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The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling

Authors: Manoshi Gayen, Marc R Benoit, Qingyuan Fan, Jacob Hudobenko, Riqiang Yan

Journal: J Biol Chem

PubMed ID: 36162508

Doi: 10.1016/j.jbc.2022.102532

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An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension

Authors: Elisabeth Fuchs, Imke Rudnik-Jansen, Anders Dinesen, Denis Selnihhin, Ole Aalund Mandrup, Kader Thiam, Jørgen Kjems, Finn Skou Pedersen, Kenneth A Howard

Journal: Acta Biomater

PubMed ID: 36162760

Doi: 10.1016/j.actbio.2022.09.048

Products & Services: Plasmid DNA Preparation

Enhanced and Potency of a T Cell Epitope in the Ebola Virus Glycoprotein Following Amino Acid Replacement at HLA-A*02:01 Binding Positions

Authors: Sylvie Chabot, Yusra Gimie, Karam Obeid, Jaekwan Kim, Clement A Meseda, Krishnamurthy Konduru, Gerardo Kaplan, Li Sheng Fowler, Jerry P Weir, Keith Peden, Marian E Major

Journal: J Virol

PubMed ID: 36069549

Doi: 10.1128/jvi.01166-21

Products & Services: Gene Synthesis

miR-3651 Participates in the Growth Cycle of Hepatocellular Carcinoma Cells and Promotes the Malignant Metastasis via the PI3K/AKT/mTOR Signalling Pathway

Authors: Yawei Liu, Litian Hu, Qinqiang Liu, Jing Ye, Jianping Zhang

Journal: J Oncol

PubMed ID: 36245984

Doi: 10.1155/2022/5744999

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Gene Promotes Muscle Growth and Development in Meat Ducks

Authors: Tingting Zhou, Yijing Wu, Yulin Bi, Hao Bai, Yong Jiang, Guohong Chen, Guobin Chang, Zhixiu Wang

Journal: Genes (Basel)

PubMed ID: 36140742

Doi: 10.3390/genes13091574

Products & Services: DNA Sequencing

Chaperonin CCT5 binding with porcine parvovirus NS1 promotes the interaction of NS1 and COPƐ to facilitate viral replication

Authors: Qian Du, Xuezhi Zhang, Ning Xu, Mengyu Ma, Bicheng Miao, Yong Huang, Dewen Tong

Journal: Vet Microbiol

PubMed ID: 36126504

Doi: 10.1016/j.vetmic.2022.109574

Products & Services: Monoclonal Antibody Services

Near Infrared Emitting Semiconductor Polymer Dots for Bioimaging and Sensing

Authors: Connor Riahin, Kushani Mendis, Brandon Busick, Marcin Ptaszek, Mengran Yang, Gary Stacey, Amar Parvate, James E Evans, Jeremiah Traeger, Dehong Hu, Galya Orr, Zeev Rosenzweig

Journal: Sensors (Basel)

PubMed ID: 36236328

Doi: 10.3390/s22197218

Products & Services: Proteins, Expression, Isolation and Analysis

High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development

Authors: Shalev Gihaz, Peter Gareiss, Jae-Yeon Choi, Isaline Renard, Anasuya Chattopadhyay Pal, Yulia Surovsteva, Joy E Chiu, Jose Thekkiniath, Mark Plummer, William Hungerford, Micaela L Montgomery, Alanah Hosford, Emily M Adams, Jorge D Lightfoot, David Fox, Kayode K Ojo, Bart L Staker, Kevin Fuller, Choukri Ben Mamoun

Journal: Structure

PubMed ID: 36167065

Doi: 10.1016/j.str.2022.09.001

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CycC1;1 negatively modulates ABA signaling by interacting with and inhibiting ABI5 during seed germination

Authors: Jia-Xing Guo, Ru-Feng Song, Kai-Kai Lu, Yu Zhang, Hui-Hui Chen, Jia-Xin Zuo, Ting-Ting Li, Xue-Feng Li, Wen-Cheng Liu

Journal: Plant Physiol

PubMed ID: 36173345

Doi: 10.1093/plphys/kiac456

Products & Services: Polyclonal Antibody Services

Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR)

Authors: Elena Erausquin, María Morán-Garrido, Jorge Sáiz, Coral Barbas, Gilda Dichiara-Rodríguez, Alejandro Urdiciain, Jacinto López-Sagaseta

