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A Novel Brighter Bioluminescent Fusion Protein Based on ZZ Domain and Firefly Luciferase for Immunoassays

Authors: Vadim R Viviani, Jaqueline Rodrigues Silva, Paulo Lee Ho

Journal: Front Bioeng Biotechnol

PubMed ID: 34733833

Doi: 10.3389/fbioe.2021.755045

Products & Services: SARS-CoV-2 qRT-PCR Detection Assay

VpreB Surrogate Light Chain Expression in B-Lineage ALL: A Report from the Children's Oncology Group

Authors: Stuart Sheldon Winter, Amanda McCaustland, Chunxu Qu, No'eau Simeona, Nyla A Heerema, Andrew J Carroll, Brent L Wood, Gabriela Gheorghe, Charles G Mullighan, Bridget S Wilson

Journal: Blood Adv

PubMed ID: 34662891

Doi: 10.1182/bloodadvances.2021005245

Products & Services: Recombinant Antibody Expression

The colorful mantle of the giant clam Tridacna squamosa expresses a homolog of electrogenic sodium: Bicarbonate cotransporter 2 that mediates the supply of inorganic carbon to photosynthesizing symbionts

Authors: Mel V Boo, Shit F Chew, Yuen K Ip

Journal: PLoS ONE

PubMed ID: 34653199

Doi: 10.1371/journal.pone.0258519

Products & Services: Protein and Antibody Isolation

A Portable RT-LAMP/CRISPR Machine for Rapid COVID-19 Screening

Authors: Meysam Rezaei, Sajad Razavi Bazaz, Dorsa Morshedi Rad, Olga Shimoni, Dayong Jin, William Rawlinson, Majid Ebrahimi Warkiani

Journal: Biosensors (Basel)

PubMed ID: 34677325

Doi: 10.3390/bios11100369

Products & Services: Protein and Antibody Isolation

A New Light on Potential Therapeutic Targets for Colorectal Cancer Treatment

Authors: Wei-Lun Tsai, Chih-Yang Wang, Yu-Cheng Lee, Wan-Chun Tang, Gangga Anuraga, Hoang Dang Khoa Ta, Yung-Fu Wu, Kuen-Haur Lee

Journal: Biomedicines

PubMed ID: 34680556

Doi: 10.3390/biomedicines9101438

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Enzalutamide-Resistant Progression of Castration-Resistant Prostate Cancer Is Driven via the JAK2/STAT1-Dependent Pathway

Authors: Yong Luo, Xiaobing Yang, Spyridon P Basourakos, Xuemei Zuo, Dechao Wei, Jiahui Zhao, Mingchuan Li, Qiankun Li, Tao Feng, Pengju Guo, Yongguang Jiang

Journal: Front Mol Biosci

PubMed ID: 34746227

Doi: 10.3389/fmolb.2021.652443

Products & Services: Plasmid DNA Preparation

miR-29a-3p promotes migration and invasion in ameloblastoma via Wnt/β-catenin signaling by targeting catenin beta interacting protein 1

Authors: Sai Liu, Dongjuan Liu, Jinwen Liu, Jiayi Liu, Ming Zhong

Journal: Head Neck

PubMed ID: 34636093

Doi: 10.1002/hed.26888

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Protein identification by nanopore peptide profiling

Authors: Florian Leonardus Rudolfus Lucas, Roderick Corstiaan Abraham Versloot, Liubov Yakovlieva, Marthe T C Walvoort, Giovanni Maglia

Journal: Nat Commun

PubMed ID: 34608150

Doi: 10.1038/s41467-021-26046-9

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Neuroblastoma differentiation in vivo excludes cranial tumors

Authors: Randall W Treffy, Sriivatsan G Rajan, Xinghang Jiang, Lynne M Nacke, Usama A Malkana, L A Naiche, Dani E Bergey, Dianicha Santana, Vinodh Rajagopalan, Jan K Kitajewski, John P O'Bryan, Ankur Saxena

Journal: Dev Cell

PubMed ID: 34610330

Doi: 10.1016/j.devcel.2021.09.014

Products & Services: Plasmid DNA Preparation

Pentavalent Disabled Infectious Single Animal (DISA)/DIVA Vaccine Provides Protection in Sheep and Cattle against Different Serotypes of Bluetongue Virus

Authors: Piet A van Rijn, Mieke A Maris-Veldhuis, Massimo Spedicato, Giovanni Savini, René G P van Gennip

Journal: Vaccines (Basel)

