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lectrochemical and Structural Study of the Buried Tryptophan in Azurin: Effects of Hydration and Polarity on the Redox Potential of W48

Authors: Kristin Tyson, Chanin B Tangtartharakul, Matthias Zeug, Nathan Findling, Alice Haddy, Eli Hvastkovs, Jun-Yong Choe, Judy E Kim, Adam R Offenbacher

Journal: The Journal of Physical Chemistry. B

PubMed ID: 36542812

Doi: 10.1021/acs.jpcb.2c06677

Products & Services: Gene Synthesis

Cryo-EM structures of orphan GPR21 signaling complexes

Authors: Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Fei Xu

Journal: nature communications

PubMed ID: 36639690

Doi: 10.1038/s41467-023-35882-w

Products & Services: Gene Services

Subunit Vaccine Targeting Phosphate ABC Transporter ATP-Binding Protein, PstB, Provides Cross-Protection against Serotype 2, 7, and 9 in Mice

Authors: Zujie Yan, Xiaohui Yao, Ruyi Pan, Junjie Zhang, Xiaochun Ma, Nihua Dong, Jianchao Wei, Ke Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A Jarvis, Mathew Upton, Xiangdong Li, Zhiyong Ma, Juxiang Liu, Beibei Li

Journal: Vet Sci

PubMed ID: 36669049

Doi: 10.3390/vetsci10010048

Products & Services: Proteins, Expression, Isolation and Analysis

A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells

Authors: Kakeru Sato, Tatsuya Seki, Asuka Mizutani, Yuka Muranaka, Shiho Hirota, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai, Masato Kobayashi

Journal: Front Pharmacol

PubMed ID: 36712667

Doi: 10.3389/fphar.2022.1069321

Products & Services: Proteins, Expression, Isolation and Analysis

Transcriptomic exploration of the Coleopteran wings reveals insight into the evolution of novel structures associated with the beetle elytron

Authors: David M Linz, Yuichiro Hara, Kevin D Deem, Shigehiro Kuraku, Shigeo Hayashi, Yoshinori Tomoyasu

Journal: J Exp Zool B Mol Dev Evol

PubMed ID: 36617687

Doi: 10.1002/jez.b.23188

Products & Services: Molecular Biology Reagents

Calmodulin variants associated with congenital arrhythmia impair selectivity for ryanodine receptors

Authors: Giuditta Dal Cortivo, Valerio Marino, Silvia Bianconi, Daniele Dell'Orco

Journal: Front Mol Biosci

PubMed ID: 36685279

Doi: 10.3389/fmolb.2022.1100992

Products & Services: DNA Sequencing

Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation

Authors: Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu, James Jeiwen Chou

Journal: Cell Res

PubMed ID: 36604598

Doi: 10.1038/s41422-022-00755-2

Products & Services: Plasmid DNA Preparation

Vaccination with S, an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice

Authors: Yongliang Zhao, Wenjia Ni, Simeng Liang, Lianghui Dong, Min Xiang, Zeng Cai, Danping Niu, Qiuhan Zhang, Dehe Wang, Yucheng Zheng, Zhen Zhang, Dan Zhou, Wenhua Guo, Yongbing Pan, Xiaoli Wu, Yimin Yang, Zhaofei Jing, Yongzhong Jiang, Yu Chen, Huan Yan, Yu Zhou, Ke Xu, Ke Lan

Journal: Sci Transl Med

PubMed ID: 36599007

Doi: 10.1126/scitranslmed.abo3332

Products & Services: Plasmids for SARS-CoV-2 Detection and Research

Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress

Authors: Samuel C Woodburn, Helina S Asrat, James K Flurer, Hana C Schwierling, Justin L Bollinger, Lauren L Vollmer, Eric S Wohleb

Journal: Brain Behav Immun

PubMed ID: 36681359

Doi: 10.1016/j.bbi.2023.01.014

Products & Services: Proteins, Expression, Isolation and Analysis

Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy

Authors: Ruifang Chi, Chanjuan Chai, Gaizhen Liu, Huili Cao, Bin Yang

Journal: Hum Cell

PubMed ID: 36627546

Doi: 10.1007/s13577-022-00851-w

Products & Services: Molecular Biology Reagents

Exploring the Expression and Function of cTyro3, a Candidate Zika Virus Receptor, in the Embryonic Chicken Brain and Inner Ear

