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Comparative analysis of adenovirus, mRNA, and protein vaccines reveals context-dependent immunogenicity and efficacy

Authors: Bakare Awakoaiye, Shiyi Li, Sarah Sanchez, Tanushree Dangi, Nahid Irani, Laura Arroyo, Gabriel Arellano, Shadi Mohammadabadi, Malika Aid, Pablo Penaloza-MacMaster

Journal: JCI Insight

PubMed ID: 41212056

Doi: 10.1172/jci.insight.198069

Products & Services: Custom mRNA synthesis

On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models

Authors: Filippo Birocchi, Antonio J Almazan, Aiyana Parker, Amanda A Bouffard, Sadie Goncalves, Christopher Kelly, Jessica Frank, Mark B Leick, Nicholas J Haradhvala, Shaw Kagawa, Gad Getz, Giulia Escobar, Diego Salas-Benito, Adele Mucci, Trisha R Berger, Marcela V Maus

Journal: Nature Communications

PubMed ID: 41176533

Doi: 10.1038/s41467-025-61858-z.

Products & Services: Monoclonal Antibody Services

Generation of antigen-specific paired-chain antibodies using large language models

Authors: Perry T Wasdin, Nicole V Johnson, Alexis K Janke, Sofia Held, Toma M Marinov, Gwen Jordaan, Rebecca A Gillespie, Léna Vandenabeele, Fani Pantouli, Olivia C Powers, Matthew J Vukovich, Clinton M Holt, Jeongryeol Kim, Grant Hansman, Jennifer Logue, Helen Y Chu, Sarah F Andrews, Masaru Kanekiyo, Giuseppe A Sautto, Ted M Ross, Daniel J Sheward, Jason S McLellan, Alexandra A Abu-Shmais, Ivelin S Georgiev

Journal: Cell

PubMed ID: 41192421

Doi: 10.1016/j.cell.2025.10.006.

Products & Services: Protein and Antibody Isolation

A plastid carbohydrate carrier mediates ribose recycling from nucleotide catabolism and glucose export from starch degradation

Authors: Luisa Voß, Isabel Keller, Rebekka Schröder, Denise Mehner-Breitfeld, André Specht, Gerald Dräger, Jannis Rinne, Jakob Franke, Nieves Medina-Escobar, Marco Herde, Thomas Brüser, H Ekkehard Neuhaus, Claus-Peter Witte

Journal: Nature Communications

PubMed ID: 41193506

Doi: 10.1038/s41467-025-65510-8

Products & Services: Monoclonal Antibody Services

Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii

Authors: Silvia Diaz-Martin, Christopher Swale, Valeria Bellini, Irina Dobrescu, Janine Wenker, Marie-Pierre Brenier-Pinchart, Laurence Braun, Alwéna Tollec, Charlotte Corrao, Yohann Couté, Caroline Mas, Fabrice Laurent, Matthew Bowler, Mohamed-Ali Hakimi, Alexandre Bougdour

Journal: Nature Communications

PubMed ID: 41193440

Doi: 10.1038/s41467-025-64701-7.

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A chromosome-level genome of Astilbe chinensis unveils the evolution of a terpene biosynthetic gene cluster

Authors: Fangfang Chen, Yan Yao, Hangzhi Zhu, Jie Hu, Aohan Geng, Zhenni Xu, Xueting Fang, Weijia Cheng, Yao Zhi, Yonghong Zhang, Zixin Deng, Tiangang Liu, Li Lu

Journal: Nature Communications

PubMed ID: 41213911

Doi: 10.1038/s41467-025-64842-9.

Products & Services: Protein and Antibody Isolation

Plexin-B1 safeguards astrocyte agility and glial alignment to facilitate wound corralling and axon pathfinding in mouse spinal cord injury model

Authors: Haofei Ni, Zhilai Zhou, Molly Estill, Dalia Halawani, Chrystian Junqueira Alves, Li Shen, Ning Xie, Roland H Friedel, Hongyan Zou

Journal: Nature Communications

PubMed ID: 41253783

Doi: 10.1038/s41467-025-65095-2.

Products & Services: Protein Electrophoresis and Western

SLC45A4 encodes a peroxisomal putrescine transporter that promotes GABA de novo synthesis

Authors: Cecilia Colson, Yujue Wang, James Atherton, Nisha Rani Dahiya, Davood Kharaghani, Xiaoyang Su

Journal: Nature Communications

PubMed ID: 41266324

Doi: 10.1038/s41467-025-62721-x.

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ARMH2 is a cytosolic component of CatSper crucial for sperm function

Authors: Qingqing Zhao, Shiyi Lin, Hang Kang, Yanfei Ru, Qikui Xu, Zijing Yu, Xiaofang Huang, Carlo De Rito, Giulia Sassi, Shaojie Wang, Shuya Sun, Rui Sun, Honghan Cheng, Yi Zhu, Mingxi Liu, Yongdeng Zhang, Min Jiang, Riccardo Percudani, Jean-Ju Chung, Xuhui Zeng, Zhen Yan, Jianping Wu

Journal: Nature Communications

PubMed ID: 41271765

Doi: 10.1038/s41467-025-65952-0.

Products & Services: Protein and Antibody Isolation

A ternary switch model governing ERα ligand binding domain conformation

Authors: Daniel P McDougal, Jordan L Pederick, Scott J Novick, Blagojce Jovcevski, Annmaree K Warrender, Bruce D Pascal, Patrick R Griffin, John B Bruning

Journal: Nature Communications

PubMed ID: 41285747

Doi: 10.1038/s41467-025-65323-9.

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