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ITGB1 Regulates Triple-Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Authors: Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T Rosen, Yingyu Wang, Chun-Wei D Chen, Cheng Zhang, Mingye Feng

Journal: Advanced Science

PubMed ID: 41632816

Doi: 10.1002/advs.202513672

Triglycerides induce endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity

Authors: Han Wu, Qing Shui, Xiaoxi Luan, Kexin Wang, Wei Zhao, Xiaopeng Qi, Bingyu Liu, Wanwei Sun, Chengjiang Gao

Journal: Molecular Therapy

PubMed ID: 41678331

Doi: 10.1016/j.celrep.2026.116976

Products & Services: Recombinant Proteins

An orthogonal CRISPR/Cpf1 platform for precise spatiotemporal gene regulation and osteoporotic fracture repair

Authors: Jie Zhao, Zengliang Wang, Lina Lu, Guoyun Bu, Zukang Miao, Yang Zhang, Yue Guo, Zhao Yang, Jianxiong Ma, Jun Jiao, Xinlong Ma

Journal: Molecular Therapy

PubMed ID: 41679307

Doi: 10.1016/j.crmeth.2025.101299

Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus

Authors: Jiawei Xiao, Donghua Guo, Xiaoxu Xing, Limin Jiang, Shanshan Qi, Jun Wang, Wenfei Bai, Shiping Yu, Fanbo Shen, Xingyang Guo, Xinglin Wang, Wei Zhou, Hansong Li, Feiyu Zhao, Li Feng, Jialin Zhang, Yaru Xu, Dan Yang, Haixin Liu, Dongbo Sun

Journal: Molecular Therapy

PubMed ID: 41720346

Doi: 10.1016/j.virs.2026.02.011

Products & Services: Peptide Synthesis

Taming immune responses to AAV gene therapy by programmed in vivo Treg expansion

Authors: Lavesh Gwalani, Mincheol Park, Alexandra B Ysasi, Mona Motwani, Robert Jackson, Jie Bu, Zhengyu Luo, John Bladon, Edith L Pfister, Christian Mueller, Sourav R Choudhury

Journal: Molecular Therapy

PubMed ID: 41691369

Doi: 10.1016/j.ymthe.2026.02.019

Products & Services: Peptide Library Services

Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading

Authors: Yu Yan, Xuesong Wang, Zhenfei Xie, Daniel L V Bader, Ryan H Lim, Krystal M Ma, Christopher A Cottrell, Jon M Steichen, Liling Xu, Paula M Villavicencio, Madhav Akauliya, Ja-Hyun Koo, Jacqueline Ming Shen, Alexandra Vernich, Oleksandr Kalyuzhniy, Joel D Allen, Ali A Albowaidey, Anthony Alicea, Bingxian Chen, Erik Georgeson, Jordan Renae Ellis-Pugh, Nushin Alavi, Abigail Esposito, Hannah Naili, Nicole Phelps, Brendon Kelley, Michael Kubitz, Quynh Anh Phan, Alessia Liguori, Thavaleak Prum, Ryan Tingle, Danny Lu, Saman Eskandarzadeh, Xiaotie Liu, John E Warner, Stephanie R Weldon, Sunny Himansu, Max Crispin, Usha Nair, Sophia Liu, William R Schief, Facundo D Batista

Journal: Immunity

PubMed ID: 41690309

Doi: 10.1016/j.immuni.2026.01.011

Selective Targeting of Immune Checkpoints HLA-G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Authors: Lisa J Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer

Journal: Advanced Science

PubMed ID: 41662489

Doi: 10.1002/advs.202521448

Attenuation of Influenza a Virus into Live Vaccines Through C-End Degrons

Authors: Ping Wang, Le Li, Yunfang Chen, Le Tong, Zhen Li, Rong Yu, Quan Shen, Qikai Wang, Jihuan Hou, Qisi Zhang, Xu Si, Ning Wang, Demin Zhou, Wen-Xia Tian, Longlong Si

Journal: Advanced Science

PubMed ID: 41721587

Doi: 10.1002/advs.202509425

Products & Services: Peptide Synthesis

A near-complete map of human cytosolic degrons and their relevance for disease

Authors: Vasileios Voutsinos, Kristoffer E Johansson, Fia B Larsen, Martin Grønbæk-Thygesen, Nicolas Jonsson, Emma Holm-Olesen, Giulio Tesei, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

Journal: SCIENCE ADVANCES

PubMed ID: 41650254

Doi: 10.1126/sciadv.adz3483

E711-19 placement and orientation dictate CD8+ T cell response in structurally defined spherical nucleic acid vaccines

Authors: Jeongmin Hwang, Tonatiuh A Ocampo, Vinzenz Mayer, Janice Kang, Krishna S Paranandi, Young Jun Kim, Zhenyu Han, John P Cavaliere, Sergej Kudruk, Jochen H Lorch, Chad A Mirkin

Journal: SCIENCE ADVANCES

PubMed ID: 41671353

Doi: 10.1126/sciadv.aec3876

Products & Services: Peptide Synthesis