Authors: Vashi Negi, Richard J Kuhn, Donna M Fekete

Journal: Viruses

PubMed ID: 36680287

Doi: 10.3390/v15010247

Products & Services: Proteins, Expression, Isolation and Analysis

Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies

Authors: Kenya Moore, Urmi Sengupta, Nicha Puangmalai, Nemil Bhatt, Rakez Kayed

Journal: Mol Neurobiol

PubMed ID: 36707462

Doi: 10.1007/s12035-023-03211-3

Products & Services: Proteins, Expression, Isolation and Analysis

A non-toxic recombinant bivalent chimeric protein rETXCSA as a potential vaccine candidate against enterotoxemia and braxy

Authors: Jige Du, Bo Liu, Tuanjie Wang, Zhen Zhu, Chunsheng Yin, Yufeng Luo, Ying Liu, Xiaoyun Chen

Journal: Vaccine

PubMed ID: 36635138

Doi: 10.1016/j.vaccine.2022.11.021

Products & Services: Molecular Biology Reagents

Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

Authors: Pei Yu, Zijian Liu, Zhuoqi Zhu, Jiaqing Yang, Min Deng, Mingxiao Chen, Changchun Lai, Weiya Kong, Shilong Xiong, Li Wan, Weikang Mai, Lu Chen, Yu Lei, Shahzad Akbar Khan, Jianfeng Ruan, An Kang, Xuguang Guo, Qiang Zhou, Wenrui Li, Zheng Chen, Yuemei Liang, Pingchao Li, Lei Zhang, Tianxing Ji

Journal: Virol Sin

PubMed ID: 36603767

Doi: 10.1016/j.virs.2022.12.008

Products & Services: Molecular Biology Reagents

Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern

Authors: Steven Y Gao, Nancy B Amaro-Mugridge, Jocelyn Madrid-Weiss, Nikolina Petkovic, Natasha Vanegas, Kumar Visvanathan, Bryan R G Williams, Jennifer A MacDiarmid, Himanshu Brahmbhatt

Journal: Front Immunol

PubMed ID: 36818474

Doi: 10.3389/fimmu.2022.1038562

Products & Services: Molecular Biology Reagents

Detection and Molecular Characterization of the SARS-CoV-2 Delta Variant and the Specific Immune Response in Companion Animals in Switzerland

Authors: Evelyn Kuhlmeier, Tatjana Chan, Cecilia Valenzuela Agüí, Barbara Willi, Aline Wolfensberger, Christian Beisel, Ivan Topolsky, Niko Beerenwinkel, Tanja Stadler, Sarah Jones, Grace Tyson, Margaret J Hosie, Katja Reitt, Julia Hüttl, Marina L Meli, Regina Hofmann-Lehmann

Journal: Viruses

PubMed ID: 36680285

Doi: 10.3390/v15010245

Products & Services: Proteins, Expression, Isolation and Analysis

Defending against SARS-CoV-2: The T cell perspective

Authors: Patricia Almendro-Vázquez, Rocío Laguna-Goya, Estela Paz-Artal

Journal: Front Immunol

PubMed ID: 36776863

Doi: 10.3389/fimmu.2023.1107803

Products & Services: Gene Synthesis

Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance

Authors: Dario Gerace, Quan Zhou, Jennifer Hyoje-Ryu Kenty, Adrian Veres, Elad Sintov, Xi Wang, Kyle R Boulanger, Hongfei Li, Douglas A Melton

Journal: Cell Rep Med

PubMed ID: 36599351

Doi: 10.1016/j.xcrm.2022.100879

Products & Services: Peptide Synthesis

Low-cost and prototype-friendly method for biocompatible encapsulation of implantable electronics with epoxy overmolding, hermetic feedthroughs and P3HT coating

Authors: Marek Novák, Jozef Rosina, Hana Bendová, Kristina Kejlová, Alena Vlková, Marian Rucki, Lada Svobodová, Robert Gürlich, Jan Hajer

Journal: Sci Rep

PubMed ID: 36717683

Doi: 10.1038/s41598-023-28699-6

Products & Services: Peptide Synthesis

Dependency of sanitation infrastructure on the discharge of faecal coliform and SARS-CoV-2 viral RNA in wastewater from COVID and non-COVID hospitals in Dhaka, Bangladesh

Authors: Nuhu Amin, Rehnuma Haque, Md Ziaur Rahman, Mohammed Ziaur Rahman, Zahid Hayat Mahmud, Rezaul Hasan, Md Tahmidul Islam, Protim Sarker, Supriya Sarker, Shaikh Daud Adnan, Nargis Akter, Dara Johnston, Mahbubur Rahman, Pengbo Liu, Yuke Wang, Tahmina Shirin, Mahbubur Rahman, Prosun Bhattacharya

