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Quadruple pegRNA enables programmable and efficient large genomic insertion

Authors: Ya-Jing Shi, Zi-Yi Ding, Ying Wu, Zhou He, Yi-Zhou Zhang, Yu-Lu Zhang, Yu-Ming Zhang, Xiang-Rui Huang, Hao Yin, Ying Zhang

Journal: Nature

PubMed ID: 42020736

Doi: 10.1038/s41586-026-10395-w

Products & Services: Cell Isolation

Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

Authors: Savanna Skeeters; Kamal Bagale; Galina Stepanyuk; David Thieker; Aaron Aguhob; Kui K. Chan; Benjamin Dutzar; Sergei Shalygin; Asif Shajahan; Xu Yang; Paul A. DaRosa; Emily Frazier; Maximilian M. Sauer; Lisa Bogatzki; Kelly A. Byrnes-Blake; Yifan Song; Parastoo Azadi; Eric Tarcha; Lianghui Zhang; Erik Procko

Journal: Molecular therapy. Methods & clinical development

PubMed ID: 39185275

Doi: 10.1016/j.omtm.2024.101301

Products & Services: Protein and Antibody Reagents

Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design

Authors: rsula L pez-Garc a; Jan Vietor; Julian A. Marschner; Jan Heering; Vasily Morozov; Thomas Wein; Daniel Merk

Journal: Communications Chemistry

PubMed ID: 40399628

Doi: 10.1038/s42004-025-01553-8

Products & Services: Plasmid DNA Preparation

An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo

Authors: Nian E. Zhou; Su Tang; Xuelin Bian; Maloy K. Parai; Inna V. Krieger; Armando Flores; Pradeep K. Jaiswal; Radha Bam; Jeremy L. Wood; Zhe Shi; Laura J. Stevens; Trevor Scobey; Meghan V. Diefenbacher; Fernando R. Moreira; Thomas J. Baric; Arjun Acharya; Joonyoung Shin; Manish M. Rathi; Karen C. Wolff; Laura Riva; Malina A. Bakowski; Case W. McNamara; Nicholas J. Catanzaro; Rachel L. Graham; David C. Schultz; Sara Cherry; Yoshihiro Kawaoka; Peter J. Halfmann; Ralph S. Baric; Mark R. Denison; Timothy P. Sheahan; James C. Sacchettini

Journal: Cell Reports

PubMed ID: 39504242

Doi: 10.1016/j.celrep.2024.114929

Multi-level Integrated Engineering Enhances Neutral β-Glucanase Production in Komagataella phaffii

Authors: Hai Xu, Xiaowei Shao, Yuzhe Peng, Xiuxia Liu, Chunli Liu, Zhonghu Bai, Yankun Yang

Journal: Journal of biotechnology

PubMed ID: 41999774

Doi: 10.1016/j.jbiotec

Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

Journal: Molecular therapy. Methods & clinical development

PubMed ID: 39185275

Doi: 10.1016/j.omtm.2024.101301

Products & Services: Protein and Antibody Reagents

Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway

Authors: Martina Lerche; Mathilde Mathieu; Hellyeh Hamidi; Megan Chastney; Guillaume Jacquemet; Bart Marlon Herwig Bruininks; Shreyas Kaptan; Lene Maler d; Nina Marie Pedersen; Andreas Brech; Nobuyuki Matoba; Yuichiro Sato; Ilpo Vattulainen; Pere Roca-Cusachs; Franck Perez; Gaelle Boncompain; St phanie Miserey; Johanna Ivaska

Journal: The Journal of cell biology

PubMed ID: 41329164

Doi: 10.1083/jcb.202508155

Products & Services: Peptide Synthesis

Artemisinin exerts antidepressant-like effects via activation of AKT and ERK signaling pathways

Authors: Ruohong Lin; Zhiwei Zhou; Yizhou Jiang; Song Liu; Jinfeng Xie; Haitao Wang; Henning Ulrich; Wenhua Zheng

Journal: Frontiers in pharmacology

PubMed ID: 41181594

Doi: 10.3389/fphar.2025.1642167

Products & Services: Protein Electrophoresis and Western

A Microbial Lipid-ATP Synthase Axis Fuels NK Cell Antitumor Activity

Authors: Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi-Song Zhang, Quan Wang

Journal: Advanced Science

PubMed ID: 41972457

Doi: 10.1002/advs.202520095

Products & Services: Endotoxin Detection & Removal System

Structural dissection of CD38 antigen engagement by CAR binders and rational affinity tuning

Authors: Zelin Cheng, Liangminghui Zhang, Ze Liang, Qianping Huang, Ziwei Tang, Xinyu Shi, Lili Liu, Guang Yang, Lei Yan

Journal: iScience

Doi: doi.org/10.1016/j.isci.2026.115937

Products & Services: Protein Electrophoresis and Western