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Neuron-Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65-Mediated ANXA2 Degradation

Authors: Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji

Journal: Advanced Science

PubMed ID: 42885139

Doi: 10.1002/advs.77808

Enzymes can activate and mobilize dense biomolecular condensates across scales

Authors: Mirco Dindo, Jakob Metson, Weitong Ren, Michalis Chatzittofi, Kiyoshi Yagi, Alessandro Bevilacqua, Erika Fukuhara, Yuji Sugita, Ramin Golestanian, Paola Laurino

Journal: Nature Communications

PubMed ID: 42963352

Doi: 10.1038/s41467-026-77666-y

Products & Services: Molecular Biology Tools

Cis-regulatory inactivation of vitamin D signaling confers extreme calcium tolerance in Jialing fish

Authors: Nan Zhang, Yongsen Zhou, Jianbin Feng, Tianhao Yang, Huilin Liu, Yongsheng Zhang, Lingyun Chen, Weiyang Xiao, Tai Wang, Aaron J W Hsueh, Jianzhen Li

Journal: Science advences

PubMed ID: 42842657

Doi: 10.1126/sciadv.aeg8398

Products & Services: Synthetic Guide RNA

Cardiomyocyte-enriched OTUD5 alleviates pathological myocardial hypertrophy by deubiquitinating STAT3 and modulating the STAT3–PGC-1α axis

Authors: Bozhi Ye, Yucheng Jiang, Zhaozheng Zheng, Yanhong Jin, Yingjie Liao, Zhihan Jia, Wante Lin, Diyun Xu, Jibo Han, Zimin Fang, Naijin Zhang, Peiren Shan, Gaojun Wu, Guang Liang

Journal: experimental & molecular medicine

PubMed ID: 42888217

Doi: 10.1038/s12276-026-01870-5

Keratin 9 regulates mechanosensitive YAP1 signalling in palmoplantar epidermis

Authors: Sarah N. Steiner, Eric N. Horst, Evelyn S. Chiu, Mitre Athaiya, Craig N. Johnson, Joseph Y. Shen, Michelle L. Kerns, Joseph D. Kirma, Rebecca L. McCarthy, Syed F. H. Shah, Ofer Sarig, Liat Samuelov, Eli Sprecher, Edel A. O’Toole, Johann E. Gudjonsson, Geeta Mehta, Ramiro Iglesias-Bartolome, Pierre A. Coulombe

Journal: Nature Cell Biology

PubMed ID: 42918816

Doi: 10.1038/s41556-026-02087-4

IRF2BP2-FOSL2 interaction regulates SOX9-mediated cartilage regeneration in osteoarthritis models

Authors: Hao Zhou, Tiantian Lu, Zhuoqun Gao, Can Cui, Zhiqiang Fang, Yu You, Jing Jiang, Jinjin Xu, Fang Wei, Jing Yu, Hu Zhou, Jinsong Li, Jian Luo, Lei Zhang, Yunyun Jin

Journal: JOURNAL OF CLINICAL INVESTIGATION

PubMed ID: 42878073

Doi: 10.1172/JCI200039

Products & Services: Peptide Synthesis

Interpretable AI-guided discovery of degradable ionizable lipids with enhanced hepatic mRNA delivery in vivo

Authors: Zhen Zhang, Yongbo Ren, Deqiang Kong, Jindong Feng, Kaiyi Hu, Xinyun Xu, Fukang Deng, Peixia Li, Jiuao Wang, Wenhui Huang, Guodan Wei, Yang Su, Ying Tan, Shuixing Zhang, Xiaodan Sun, Feiyu Kang, Hao Yan

Journal: nature communications

Doi: doi.org/10.1038/s41467-026-78635-1

Products & Services: Custom mRNA synthesis

Lysostaphin bioengineered cascade nanoreactor for bacterial eradication and inflammatory remodeling in MRSA pneumonia

Authors: Xiuhua Pan, Feiyang Liu, Ruixin Kang, Yueru Pang, Siyuan Yu, Ziqi Shen, Qi Shen

Journal: Journal of Controlled Release

PubMed ID: 42843528

Doi: 10.1016/j.jconrel.2026.115444

Products & Services: Protein Electrophoresis and Western

WTAP resists cholestatic liver injury by m6A-IGF2BP1-dependent regulation of the nuclear receptor FXR

Authors: Guomin Ju, Tong Wu, Yu Wu, Xueyu Zhou, Yang Yang, Xiangwen Meng, Cheng Jin, Hui Chen, Ke Sun, Ming Yu, Qinfen Xie, Shusen Zheng, Jian Wu, Chuanhui Peng

Journal: GUT

PubMed ID: 42919657

Doi: 10.1136/gutjnl-2025-337845

Products & Services: Protein Electrophoresis and Western

Aromaticity at spike position 456 affects functional immunogenicity of SARS-CoV-2 Omicron variant receptor-binding domain

Authors: Dandan Peng, Zimin Chen, Minyang Fu, Weiqi Hong, Mengzhe Dai, Hao Zeng, Sheng Lin, Hong Lei, Jingyun Yang, Jie Shi, Xiya Huang, Chunjun Ye, Furong Qin, Yu Zhang, Ying Hao, Binhan Wang, Wenyan Ren, Li Chen, Jian Liu, Aqu Alu, Yishan Lu, Xinyi Du, Jiong Li, Huashan Shi, Yuquan Wei, Yi Chen, Shuaiyao Lu, Cai He, Guangwen Lu, Xiawei Wei

Journal: Signal transduction and targeted therapy

PubMed ID: 42957648

Doi: 10.1038/s41392-026-02939-3

Products & Services: Peptide Library Services