Journal: Sci Rep

PubMed ID: 36068249

Doi: 10.1038/s41598-022-18844-y

Products & Services: Mammalian Expression

Novel method for detecting complement C3 deposition on Staphylococcus aureus

Authors: Toska Wonfor, Shuxian Li, Rhys W Dunphy, Alex Macpherson, Jean van den Elsen, Maisem Laabei

Journal: Sci Rep

PubMed ID: 36130996

Doi: 10.1038/s41598-022-20098-7

Products & Services: GenParts™ DNA Fragments

Phospholipase C-related catalytically inactive protein enhances cisplatin-induced apoptotic cell death

Authors: Satoshi Asano, Yuka Maetani, Yukio Ago, Takashi Kanematsu

Journal: Eur J Pharmacol

PubMed ID: 36108738

Doi: 10.1016/j.ejphar.2022.175273

Products & Services: Gene Synthesis

TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy

Authors: Chengyang Li, Patrick Duckney, Tong Zhang, Yanshu Fu, Xin Li, Johan Kroon, Geert De Jaeger, Yunjiang Cheng, Patrick J Hussey, Pengwei Wang

Journal: Nat Commun

PubMed ID: 36163196

Doi: 10.1038/s41467-022-33402-w

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Tumor-Intrinsic PD-L1 Exerts an Oncogenic Function through the Activation of the Wnt/β-Catenin Pathway in Human Non-Small Cell Lung Cancer

Authors: Yunxia Ma, Rumyana Marinkova, Miljana Nenkov, Lai Jin, Otmar Huber, Jürgen Sonnemann, Natália Peca, Nikolaus Gaßler, Yuan Chen

Journal: Int J Mol Sci

PubMed ID: 36232331

Doi: 10.3390/ijms231911031

Products & Services: Mammalian Expression

Nuclear Factor Kappa B Promotes Ferritin Heavy Chain Expression in in Response to Nucleopolyhedrovirus Infection

Authors: Linbao Zhu, Yingxue Liu, Ancheng Wang, Xiya Chen, Handan Zhu, Zhihao Huang, Huihua Cao, Shihuo Liu, Jiaping Xu

Journal: Int J Mol Sci

PubMed ID: 36142290

Doi: 10.3390/ijms231810380

Products & Services: Recombinant Antibody Expression

Removal of redox-sensitive Rubisco Activase does not alter Rubisco regulation in soybean

Authors: Christopher M Harvey, Amanda P Cavanagh, Sang Yeol Kim, David A Wright, Ron G Edquilang, Kayla S Shreeves, Juan Alejandro Perdomo, Martin H Spalding, Donald R Ort, Carl J Bernacchi, Steven C Huber

Journal: Photosynth Res

PubMed ID: 36163583

Doi: 10.1007/s11120-022-00962-3

Products & Services: Polyclonal Antibody Services

A review post-vaccination SARS-CoV-2 serological test: Method and antibody titer response

Authors: Melania Janisha Devi, Shabarni Gaffar, Yeni Wahyuni Hartati

Journal: Anal Biochem

PubMed ID: 36122603

Doi: 10.1016/j.ab.2022.114902

Products & Services: Recombinant Proteins

Targeting of palpable B16-F10 melanoma tumors with polyclonal antibodies on white blood cells

Authors: Girja S Shukla, Stephanie C Pero, Linda Mei, Yu-Jing Sun, David N Krag

Journal: J Immunol Methods

PubMed ID: 36174735

Doi: 10.1016/j.jim.2022.113362

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Plant transcripts with long or structured uORFs in NDL2 5' UTR can escape NMD in a reinitiation independent manner

Authors: Miryam A Cymerman, Helen Saul, Ronit Farhi, Karina Vexler, Dror Gottlieb, Irina Berezin, Orit Shaul

Journal: J Exp Bot

PubMed ID: 36169317

Doi: 10.1093/jxb/erac385

Products & Services: Proteins, Expression, Isolation and Analysis

Fluorescence Spectroscopy of Low-Level Endogenous β-Adrenergic Receptor Expression at the Plasma Membrane of Differentiating Human iPSC-Derived Cardiomyocytes

Authors: Philipp Gmach, Marc Bathe-Peters, Narasimha Telugu, Duncan C Miller, Paolo Annibale

Journal: Int J Mol Sci

PubMed ID: 36142320

Doi: 10.3390/ijms231810405

Products & Services: Plasmid DNA Preparation

Herpes simplex virus lymphadenitis is associated with tumor reduction in a patient with chronic lymphocytic leukemia