Journal: Sci Total Environ

PubMed ID: 36623655

Doi: 10.1016/j.scitotenv.2023.161424

Products & Services: Custom DNA/RNA Oligos

Exploiting natural riboswitches for aptamer engineering and validation

Authors: Michael G Mohsen, Matthew K Midy, Aparaajita Balaji, Ronald R Breaker

Journal: Nucleic Acids Res

PubMed ID: 36617976

Doi: 10.1093/nar/gkac1218

Products & Services: CRISPR Plasmids

Monosynaptic restriction of the anterograde herpes simplex virus strain H129 for neural circuit tracing

Authors: Kyle B Fischer, Hannah K Collins, Yan Pang, Dheeraj S Roy, Ying Zhang, Guoping Feng, Shu-Jing Li, Adam Kepecs, Edward M Callaway

Journal: J Comp Neurol

PubMed ID: 36606699

Doi: 10.1002/cne.25451

Products & Services: Molecular Biology Reagents

Evaluation of a biotin-based surrogate virus neutralization test for detecting postvaccination antibodies against SARS-CoV-2 variants in sera

Authors: Min-Ju Ahn, Jung-Ah Kang, Su Min Hong, Kyu-Sun Lee, Dong Ho Kim, Daesub Song, Dae Gwin Jeong

Journal: Biochem Biophys Res Commun

PubMed ID: 36696754

Doi: 10.1016/j.bbrc.2023.01.052

Products & Services: Molecular Biology Reagents

PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer

Authors: Chakravarthy Garlapati, Shriya Joshi, Shristi Bhattarai, Jayashree Krishnamurthy, Ravi Chakra Turaga, Thi Nguyen, Xiaoxian Li, Ritu Aneja

Journal: Cell Death Dis

PubMed ID: 36627281

Doi: 10.1038/s41419-022-05539-5

Products & Services: Molecular Biology Reagents

Pold4 is dispensable for mouse development, DNA replication and DNA repair

Authors: Xueping Gu , Qinjin Dai , Peng Du , Ning Li , Jiahui Li , Simiao Zeng , Shuyi Peng , Shengjun Tang , Lei Wang , Zhongcheng Zhou

Journal: Gene

PubMed ID: 36356905

Doi: 10.1016/j.gene.2022.147029

Products & Services: Proteins, Expression, Isolation and Analysis

Expression and kinetic characterization of PYCR3 Kaylen

Authors: Kaylen R Meeks , John J Tanner

Journal: Arch Biochem Biophys

PubMed ID: 36414121

Doi: 10.1016/j.abb.2022.109468

Products & Services: Codon Optimization

Radiotherapy-Triggered Proteolysis Targeting Chimera Prodrug Activation in Tumors

Authors: Chunrong Yang , Yuchen Yang , Yujie Li , Qiankun Ni , Jinghong Li

Journal: J Am Chem Soc.

PubMed ID: 36542856

Doi: 10.1021/jacs.2c10177

Products & Services: Proteins, Expression, Isolation and Analysis

RsCLE22a regulates taproot growth through an auxin signaling-related pathway in radish (Raphanus sativus L)

Authors: Junhui Dong, Yan Wang, Liang Xu, Bingshuang Li, Kai Wang, Jiali Ying, Qing He, Liwang Liu

Journal: J Exp Bot

PubMed ID: 36239471

Doi: 10.1093/jxb/erac406

Products & Services: Peptide Synthesis

Atlantic cod () MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals

Authors: Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida

Journal: Front Cell Dev Biol

PubMed ID: 36760361

Doi: 10.3389/fcell.2023.1050323

Products & Services: Peptide Synthesis

Linoleic acid ameliorates intestinal mucosal barrier injury in early weaned pigeon squabs (Columba livia)

Authors: Qianqian Xu, Jin Zhao, Huafeng Jian, Jiangcheng Ye, Mingxiu Gong, Xiaoting Zou, Xinyang Dong

Journal: J Anim Sci

PubMed ID: 37186172

Doi: 10.1093/jas/skad125

Products & Services: Proteins, Expression, Isolation and Analysis

Mesenchymal stem cell-derived extracellular vesicles transfer miR-598 to inhibit the growth and metastasis of non-small-cell lung cancer by targeting THBS2