PubMed ID: 34696258

Doi: 10.3390/vaccines9101150

Products & Services: Plasmid DNA Preparation

Cytochalasin B-induced membrane vesicles from human mesenchymal stem cells overexpressing TRAIL, PTEN and IFN-β1 can kill carcinoma cancer cells

Authors: Daria S Chulpanova, Zarema E Gilazieva, Elvira R Akhmetzyanova, Sevindzh K Kletukhina, Albert A Rizvanov, Valeriya V Solovyeva

Journal: Tissue Cell

PubMed ID: 34678531

Doi: 10.1016/j.tice.2021.101664

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Identification and evaluation of an appropriate housekeeping gene for real time gene profiling of hepatocellular carcinoma cells cultured in three dimensional scaffold

Authors: Anjana Kaveri Badekila, Praveen Rai, Sudarshan Kini

Journal: Mol Biol Rep

PubMed ID: 34665400

Doi: 10.1007/s11033-021-06830-y

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miR-301a-5p Regulates during Chicken Spermatogenesis

Authors: Qixin Guo, Yong Jiang, Hao Bai, Guohong Chen, Guobin Chang

Journal: Genes (Basel)

PubMed ID: 34828300

Doi: 10.3390/genes12111695

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Design of a chitosan-based nano vaccine against epsilon toxin of type D and evaluation of its immunogenicity in BALB/c mice

Authors: Farnaz Poorhassan, Fahimeh Nemati, Parvaneh Saffarian, Seyed Ali Mirhosseini, Mohammad Javad Motamedi

Journal: Res Pharm Sci

PubMed ID: 34760006

Doi: 10.4103/1735-5362.327504

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Serological response to mRNA and inactivated COVID-19 vaccine in healthcare workers in Hong Kong: decline in antibodies 12 weeks after two doses

Authors: J S T Zee, K T W Lai, M K S Ho, A C P Leung, L H Fung, W P Luk, L F Kwok, K M Kee, Q W L Chan, S F Tang, E S K Ma, K H Lee, C C Lau, R W H Yung

Journal: Hong Kong Med J

PubMed ID: 34657837

Doi: 10.12809/hkmj219744

Bright and stable luminescent probes for target engagement profiling in live cells

Authors: N Connor Payne, Alena S Kalyakina, Kritika Singh, Mark A Tye, Ralph Mazitschek

Journal: Nat Chem Biol

PubMed ID: 34675420

Doi: 10.1038/s41589-021-00877-5

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Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle-Based Small Interfering RNA

Authors: Xin Duan, Lei Cai, Christine T N Pham, Yousef Abu-Amer, Hua Pan, Robert H Brophy, Samuel A Wickline, Muhammad Farooq Rai

Journal: Arthritis Rheumatol

PubMed ID: 33982891

Doi: 10.1002/art.41794

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Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro

Authors: Masanori Tsubosaka, Masahiro Maruyama, Elijah Ejun Huang, Ning Zhang, Takeshi Utsunomiya, Qi Gao, Huaishuang Shen, Xueping Li, Junichi Kushioka, Hirohito Hirata, Zhenyu Yao, Yunzhi Peter Yang, Stuart B Goodman

Journal: Bioengineering (Basel)

PubMed ID: 34821731

Doi: 10.3390/bioengineering8110165

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Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effects

Authors: Sabrina Lusvarghi, Wei Wang, Rachel Herrup, Sabari Nath Neerukonda, Russell Vassell, Lisa Bentley, Ann E Eakin, Karl J Erlandson, Carol D Weiss

Journal: J Virol

PubMed ID: 34668774

Doi: 10.1128/JVI.01110-21

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The glycan hole area of HIV-1 envelope trimers contributes prominently to the induction of autologous neutralization

Authors: Anna Schorcht, Christopher A Cottrell, Pavel Pugach, Rajesh P Ringe, Alvin X Han, Joel D Allen, Tom L G M van den Kerkhof, Gemma E Seabright, Edith E Schermer, Thomas J Ketas, Judith A Burger, Jelle van Schooten, Celia C LaBranche, Gabriel Ozorowski, Natalia de Val, Daniel L V Bader, Hanneke Schuitemaker, Colin A Russell, David C Montefiori, Marit J van Gils, Max Crispin, P J Klasse, Andrew B Ward, John P Moore, Rogier W Sanders

Journal: J Virol

PubMed ID: 34669426

Doi: 10.1128/JVI.01552-21

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A dedicated flavin-dependent monooxygenase catalyzes the hydroxylation of demethoxyubiquinone into ubiquinone (coenzyme Q) in Arabidopsis

