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Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I

Authors: Bryan Neumann, Stephen McCarthy, Shane Gonen

Journal: Nature Communications

PubMed ID: 39920100

Doi: 10.1038/s41467-024-55764-z

Products & Services: Codon Optimization

Sequence Context-Agnostic TadA-Derived Cytosine Base Editors for Genome-Wide Editing in Zebrafish

Authors: Shaohui Zheng 1 2, Yang Liu 1 2, Xinxin Xia 1 2, Jiawang Xiao 1 2, Hui Ma 3, Xuanyao Yuan 1 2, Yan Zhang 1 2, Zixi Chen 1 2, Guangcong Peng 1 2, Wenyuan Li 4, Ji-Feng Fei 3 5 6, Yanmei Liu

Journal: Advanced Science

PubMed ID: 39960330

Doi: 10.1002/advs.202411478

Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.

Authors: Qiyu Tang, Keyi Tang, Greg R Markby, Maciej Parys, Kanchan Phadwal, Vicky E MacRae, Brendan M Corcoran

Journal: Autophagy

PubMed ID: 39988732

Doi: 10.1080/15548627.2025.2469315

Products & Services: CRISPR Plasmids

Pan-Variant SARS-CoV-2 Vaccines Induce Protective Immunity by Targeting Conserved Epitopes

Authors: Masaud Shah, Sung Ung Moon, Ji-Yon Shin, Ji-Hye Choi, Doyoon Kim, Hyun Goo Woo

Journal: Advanced Science

PubMed ID: 40014015

Doi: 10.1002/advs.202409919

Products & Services: Peptide Synthesis

Alternatively spliced NFKB1 transcripts enriched in Andean Aymara modulate inflammation, HIF and hemoglobin

Authors: Jihyun Song, Seonggyun Han, Ricardo Amaru, Lucie Lanikova, Teddy Quispe, Dongwook Kim, Jacob E Crawford, Soo Jin Kim, Younghee Lee, Josef T Prchal

Journal: Nature Communications

PubMed ID: 39971917

Doi: 10.1038/s41467-025-56848-0

Products & Services: Protein Electrophoresis and Western

GMRSP encoded by lncRNA H19 regulates metabolic reprogramming and alleviates aortic dissection

Authors: Jizhong Wang, Jitao Liu, Fan Yang, Yinghao Sun, Jiaohua Chen, Jie Liu, Tucheng Sun, Ruixin Fan, Fang Pei, Songyuan Luo, Jie Li, Jianfang Luo

Journal: Nature Communications

PubMed ID: 39966416

Doi: 10.1038/s41467-025-57011-5

Perturbing Organelle-Level K+/Ca2+ Homeostasis by Nanotherapeutics for Enhancing Ion-Mediated Cancer Immunotherapy

Authors: Jun-Long Liang , Qian-Xiao Huang , Qi-Wen Chen , Xiao-Kang Jin , Zi-Yi Han 1, Ping Ji , Si-Xue Cheng , Wei-Hai Chen , Xian-Zheng Zhang

Journal: Adv Mater

PubMed ID: 39955648

Doi: 10.1002/adma.202416574

Products & Services: Recombinant Proteins

Elastin-like polypeptide: A novel titanification biomacromolecule for green and ultrafast synthesis of biotitania nanoparticles via biomimetic mineralization

Authors: Lixi Cai, Jinlin Zheng, Lixing Liu, Guangya Zhang, Yuanqing Lin

Journal: Int J Biol Macromol

PubMed ID: 40015400

Doi: 10.1016/j.ijbiomac.2025.141449

Products & Services: Gene Synthesis

A Granzyme B‑Cleavable T Cell-Targeted Bispecific Cell Vesicle Connector for Reversing New-Onset Type 1 Diabetes

Authors: Yanfang Wang, Yanping Sun, Xiuwen Zhang, Shenqiang Wang, Xuehui Huang, Kairui Xu, Yun Liu, Yingqi Huang, Jianchang Xu, Xinwei Wei, Hao Cheng, Liqiang Pan, Jinqiang Wang, Zhen Gu

Journal: Journal of the American Chemical Society

PubMed ID: 39869523

Doi: 10.1021/jacs.4c13644

Products & Services: Gene Synthesis

Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival

Authors: Wen Wei, Xueqin Gao, Jiawei Qian, Lei Li, Chen Zhao, Li Xu, Yanfei Zhu, Zhenzhen Liu, Nengrong Liu, Xueqing Wang, Zhicong Jin, Bowen Liu, Lan Xu, Jin Dong, Suping Zhang, Jiarong Wang, Yumu Zhang, Yao Yu, Zhanjun Yan, Yanjun Yang, Jie Lu, Yixuan Fang, Na Yuan, Jianrong Wang

Journal: Journal of Clinical Investigation

PubMed ID: 39589832

Doi: 10.1172/JCI177375.

Products & Services: Protein and Antibody Isolation