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ABT1 modifies SMARD1 pathology via interactions with IGHMBP2 and stimulation of ATPase and helicase activity

Authors: Gangadhar P Vadla, Sara M Ricardez Hernandez, Jiude Mao, Mona O Garro-Kacher, Zachary C Lorson, Ronin P Rice, Sarah A Hansen, Christian L Lorson, Kamal Singh, Monique A Lorson

Journal: JCI Insight

PubMed ID: 36480289

Doi: 10.1172/jci.insight.164608

Products & Services: Molecular Biology Reagents

Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate

Authors: Weam S Shahin, Shima O Ebed, Scott R Tyler, Branko Miljkovic, Soon H Choi, Yulong Zhang, Weihong Zhou, Idil A Evans, Charles Yeaman, John F Engelhardt

Journal: Nat Commun

PubMed ID: 36707536

Doi: 10.1038/s41467-023-36174-z

Products & Services: Molecular Biology Reagents

CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

Authors: Jack T Whelan, Ragunath Singaravelu, Fuan Wang, Adrian Pelin, Levi A Tamming, Giuseppe Pugliese, Nikolas T Martin, Mathieu J F Crupi, Julia Petryk, Bradley Austin, Xiaohong He, Ricardo Marius, Jessie Duong, Carter Jones, Emily E F Fekete, Nouf Alluqmani, Andrew Chen, Stephen Boulton, Michael S Huh, Matt Y Tang, Zaid Taha, Elena Scut, Jean-Simon Diallo, Taha Azad, Brian D Lichty, Carolina S Ilkow, John C Bell

Journal: Front Immunol

PubMed ID: 36713447

Doi: 10.3389/fimmu.2022.1050250

Products & Services: Molecular Biology Reagents

Generation of RUNX1c-eGFP induced pluripotent stem cell, MUSIi012-A-4, using CRISPR/Cas9

Authors: Pimonwan Srisook, Chuti Laowtammathron, Chanchao Lorthongpanich, Phatchanat Klaihmon, Papussorn Terbto, Supaporn Waeteekul, Yaowalak U-Pratya, Surapol Issaragrisil

Journal: Stem Cell Res

PubMed ID: 36753833

Doi: 10.1016/j.scr.2023.103035

Products & Services: Gene Synthesis

Changes in Gene Chromatin Organization during Odontogenic Lineage Specification

Authors: Gokul Gopinathan, Xinmin Zhang, Xianghong Luan, Thomas G H Diekwisch

Journal: Genes (Basel)

PubMed ID: 36672939

Doi: 10.3390/genes14010198

Products & Services: Gene Synthesis

BML-111, the agonist of lipoxin A4, suppresses epithelial-mesenchymal transition and migration of MCF-7 cells regulating the lipoxygenase pathway

Authors: Fen Xu, Xiaoyan Zhou, Lan Lin, Jing Xu, Yu Feng, Yuanqiao He, Hua Hao

Journal: Int J Immunopathol Pharmacol

PubMed ID: 38134963

Doi: 10.1177/03946320231223826

Products & Services: Molecular Biology Reagents

SaaS sRNA promotes Salmonella intestinal invasion via modulating MAPK inflammatory pathway

Authors: Linlin Cai , Yunting Xie , Liangting Shao , Haijing Hu , Xinglian Xu , Huhu Wang , Guanghong Zhou

Journal: Gut Microbes .