Authors: Scott Latimer, Shea A Keene, Lauren R Stutts, Antoine Berger, Ann C Bernert, Eric Soubeyrand, Janet Wright, Catherine F Clarke, Anna K Block, Thomas A Colquhoun, Christian Elowsky, Alan Christensen, Mark A Wilson, Gilles J Basset

Journal: J Biol Chem

PubMed ID: 34626646

Doi: 10.1016/j.jbc.2021.101283

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Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems

Authors: Virginia Hill, Hatice Akarsu, Rubén Sánchez Barbarroja, Valentina L Cippà, Peter Kuhnert, Martin Heller, Laurent Falquet, Manfred Heller, Michael H Stoffel, Fabien Labroussaa, Joerg Jores

Journal: PLoS Genet

PubMed ID: 34673769

Doi: 10.1371/journal.pgen.1009365

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The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains

Authors: Jocelyn D Weissman, Amit K Singh, Ballachanda N Devaiah, Peter Schuck, Ross C LaRue, Dinah S Singer

Journal: J Biol Chem

PubMed ID: 34688663

Doi: 10.1016/j.jbc.2021.101326

Products & Services: Protein and Antibody Isolation

Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases

Authors: Xiaojie Chu, Zehua Sun, Du-San Baek, Wei Li, John W Mellors, Steven D Shapiro, Dimiter S Dimitrov

Journal: Int J Mol Sci

PubMed ID: 34681796

Doi: 10.3390/ijms222011136

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A New Hybrid Protein Is a Novel Regulator for Experimental Colitis in Rats

Authors: Kohki Okada, Masaki Ikemoto

Journal: Inflammation

PubMed ID: 34628574

Doi: 10.1007/s10753-021-01537-5

Products & Services: Protein and Antibody Isolation

Characterization of a P-glycoprotein drug transporter from Toxocara canis with a novel pharmacological profile

Authors: Jeba R J Jesudoss Chelladurai, Douglas E Jones, Matthew T Brewer

Journal: Int J Parasitol Drugs Drug Resist

PubMed ID: 34753107

Doi: 10.1016/j.ijpddr.2021.10.002

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Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses

Authors: Xia Bu, Vikram R Juneja, Carol G Reynolds, Kathleen M Mahoney, Melissa T Bu, Kathleen A McGuire, Seth Maleri, Ping Hua, Baogong Zhu, Sarah R Klein, Edward A Greenfield, Philippe Armand, Jerome Ritz, Arlene H Sharpe, Gordon J Freeman

Journal: Cancer Immunol Res

PubMed ID: 34635486

Doi: 10.1158/2326-6066.CIR-21-0493

Products & Services: Peptide Synthesis

8-Hydroxyquinoline-Amino Acid Hybrids and Their Half-Sandwich Rh and Ru Complexes: Synthesis, Anticancer Activities, Solution Chemistry and Interaction with Biomolecules

Authors: Tamás Pivarcsik, Orsolya Dömötör, János P Mészáros, Nóra V May, Gabriella Spengler, Oszkár Csuvik, István Szatmári, Éva A Enyedy

Journal: Int J Mol Sci

PubMed ID: 34681939

Doi: 10.3390/ijms222011281

Products & Services: Gene Synthesis

Rapid development of analytical methods for evaluating pandemic vaccines: a COVID-19 perspective

Authors: Jeremy Baldwin, Sakshi Piplani, Isaac G Sakala, Yoshikazu Honda-Okubo, Lei Li, Nikolai Petrovsky

Journal: Bioanalysis

PubMed ID: 34645288

Doi: 10.4155/bio-2021-0096

Products & Services: Recombinant Proteins

High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1

Authors: Anja Bernhardt, Saskia Häberer, JingJing Xu, Hannah Damerau, Johannes Steffen, Charlotte Reichardt, Katharina Wolters, Hannes Steffen, Berend Isermann, Katrin Borucki, Nadine Artelt, Nicole Endlich, Renata Kozyraki, Sabine Brandt, Jonathan A Lindquist, Peter R Mertens

Journal: FASEB J

PubMed ID: 34533842

Doi: 10.1096/fj.202100667RR

Products & Services: Protein and Antibody Isolation

A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates

Authors: Chang Guo, Yanan Peng, Lin Lin, Xiaoyan Pan, Mengqi Fang, Yun Zhao, Keyan Bao, Runhan Li, Jianbao Han, Jiaorong Chen, Tian-Zhang Song, Xiao-Li Feng, Yahong Zhou, Gan Zhao, Leike Zhang, Yongtang Zheng, Ping Zhu, Haiying Hang, Linqi Zhang, Zhaolin Hua, Hongyu Deng, Baidong Hou

