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PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma

Authors: Binfeng Liu, Wei Li, Wenchao Zhang, Chengyao Feng, Lu Wan, Shasha He, Ruiling Xu, Zheng Fu, Zhongyue Liu, Haodong Xu, Xin Jin, Chao Tu, Zhihong Li

Journal: Signal Transduct Target Ther

PubMed ID: 40393983

Doi: 10.1038/s41392-025-02250-7

Products & Services: Catalog Antibody

Fe(III)−H2O2 as an Alternative Oxidant for Catalytic Sulfoxidation in Cytochrome P450 Enzymes: Combined Theoretical and Experimental Evidence

Authors: Musen Li, Langxing Liao, Zhihui Jiang, Zongyu Bao, Shengbiao Ji, Binju Wang

Journal: ACS Catalysis

Doi: doi.org/10.1021/acscatal.5c01673

Products & Services: Gene Synthesis Codon Optimization

A general assay platform to study protein pharmacology using ligand-dependent structural dynamics

Authors: Daniel A Ciulla, Patricia K Dranchak, Mahesh Aitha, Renier H P van Neer, Divia Shah, Ravi Tharakan, Kelli M Wilson, Yuhong Wang, John C Braisted, James Inglese

Journal: Nature Communication

PubMed ID: 40346061

Doi: 10.1038/s41467-025-59658-6

Products & Services: Custom DNA/RNA Oligos

Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1

Authors: Seow Theng Ong, Young-Woo Nam, Joshua A Nasburg, Alena Ramanishka, Xuan Rui Ng, Zhong Zhuang, Stephanie Shee Min Goay, Hai M Nguyen, Latika Singh, Vikrant Singh, Alicia Rivera, M Elaine Eyster, Yang Xu, Seth L Alper, Heike Wulff, Miao Zhang, K George Chandy

Journal: Proc Natl Acad Sci U S A

PubMed ID: 40294255

Doi: 10.1073/pnas.2425494122

Products & Services: Molecular Biology Tools

The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin

Authors: Irina S Abaeva, Alexander G Bulakhov, Christopher U T Hellen, Tatyana V Pestova

Journal: Genes Dev

PubMed ID: 40169231

Doi: 10.1101/gad.352389.124

Products & Services: Mutagenesis Services Custom Vector Construction Proteins, Expression, Isolation and Analysis Custom Vector Construction Mutagenesis Services Protein Reagents and Products

BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner

Authors: Xianyang Liu, Shuhao Zeng, Jiayu Meng, Qian Zhou, Fan Cao, Baorui Chu, Chao Wu, Yakun Wang, Hui Feng, Xiaorui Bi, Xinyuan Chen, Wenxian Yang, Meng Tian, Hui Yang, Ke Hu, Shengping Hou

Journal: Theranostics

Doi: 10.7150/thno.110122

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Teleost GSDMEc regulates GSDMEa-mediated pyroptos

Authors: Hang Xu, Meng Wu, Yujian Wang, Yaoming Jiao, Yuan Chen, Zihao Yuan, Li Sun

Journal: J Adv Res

PubMed ID: 40210150

Doi: doi.org/10.1016/j.jare.2025.04.007

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a highly sensitive C1QC-targeting aptamer and its application in a modified antibody-aptamer sandwich biosensor for C1QC biomarker detection

Authors: Wenwei Wu, Lixia Qian, Jie Shen, Hongmei Li, Liang-cheng Li

Journal: Sensors and Actuators: B. Chemical