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Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain

Authors: Jing-Yi Zhou, Rui-Rui Yang, Jie Chang, Jia Song, Zi-Sheng Fan, Ying-Hui Zhang, Cheng-Hao Lu, Hua-Liang Jiang, Ming-Yue Zheng, Su-Lin Zhang

Journal: Acta Pharmacol Sin

PubMed ID: 35918411

Doi: 10.1038/s41401-022-00936-0

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A Localized Materials-Based Strategy to Non-Virally Deliver Chondroitinase ABC mRNA Improves Hindlimb Function in a Rat Spinal Cord Injury Model

Authors: Andrew S Khalil, Daniel Hellenbrand, Kaitlyn Reichl, Jennifer Umhoefer, Mallory Filipp, Joshua Choe, Amgad Hanna, William L Murphy

Journal: Adv Healthc Mater

PubMed ID: 35882512

Doi: 10.1002/adhm.202200206

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The NCF1 variant pR90H aggravates autoimmunity by facilitating the activation of plasmacytoid dendritic cells

Authors: Yao Meng, Jianyang Ma, Chao Yao, Zhizhong Ye, Huihua Ding, Can Liu, Jun Li, Guanhua Li, Yuke He, Jia Li, Zhihua Yin, Li Wu, Haibo Zhou, Nan Shen

Journal: J Clin Invest

PubMed ID: 35788118

Doi: 10.1172/JCI153619

Products & Services: Protein and Antibody Isolation

Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections

Authors: Rani Burm, Panagiota Maravelia, Gustaf Ahlen, Sandra Ciesek, Noelia Caro Perez, Anna Pasetto, Stephan Urban, Freya Van Houtte, Lieven Verhoye, Heiner Wedemeyer, Magnus Johansson, Lars Frelin, Matti Sällberg, Philip Meuleman

Journal: Gut

PubMed ID: 35977815

Doi: 10.1136/gutjnl-2022-327216

Products & Services: Protein and Antibody Isolation

PpZAT10 negatively regulates peach cold resistance predominantly mediated by inhibiting VIN activity

Authors: YiChen ,JiachangSun ,YingyingWei ,KefengCao ,ShuJiang ,XingfengShao

Journal: Postharvest Biology and Technology

Doi: 10.1016/j.postharvbio.2022.111952

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Non-viral，specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL

Authors: Jiqin Zhang , Yongxian Hu , Jiaxuan Yang , Wei Li , Mingming Zhang , Qingcan Wang , Linjie Zhang , Guoqing Wei , Yue Tian , Kui Zhao , Ang Chen , Binghe Tan , Jiazhen Cui , Deqi Li , Yi Li , Yalei Qi , Dongrui Wang , Yuxuan Wu , Dali Li , Bing Du , Mingyao Liu , He Huang

Journal: Nature

PubMed ID: 36045296

Doi: 10.1038/s41586-022-05140-y

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Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.

Authors: Zuben P Brown , Irina S Abaeva , Swastik De , Christopher U T Hellen , Tatyana V Pestova , Joachim Frank

Journal: EMBO J

PubMed ID: 35822879

Doi: 10.15252/embj.2022110581

Products & Services: Gene Synthesis

DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates

Authors: Lijie Zhao , Naizhe Huang , Jun Mencius , Yanjing Li , Ying Xu , Yongxin Zheng , Wei He , Na Li , Jun Zheng , Min Zhuang , Shu Quan , Yong Chen

Journal: iScience

PubMed ID: 36065180

Doi: 10.1016/j.isci.2022.104948

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A novel ZsGreen knock-in melanoma cell line reveals the function of CD11b in tumor phagocytosis

Authors: Lichen Zhang, Xinyu Feng, Yingzhuo Shen, Yingbin Wang, Zhuangzhuang Liu, Yuang Ma, Yanrong Gu, Guo Guo, Liangwei Duan, Liaoxun Lu, Yinming Liang, Toby Lawrence, Rong Huang

Journal: Immunol Cell Biol

PubMed ID: 35849045

Doi: 10.1111/imcb.12575

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Crucial role of Ca /CN signalling pathway in the antifungal activity of disenecioyl-cis-khellactone against Botrytis cinerea

Authors: Ping-Ping Song, Yu Wang, Yi-Ping Hou, Xue-Wei Mao, Zong-Liang Liu, Min Wei, Jin-Ping Yu, Bi Wang, Yi-Yun Qian, Lu Yan, Shu Xu, Yan-Qin Jiang, Dong-Qin Zhou, Min Yin, Jian Dou

Journal: Pest Manag Sci

PubMed ID: 35866518

Doi: 10.1002/ps.7085

Products & Services: Gene Synthesis