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Cas9-orthologue-mediated cytosine and adenine base editors recognizing NNAAAA PAM sequences

Authors: Min Li, Yuting Zhao, Xiaowen Xue, Jingli Zhong, Jianxiang Lin, Jiankui Zhou, Wenhua Yu, Jun Chen, Yunbo Qiao

Journal: Biotechnol J

PubMed ID: 36800529

Doi: 10.1002/biot.202200533

Products & Services: Protein and Antibody Isolation

Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes

Authors: Amanda Fabra-García, Sophia Hailemariam, Roos M de Jong, Kirsten Janssen, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Danton Ivanochko, Anthony Semesi, Brandon McLeod, Martijn W Vos, Marloes H C de Bruijni, Judith M Bolscher, Marta Szabat, Stefanie Vogt, Lucas Kraft, Sherie Duncan, Moses R Kamya, Margaret E Feeney, Prasanna Jagannathan, Bryan Greenhouse, Koen J Dechering, Robert W Sauerwein, C Richter King, Randall S MacGill, Teun Bousema, Jean-Philippe Julien, Matthijs M Jore

Journal: Immunity

PubMed ID: 36792574

Doi: 10.1016/j.immuni.2023.01.009

Products & Services: Protein and Antibody Isolation

Planthopper salivary sheath protein LsSP1 contributes to manipulation of rice plant defenses

Authors: Hai-Jian Huang, Yi-Zhe Wang , Li-Li Li , Hai-Bin Lu, Jia-Bao Lu, Xin Wang , Zhuang-Xin Ye , Ze-Long Zhang, Yu-Juan He, Gang Lu , Ji-Chong Zhuo , Qian-Zhuo Mao , Zong-Tao Sun , Jian-Ping Chen, Jun-Min Li , Chuan-Xi Zhang

Journal: Nat Commun .

PubMed ID: 36759625

Doi: 10.1038/s41467-023-36403-5

Products & Services: Antibody Services

Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal

Authors: Michele D. Kattke; Albert H. Chan; Andrew Duong; Danielle L. Sexton; Michael R. Sawaya; Duilio Cascio; Marie A. Elliot; Robert T. Clubb

Journal: PLoS ONE

PubMed ID: 27936128

Doi: 10.1371/journal.pone.0167763

Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal

Authors: Michele D. Kattke; Albert H. Chan; Andrew Duong; Danielle L. Sexton; Michael R. Sawaya; Duilio Cascio; Marie A. Elliot; Robert T. Clubb

Journal: PLoS ONE

PubMed ID: 27936128

Doi: 10.1371/journal.pone.0167763

Functionalized biomimetic nanoparticles combining programmed death-1/programmed death-ligand 1 blockade with photothermal ablation for enhanced colorectal cancer immunotherapy.

Authors: Yuchen Xiao, Tianchuan Zhu, Qi Zeng, Qingqin Tan, Guanmin Jiang, Xi Huang

Journal: Acta Biomater

PubMed ID: 36442821

Doi: 10.1016/j.actbio.2022.11.043

Products & Services: Protein and Antibody Isolation

A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis-Targeting Chimeras Enhanced Immunotherapy

Authors: Yaping Wu, Xiaowei Chang, Guizhu Yang, Li Chen, Qi Wu, Jiamin Gao, Ran Tian, Wenyun Mu, John Justin Gooding, Xin Chen, Shuyang Sun

Journal: Adv Mater

PubMed ID: 36656993

Doi: 10.1002/adma.202210787

Products & Services: Peptide Synthesis

Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation

Authors: Cécily Lucas, Kay-Sara Sauter, Michael Steigert, Delphine Mallet, James Wilmouth, Julie Olabe, Ingrid Plotton, Yves Morel, Daniel Aeberli, Franca Wagner, Hans Clevers, Amit V Pandey, Pierre Val, Florence Roucher-Boulez, Christa E Flück

Journal: JOURNAL OF CLINICAL INVESTIGATION

PubMed ID: 36538378

Doi: 10.1172/JCI164915

Products & Services: Protein and Antibody Isolation

Single-cell resolution reveals RalA GTPase expanding hematopoietic stem cells and facilitating of BCR-ABL1-driven leukemogenesis in a CRISPR/Cas9 gene editing mouse model

Authors: Zhao Yin, Rui Su, Lanlan Ge, Xiuyuan Wang, Juhua Yang, Guiping Huang, Chuting Li, Yanjun Liu, Keda Zhang, Lan Deng, Jia Fei

Journal: International journal of biological sciences

PubMed ID: 36923939

Doi: 10.7150/ijbs.76993

Products & Services: CRISPR KI Templates

Mechanistic Basis for a Connection between the Catalytic Step and Slow Opening Dynamics of Adenylate Kinase

Authors: Beata Dulko-Smith, Pedro Ojeda-May, Jörgen Ådén, Magnus Wolf-Watz, Kwangho Nam