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A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome

Authors: Louise Fairall, Kristupas Sirvydis, Robert E Turnbull, Suzan Jg Knottnerus, Oksana Gonchar, Frederick W Muskett, Rebekah Jukes-Jones, Lonneke van Brussel, Ellen van de Geer, Koen van Gassen, Paul Badenhorst, Diana Johnson, Paulien A Terhal, Peter M van Hasselt, Richard H van Jaarsveld, John Wr Schwabe

Journal: Nature Communications

PubMed ID: 41290615

Doi: 10.1038/s41467-025-65472-x.

Products & Services: Catalog Peptides

Glycosaminoglycans activate peptidylarginine deiminase 4 by enhancing calcium affinity

Authors: Grzegorz P. Bereta， Ewa Bielecka， Karolina Marzec， Łukasz Pijanowski， Artur P. Biela， Piotr Wilk， Marta Kamińska， Jakub Nowak， Elżbieta Wątor-Wilk， Przemysław Grudnik， Dominik Kowalczyk， Joanna Kozieł， Piotr Mydel， Marcin Poręba， Tomasz Kantyka

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41166417

Doi: doi.org/10.1073/pnas.2508369122

Products & Services: Gene Synthesis

SmallTalk: a novel small-sized fusion tag for peptide expression and purification

Authors: Atika Tariq, Nestor G Casillas-Vega, Alma Gomez-Loredo, Xristo Zarate

Journal: FEBS Open Bio

PubMed ID: 41220226

Doi: 10.1002/2211-5463.70147

Products & Services: Gene Synthesis

Structural insights into antagonist recognition by the vasopressin V2 receptor

Authors: Tianwei Zhang, Hongli Liu, Chongzhao You, Yixiao Zhang, Youwei Xu, Benxun Pan, Canrong Wu, Sanshan Jin, Yu-Ling Yin, Kai Wu, Yue Chen, Hong Sun, Yuan Si, Yangxia Tan, Wanchao Yin, H Eric Xu, Dong Guo, Yi Jiang

Journal: Nature Communications

PubMed ID: 41188237

Doi: 10.1038/s41467-025-64735-x

Products & Services: Protein and Antibody Isolation

Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development

Authors: Hadiatullah Hadiatullah, Lianyun Lin, Zhiyan Wang, Rajamanikandan Sundarraj, Qing Wang, Xinru Lai, Nagomi Kurebayashi, Takuya Kobayashi, Toshiko Yamazawa, Yu Seby Chen, Wenlan Wang, Hongxia Zhao, Yiqing Yin, Takashi Murayama, Filip Van Petegem, Zhiguang Yuchi

Journal: Nature Communications

PubMed ID: 41253812

Doi: 10.1038/s41467-025-65096-1.

Products & Services: Protein and Antibody Isolation

Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling

Authors: Carlos O Ontiveros, Myrna G Garcia, Clare E Murray, Yilun Deng, Haiyan Bai, Christopher Tanner, Bernice Leung, Xin Li, Alvaro Padron, Ryan M Reyes, Aravind Kancharla, Kah Teong Soh, Shanmugarajan Krishnan, Dhan Chand, Akshaya Balasubramanian, Courtney Hegner, Claudia V Jakubzick, Harshita B Gupta, Mary Jo Turk, Mark Sundrud, Jose R Conejo-Garcia, Tyler J Curiel

Journal: Nature Communications

PubMed ID: 41261166

Doi: 10.1038/s41467-025-65025-2.

Products & Services: CRISPR Libraries

Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses

Authors: Tosca Holtrop, Arianne M Brandsma, Louris J Feitsma, Steffen Krohn, Petra Moerer, Frederique van den Haak, Anouk Versnel, Leonie Voss, Elsemieke M Passchier, Maaike Nederend, J H Marco Jansen, Anouk G van Mourik, Rolf T Urbanus, Diane van der Woude, Roger E G Schutgens, Rene E M Toes, Bert J C Janssen, Anja Lux, Kevin Budding, Matthias Peipp, Jeanette H W Leusen

Journal: Nature Communications

PubMed ID: 41258113

Doi: 10.1038/s41467-025-65133-z.

Products & Services: Catalog Antibodies

Structural basis of regulated N-glycosylation at the secretory translocon

Authors: Melvin Yamsek, Mengxiao Ma, Roshan Jha, Yu Wan, Qianru Li, Frank Zhong, Katherine DeLong, Zhe Ji, Rajat Rohatgi, Robert J Keenan

Journal: Nature

PubMed ID: 41261126

Doi: 10.1038/s41586-025-09756-8.

Products & Services: Catalog Antibodies

ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes

Authors: Bing Dai, Adrian W Sperl, Lucas Polack, Isabel Mejia, Haley Dame, Tien Huynh, Chloe Deveney, Nathalie Lavoie, Chanyoung Lee, John G Doench, Matthew D Daugherty, Ekaterina E Heldwein

Journal: Nature Communications

PubMed ID: 41271665

Doi: 10.1038/s41467-025-65115-1.

Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22

Authors: Elisia Villemure, Tom Januario, Mingshuo Zeng, Hanna G Budayeva, Benjamin T Walters, Aaron Lictao, Ke Sherry Li, Xiaofen Ye, Caroline L Gilchrist, Bridget Hoag, Nicholas F Endres, Peter L Hsu, John Chan, Tommy K Cheung, Michael R Costa, Jean-Philippe Fortin, Noriko Ishisoko, Brett M Babin, Joyce Liu, Alexandra Frommlet, Joachim Rudolph, Robert L Yauch

Journal: Nature Communications

PubMed ID: 41184243

Doi: 10.1038/s41467-025-64669-4.