Authors: Andres Chang, Anton M Sholukh, Andreas Wieland, David L Jaye, Mary Carrington, Meei-Li Huang, Hong Xie, Keith R Jerome, Pavitra Roychoudhury, Alexander L Greninger, Jean L Koff, Jonathon B Cohen, David M Koelle, Lawrence Corey, Christopher R Flowers, Rafi Ahmed

Journal: J Clin Invest

PubMed ID: 35862190

Doi: 10.1172/JCI161109

Products & Services: Peptide Synthesis

Microarray-guided evaluation of the frequency, B-cell origins, and selectivity of human glycan-binding antibodies reveals new insights and novel antibodies

Authors: J Sebastian Temme, Jennifer A Crainic, Laura M Walker, Weizhun Yang, Zibin Tan, Xuefei Huang, Jeffrey C Gildersleeve

Journal: J Biol Chem

PubMed ID: 36087840

Doi: 10.1016/j.jbc.2022.102468

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Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

Authors: Xiyuan Zhang, Hannah E Lou, Vishaka Gopalan, Zhihui Liu, Hilda M Jafarah, Haiyan Lei, Paige Jones, Carly M Sayers, Marielle E Yohe, Prashant Chittiboina, Brigitte C Widemann, Carol J Thiele, Michael C Kelly, Sridhar Hannenhalli, Jack F Shern

Journal: Cell Rep

PubMed ID: 36130486

Doi: 10.1016/j.celrep.2022.111363

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Alamandine alleviated heart failure and fibrosis in myocardial infarction mice

Authors: Kun Zhao, Tianhua Xu, Yukang Mao, Xiaoguang Wu, Dongxu Hua, Yanhui Sheng, Peng Li

Journal: Biol Direct

PubMed ID: 36167556

Doi: 10.1186/s13062-022-00338-6

Products & Services: Custom DNA/RNA Oligos

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors

Authors: Jordan R Willis, Zachary T Berndsen, Krystal M Ma, Jon M Steichen, Torben Schiffner, Elise Landais, Alessia Liguori, Oleksandr Kalyuzhniy, Joel D Allen, Sabyasachi Baboo, Oluwarotimi Omorodion, Jolene K Diedrich, Xiaozhen Hu, Erik Georgeson, Nicole Phelps, Saman Eskandarzadeh, Bettina Groschel, Michael Kubitz, Yumiko Adachi, Tina-Marie Mullin, Nushin B Alavi, Samantha Falcone, Sunny Himansu, Andrea Carfi, Ian A Wilson, John R Yates, James C Paulson, Max Crispin, Andrew B Ward, William R Schief

Journal: Immunity

PubMed ID: 36179689

Doi: 10.1016/j.immuni.2022.09.001

Products & Services: Recombinant Antibody Expression

Intranasal Immunization with Liposome-Displayed Receptor-Binding Domain Induces Mucosal Immunity and Protection against SARS-CoV-2

Authors: Wei-Chiao Huang, Kevin Chiem, Luis Martinez-Sobrido, Jonathan F Lovell

Journal: Pathogens

PubMed ID: 36145467

Doi: 10.3390/pathogens11091035

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Inactivated COVID-19 vaccines: durability of Covaxin/BBV152 induced immunity against variants of concern

Authors: Nathella Pavan Kumar, V V Banurekha, C P Girish Kumar, Arul Nancy, Chandrasekaran Padmapriyadarsini, Sakila Shankar, Luke Elizabeth Hanna, Manoj Murhekar, K R Uma Devi, Subash Babu

Journal: J Travel Med

PubMed ID: 35900009

Doi: 10.1093/jtm/taac088

Products & Services: Recombinant Proteins

High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity

Authors: Rodrigo Vazquez-Lombardi, Johanna S Jung, Fabrice S Schlatter, Anna Mei, Natalia Rodrigues Mantuano, Florian Bieberich, Kai-Lin Hong, Jakub Kucharczyk, Edo Kapetanovic, Erik Aznauryan, Cédric R Weber, Alfred Zippelius, Heinz Läubli, Sai T Reddy

Journal: Immunity

PubMed ID: 36174557

Doi: 10.1016/j.immuni.2022.09.004

Products & Services: Peptide Synthesis

mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts

Authors: Denzil Furtado, Christina Cortez-Jugo, Ya Hui Hung, Ashley I Bush, Frank Caruso

