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A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions

Authors: Mebratu A Bitew, Tatiana C Paredes-Santos, Parag Maru, Shruthi Krishnamurthy, Yifan Wang, Lamba O Sangaré, Samuel Duley, Yoshiki Yamaryo-Botté, Cyrille Y Botté, Jeroen P J Saeij

Journal: Nature Communications

PubMed ID: 41407671

Doi: 10.1038/s41467-025-66137-5

Products & Services: Protein and Antibody Isolation

Efficient high-precision transgene knock-in by Recombinases (Redα/β)-enhanced DNA integration-CRISPR-Cas9 (RED-CRISPR)

Authors: Wenqing Li, Senquan Liu, Xiaoyu Fang, Jiaqi Zou, Qin Jiang, Xiaolin Min, Xiaoli Zhu, Yuzhu Cao, Xiaoxiao Gao, Wenjie Han, Muhammad Azhar, Xuemei Xing, Fudong Li, Youming Zhang, Hongbin Liu, Linzhao Cheng, Chengkun Wang, Jianqiang Bao

Journal: Nature Communications

PubMed ID: 41365890

Doi: 10.1038/s41467-025-67239-w

Products & Services: Catalog IVT RNA products

The prion-like characteristic of ORF3 contributes to virion release and pathogenesis of hepatitis E virus

Authors: Yajing Wang, Houlu Tian, Na Shi, Chunyan Wu, Yaowei Huang, Yongling Yang, Qiang Ding, Xu Zheng, Qin Zhao, Zhaonong Hu, Jiaojiao Luo, Lele Feng, Lingdong Xu, Mick F Tuite, Hongying Chen, Yuchen Nan

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41343667

Doi: 10.1073/pnas.2511801122

Products & Services: Polyclonal Antibody Services

Targeting SKAP2 restores sperm motility and morphology through modulating mitochondrial organization and cytoskeletal remodeling

Authors: Shiming Gan, Lin Yin, Jiaming Zhou, Sisi Li, Shumin Zhou, Xiaotong Yang, Rui Liu, Xu Fan, Yangyang Li, Zhendong Yao, Jingshou Chen, Peiran Hu, Wenjing Xiong, Yuan Yuan, Yujiao Wen, Youjiang Li, Ge Jin, Jianzhong Sheng, Yuzhen Gao, Hefeng Huang, Chen Zhang

Journal: Signal transduction and targeted therapy

PubMed ID: 41436426

Doi: 10.1038/s41392-025-02513-3

Products & Services: Protein and Antibody Isolation

Natural variation in OsTPS8 confers differential regulation of chalkiness and seed vigor in indica and japonica rice

Authors: Xiaoli Chen, Yulong Ren, Hui Dong, Xiaokang Jiang, Xiaoming Zheng, Erchao Duan, Xuan Teng, Yunlong Wang, Chuanwei Gu, Rongbo Chen, Qingkai Wang, Yongfei Wang, Yipeng Zhang, Rushuang Zhang, Yunpeng Zhang, Wenjie Zhao, Yu Zhang, Xue Yang, Lei Zhou, Chao Li, Tiaofeng Shan, Yiqun Bao, Yunlu Tian, Xi Liu, Shijia Liu, Tao Guo, Mingjiang Chen, Haiyang Wang, Yihua Wang, Jianmin Wan

Journal: Nature Genetics

PubMed ID: 41398376

Doi: 10.1038/s41588-025-02429-2

Products & Services: Protein Electrophoresis and Western Recombinant Proteins

Acyl-CoA-binding protein AcbdA is required for peroxisome hitchhiking on early endosomes in Aspergillus nidulans

Authors: Bellana E Driscoll, Madison B Fountain, Isabella N Gates, Reihane Abdollahi, Allison M Langley, Matthew B Owens, Jenna R Christensen, John Salogiannis

Journal: Molecular biology of the cell

PubMed ID: 40901736

Doi: 10.1091/mbc.e25-04-0186

Products & Services: Gene Synthesis PCR Cloning and Subcloning

Structural insights into kainate receptor desensitization

Authors: Changping Zhou, Guadalupe Segura-Covarrubias, Nami Tajima

Journal: Nature Communications

PubMed ID: 41365859

Doi: 10.1038/s41467-025-65920-8

Gene-corrected regulatory T cell therapy for IL2RA deficiency

Authors: Alvin S Ha, Nechama Kalter, Michael Rosenberg, Luis A Acevedo, Brianna Liang, Weihong Liu, Sreenivasan Paruthiyil, Meenal Sinha, Alexander Vu, Vinh Nguyen, Zhongxia Qi, Netravathi Krishnappa, Jinna Shu, Jingwei Yu, Jason Catanzaro, Jeffrey A Bluestone, Qizhi Tang, Fyodor D Urnov, Alexander Marson, Ayal Hendel, Kevan C Herold, Brian R Shy, Jonathan H Esensten

Journal: Molecular Therapy

PubMed ID: 41376159

Doi: 10.1016/j.ymthe.2025.12.004

Products & Services: Molecular Biology Reagents

A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion

Authors: Guosong Wang, Yu Li, Chongxin Wu, Tian Chen, Mengxuan Gui, Yue Zeng, Hui Sun, Kaiyun Chen, Xiangfeng Xi, Yanbo Yang, Yuchen Jiang, Yanan Jiang, Liqin Liu, Chengyu Yang, Jiarui Xin, Caihong Liu, Yiyi Li, Ningning Huo, Yang Huang, Lina Lin, Hai Yu, Chenghao Huang, Quan Yuan, Shaowei Li, Kegong Tian, Qingbing Zheng, Ningshao Xia, Yixin Chen

Journal: Nature Communications

PubMed ID: 41402251

Doi: 10.1038/s41467-025-66099-8

Products & Services: Antibody Modification and Purification Services

Semisynthetic, Multicolor Probes for Bioluminescence Imaging

Authors: Suong Tran, Kat Usavage, Lila P Halbers, Claire Choplick, Grace Helton, Brenden Young, Jennifer A Prescher, Colin M Rathbun

Journal: ACS Omega

PubMed ID: 41427193

Doi: 10.1021.5c07587

Products & Services: Peptide Synthesis