Journal: Cell Rep Med

PubMed ID: 34723223

Doi: 10.1016/j.xcrm.2021.100448

Products & Services: Protein and Antibody Isolation

Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence in blood and virulence in pigs infected with BeninΔDP148R

Authors: Vlad Petrovan, Anusyah Rathakrishnan, Muneeb Islam, Lynnette C Goatley, Katy Moffat, Pedro J Sanchez-Cordon, Ana L Reis, Linda K Dixon

Journal: J Virol

PubMed ID: 34643433

Doi: 10.1128/JVI.01340-21

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Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency

Authors: Hsi-En Ho, Lin Radigan, Gerold Bongers, Ahmed El-Shamy, Charlotte Cunningham-Rundles

Journal: JCI Insight

PubMed ID: 34622805

Doi: 10.1172/jci.insight.144777

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Self-inhibitory peptides targeting the MtrCDE efflux pump increase antibiotic susceptibility

Authors: Benjamin J Evert, Valentin A Slesarenko, Jilsy M J Punnasseril, Jian Zhan, Yaoqi Zhou, Evgeny A Semchenko, Kate L Seib

Journal: Antimicrob Agents Chemother

PubMed ID: 34633841

Doi: 10.1128/AAC.01542-21

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Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to regulate proliferation, migration, invasion and apoptosis of oral squamous cell carcinoma cells

Authors: Ying Zhou, Shuhong Zhang, Zhonghan Min, Zhongwei Yu, Huaiwei Zhang, Jiao Jiao

Journal: BMC Cancer

PubMed ID: 34620126

Doi: 10.1186/s12885-021-08779-4

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The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2

Authors: Ria Aryani Hayuningtyas, Myeonggil Han, Seoyeon Choi, Man Sup Kwak, In Ho Park, Ji-Hyun Lee, Ji Eun Choi, Dae Ki Kim, Myoungsun Son, Jeon-Soo Shin

Journal: Mol Med

PubMed ID: 34602056

Doi: 10.1186/s10020-021-00388-y

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Biochemical and structural studies of two tetrameric nucleoside 2'-deoxyribosyltransferases from psychrophilic and mesophilic bacteria: Insights into cold-adaptation

Authors: Jesús Fernández-Lucas, Iván Acebrón, Ruiying Y Wu, Yohana Alfaro, Javier Acosta, Pierre A Kaminski, Miguel Arroyo, Andrzej Joachimiak, Boguslaw P Nocek, Isabel De la Mata, José M Mancheño

Journal: Int J Biol Macromol

PubMed ID: 34624379

Doi: 10.1016/j.ijbiomac.2021.09.164

Products & Services: Molecular Biology Reagents

The Slower Antibody Response in Myelofibrosis Patients after Two Doses of mRNA SARS-CoV-2 Vaccine Calls for a Third Dose

Authors: Fabio Fiorino, Anna Sicuranza, Annalisa Ciabattini, Adele Santoni, Gabiria Pastore, Martina Simoncelli, Jacopo Polvere, Sara Galimberti, Stefano Auddino, Claudia Baratè, Francesca Montagnani, Vincenzo Sammartano, Monica Bocchia, Donata Medaglini

Journal: Biomedicines

PubMed ID: 34680595

Doi: 10.3390/biomedicines9101480

Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid protein

Authors: Chao Wu, Abraham J Qavi, Austin B Moyle, Nicole D Wagner, Asmaa Hachim, Niloufar Kavian, Aidan R Cole, Joyce Sweeney-Gibbons, Henry W Rohrs, J S Malik Peiris, Christopher F Basler, Michael L Gross, Sophie A Valkenburg, Christopher W Farnsworth, Gaya K Amarasinghe, Daisy W Leung

Journal: STAR Protoc

PubMed ID: 34642671

Doi: 10.1016/j.xpro.2021.100906

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Protective effect of sargahydroquinoic acid against Aβ-evoked damage via PI3K/Akt mediated Nrf2 antioxidant defense system

Authors: Jeong-Hyun Yoon, Kumju Youn, Mira Jun

Journal: Biomed Pharmacother

PubMed ID: 34619494

Doi: 10.1016/j.biopha.2021.112271

Products & Services: Protein and Antibody Isolation

Systemic autoimmune myopathies: A prospective phase 4 controlled trial of an inactivated virus vaccine against SARS-CoV-2