PubMed ID: 37158502

Doi: 10.1080/19490976.2023.2211184

Products & Services: Gene Synthesis

Genetic diversity of Newcastle disease viruses circulating in wild and synanthropic birds in Ukraine between 2006 and 2015

Authors: Iryna V Goraichuk, Anton Gerilovych, Vitaliy Bolotin, Olexii Solodiankin, Kiril M Dimitrov, Oleksandr Rula, Nataliia Muzyka, Oleksandr Mezinov, Borys Stegniy, Olena Kolesnyk, Mary J Pantin-Jackwood, Patti J Miller, Claudio L Afonso, Denys Muzyka

Journal: Front Vet Sci

PubMed ID: 36742982

Doi: 10.3389/fvets.2023.1026296

Products & Services: Proteins, Expression, Isolation and Analysis

Nanoparticle vaccines can be designed to induce pDC support of mDCs for increased antigen display

Authors: Nina Butkovich, Jo Anne Tucker, Aaron Ramirez, Enya Li, Vijaykumar S Meli, Edward L Nelson, Szu-Wen Wang

Journal: Biomater Sci

PubMed ID: 36476811

Doi: 10.1039/d2bm01132h

Products & Services: Proteins, Expression, Isolation and Analysis

Potential Protective Function of Aβ Monomer on Tauopathies

Authors: Amber L H Gray, Victoria Norman, Damilola S Oluwatoba, Rebecca A Prosser, Thanh D Do

Journal: J Am Soc Mass Spectrom

PubMed ID: 36693165

Doi: 10.1021/jasms.2c00343

Products & Services: Proteins, Expression, Isolation and Analysis

MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma

Authors: Laura S Danielson, Maria V Guijarro, Silvia Menendez, Brett Higgins, Qiang Sun, Khushbakhat Mittal, Dorota A Popiolek, Michael Overholtzer, Glyn D Palmer, Eva Hernando

Journal: PLoS ONE

PubMed ID: 36701370

Doi: 10.1371/journal.pone.0278844

Products & Services: Molecular Biology Reagents

Differentially Expressed Genes and Signalling Pathways Regulated by High Selenium Involved in Antioxidant and Immune Functions of Goats Based on Transcriptome Sequencing

Authors: Xu Wang, Chao Ban, Jia-Xuan Li, Qing-Yuan Luo, Ji-Xiao Qin, Yi-Qing Xu, Qi Lu, Xing-Zhou Tian

Journal: Int J Mol Sci

PubMed ID: 36674636

Doi: 10.3390/ijms24021124

Products & Services: Molecular Biology Reagents

Ligand-dependent protein interactions of the juvenile hormone receptor captured in real time

Authors: Sarka Tumova, Marek Jindra

Journal: FEBS J

PubMed ID: 36609881

Doi: 10.1111/febs.16719

Products & Services: Molecular Biology Reagents

Discovery and validation of new Hv1 proton channel inhibitors with onco-therapeutic potential

Authors: Antoun El Chemaly, Vincent Jaquet, Yves Cambet, Aurélie Caillon, Ophélie Cherpin, Alexia Balafa, Karl-Heinz Krause, Nicolas Demaurex

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 36640925

Doi: 10.1016/j.bbamcr.2022.119415

Products & Services: Molecular Biology Reagents

His-tagged lactate oxidase production for industrial applications using fed-batch fermentation

Authors: Agustina Godino, Marilla Amaranto, Agustina Manassero, Fausto Comba, Martín Alonzo Pérez, Lucio Simonella, Martín Pernigotti, José L Barra

Journal: J Biotechnol

PubMed ID: 36608873

Doi: 10.1016/j.jbiotec.2022.12.011

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Protective Effects of against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles

Authors: Tianhua He, Nikita Lykov, Xu Luo, Huiling Wang, Zhanxiang Du, Ziyi Chen, Shitian Chen, Lin Zhu, Ye Zhao, Chimeng Tzeng

Journal: Int J Mol Sci

PubMed ID: 36768377

Doi: 10.3390/ijms24032053

Products & Services: Proteins, Expression, Isolation and Analysis

Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation

Authors: Pedro Madrigal, Siwei Deng, Yuliang Feng, Stefania Militi, Kim Jee Goh, Reshma Nibhani, Rodrigo Grandy, Anna Osnato, Daniel Ortmann, Stephanie Brown, Siim Pauklin