Journal: Mol Pharm

PubMed ID: 36125338

Doi: 10.1021/acs.molpharmaceut.2c00463

Products & Services: GenParts™ DNA Fragments

A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity

Authors: Lian-Sheng Cheng, Yong-Feng Cheng, Wen-Ting Liu, Aolin Shen, Dayan Zhang, Tingjuan Xu, Wu Yin, Min Cheng, Xiaopeng Ma, Fengrong Wang, Qun Zhao, Xiaoli Zeng, Yan Zhang, Guodong Shen

Journal: J Transl Med

PubMed ID: 36076251

Doi: 10.1186/s12967-022-03619-w

Products & Services: Mammalian Expression

H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity

Authors: Huasong Ai , Maoshen Sun , Aijun Liu , Zixian Sun , Tingting Liu , Lin Cao , Lujun Liang , Qian Qu , Zichen Li , Zhiheng Deng , Zebin Tong , Guochao Chu , Xiaolin Tian , Haiteng Deng , Suwen Zhao , Jia-Bin Li , Zhiyong Lou , Lei Liu

Journal: Nat Chem Biol

PubMed ID: 35739357

Doi: 10.1038/s41589-022-01067-7

Products & Services: Gene Synthesis

The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA–protein cross-link

Authors: Katherine A Paulin , David Cortez , Brandt F Eichman

Journal: J Biol Chem

PubMed ID: 35934051

Doi: 10.1016/j.jbc.2022.102307

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Guide RNA engineering enables efficient CRISPR editing with a miniature Syntrophomonas palmitatica Cas12f1 nuclease

Authors: Yujue Wang , Yannan Wang ， Deng Pan , Haopeng Yu , Yifei Zhang , Weizhong Chen , Fan Li , Zhaowei Wu , Quanjiang Ji

Journal: Cell Rep

PubMed ID: 36170834

Doi: doi.org/10.1016/j.celrep.2022.111418

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Nilaparvata lugens salivary protein NlG14 triggers defense response in plants

Authors: Haoli Gao , Jianzheng Zou , Xumin Lin , Huihui Zhang , Na Yu , Zewen Liu

Journal: J Exp Bot

PubMed ID: 36056768

Doi: 10.1093/jxb/erac354

Products & Services: Proteins, Expression, Isolation and Analysis

Proposal to Consider Chemical/Physical Microenvironment as a New Therapeutic Off-Target Approach

Authors: Alessandro Giuliani, Stefano Fais

Journal: Pharmaceutics

PubMed ID: 36297518

Doi: 10.3390/pharmaceutics14102084

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Autophagic flux restoration of senescent T cells improves antitumor activity of TCR-engineered T cells

Authors: Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Ping Zhou, Zheming Lu

Journal: Clin Transl Immunology

PubMed ID: 36188121

Doi: 10.1002/cti2.1419

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Development of a GalNAc-Tyrosine-Specific Monoclonal Antibody and Detection of Tyrosine -GalNAcylation in Numerous Human Tissues and Cell Lines

Authors: Li Xia, Tiffany R Bellomo, Ruslan Gibadullin, Molly D Congdon, Elijah F Edmondson, Mi Li, Alexander Wlodawer, Crystal Li, J Sebastian Temme, Pavan Patel, Donna Butcher, Jeffrey C Gildersleeve

Journal: J Am Chem Soc

PubMed ID: 36054098

Doi: 10.1021/jacs.2c04477

Products & Services: Mammalian Expression

Febuxostat Alleviates Allergic Rhinitis by Inhibiting Inflammation and Monocyte Adhesion in Human Nasal Epithelial Cells via Regulating KLF6

Authors: Yuting Yao, Ran Wei, Hui Jiang

Journal: Evid Based Complement Alternat Med

PubMed ID: 36118091

Doi: 10.1155/2022/9092311

Products & Services: Gene Synthesis

Mitochondrial derived peptide MOTS-c prevents the development of heart failure under pressure overload conditions in mice

Authors: Peng Zhong, Jianye Peng, Yewen Hu, Jun Zhang, Caijie Shen

Journal: J Cell Mol Med

PubMed ID: 36156853

Doi: 10.1111/jcmm.17551

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Simple and practical sialoglycan encoding system reveals vast diversity in nature and identifies a universal sialoglycan-recognizing probe derived from AB5 toxin B subunits

