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Dynamic U2AF cycling defines two phases of cotranscriptional pre-mRNA splicing

Authors: Changwei Shao, Yajing Hao, Li Jiang, Dong Wang, Rui Wang, Yuanjun Li, Hui Wang, Yaping Ge, Rui Bai, Xiangjuan Du, Xizi Chen, Tan Wu, Lan-Tao Gou, Ruixue Wan, Yanhui Xu, Xiong Ji, Xiang-Dong Fu

Journal: Science

PubMed ID: 40997183

Doi: 10.1126/science.adj9141

Products & Services: Protein Electrophoresis and Western

SMAD3 and p300 complex scaffolding by long non-coding RNA LIMD1-AS1 promotes TGF-β-induced breast cancer cell plasticity

Authors: Chuannan Fan， Davy Cats， Miriam Selle， Olga Khorosjutina， Soniya Dhanjal， Bernhard Schmierer， Hailiang Mei， Peter Ten Dijke， Qian Wang

Journal: Nucleic Acids Research

PubMed ID: 40889156

Doi: 10.1093/nar/gkaf841

Products & Services: CRISPR Services

A NanoLock-enabled, Craspase-based strategy for highly sensitive RNA detection

Authors: Yumeng Xiao, Junyu Chen, Xincan Hou, Hongwei Wang, Kundi Zhang, Sujuan Xu, Tao Jiang, Yangao Huo, Fengyu Zhang, Lichuan Gu

Journal: Nucleic Acids Research

PubMed ID: 40966498

Doi: 10.1093/nar/gkaf907

Products & Services: Gene Services

OLD amputates the anticodon arm of tRNAs during P2–Lambda interference

Authors: Apurva A Govande, Brian D Matibag, Irem Ünlü, Eric J Wolf, Molly R Sargen, Brooke Ramsey, Sangjin Kim, Sophie Helaine, Ivan R Corrêa Jr, Hoong Chuin Lim

Journal: Nucleic Acids Research

PubMed ID: 40966496

Doi: 10.1093/nar/gkaf874

Products & Services: Gene Services

Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation

Authors: Edgar J. Soto-Moreno, Nourhan N. Ali, Florian Küllmer, Veselin Nasufovic, Michaela Frolikova, Olga Tepla, Jaromir Masata, Dirk Trauner, Amanda A. Patterson, Hans-Dieter Arndt, Katerina Komrskova, Magdalena Zernicka-Goetz, David M. Glover & Ahmed Z. Balboula

Journal: Nature Communications

PubMed ID: 40973727

Doi: 10.1038/s41467-025-63586-w

Products & Services: Gene Services

α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion

Authors: Canqi Cui, Danielle C Leander, Sarah M Gray, Kimberley El, Alex Chen, Paul A Grimsrud, Jessica O Becker, Austin Taylor, Guo-Fang Zhang, Kyle W Sloop, C Bruce Verchere, Andrew N Hoofnagle, David A D'Alessio, Jonathan E Campbell

Journal: SCIENCE ADVANCES

PubMed ID: 40971442

Doi: 10.1126/sciadv.ady8048

Translesion DNA polymerases Rev1 and PolH promote LTR-retrotransposon transcription by safeguarding Pol II occupancy in both germline and somatic tissues of Drosophila

Authors: Chongyang Li, Zhe Meng, Qiuju Wen, Wenjuan Yang, Yaqian Xu, Yuening Lyu, Yile Guo, Tong Lyu, Dan Shen, Kun Dou

Journal: Nucleic Acids Research

PubMed ID: 40966519

Doi: 10.1093/nar/gkaf903

Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect

Authors: Bin Liu, Yansi Xian, Tao Shen, Yu Ben, Wenshu Wu, Yong Shi, Xueying An, Rui Peng, Wentian Gao, Wang Gong, Xiang Chen, Baosheng Guo, Qing Jiang

Journal: Journal of extracellular vesicles

PubMed ID: 40919882

Doi: 10.1002/jev2.70162

Products & Services: Protein and Antibody Isolation

PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunity

Authors: Shen Yang, Eugenio Santelli, Carlos G Gonzalez, Wade T Johnson, Irene V Choi, Chuling Zhuang, Myungja Ro, Leigh-Ana M Rossitto, I-Shing Yu, Shu-Wha Lin, Yuan Zhan, Qinwei Chen, Jonathan D Yoshihara, Daniel J Wallace, Caroline A Jefferies, Michifumi Yamashita, David J Gonzalez, Richard I Ainsworth, Nisarg J Shah, Stephanie M Stanford, Nunzio Bottini

Journal: SCIENCE ADVANCES

PubMed ID: 40911684

Doi: 10.1126/sciadv.adw2568

Products & Services: Gene Services

Molecular Chain Elongation Mechanism for n-Caproate Biosynthesis by Megasphaera Hexanoica

Authors: Byoung Seung Jeon, Eun-Jung Kim, Hogyun Seo, Hyunjin Kim, Seungjin Shin, Caroline Schlaiß, Largus T Angenent, Kyung-Jin Kim, Byoung-In Sang

Journal: Advanced Science

PubMed ID: 40932660

Doi: 10.1002/advs.202506069