Journal: Nat Commun

PubMed ID: 36697417

Doi: 10.1038/s41467-023-36116-9

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Hyaluronate decorated polyethylene glycol linked poly(lactide-co-glycolide) nanoparticles encapsulating MUC-1 peptide augmented mucosal immune response in Balb/c mice through inhalation route

Authors: Kiran Jyoti, Garima Malik, Monika Chaudhary, Jitender Madan, Anjoo Kamboj

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 36731729

Doi: 10.1016/j.bbagen.2023.130317

Products & Services: Peptide Synthesis

Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates

Authors: Yuanyuan Zhang, Xinyu Zhao, Xiaona Dong, Yuying Zhang, Haixia Zou, Yaoguang Jin, Wei Guo, Peng Zhai, Xu Chen, Alexei Kharitonenkov

Journal: Cell Metab

PubMed ID: 36706758

Doi: 10.1016/j.cmet.2023.01.001

Products & Services: Proteins, Expression, Isolation and Analysis

Comparative analysis of allergenicity and predicted linear epitopes in α and β parvalbumin from turbot (Scophthalmus maximus)

Authors: Yuhao Huang, Zhenxing Li, Yeting Wu, Yonghong Li, Siddanakoppalu Pramod, Guanzhi Chen, Wenjia Zhu, Ziye Zhang, Hao Wang, Hong Lin

Journal: J Sci Food Agric

PubMed ID: 36606403

Doi: 10.1002/jsfa.12432

Products & Services: Proteins, Expression, Isolation and Analysis

Spike-mediated viral membrane fusion is inhibited by a specific anti-IFITM2 monoclonal antibody

Authors: Anna Basile , Carla Zannella , Margot De Marco , Giuseppina Sanna , Gianluigi Franci , Massimiliano Galdiero , Aldo Manzin , Vincenzo De Laurenzi , Massimiliano Chetta , Alessandra Rosati , Maria Caterina Turco , Liberato Marzullo

Journal: Antiviral Res

PubMed ID: 36669656

Doi: 10.1016/j.antiviral.2023.105546

Products & Services: Monoclonal Antibody Services

Click and bioorthogonal hyaluronic acid hydrogels as an ultra-tunable platform for the investigation of cell-material interactions

Authors: Nathan Lagneau, Pierre Tournier, Boris Halgand, François Loll, Yves Maugars, Jérôme Guicheux, Catherine Le Visage, Vianney Delplace

Journal: Bioact Mater

PubMed ID: 36632500

Doi: 10.1016/j.bioactmat.2022.12.022

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The establishment of multiple knockout mutants of Colletotrichum orbiculare by CRISPR-Cas9 and Cre-loxP systems

Authors: Kohji Yamada, Toya Yamamoto, Kanon Uwasa, Keishi Osakabe, Yoshitaka Takano

Journal: Fungal Genet Biol

PubMed ID: 36669556

Doi: 10.1016/j.fgb.2023.103777

Products & Services: Proteins, Expression, Isolation and Analysis

Association Between Human Immunodeficiency Virus Viremia and Compromised Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Beta Variant

Authors: Shi-Hsia Hwa, Jumari Snyman, Mallory Bernstein, Yashica Ganga, Sandile Cele, Daniel Muema, Chee Wah Tan, Khadija Khan, Farina Karim, Willem Hanekom, Leslie Bernstein, Stefan H E Kaufmann, Lin-Fa Wang, Thumbi Ndung'u, Alex Sigal

Journal: J Infect Dis

PubMed ID: 35975942

Doi: 10.1093/infdis/jiac343

Products & Services: Proteins, Expression, Isolation and Analysis

The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma

Authors: Yue Yan, Marc-Andre Gauthier, Ahmad Malik, Iosifina Fotiadou, Michael Ostrovski, Dzana Dervovic, Logine Ghadban, Ricky Tsai, Gerald Gish, Sampath Kumar Loganathan, Daniel Schramek

Journal: Cancers (Basel)