Authors: Aniruddha Sasmal, Naazneen Khan, Zahra Khedri, Benjamin P Kellman, Saurabh Srivastava, Andrea Verhagen, Hai Yu, Anders Bech Bruntse, Sandra Diaz, Nissi Varki, Travis Beddoe, Adrienne W Paton, James C Paton, Xi Chen, Nathan E Lewis, Ajit Varki

Journal: Glycobiology

PubMed ID: 36048714

Doi: 10.1093/glycob/cwac057

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Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunity

Authors: Amir Ghaemi, Parisa Roshani Asl, Hedieh Zargaran, Delaram Ahmadi, Asim Ali Hashimi, Elahe Abdolalipour, Sahar Bathaeian, Seyed Mohammad Miri

Journal: Front Immunol

PubMed ID: 36159845

Doi: 10.3389/fimmu.2022.974364

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Effects of TAMP family on the tight junction strand network and barrier function in epithelial cells

Authors: Akira C Saito, Chisato Endo, Yugo Fukazawa, Tomohito Higashi, Hideki Chiba

Journal: Ann N Y Acad Sci

PubMed ID: 36069127

Doi: 10.1111/nyas.14889

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Riboflavin salvage by Borrelia burgdorferi supports carbon metabolism and is essential for survival in the tick vector

Authors: Darlene Ramos, Amanda G Lasseter, Crystal L Richards, Benjamin Schwarz, Susmita Ghosh, Berta Victoria, Catharine M Bosio, Frank C Gherardini, Mollie W Jewett

Journal: Mol Microbiol

PubMed ID: 36054485

Doi: 10.1111/mmi.14977

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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

Authors: Meghan E Spears, Namgyu Lee, Sunyoung Hwang, Sung Jin Park, Anne E Carlisle, Rui Li, Mihir B Doshi, Aaron M Armando, Jenny Gao, Karl Simin, Lihua Julie Zhu, Paul L Greer, Oswald Quehenberger, Eduardo M Torres, Dohoon Kim

Journal: Cell Rep

PubMed ID: 36170811

Doi: 10.1016/j.celrep.2022.111415

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Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein

Authors: Xiaoxiao Ren, Huijuan Zhu, Keyong Deng, Xiaotong Ning, Lin Li, Dan Liu, Bin Yang, Chenyang Shen, Xianqiang Wang, Naqiong Wu, Shufeng Chen, Dongfeng Gu, Laiyuan Wang

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 36172865

Doi: 10.1161/ATVBAHA.122.318158

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RUP2 facilitates UVR8 redimerization via two interfaces

Authors: Lixia Wang, Yidong Wang, Hongfei Chang, Hui Ren, Xinquan Wu, Jia Wen, Zeyuan Guan, Ling Ma, Liang Qiu, Junjie Yan, Delin Zhang, Xi Huang, Ping Yin

Journal: Plant Commun

PubMed ID: 36065466

Doi: 10.1016/j.xplc.2022.100428

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Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

Authors: Cathrine Scheepers, Prudence Kgagudi, Nonkululeko Mzindle, Elin S Gray, Thandeka Moyo-Gwete, Bronwen E Lambson, Brent Oosthuysen, Batsirai Mabvakure, Nigel J Garrett, Salim S Abdool Karim, Lynn Morris, Penny L Moore

Journal: PLoS Pathog

PubMed ID: 36054228

Doi: 10.1371/journal.ppat.1010450

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Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins

Authors: Edem Gavor, Yeu Khai Choong, Yonghao Liu, Julien Pompon, Eng Eong Ooi, Yu Keung Mok, Haiyan Liu, R Manjunatha Kini, J Sivaraman

Journal: PLoS Negl Trop Dis

PubMed ID: 36070318

Doi: 10.1371/journal.pntd.0010743

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Anti-Phytophthora Activity of Halofuginone and the Corresponding Mode of Action

Authors: Saisai Zhang, Jialing Cai, Yimeng Xie, Xinyu Zhang, Xilang Yang, Shenyuan Lin, Wensheng Xiang, Ji Zhang

Journal: J Agric Food Chem

PubMed ID: 36126316

Doi: 10.1021/acs.jafc.2c04266

Products & Services: Proteins, Expression, Isolation and Analysis

SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins

Authors: Tyler D R Vance, Patrick Yip, Elisabet Jiménez, Sheng Li, Diana Gawol, James Byrnes, Isabel Usón, Ahmed Ziyyat, Jeffrey E Lee

Journal: Commun Biol

PubMed ID: 36115925

Doi: 10.1038/s42003-022-03883-y

Products & Services: Proteins, Expression, Isolation and Analysis

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