Authors: Xuebo Li, Fan Wu

Journal: Cell Death Discov

PubMed ID: 36609437

Doi: 10.1038/s41420-022-01283-z

Products & Services: Custom DNA/RNA Oligos

Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates

Authors: Daehun Park, Yumei Wu, Xinbo Wang, Swetha Gowrishankar, Aaron Baublis, Pietro De Camilli

Journal: Nat Commun

PubMed ID: 36709207

Doi: 10.1038/s41467-023-36081-3

Products & Services: Custom Vector Construction

CRISPR mediated transactivation in the human disease vector Aedes aegypti

Authors: Michelle Bui, Elena Dalla Benetta, Yuemei Dong, Yunchong Zhao, Ting Yang, Ming Li, Igor A Antoshechkin, Anna Buchman, Vanessa Bottino-Rojas, Anthony A James, Michael W Perry, George Dimopoulos, Omar S Akbari

Journal: PLoS Pathog

PubMed ID: 36656895

Doi: 10.1371/journal.ppat.1010842

Products & Services: Proteins, Expression, Isolation and Analysis

A method for mapping the linear epitopes targeted by the natural antibody response to Zika virus infection using a VLP platform technology

Authors: Alexandra Fowler, Chunyan Ye, Elizabeth C Clarke, Juan M Pascale, David S Peabody, Steven B Bradfute, Kathryn M Frietze, Bryce Chackerian

Journal: Virology

PubMed ID: 36623351

Doi: 10.1016/j.virol.2023.01.001

Products & Services: Peptide Synthesis

SARS-CoV-2-free residual proteins mediated phenotypic and metabolic changes in peripheral blood monocytic-derived macrophages in support of viral pathogenesis

Authors: Mohammad G Mohammad, Naglaa S Ashmawy, Ahmed M Al-Rawi, Ameera Abu-Qiyas, Alshaimaa M Hamoda, Rania Hamdy, Salam Dakalbab, Shahad Arikat, Dana Salahat, Mohamed Madkour, Sameh S M Soliman

Journal: PLoS ONE

PubMed ID: 36656874

Doi: 10.1371/journal.pone.0280592

Products & Services: Molecular Biology Reagents

RACK1 release from the Ribosome Couples Translational Regulation with Starving Signaling and Possibly Depends on Phosphorylation of Key Serine and Threonine Residues

Authors: Maria Kiratzis, Giancarlo Lai, Piera Calamita, Marilena Mancino, Marcello Iriti, Nicola Manfrini, Simone Gallo

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 37213164

Doi: 10.14715/cmb/2022.69.1.2

Products & Services: Proteins, Expression, Isolation and Analysis

Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal

Authors: Mikayla Hoad, Emily M Cross, Camilla M Donnelly, Subir Sarker, Justin A Roby, Jade K Forwood

Journal: Viruses

PubMed ID: 36851528

Doi: 10.3390/v15020315

Products & Services: Proteins, Expression, Isolation and Analysis

Maltose-Enhanced Exopolysaccharide Synthesis of through CRP-like Protein

Authors: Fanqiang Meng, Yunbin Lyu, Xiaoyu Chen, Fengxia Lu, Haizhen Zhao, Yingjian Lu, Mingwen Zhao, Zhaoxin Lu

Journal: J Agric Food Chem

PubMed ID: 36602107

Doi: 10.1021/acs.jafc.2c07880

Products & Services: Proteins, Expression, Isolation and Analysis

Loss-of-function KCa2.2 mutations abolish channel activity

Authors: Young-Woo Nam , Mohammad Asikur Rahman , Grace Yang , Razan Orfali , Meng Cui , Miao Zhang

Journal: Am J Physiol Cell Physiol

PubMed ID: 36717104

Doi: 10.1152/ajpcell.00584.2022

Products & Services: PCR Cloning and Subcloning

Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus

Authors: Laura Sandra Lello, Agneta Miilimäe, Liubov Cherkashchenko, Ailar Omler, Rachel Skilton, Rachel Ireland, David Ulaeto, Andres Merits

Journal: J Virol

PubMed ID: 36533950

Doi: 10.1128/jvi.01368-22

Products & Services: Gene Synthesis

Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Authors: Sangwook Oh, Xuming Mao, Silvio Manfredo-Vieira, Jinmin Lee, Darshil Patel, Eun Jung Choi, Andrea Alvarado, Ebony Cottman-Thomas, Damian Maseda, Patricia Y Tsao, Christoph T Ellebrecht, Sami L Khella, David P Richman, Kevin C O'Connor, Uri Herzberg, Gwendolyn K Binder, Michael C Milone, Samik Basu, Aimee S Payne