PubMed ID: 36765696

Doi: 10.3390/cancers15030737

Products & Services: Proteins, Expression, Isolation and Analysis

The FACT-targeted drug CBL0137 enhances the effects of rituximab to inhibit B-cell non-Hodgkin's lymphoma tumor growth by promoting apoptosis and autophagy

Authors: Yan Lv, Yuxin Du, Kening Li, Xiao Ma, Juan Wang, Tongde Du, Yuxin Ma, Yue Teng, Weiyan Tang, Rong Ma, Jianqiu Wu, Jianzhong Wu, Jifeng Feng

Journal: Cell Commun Signal

PubMed ID: 36691066

Doi: 10.1186/s12964-022-01031-x

Products & Services: Proteins, Expression, Isolation and Analysis

Functions of human olfactory mucus and age-dependent changes

Authors: Tomohiro Shirai, Dan Takase, Junkichi Yokoyama, Kuniyuki Nakanishi, Chisaki Uehara, Naoko Saito, Aya Kato-Namba, Keiichi Yoshikawa

Journal: Sci Rep

PubMed ID: 36653421

Doi: 10.1038/s41598-023-27937-1

Products & Services: Gene Synthesis

Plant production of a virus-like particle-based vaccine candidate against porcine reproductive and respiratory syndrome

Authors: Jordan T VanderBurgt, Ondre Harper, Christopher P Garnham, Susanne E Kohalmi, Rima Menassa

Journal: Front Plant Sci

PubMed ID: 36760639

Doi: 10.3389/fpls.2023.1044675

Products & Services: Proteins, Expression, Isolation and Analysis

Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs

Authors: Yuki Ono, Kouki Kawakami, Gaku Nakamura, Satoru Ishida, Junken Aoki, Asuka Inoue

Journal: Commun Biol

PubMed ID: 36709222

Doi: 10.1038/s42003-023-04465-2

Products & Services: Gene Synthesis

Unusual crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing in antigen presentation

Authors: Lenong Li, Xubiao Peng, Mansoor Batliwala, Marlene Bouvier

Journal: Res Sq

PubMed ID: 36747752

Doi: 10.21203/rs.3.rs-2500847/v1

Products & Services: Proteins, Expression, Isolation and Analysis

Comprehensive Comparison of Seven SARS-CoV-2-Specific Surrogate Virus Neutralization and Anti-Spike IgG Antibody Assays Using a Live-Virus Neutralization Assay as a Reference

Authors: Marianne Graninger, Claudia Maria Jani, Elisabeth Reuberger, Katja Prüger, Philipp Gaspar, David Niklas Springer, Christian Borsodi, Lisa Weidner, Susanne Rabady, Elisabeth Puchhammer-Stöckl, Christof Jungbauer, Eva Höltl, Judith Helene Aberle, Karin Stiasny, Lukas Weseslindtner

Journal: Microbiol Spectr

PubMed ID: 36622205

Doi: 10.1128/spectrum.02314-22

Products & Services: Proteins, Expression, Isolation and Analysis

Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47

Authors: Huanhuan Hu, Rongjie Cheng, Yanbo Wang, Xiaojun Wang, Jianzhuang Wu, Yan Kong, Shoubin Zhan, Zhen Zhou, Hongyu Zhu, Ranran Yu, Gaoli Liang, Qingyan Wang, Xiaoju Zhu, Chen-Yu Zhang, Rong Yin, Chao Yan , Xi Chen

Journal: The Journal of Clinical Investigation

PubMed ID: 36413402

Doi: 10.1172/JCI153470

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Identification of B-Cell Epitopes on Capsid Protein Reveals Two Potential Neutralization Mechanisms in Red-Spotted Grouper Nervous Necrosis Virus

Authors: Zhiqi Zhang, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan

Journal: J Virol

PubMed ID: 36633407

Doi: 10.1128/jvi.01748-22

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Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy

Authors: Justin M Quiles, Rita H Najor, Eileen Gonzalez, Monica Jeung, Wenjing Liang, Sarah M Burbach, Erika A Zumaya, Rachel Y Diao, Mark A Lampert, Åsa B Gustafsson

Journal: Sci Signal

PubMed ID: 36719945

Doi: 10.1126/scisignal.abo4457

Products & Services: Proteins, Expression, Isolation and Analysis

Functional characterization of a novel aminoglycoside phosphotransferase, APH(9)-Ic, and its variant from

Authors: Weina Shi, Junwan Lu, Chunlin Feng, Mengdi Gao, Anqi Li, Shuang Liu, Lei Zhang, Xueya Zhang, Qiaoling Li, Hailong Lin, Xi Lin, Kewei Li, Hailin Zhang, Yunliang Hu, Guangli Wang, Qiyu Bao, Weiyan Jiang

Journal: Front Cell Infect Microbiol

PubMed ID: 36699730

Doi: 10.3389/fcimb.2022.1097561

Products & Services: Proteins, Expression, Isolation and Analysis

Lactate oxidase/catalase-displaying nanoparticles efficiently consume lactate in the tumor microenvironment to effectively suppress tumor growth

Authors: Hyukjun Choi, Mirae Yeo, Yujin Kang, Hyo Jeong Kim, Seong Guk Park, Eunjung Jang, Sung Ho Park, Eunhee Kim, Sebyung Kang

Journal: J Nanobiotechnology

PubMed ID: 36597089

Doi: 10.1186/s12951-022-01762-6

Products & Services: Proteins, Expression, Isolation and Analysis

A linear DNA encoding the SARS-CoV-2 receptor binding domain elicits potent immune response and neutralizing antibodies in domestic cats

Authors: Antonella Conforti, Elisa Sanchez, Erika Salvatori, Lucia Lione, Mirco Compagnone, Eleonora Pinto, Fabio Palombo, Emanuela D'Acunto, Alessia Muzi, Giuseppe Roscilli, Yuhua Sun, Brian Viscount, James Hayward, Clay Shorrock, Diego G Diel, Joseph A Impellizeri, Luigi Aurisicchio

Journal: Mol Ther Methods Clin Dev

PubMed ID: 36618106

Doi: 10.1016/j.omtm.2022.12.015

Products & Services: Molecular Biology Reagents

AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer

Authors: Yongming Fu, Tuoyu Cao, Xiaorui Zou, Yubing Ye, Youhong Liu, Yuchong Peng, Tanggang Deng, Linglong Yin, Xiong Li

Journal: Oncogenesis

PubMed ID: 36593255

Doi: 10.1038/s41389-022-00446-y

Products & Services: Molecular Biology Reagents

The NLRP6 protein is very faintly expressed in several normal and cancerous epithelial cells and may be confused with an unrelated protein

Authors: Abdallah Mound, Gautier Goormachtigh, Fabrice Bray, Stéphanie Flament, Christian Rolando, Richard Ruez, Nathalie Martin, Amélie Decourcelle, Vanessa Dehennaut, Jean-Michel Saliou, Mathias Chamaillard, Corinne Abbadie

Journal: PLoS ONE

PubMed ID: 36662875

Doi: 10.1371/journal.pone.0279028

Products & Services: Plasmid DNA Preparation

Genomewide Association Study Identifies Copy Number Variants Associated With Warfarin Dose Response and Risk of Venous Thromboembolism in African Americans

Authors: Honghong Zhang, Cristina Alarcon, Larisa H Cavallari, Edith Nutescu, Gemma L Carvill, Minoli A Perera, Wenndy Hernandez

Journal: Clin Pharmacol Ther

PubMed ID: 36507737

Doi: 10.1002/cpt.2820

Products & Services: Molecular Biology Reagents

Cytochalasin B-Induced Membrane Vesicles from TRAIL-Overexpressing Mesenchymal Stem Cells Induce Extrinsic Pathway of Apoptosis in Breast Cancer Mouse Model

Authors: Daria S Chulpanova , Tamara V Pukhalskaia , Zarema E Gilazieva , Yuliya V Filina 1, Milana N Mansurova 1, Albert A Rizvanov 1, Valeriya V Solovyeva

Journal: Curr Issues Mol Biol .

