari, Sabry M Attia, Saleh A Bakheet, Mohammad R Khan, Thamer H Albekairi, Abdullah F Alasmari, Khaled Alhosaini, Faleh Alqahtani, Haneen A Al-Mazroua, Sheikh F Ahmad

Journal: Exp Neurol

PubMed ID: 35122866

Doi: 10.1016/j.expneurol.2022.113997

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Serum TK1 protein and C-reactive protein correlate to treatment response and predict survival in dogs with hematologic malignancies

Authors: S Saellström, H Sharif, K K Jagarlamudi, H Rönnberg, L Wang, S Eriksson

Journal: Res Vet Sci

PubMed ID: 35245727

Doi: 10.1016/j.rvsc.2022.02.019

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Rapid screening of aptamers for fluorescent targets by integrated digital PCR and flow cytometry

Authors: Xiaona Fang, Wenjing Li, Tian Gao, Qurat Ul Ain Zahra, Zhaofeng Luo, Renjun Pei

Journal: Talanta

PubMed ID: 35180537

Doi: 10.1016/j.talanta.2022.123302

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Immunological characterization of chicken tumor necrosis factor-α (TNF-α) using new sets of monoclonal antibodies specific for poultry TNF-α

Authors: Mingmin Lu, Youngsub Lee, Charles Li, Hyun S Lillehoj

Journal: Dev Comp Immunol

PubMed ID: 35157961

Doi: 10.1016/j.dci.2022.104374

Products & Services: Proteins, Expression, Isolation and Analysis

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