Authors: Samuel K Shinjo, Fernando H C de Souza, Isabela B P Borges, Alexandre M Dos Santos, Renata Miossi, Rafael G Misse, Ana C Medeiros-Ribeiro, Carla G S Saad, Emily F N Yuki, Sandra G Pasoto, Léonard V K Kupa, Carina Ceneviva, Júlia C Seraphim, Tatiana N Pedrosa, Margarete B G Vendramini, Clóvis A Silva, Nádia E Aikawa, Eloisa Bonfá

Journal: Rheumatology (Oxford)

PubMed ID: 34664616

Doi: 10.1093/rheumatology/keab773

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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Authors: Thushan I de Silva, Guihai Liu, Benjamin B Lindsey, Danning Dong, Shona C Moore, Nienyun Sharon Hsu, Dhruv Shah, Dannielle Wellington, Alexander J Mentzer, Adrienn Angyal, Rebecca Brown, Matthew D Parker, Zixi Ying, Xuan Yao, Lance Turtle, Susanna Dunachie, Mala K Maini, Graham Ogg, Julian C Knight, Yanchun Peng, Sarah L Rowland-Jones, Tao Dong

Journal: iScience

PubMed ID: 34729465

Doi: 10.1016/j.isci.2021.103353

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Transgenic genome editing-derived antiviral therapy to nucleopolyhedrovirus infection in the industrial strain of the silkworm

Authors: Xu Yang, Xiaoqian Zhang, Yujia Liu, Dehong Yang, Zulian Liu, Kai Chen, Linmeng Tang, Manli Wang, Zhihong Hu, Shengxiang Zhang, Yongping Huang

Journal: Insect Biochem Mol Biol

PubMed ID: 34700022

Doi: 10.1016/j.ibmb.2021.103672

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Establishment of a pig CRISPR/Cas9 knockout library for functional gene screening in pig cells

Authors: Chuanzhao Yu, Haiwen Zhong, Xiaohui Yang, Guoling Li, Zhenfang Wu, Huaqiang Yang

Journal: Biotechnol J

PubMed ID: 34705337

Doi: 10.1002/biot.202100408

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Tong‑fu‑li‑fei decoction attenuates immunosuppression to protect the intestinal‑mucosal barrier in sepsis by inhibiting the PD‑1/PD‑L1 signaling pathway

Authors: Li Chen, Lan Li, Suzhao Zou, Qianhua Liao, Bo Lv

Journal: Mol Med Rep

PubMed ID: 34633052

Doi: 10.3892/mmr.2021.12480

Products & Services: Nucleic Acid Purification

Topmouth culter melanocortin-3 receptor: regulation by two isoforms of melanocortin-2 receptor accessory protein 2

Authors: Ren-Lei Ji, Lu Huang, Yin Wang, Ting Liu, Si-Yu Fan, Min Tao, Ya-Xiong Tao

Journal: Endocr Connect

PubMed ID: 34678761

Doi: 10.1530/EC-21-0459

Products & Services: Nucleic Acid Purification

Determining folding and binding properties of the C-terminal SH2 domain of SHP2

Authors: Caterina Nardella, Francesca Malagrinò, Livia Pagano, Serena Rinaldo, Stefano Gianni, Angelo Toto

Journal: Protein Sci

PubMed ID: 34605082

Doi: 10.1002/pro.4201

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Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination

Authors: Dong-Ho Jo, Dohsik Minn, Jaegyun Lim, Ki-Deok Lee, Yu-Min Kang, Kang-Won Choe, Kwang-Nam Kim

Journal: Vaccines (Basel)

PubMed ID: 34696253

Doi: 10.3390/vaccines9101145

Products & Services: Mammalian Expression

Structural basis of cytokine-mediated activation of ALK family receptors

Authors: Steven De Munck, Mathias Provost, Michiko Kurikawa, Ikuko Omori, Junko Mukohyama, Jan Felix, Yehudi Bloch, Omar Abdel-Wahab, J Fernando Bazan, Akihide Yoshimi, Savvas N Savvides

Journal: Nature

PubMed ID: 34646012

Doi: 10.1038/s41586-021-03959-5

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Nanobody-based CTLA4 inhibitors for immune checkpoint blockade therapy of canine cancer patients

Authors: Jonathan Marable, Damien Ruiz, Anil K Jaiswal, Ritankar Bhattacharya, Robert Pantazes, Payal Agarwal, Amol S Suryawanshi, Deepa Bedi, Amarjit Mishra, Bruce F Smith, Maninder Sandey

Journal: Sci Rep

PubMed ID: 34675296

Doi: 10.1038/s41598-021-00325-3

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