PubMed ID: 36661524

Doi: 10.3390/cimb45010038

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α-Synuclein as a Target for Metallo-Anti-Neurodegenerative Agents

Authors: Kaiming Cao , Yang Zhu , Zhuanghao Hou , Manman Liu , Yanyan Yang , Hongze Hu , Yi Dai , Yu Wang , Siming Yuan , Guangming Huang , Jiaming Mei , Peter J Sadler , Yangzhong Liu

Journal: Angew Chem Int Ed Engl .

PubMed ID: 36345707

Doi: 10.1002/anie.202215360

Products & Services: Peptide Synthesis

Investigating the Sequence Specific Adsorption Behavior of Polypeptides at the Solid/Liquid Interface

Authors: Christopher S O'Bryan, Timothy J Murdoch, Daniel J Strickland, Katie A Rose, Denis Bendejacq, Daeyeon Lee, Russell J Composto

Journal: Langmuir

PubMed ID: 36637895

Doi: 10.1021/acs.langmuir.2c02292

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Vimentin epigenetic deregulation in Bladder Cancer associates with acquisition of invasive and metastatic phenotype through epithelial-to-mesenchymal transition

Authors: Sara Monteiro-Reis, Vera Miranda-Gonçalves, Catarina Guimarães-Teixeira, Cláudia Martins-Lima, João Lobo, Diana Montezuma, Paula C Dias, Helene Neyret-Kahn, Isabelle Bernard-Pierrot, Rui Henrique, Carmen Jerónimo

Journal: Int J Biol Sci

PubMed ID: 36594099

Doi: 10.7150/ijbs.77181

Products & Services: Proteins, Expression, Isolation and Analysis

SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression

Authors: Laura Cioetto-Mazzabò, Francesca Boldrin, Claire Beauvineau, Martin Speth, Alberto Marina, Amine Namouchi, Greta Segafreddo, Mena Cimino, Sandrine Favre-Rochex, Seetha Balasingham, Beatriz Trastoy, Hélène Munier-Lehmann, Gareth Griffiths, Brigitte Gicquel, Marcelo E Guerin, Riccardo Manganelli, Noelia Alonso-Rodríguez

Journal: Nucleic Acids Res

PubMed ID: 36546765

Doi: 10.1093/nar/gkac1173

Products & Services: Proteins, Expression, Isolation and Analysis

B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV

Authors: Jacopo Polvere, Massimiliano Fabbiani, Gabiria Pastore, Ilaria Rancan, Barbara Rossetti, Miriam Durante, Sara Zirpoli, Enrico Morelli, Elena Pettini, Simone Lucchesi, Fabio Fiorino, Mario Tumbarello, Annalisa Ciabattini, Francesca Montagnani, Donata Medaglini

Journal: Commun Med (Lond)

PubMed ID: 36717688

Doi: 10.1038/s43856-023-00245-5

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Identification of a Novel Interaction between Prohibitin (PHB-1) and Bovine RuvB-Like AAA ATPase 1

Authors: Prasanna Babu Araveti, Prajna Parimita Kar, Akshay Kuriakose, Achintya Sanju, Kota Arun Kumar, Anand Srivastava

Journal: Microbiol Spectr

PubMed ID: 36651733

Doi: 10.1128/spectrum.02502-22

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Cellular and humoral immunity to Ebola Zaire glycoprotein and viral vector proteins following immunization with recombinant vesicular stomatitis virus-based Ebola vaccine (rVSVΔG-ZEBOV-GP)

Authors: Vanessa Raabe, Lilin Lai, Juliet Morales, Yongxian Xu, Nadine Rouphael, Richard T Davey, Mark J Mulligan