Journal: Nat Biotechnol

PubMed ID: 36658341

Doi: 10.1038/s41587-022-01637-z

Products & Services: Proteins, Expression, Isolation and Analysis

Circ-N4BP2L2 enhances mitochondrial function in non-small cell lung cancer cells through regulating the miR-135a-5p/ARL5B axis

Authors: Hongyang Shi, Yuqiang Ji, Yonghong Zhang, Yu Wang, Wei Li

Journal: Environ Toxicol

PubMed ID: 36637163

Doi: 10.1002/tox.23736

Products & Services: Proteins, Expression, Isolation and Analysis

Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines

Authors: Stephen J Staklinski, Mario C Chang, Rebecca C Ahrens-Nicklas, Shagun Kaur, Arianna K Stefanatos, Elizabeth E Dudenhausen, Matthew E Merritt, Michael S Kilberg

Journal: JIMD Rep

PubMed ID: 36873094

Doi: 10.1002/jmd2.12356

Products & Services: Molecular Biology Reagents

Magnaporthe oryzae pathotype Triticum (MoT) can act as a heterologous expression system for fungal effectors with high transcript abundance in wheat

Authors: Cassandra Jensen, Diane G O Saunders

Journal: Sci Rep

PubMed ID: 36596834

Doi: 10.1038/s41598-022-27030-z

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Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W

Authors: Jia Zang, Yulin Chen, Chao Liu, Linzhen Hu, Hongxia Zhao, Wenlong Ding, Ying Yuan, Shixian Lin

Journal: Nat Struct Mol Biol

PubMed ID: 36593310

Doi: 10.1038/s41594-022-00866-9

Products & Services: Proteins, Expression, Isolation and Analysis

Label-free impedimetric immunosensor for point-of-care detection of COVID-19 antibodies

Authors: Lian C T Shoute, Gaser N Abdelrasoul, Yuhao Ma, Pedro A Duarte, Cole Edwards, Ran Zhuo, Jie Zeng, Yiwei Feng, Carmen L Charlton, Jamil N Kanji, Shawn Babiuk, Jie Chen

Journal: Microsyst Nanoeng

PubMed ID: 36597510

Doi: 10.1038/s41378-022-00460-5

Products & Services: PCR Cloning and Subcloning

Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats

Authors: NicolasG.Glynos, Lily Carter, Soo Jung Lee, Youngsoo Kim , RobertT. Kennedy, GeorgeA. Mashour, Michael M. Wang & Jimo Borjigin

Journal: Scientific Reports

PubMed ID: 36609666

Products & Services: Polyclonal Antibody Services

The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae

Authors: Giovanni Covaleda-Cortés, Ariel Mechaly, Terry Brissac, Heike Baehre, Laura Devaux, Patrick England, Bertrand Raynal, Sylviane Hoos, Myriam Gominet, Arnaud Firon, Patrick Trieu-Cuot, Pierre Alexandre Kaminski

Journal: FEBS J

PubMed ID: 36629470

Doi: 10.1111/febs.16724

Products & Services: Molecular Biology Reagents

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q133 microdeletion syndrome

Authors: Brianna K Unda, Leon Chalil, Sehyoun Yoon, Savannah Kilpatrick, Courtney Irwin, Sansi Xing, Nadeem Murtaza, Anran Cheng, Chad Brown, Alexandria Afonso, Elizabeth McCready, Gabriel M Ronen, Jennifer Howe, Aurélie Caye-Eude, Alain Verloes, Brad W Doble, Laurence Faivre, Antonio Vitobello, Stephen W Scherer, Yu Lu, Peter Penzes, Karun K Singh

Journal: Mol Psychiatry

PubMed ID: 36604605

Doi: 10.1038/s41380-022-01937-5

Products & Services: DNA Sequencing

Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro

Authors: Liyin Wang, Xin Yu, Dongyan Zhang, Yingying Wen, Liyue Zhang, Yutong Xia, Jinbo Chen, Chen Xie, Hong Zhu, Jianping Tong, Ye Shen

Journal: J Photochem Photobiol B

PubMed ID: 36724628

Doi: 10.1016/j.jphotobiol.2023.112654

Products & Services: Proteins, Expression, Isolation and Analysis

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