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Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity

Authors: Christopher R Horne, Tingting Wang, Samuel N Young, Toby A Dite, Hunter G Nyvall, Sushant Suresh, Katherine A Davies, Abner Gonzalez Castro, Vineet Vaibhav, Lucy J Mather, Laura F Dagley, Matthew J Belousoff, Gerard Manning, Anthony R Means, John E Burke, Janni Petersen, John W Scott, James M Murphy

Journal: The Biochemical journal

PubMed ID: 41003242

Doi: doi.org/10.1042/BCJ20253431

Products & Services: Peptide Synthesis

Iterative Epitope Expansion Enables Structure-Guided de novo Design of IgE-Binding Miniproteins Targeting the FcεRI Interface

Authors: Ido Calman, Hamed Shaykhalishahi, Puwanat Sangkhapreecha, Sharrol Bachas

Journal: bioRxiv

Doi: 10.64898/2025.12.27.696647

Products & Services: Protein portfolio

A Multimodal Ensemble Framework for Optimal Mutant Prediction and Computational Enzyme Engineering

Authors: Ding Luo, Huining Ji, Baodong Hu, Jinxing Cai, Kaiqi Wen, Xiaoyang Qu, Mingfeng Cao, Xinrui Zhao, Binju Wang

Journal: ANGEWANDTE CHEMIE

PubMed ID: 41410226

Doi: 10.1002/anie.202521396

Products & Services: Gene Synthesis PCR Cloning and Subcloning

Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection

Authors: Rui Chao, Yexin Wang, Zhan Liu, Tianhao Wan, Yi Mao, Xinru Xie, Lei Sun, Weifeng Xu, Xuzhuo Chen, Shanyong Zhang

Journal: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PubMed ID: PMC12488209

Doi: 10.3892/ijmm.2025.5647

Products & Services: Protein and Antibody Isolation

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender

Authors: Yan Huang, Biao Hu, Ya Liu, Ling-Qi Xie, Yu Dai, Yu-Ze An, Xin-Yi Peng, Ya-Lun Cheng, Yi-Fan Guo, Wei-Hong Kuang, Yao Xiao, Xin Chen, Yong-Jun Zheng, Gen-Qing Xie, Jian-Ping Wang, Hui Peng, Xiang-Hang Luo

Journal: Cell metabolism

PubMed ID: 41344322

Doi: doi.org/10.1016/j.cmet.2025.11.002

Products & Services: Nucleic Acid Purification

RING- Type E3 Ligase OsRFPH2- 6 Ubiquitinates Nuclear Factor Y Subunit OsNF- YA1 to Suppress Rice Immunity

Authors: Yan Bi, Leeza Tariq, Hui Wang, Yuqing Yan, Dayong Li, Fengming Song

Journal: Molecular plant pathology

PubMed ID: 41424058

Doi: 10.1111/mpp.70193

Products & Services: Catalog Antibodies

Supramolecular lipid nanoparticle reprograms tumor microenvironment by cucurbit[7]uril-based host–guest recognition for STING-activating cancer immunotherapy

Authors: Yunxuan Feng, Yuan Yu, Xinyang Yu, Mengyao Li, Jiaqi Lei, Yongcan Li, Zhida Liu, Shaolong Qi, Guocan Yu

Journal: Materials Today

Doi: doi.org/10.1016/j.mattod.2025.11.029

Products & Services: Protein Electrophoresis and Western

OMP16-targeting monoclonal antibodies H4 and E6 reveal essential linear epitopes for Brucella immunoprotection

Authors: Yunyi Zhai, Kaihui Sun, Ye Yuan, Xiaofang Liu, Gaowa Wudong, Yuanhao Yang, Shuan Qu, Yaxin Li, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang

Journal: International Journal of Biological Macromolecules

PubMed ID: 41448303

Doi: 10.1016/j.ijbiomac.2025.149881

Products & Services: Bacterial Expression Mutagenesis Services Peptide Synthesis

The prion-like characteristic of ORF3 contributes to virion release and pathogenesis of hepatitis E virus

Authors: Yajing Wang, Houlu Tian, Na Shi, Chunyan Wu, Yaowei Huang, Yongling Yang, Qiang Ding, Xu Zheng, Qin Zhao, Zhaonong Hu, Jiaojiao Luo, Lele Feng, Lingdong Xu, Mick F Tuite, Hongying Chen, Yuchen Nan

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41343667

Doi: 10.1073/pnas.2511801122

Products & Services: Polyclonal Antibody Services

Targeting SKAP2 restores sperm motility and morphology through modulating mitochondrial organization and cytoskeletal remodeling

Authors: Shiming Gan, Lin Yin, Jiaming Zhou, Sisi Li, Shumin Zhou, Xiaotong Yang, Rui Liu, Xu Fan, Yangyang Li, Zhendong Yao, Jingshou Chen, Peiran Hu, Wenjing Xiong, Yuan Yuan, Yujiao Wen, Youjiang Li, Ge Jin, Jianzhong Sheng, Yuzhen Gao, Hefeng Huang, Chen Zhang

Journal: Signal transduction and targeted therapy

PubMed ID: 41436426

Doi: 10.1038/s41392-025-02513-3

Products & Services: Protein and Antibody Isolation